Abstracts Archive - Page 2163 of 2607 - ACR Meeting Abstracts

Abstract Number: 1054 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Factor, Not ACPA, Is Associated with Disease Activity in Rheumatoid Arthritis
Daniel Aletaha¹, Farideh Alasti² and Josef Smolen³, ¹Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose To investigate the associations of rheumatoid factor (RF) and autoantibodies against citrullinated proteins (ACPA) with rheumatoid arthritis (RA) disease activity.Methods We analyzed the association…
Abstract Number: 1053 • 2014 ACR/ARHP Annual Meeting
Co-Morbidity Is Associated with Disease Severity in Early Rheumatoid Arthritis
Christopher Sparks¹, Aleena Abdullah², Steven Zhao³, Cristina Estrach³ and Nicola Goodson¹, ¹Musculoskeletal Biology1, University of Liverpool, Liverpool, United Kingdom, ²Musculoskeletal biology1, University of Liverpool, Liverpool, United Kingdom, ³Rheumatology, University Hospital Aintree, Liverpool, United Kingdom
Background/Purpose Co-morbidity has been shown to increase length of hospital stay and mortality in hospitalised patients. However, in early rheumatoid arthritis (eRA) co-morbidity may confound…
Abstract Number: 1052 • 2014 ACR/ARHP Annual Meeting
Time Trends in Comorbidities Among Patients with Rheumatoid Arthritis Compared to the General Population
Cynthia S. Crowson¹, John M. Davis III², Brittny T. Major¹, Eric L. Matteson², Terry M. Therneau³ and Sherine E. Gabriel⁴, ¹Health Sciences Research, Mayo Clinic, Rochester, MN, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Health Sciences Research & Div of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Rheumatoid arthritis (RA) related comorbidities are major determinants of morbidity and mortality. Little is known regarding the trends in these conditions. The purpose of…
Abstract Number: 1051 • 2014 ACR/ARHP Annual Meeting
Rates of Renal Remission with Immunosuppressives in Lupus Nephritis: A Systematic Review and Network Meta-Analysis
Jasvinder A. Singh¹, Ahmed Kotb², Alomgir Hossain², Amy Mudano³ and George Wells⁴, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Ottawa, Ottawa, ON, Canada, ³Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, ⁴Cardiovascular Resarch Methods Centre, University of Ottawa Heart Institute, Ottawa, ON, Canada
Background/Purpose To compare renal remission rates with immunosuppressives by performing a systematic review and network meta-analyses (NMA) of RCTs of lupus nephritis. Methods We performed…
Abstract Number: 1050 • 2014 ACR/ARHP Annual Meeting
A Role for Purinergic Receptor Signalling in Basic Calcium Phosphate Crystal-Induced Inflammation
Clare C. Cunningham¹, Emma M. Corr¹, Geraldine M. McCarthy² and Aisling Dunne¹, ¹School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, ²Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Basic calcium phosphate (BCP) crystals are uniquely associated with osteoarthritis (OA). They are found in the majority of affected joints and closely correlate with…
Abstract Number: 1049 • 2014 ACR/ARHP Annual Meeting
Bioactive TGF-β Is Present on Bovine Milk-Derived Exosomes: Consequences for Patients?
Bartijn C.H. Pieters, Onno J. Arntz, Mathijs G.A. Broeren, Arjan van Caam, Peter M. van der Kraan, Marieke de Vries and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Development of rheumatoid arthritis (RA) is associated with different genetic and environmental factors. We postulate that cow milk could be such an environmental trigger…
Abstract Number: 1048 • 2014 ACR/ARHP Annual Meeting
Oncostatin M Suppresses Activation of IL-17/Th17 Via Suppressor of Cytokine signaling3 (SOCS3) Regulation in CD4+ T Cells
Young Ok Jung^1,2, seon Yeong Lee³, Sung Yeon Lee⁴, Mi-La Cho³ and Hea-Jin Son⁵, ¹Rheumatology dept, Internal medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, ²Rheumatology dept, Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Department of Internal Medicine, Hallym University Sacred Heart Hospital, Gyeonggi-do, South Korea, ⁵Rheumatism Research Center, Catholic Institutes of Medical Science, The Catholic University of Korea, Seoul, South Korea
Background/Purpose Oncostatin M (OSM) is a pleiotropic cytokine that belongs to the interleukin(IL)-6 group of cytokines. High level of OSM were detected in synoviums of…
Abstract Number: 1047 • 2014 ACR/ARHP Annual Meeting
Type I and II Interferon Signatures in Sjogren’s Syndrome: Contributions in Distinct Clinical Phenotypes and Sjogren’s Related Lymphomagenesis
Adrianos Nezos¹, Fotini Gravani², Efstathia K. Kapsogeorgou³, Michael Voulgarelis⁴, Haralampos M. Moutsopoulos⁴, Mary K. Crow⁵ and Clio Mavragani⁶, ¹Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Department of Rheumatology, General Hospital of Athens "G.Gennimatas", Athens, Greece, ³Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece, ⁴Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ⁵Department of Medicine, Hospital for Special Surgery, New York, NY, ⁶Department of Physiology, School of Medicine, University of Athens, Athens, Greece
Background/Purpose: Both type I and II interferons (IFNs) have been implicated in the pathogenesis of Sjogren’s syndrome (SS). We aimed to explore the contribution of…
Abstract Number: 1046 • 2014 ACR/ARHP Annual Meeting
Modulatory Effect of Adiponectin on Apoptosis and Proliferation of Synovial Fibroblasts from Rheumatoid Arthritis Patients
Wei Yu¹, Wenfeng Tan² and Miaojia Zhang³, ¹Department of Rheumatology, The First Affiliated Hospital of Nanjing Medical University, nanjing, China, ²Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ³the first affliated hospital with nanjing medical univercity, nanjing, China
Background/Purpose We previously reported that adiponectin (AD) is highly expressed in the inflammatory joint of rheumatoid arthritis (RA) patients and closely correlated with progressive bone…
Abstract Number: 1045 • 2014 ACR/ARHP Annual Meeting
Tertiary Lymphoid Organ Developmental Program: Diversgent Paradigm of Lymphoid Organogenesis
Saba Nayar¹, Bridget Glaysher², Joana Campos³, Jorge Caamano³, David Withers⁴, Kai Toellner³, Sanjiv Luther⁵, Mark Coles⁶, Christopher Buckley⁷ and Francesca Barone¹, ¹Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, ²Centre for Immunology and Infection, University of York, york, United Kingdom, ³University of Birmingham, Birmingham, United Kingdom, ⁴Infection and Immunity, University of Birmingham, Birmingham, United Kingdom, ⁵Chemin Des Boveresses 155, Losanne University, Epalinges, Switzerland, ⁶Centre for Immunology and Infection, University of York, York, United Kingdom, ⁷Rheumatology Research Group, The University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Tertiary lymphoid organs (TLOs) represent the histological hallmark of many immune-mediated inflammatory diseases. TLOs are characterized by a functional leukocyte aggregation and network of…
Abstract Number: 1044 • 2014 ACR/ARHP Annual Meeting
Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis
Trudy McGarry¹, Mary Connolly¹, Rebecca C. Coll², Avril A. B. Robertson³, Matthew A. Cooper³, Luke A. O'Neill², Douglas J. Veale¹ and Ursula Fearon¹, ¹Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ²Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland, ³The University of Queensland, Brisbane, Australia
Background/Purpose: The NLRP3 inflammasome is a multi-protein complex activated in response to environmental pathogens. This results in caspase-1-dependant cleavage of pro-IL-1β and IL-18 to their…
Abstract Number: 1043 • 2014 ACR/ARHP Annual Meeting
Identification of Putative Biomarkers and Molecular Mechanisms Associated with Adverse Tissue Reactions to Metal-on-Metal and Modular Neck Hip Implants
Ed Purdue¹, Gabrielle Wilner², Kritti Kolatat², Geoffrey H. Westrich³, Friedrich Boettner⁴, Seth Jerabek⁴ and Steven R. Goldring⁵, ¹535 East 70th Street, Hospital for Special Surgery, New York, NY, ²Research, Hospital for Special Surgery, New York, NY, ³Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, New York, NY
Background/Purpose Total hip replacement (THR) is a highly successful treatment for degenerative arthritis, alleviating pain and restoring joint function in the vast majority of patients.…
Abstract Number: 1042 • 2014 ACR/ARHP Annual Meeting
IL-1β and TNF-α Promote Monocyte Viability through the Induction of GM-CSF Expression By Rheumatoid Arthritis Synovial Fibroblasts
Christelle Darrieutort-Laffite^1,2, Marie Astrid Boutet¹, Mathias Chatelais¹, Regis Brion³, Frederic Blanchard¹, Dominique Heymann³ and Benoit Le Goff^1,2, ¹Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, INSERM, UMR 957, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, INSERM, UMR 957, Nantes, France
Background/Purpose Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). They can interact in the synovial micro-environment…
Abstract Number: 1041 • 2014 ACR/ARHP Annual Meeting
Imaging the Role of Chemoattractants in Inflammatory Arthritis
Yoshishige Miyabe¹, Thomas T. Murooka¹, Chie Miyabe¹, Nancy Kim², Thorsten R. Mempel¹ and Andrew D. Luster¹, ¹Massachusetts General Hospital, Charlestown, MA, ²Div of Rheumatology, Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil recruitment into the diseased joint. Our previous studies and the work of others have demonstrated…
Abstract Number: 1060 • 2014 ACR/ARHP Annual Meeting
Musculoskeletal Surgeries and Procedures in Patients with RA: Results from a UK Retrospective Study
H Cawston¹, F Bourhis¹, T Le² and E Alemao³, ¹OptumInsight, Nanterre, France, ²Bristol-Myers Squibb, Hopewell, NJ, ³Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Musculoskeletal surgeries and procedures substantially improve the quality of life of patients with RA, but represent an important burden in terms of medical costs.…

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