Abstract Number: 1233 • 2014 ACR/ARHP Annual Meeting
Tocilizumab (TCZ) in the Treatment of AA Amyloidosis in Patients with Familial Mediterranean Fever
Background/Purpose: AA amyloidosis is the major long-term complication of various chronic inflammatory diseases like rheumatoid arthritis, ankylosing spondylitis, FMF and other autoinflammatory syndromes. Treatment of…Abstract Number: 1232 • 2014 ACR/ARHP Annual Meeting
Canakinumab Therapy in Patients with Familial Mediterranean Fever
Background/Purpose: According to a recent pilot study Canakinumab reduced the frequency of attacks in 9 patients with Familial Mediterranean Fever (FMF) resistant to colchicine with no…Abstract Number: 1231 • 2014 ACR/ARHP Annual Meeting
Evidence Based Recommendations for Genetic Diagnosis of Familial Mediterranean Fever
Background/Purpose: Familial Mediterranean Fever (FMF) is a disease that starts in childhood and can lead to significant morbidity. In 2013, an initiative called SHARE (Single…Abstract Number: 1230 • 2014 ACR/ARHP Annual Meeting
Efficacy of Interleukin-1 Targeting Drugs in Familial Mediterranean Fever Patients
Background/Purpose Familial Mediterranean fever (FMF) is an autosomal-recessive autoinflammatory disorder characterized by recurrent episodes of fever accompanied by sterile peritonitis. The most devastating complication of…Abstract Number: 1214 • 2014 ACR/ARHP Annual Meeting
Oxidative Stress from Use of Allopurinol – Is There a Reason for Patients with Gout to Take Vitamin C?
Background/Purpose During acute gout attacks neutrophils are activated and release a number of pro-inflammatory cytokines and enzymes. One of these enzymes is myeloperoxidase (MPO), which…Abstract Number: 1212 • 2014 ACR/ARHP Annual Meeting
Behcets Disease in Females Due to Mutation in NEMO, the NF-Kb Essential Modulator
Background/Purpose: Behçet's disease (BD) is a chronic multi-system inflammatory disorder associated clinically with oral and genital ulceration, uveitis, erythema nodosum, and other inflammatory disease. The…Abstract Number: 1213 • 2014 ACR/ARHP Annual Meeting
Absence of Hormone Responsive Estrogen Receptor Alpha Reduces the Activation of Plasmacytoid Dendritic Cells in Lupus Prone Mice
Background/Purpose Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9 to 1 ratio compared to men. To further understand…Abstract Number: 1211 • 2014 ACR/ARHP Annual Meeting
Gene Expression Profile in Muscle Tissue before and after Immunosuppressive Treatment in Patients with Myositis
Background/Purpose Autoimmune muscle diseases such as polymyositis (PM) and dermatomyositis (DM) are characterized by infiltration of inflammatory cells, production of cytokines and chemokines, as well…Abstract Number: 1210 • 2014 ACR/ARHP Annual Meeting
The Role of the Transcription Factor cAMP Responsive Element Binding Protein 1 in Lipopolysaccharide-Induced Tolerance
Background/Purpose In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to adaptation of signaling pathways and epigenetic modifications resulting in a tolerant state of…Abstract Number: 1209 • 2014 ACR/ARHP Annual Meeting
Anti-Scavenger Receptor Autoantibodies Disrupted Marginal Zone Macrophage Integrity Via Bruton’s Tyrosine Kinase
Background/Purpose Ibrutinib, a Btk kinase activity inhibitor, is a novel inhibitor under development for autoimmune disease therapy. We have shown that Btk was significantly upregulated…Abstract Number: 1208 • 2014 ACR/ARHP Annual Meeting
Cholesterol Loading Induces Neutrophil Extracellular Traps, and Atorvastatin Attenuates This Effect
Background/Purpose Neutrophils are the most common white blood cell, but their role in autoimmune and cardiovascular diseases has been underestimated. As part of host defense,…Abstract Number: 1207 • 2014 ACR/ARHP Annual Meeting
Novel Role of Liver X Receptor Alpha (LXRα) in the Attenuation of TLR Signalling: Implications in Congenital Heart Block
Background/Purpose: Anti-SSA/Ro associated congenital heart block provides a unique opportunity to examine the effector arm of immunity and define the molecular mechanisms that link maternal…Abstract Number: 1206 • 2014 ACR/ARHP Annual Meeting
Low Dose Colchicine Anti-Inflammatory Effects Are Transduced By AMP-Activated Protein Kinase (AMPK)
Background/Purpose AMPK is a master metabolic energy regulator, whose tissue activity drops in response to nutritional excesses, alcohol consumption, and in obesity, metabolic syndrome and…Abstract Number: 1205 • 2014 ACR/ARHP Annual Meeting
Expression of Lectin-like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis
Background/Purpose Precursor Th17 lineage cells expressing CD161 are implicated in rheumatoid arthritis (RA) pathogenesis. CD4+CD161+ T cells were found to accumulate in RA synovial fluid…Abstract Number: 1204 • 2014 ACR/ARHP Annual Meeting
Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFkB Signaling and Macrophage Migration
Background/Purpose: The major obstacles to successful use of curcumin as an anti-inflammatory agent are its low solubility in water and rapid metabolism, which both translate…
ACR Meeting Abstracts