Abstract Number: 1010 • 2014 ACR/ARHP Annual Meeting
Catecholaminergic-to-Cholinergic Transition of Sympathetic Nerve Fibers in Arthritis and in a Co-Culture System of Sympathetic Ganglia in Vitro
Background/Purpose: Sympathetic nerve fibers play an important role in bone and tissue homeostasis of joints. However sympathetic nerve fibers are able to switch their phenotype…Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting
Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis
Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…Abstract Number: 1009 • 2014 ACR/ARHP Annual Meeting
Regeneration of Articular Cartilage in Situ with Bone Marrow-Derived Mesenchymal Stem Cells
Background/Purpose Regeneration of hyaline cartilage has been an attractive approach to cartilage repair and therapy of osteoarthritis (OA), but remains to be a challenge. SOX9…Abstract Number: 1008 • 2014 ACR/ARHP Annual Meeting
Autophagy Activation Protects from Mitochondrial Dysfunction in Human Chondrocytes
Background/Purpose Autophagy, is a key pathway of cellular homeostasis for removing damaged macromolecules and organelles, including mitochondria. Recent studies indicate that autophagy activation is defective…Abstract Number: 1007 • 2014 ACR/ARHP Annual Meeting
Markedly Increased Mesenchymal Stem Cell Activity in MRI Bone Marrow Lesions Compared with Non-Involved Bone in Osteoarthritic Hips
Background/Purpose Multipotent mesenchymal stem cells (MSCs) are critical for bone and cartilage repair but the role of such cells in vivo in hip OA is…Abstract Number: 1006 • 2014 ACR/ARHP Annual Meeting
Interleukin-4 As Promising, Anti-Inflammatory Transgene for Gene Therapeutic Application in Joint Diseases
Background/Purpose Interleukin- 4 (IL-4), a Th2-cell released immunomodulatory factor, has potent chondroprotective and anti-inflammatory properties able to inhibit the synthesis of IL-1β and TNFα, and…Abstract Number: 1004 • 2014 ACR/ARHP Annual Meeting
Elevated Levels of BMP2 Compensate for Loss of TGF-Beta in Articular Cartilage during Experimental Osteoarthritis
Background/Purpose: We have demonstrated that TGF-beta signaling via Smad2/3 is drastically reduced in articular cartilage (AC) with age and loss of Smad2/3-signaling predisposed AC for…Abstract Number: 1005 • 2014 ACR/ARHP Annual Meeting
Histone Lysine Demethylase KDM6A Mediates Joint Destruction in Osteoarthritic Knees By Epigenetic Disturbance of SOX9 Promoter and Histone H3K27
Background/Purpose: Intensive articular cartilage deterioration and synovial fibrosis in joints are prominently pathogenic features of osteoarthritic (OA) knees. Epigenetic reactions in joint microenvironments are linked…Abstract Number: 1003 • 2014 ACR/ARHP Annual Meeting
Proteomic Analysis of Connexin 43 Reveals Novel Interactors Related to Osteoarthritis
Background/Purpose: We have previously reported that articular chondrocytes in tissue contain long cytoplasmic arms that physically connect two distant cells. Cell-to-cell communication occurs through connexin…Abstract Number: 1002 • 2014 ACR/ARHP Annual Meeting
Global Transcriptome Analysis in Osteoarthritic Cartilage Reveals Significant Differential Gene Expression and Associations with Histologic Disease Progression
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability affecting 40% of individuals over the age of 70 and costing $128 billion annually in…Abstract Number: 1001 • 2014 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes Inhibit Wnt Signaling Pathway By Secreting Dockcop-1
Background/Purpose: There is evidence of osteoclast activation in the inflamed joints of patients with rheumatoid arthritis (RA). Studies that focus on osteoblasts are not sufficient…Abstract Number: 1020 • 2014 ACR/ARHP Annual Meeting
Changes in Peripheral Blood Immune Cell Composition in Osteoarthritis
Background/Purpose: Healthy ageing and the occurrence of the common age-related disease osteoarthritis (OA) result from varying degrees of interaction between many determinants (genetic, lifestyle). Immuno-senescence…Abstract Number: 1019 • 2014 ACR/ARHP Annual Meeting
Targeting the Bone-Driven Metabolic OA Phenotype By a Novel Dual Amylin Calcitonin Receptor Agonist, KBP-056
Background/Purpose: Osteoarthritis (OA) may be segregated into different disease phenotypes based on disease drivers; cartilage damage, joint inflammation or subchondral bone remodelling. Each phenotype may…Abstract Number: 1018 • 2014 ACR/ARHP Annual Meeting
Monolayer Culture Induced the Expression of Zyxin-Related Protein 1 (ZRP-1), αvβ3 integrin Complex and Leptin in Human Articular Chondrocytes
Background/Purpose During Osteoarthritis (OA), chondrocytes loose their initial anabolic properties, undergoing morphological and biochemical modifications similar to those encountered during chondrocyte dedifferentiation. However, the molecular…Abstract Number: 989 • 2014 ACR/ARHP Annual Meeting
Fcgamma Receptor IIb Facilitates Rapid Internalisation of Rituximab (type 1 anti-CD20 antibody) in B Cells from Patients with RA and SLE and Contributes to Less Efficient B Cell Lysis Than Type 2 Anti-CD20 Antibodies, in Vitro
Background/Purpose Incomplete B-cell depletion using rituximab (RTX) is associated with poor clinical response in some individuals with RA and SLE, in particular. However, the precise…
ACR Meeting Abstracts