Abstracts Archive - Page 2149 of 2607 - ACR Meeting Abstracts

Abstract Number: 1272 • 2014 ACR/ARHP Annual Meeting
Myositis-Specific and Myositis Associated Autoantibodies in Indian Patients with Inflammatory Myositis
Puja Srivastava, Ramnath Misra, Able Lawrence, Amita Aggarwal and Vikas Agarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose Recently, idiopathic inflammatory myositis (IIM) has been categorised into distinct subsets based on myositis specific autoantibodies (MSA) and myositis associated autoantibodies (MAA). However, there is…
Abstract Number: 1271 • 2014 ACR/ARHP Annual Meeting
Myocarditis in Antisynthetase Syndrome
Céline Dieval¹, Olivier Benveniste², Christophe Deligny³, Alain Meyer⁴, Guillaume Lefevre⁵, Yoland Schoindre⁶, Aude Rigolet⁷ and Baptiste Hervier⁸, ¹Internal Medicine, Rochefort Hospital, Rochefort, France, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³Internal Medicine, CHU Fort de France, Fort de France, France, ⁴Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ⁵Internal Medicine, CHRU Lille, Lille, France, ⁶DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, PARIS, France, ⁷Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ⁸Internal Medicine & Clinical Immunology Dpt, Pitié-Salpêtrière Hospital, APHP, Paris, France
Background/Purpose Antisynthetase syndrome (aSS) corresponds to an overlapping inflammatory myopathy identified by different myositis specific autoantibodies (directed against tRNA-synthetases). Myocardial involvement in this condition is poorly…
Abstract Number: 1270 • 2014 ACR/ARHP Annual Meeting
Distinctive Muscle Histopathological Features of Anti-Synthetase Syndrome
Baptiste Hervier¹, Yves Allenbach², Lenaig Mescam-Mancini³, Thierry Maisonobe⁴, Werner Stenzel⁵, Aude Rigolet⁶ and Olivier Benveniste², ¹Internal Medicine & Clinical Immunology Dpt, Pitié-Salpêtrière Hospital, APHP, Paris, France, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³Pathology Dpt, University hospital, Grenoble, France, ⁴Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ⁵Department of Neuropathology, Charite Hospital, Berlin, Germany, ⁶Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France
Background/Purpose As supported by recent studies, anti-histidyl tRNA synthetase (anti-Jo1) antibodies are specific for clinico-biological features and outcomes. Though, anti-Jo1 synthetase syndrome is a clinical…
Abstract Number: 1269 • 2014 ACR/ARHP Annual Meeting
Epidemiology and Characteristics of Antisynthetase Syndrome in the African Descent Population of Martinique
Christophe Deligny¹, Maryvonne Dueymes², Serge Arfi¹, José Zécler³, Maia Forgues⁴, Véronique Dehlinger⁵, Michel DeBandt⁶, Lauren Brunier-Agot⁶, Remi Bellance⁷, Isabelle Lamaury⁸, Nadege Cordel⁸, Nicolas Baillet⁹, Gilbert. Cadelis¹⁰, Georges Jean Baptiste¹¹ and Katlyne Polomat¹², ¹Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, ²Immunology, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, ³Respiratory, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, ⁴Internal medicine, Centre Hospitalier Andre Rosemon, Cayenne, French Guiana, ⁵Rheumatology, Centre Hospitalier universitaire de Fort de France, Fort De France - Martinique, Martinique, ⁶Rheumatology, Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique, ⁷National center for rare neuromuscular disorders, Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique, ⁸Infectious diseases, dermatology and internal medicine, Centre Hospitalier universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, ⁹internal medicine, Centre Hospitalier de la Basse Terre, Basse Terre, Guadeloupe, ¹⁰Respiratory, Cnetre Hospitalier Universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, ¹¹Rheumatology, Centre Hospitalier Universitaire de Fort de France, Fort de France, Guadeloupe, ¹²Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique
Background/Purpose : There is no population based epidemiologic studies of antisynthetase syndrome (ASS). We described characteristics and epidemiology of this disease in Martinique, populated by…
Abstract Number: 1268 • 2014 ACR/ARHP Annual Meeting
Study of Autoantibodies in a cohort of Mexican patients with idiopathic inflammatory myopathies
Yelitza Gonzalez-Bello¹, Miguel Angel Ortiz-Villalvazo², Ignacio Garcia-Valladares¹, Gabriel Medrano-Ramírez³, José E. Navarro-Zarza⁴, Lilia Andrade-Ortega⁵, Arnulfo Nava-Zavala⁶, Gerardo Orozco-Barocio¹, Marco Maradiaga-Ceceña⁷, Marvin Fritzler⁸ and Ignacio Garcia-De La Torre⁹, ¹Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, ²Internal Medicine, Hospital Civil de Guadalajara, Guadalajara, Jal., Mexico, ³Rheumatology, Hospital General de Mexico de la Secretaría de Salud, Mexico City, Mexico, ⁴Rheumatology, Hospital General de Chilpancingo, Chilpancingo, Gro., Mexico, ⁵Rheumatology, CMN 20 Noviembre ISSSTE, Mexico City, Mexico, ⁶Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, ⁷Rheumatology, Hospital General de Culiacan de la Secretaría de Salud, Culiacan, Sin., Mexico, ⁸Medicine, University of Calgary, Calgary, AB, Canada, ⁹Immunology and Rheumatology, Universidad de Guadalajara, Guadalajara, Jal., Mexico
Background/Purpose Idiopathic inflammatory myopathies (IIM) are a group of autoimmune disorders characterized by muscle inflammation, progressive weakness with a combination of clinical, electromyography and laboratory…
Abstract Number: 1267 • 2014 ACR/ARHP Annual Meeting
Are Anti-SRP Auto-Antibodies Specific for Myositis?
Samantha Rodriguez-Muguruza¹, Ines Lozano², Jaume Coll³, Maria Lourdes Mateo¹, Susana Holgado¹, Eva Martínez-Cácerez² and Alejandro Olivé Marqués¹, ¹Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ²Immunology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ³Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
Background/Purpose . Myositis-specific auto-antibodies (Ab) include those directed against aminoacyl-tRNA synthetases (ARS), signal recognition particle (SRP) and nuclear helicase Mi-2. Anti-SRP Ab are among the…
Abstract Number: 1266 • 2014 ACR/ARHP Annual Meeting
Anti-MDA5 Is Associated with Rapidly-Progressive Interstitial Lung Disease and Poor Survival in U.S. Patients with Amyopathic and Myopathic Dermatomyositis
Siamak Moghadam-Kia¹, Chester V. Oddis², Shinji Sato³, Masataka Kuwana⁴ and Rohit Aggarwal¹, ¹Medicine, University of Pittsburgh, Pittsburgh, PA, ²Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose : Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash(es) of DM without objective muscle weakness. Asian studies…
Abstract Number: 1265 • 2014 ACR/ARHP Annual Meeting
Diabetes and Atorvastatin Are Potential Risk Factors for Statin-Associated Myopathy with Autoantibodies Against 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase
Pari Basharat¹, Arash Lahouti H.¹, Andrew L. Mammen², Iago Pinal-Fernandez¹, Tanmayee Bichile³, Thomas E. Lloyd⁴, Sonye K. Danoff⁵, Livia Casciola-Rosen⁶ and Lisa Christopher-Stine⁷, ¹Medicine, Johns Hopkins University, Baltimore, MD, ²Neurology and Medicine, Johns Hopkins University, Baltimore, MD, ³Rehumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Neurology, Johns Hopkins, Baltimore, MD, ⁵Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, ⁶Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Medicine and Neurology, Johns Hopkins University, Baltimore, MD
Background/Purpose The idiopathic inflammatory myopathies (IIM) comprise a group of autoimmune disorders that target skeletal muscle. Some IIM cases may be associated with an autoantibody…
Abstract Number: 1264 • 2014 ACR/ARHP Annual Meeting
Analysis of Clinical Manifestations and Myositis-Specific Autoantibodies Associated with Severity of Physical Dysfunction after Treatment for Polymyositis and Dermatomyositis
Hidenaga Kawasumi¹, Takahisa Gono¹, Yasushi Kawaguchi¹, Yasuhiro Katsumata¹, Hisae Ichida¹, Akiko Tochimoto¹, Masanori Hanaoka¹, Yuko Okamoto¹, Sayuri Kataoka¹ and Hisashi Yamanaka², ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Half of all polymyositis (PM)/dermatomyositis (DM) patients suffer from muscle weakness after initial treatment. Therefore, many patients with PM/DM have trouble with daily living…
Abstract Number: 1246 • 2014 ACR/ARHP Annual Meeting
Assessment of Protective Factors of Bone Mineral Density in a New Orleans Sarcoidosis Population
McCall Walker¹, Harmanjot K. Grewal², Adam Janot³, Mary Yu⁴, Sophia Cenac⁵, Matthew R. Lammi^6,7 and Lesley Ann Saketkoo⁸, ¹LSUHSC School of Medicine, New Orleans, LA, ²Rheumatology, Lousiana State University Health Sciences Center, New Orleans, LA, ³Department of Ophthalmology, Virginia Commonwealth University –Medical College of Virginia, Charlottesville, VA, ⁴Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, ⁵Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University Health Science Center, New Orleans, LA, ⁶Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, ⁷Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ⁸Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA
Background/Purpose: Sarcoidosis often involves pathological dysregulation of dependent factors of bone metabolism, e.g. calcitriol /calcium, and administration of high dose glucocorticoids (GCs) leading to low…
Abstract Number: 1245 • 2014 ACR/ARHP Annual Meeting
Long Term Outcome of Infliximab in Severe and Refractory Systemic Sarcoidosis: Report of 16 Cases
Catherine Chapelon¹, David Saadoun¹, Lucie Biard², Matthieu Resche-Rigon³, Baptiste Hervier⁴, Nathalie Costedoat-Chalumeau⁵, Aurélie Drier⁶, Jean-Marc Léger⁷ and Patrice Cacoub⁸, ¹DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ²Hôpital St Louis, Biostatistics, Paris, France, ³Biostatistics, Hopital Saint-Louis, Paris, France, ⁴Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, PARIS, France, ⁵Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁶Hôpital Pitié-Salpêtrière, Neuroradiology, Paris, France, ⁷Neurology, Hôpital Pitié-Salpêtrière, Neurology, Paris, France, ⁸Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France
Background/Purpose: Infliximab (IFX) appears to be effective in refractory sarcoidosis. However, data are lacking regarding its efficacy in severe sarcoidosis (i.e. with cardiac and/or neurological…
Abstract Number: 1244 • 2014 ACR/ARHP Annual Meeting
The Prevalence of Malignancy in Adult-Onset Still’s Disease
Rupal Chavda¹, Melissa R. Bussey², Rodney Tehrani³ and Rochella A. Ostrowski¹, ¹Rheumatology, Loyola University Medical Center, Maywood, IL, ²Rheumatology, Division of Rheumatology, Loyola University Medical Center, Maywood, IL, ³Division of Rheumatology, Loyola University Medical Center, Maywood, IL
Background/Purpose: Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology. It is characterized by high fever, evanescent salmon-colored rash, sore throat, liver…
Abstract Number: 1243 • 2014 ACR/ARHP Annual Meeting
Macrophage Activation Syndrome Complicating Adult Onset Still’s Disease – Single Center Experience and Literature Review
Aleksander Lenert¹ and Qingping Yao², ¹Orthopaedic and Rheumatologic Institute, Dept. of Rheumatic & Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ²Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH
Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening complication typically associated with hematologic malignancies and infections. HLH, also referred to as macrophage activation syndrome (MAS),…
Abstract Number: 1242 • 2014 ACR/ARHP Annual Meeting
Switching Biologic Agents in Refractory Adult-Onset Still’s Disease: Efficacy and Safety in a Cohort of 20 Patients at a Single Referral Center
Giulio Cavalli¹, Stefano Franchini¹, Corrado Campochiaro¹, Elena Baldissera², Lorenzo Dagna³ and Maria Grazia Sabbadini³, ¹Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, ²Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy, ³Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milano, Italy
Background/Purpose No data is available on the long-term clinical outcome of Adult-Onset Still's Disease (AOSD) patients treated with biological drugs, nor on the efficacy and…
Abstract Number: 1241 • 2014 ACR/ARHP Annual Meeting
Efficacy of Tocilizumab Therapy in Korean Patients with Adults Onset Still’s Disease: Multicenter Retrospective Study of 20 Cases
Jin Ju Kim¹, Joo Hyun Lee², Chang-Nam Son³, Hyoun-Ah Kim⁴, Kwang-Hoon Lee⁵, Sang Tae Choi⁶, Eun Young Lee⁷, Ki Chul Shin⁸, Hoon-Suk Cha⁹ and Dae-Hyun Yoo¹, ¹Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Department of Rheumatology, Ilsan Paik Hospital, Inje University, Goyang, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea, ⁴Department of Rheumatology, Ajou University School of Medicine, Suwan, South Korea, ⁵Dongguk University Ilsan Hospital, Goyang, South Korea, ⁶Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, ⁷Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁸Rheumatology, Seoul National University College of Medicine, Seoul, South Korea, ⁹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose Adult onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Refractory cases to conventional therapy require biologic agents. Although IL-1 targeting…

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