ACR Meeting Abstracts

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  • Abstract Number: 1567 • 2013 ACR/ARHP Annual Meeting

    Desensitization To Trimethoprim/Sulfamethoxazole In Systemic Lupus Erythematosus Patients : A Retrospective Cohort Study

    Yasuhiro Suyama1, Mitsumasa Kishimoto1, Hiroto Nakano2, Chisun Min3, Yoichiro Haji1, Ryo Rokutanda1, Yuri Ohara1, Hisanori Shimizu1, Ken-ichi Yamaguchi4, Yukio Matsui4, Kazuo Matsui2 and Masato Okada4, 1Division of Allergy & Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 2Department of Rheumatology, Kameda Medical Center, Kamogawa, Japan, 3Division of Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 4Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan

    Background/Purpose: A high incidence of trimethoprin-sulfamethoxazole (TMP/SMX) hypersensitivity is reported in patients with systemic lupus erythematosus (SLE), and reactions are often severe. Desensitization protocol is…
  • Abstract Number: 1568 • 2013 ACR/ARHP Annual Meeting

    A Comparative Study For High Prevalence Of A Positive Family History Of Systemic LUPUS Erythematosus In Juvenile-Onset Systemic LUPUS Erythematosus Versus Adult-Onset Disease

    Maumer Durrani1, Shirish Sangle1, Natasha Jordan2 and David P. D'Cruz1, 1Louise Coote Lupus Unit, Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom, 2Louise Coote Lupus Unit, St Thomas' Hospital, London, United Kingdom

    Background/Purpose: The pathogenesis of SLE is complex and poorly understood.  Infectious triggers, immunological abnormalities, environmental factors and genetic background play a combined role in disease…
  • Abstract Number: 1569 • 2013 ACR/ARHP Annual Meeting

    The Accuracy Of The ICD-9 Code 710.0 To Identify a Cohort Of SLE Patients From The Electronic Medical Record

    Arshad Mustafa1, Jennifer Cai2, Teresa Bosler2, Nancy J. Olsen3 and David R. Karp1, 1Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, 2Academic Information Systems, UT Southwestern Medical Center, Dallas, TX, 3Medicine, Penn State MS Hershey Medical Center, Hershey, PA

    Background/Purpose: The electronic medical record (EMR) is increasingly used as a primary source of retrospective research data from large 'virtual cohorts' of patients. The accuracy…
  • Abstract Number: 1570 • 2013 ACR/ARHP Annual Meeting

    Maintenance Therapy With Taclorimus and Mizoribine Pulse In SLE

    Hiroshi Kajiyama1, Daisuke Ikuma1, Muneo Ota2, Yuki Shimada1, Kazuhiro Yokota3, Yasuto Araki1, Kojiro Sato1, Yu F. Asanuma1, Yuji Akiyama1 and Toshihide Mimura4, 1Department of Rheumatology and Applied Immunology, Saitama Medical University, Saitama, Japan, 2Saitama Medical University, Saitama, Japan, 3Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 4Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose: It was reported in 2008 that multitarget therapy, consisting of taclorimus (TAC), mycophenolate mofetil (MMF) and glucocorticoid, is effictive and safe in induction therapy…
  • Abstract Number: 1571 • 2013 ACR/ARHP Annual Meeting

    Efficacy Of Tacrolimus Combination Therapy During The Maintenance Phase Of Systemic Lupus Erythematosus

    Kumiko Ohtsuka1, Yusuke Miwa1, Nao Oguro2, Yoko Miura1, Sho Ishii1, Shinya Seki1, Hidekazu Furuya1, Ryo Yanai1, Ryo Takahashi1, Kuninobu Wakabayashi1, Nobuyuki Yajima1 and Tsuyoshi Kasama1, 1Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, 2Div of Rhemuatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: In Japan, a placebo-controlled clinical trial was undertaken to investigate the efficacy and safety of tacrolimus (TAC) for lupus nephritis. Based on the results…
  • Abstract Number: 1572 • 2013 ACR/ARHP Annual Meeting

    High Type I Interferon In Systemic Lupus Erythematosus Plasma Predicts Future Renal Disease

    Kyriakos A. Kirou1, Mikhail Olferiev1, Elzbieta E. Jacek1, Mari Lliguicota1, Margaret Robotham1, Wei-Ti Huang2, Elena Gkrouzman1 and Mary K. Crow3, 1Hospital for Special Surgery, New York, NY, 2Biostatistics, Hospital for Special Surgery, New York, NY, 3Department of Medicine, Hospital for Special Surgery, New York, NY

    Background/Purpose: Type I interferon (IFN-I) is elevated in many patients with SLE and is associated with more severe disease. However, the relationship between elevated levels…
  • Abstract Number: 1573 • 2013 ACR/ARHP Annual Meeting

    Longer Duration Of B Cell Depletion In Patients With Systemic Lupus Erythematosus Is Associated With a Better Outcome

    Sofia Dias1, Veronica Rodriguez2, Hanh Nguyen3, Charis Pericleous4 and David A. Isenberg5, 1Internal Medicine Department 1, Hospital de Santa Maria, Lisbon, Portugal, 2Hospital Regional Universitario Carlos Haya, Malaga, Spain, 3Centre of Rheumatology. Medicine., University College of London Hospital, london, United Kingdom, 4Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 5Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom

    Background/Purpose: We were alerted to the possibility of very long term B cell depletion (BCD) in Systemic Lupus Erythematosus (SLE) by a patient treated with…
  • Abstract Number: 1574 • 2013 ACR/ARHP Annual Meeting

    Favorable Clinical Response To Belimumab At Three Months

    Anca Askanase1, Arthi Reddy1, Jill P. Buyon2, Andrew G. Franks Jr.3, Richard A. Furie4, Diane L. Kamen5, Susan Manzi6, Michelle Petri7, Rosalind Ramsey-Goldman8, Chung-E Tseng9, Ronald F. van Vollenhoven10 and Daniel J. Wallace11, 1Rheumatology, New York University School of Medicine, New York, NY, 2Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Dermatology & Medicine (Rheumatology), New York University, New York, NY, 4The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, 5Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 6Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 7Johns Hopkins University School of Medicine, Baltimore, MD, 8Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 9NYU School of Medicine, New York, NY, 10Clinical Trials Unit Department of Rheumatology, The Karolinska Institute, Stockholm, Sweden, 11Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Belimumab (Benlysta) is a human monoclonal antibody that inhibits soluble B-Lymphocyte Stimulator and improves SLE disease activity. This study was initiated to evaluate the…
  • Abstract Number: 1575 • 2013 ACR/ARHP Annual Meeting

    Identification Of Novel Distinct Autoantigen Clusters Reflecting The Heterogeneity Of Systemic Lupus Erythematosus

    Petra Budde1, Angelika Lueking1, Stefan Vordenbäumen2, Heike Göhler1, Martin Gamer1, Klaus Marquardt1, Anna Telaar1, Daniel Chamrad1, Carmen Theek1, Peter Schulz-Knappe1 and Matthias Schneider2, 1Protagen AG, Dortmund, Germany, 2Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Diagnosis of systemic lupus erythematosus (SLE) is based on a combination of clinical findings and laboratory evidence such as anti-nuclear autoantibodies (ANA), anti-Smith and…
  • Abstract Number: 1576 • 2013 ACR/ARHP Annual Meeting

    Type I Interferon-Mediated Skewing Of The Serotonin Synthesis In Systemic Lupus Erythematosus Is Associated To Cardiovascular Disease

    Christian Lood1, Helena Tydén1, Birgitta Gullstrand2, Cecilia Klint3, Christina Wenglén3, Christoffer T. Nielsen4, Niels H. H. Heegaard5, Andreas Jönsen1 and Anders A. Bengtsson1, 1Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, 2Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, 3R&D, AnaMar AB, Lund, Sweden, 4Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen S, Denmark, 5Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized by increased expression of type I interferons (IFNs). Indoleamine 2,3-dioxygenase (IDO), a type I…
  • Abstract Number: 1577 • 2013 ACR/ARHP Annual Meeting

    Comparison Of Clinical and Serological Manifestations Among Juvenile-, Adult-, and Late-Onset Systemic Lupus Erythematosus Patients In Korea

    Dong-Jin Park1, Ji-Hyoun Kang2, Kyung-Eun Lee1, Jeong-Won Lee2, Lihui Wen1, Tae-Jong Kim3, Yong-Wook Park1 and Shin-Seok Lee4, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Chonnam National University Medical School, Gwangju, South Korea, 3Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, 4Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose: Up to 30‑40% of patients with systemic lupus erythematosus (SLE) experience their onset prior to adulthood or at over 50 years of age. Patients…
  • Abstract Number: 1578 • 2013 ACR/ARHP Annual Meeting

    Decreased Sensitivity Of a Commercial Anti-dsDNA Assay In Patients With Moderately To Severely Active Systemic Lupus Erythematosus

    Munther A. Khamashta1, Gabor G. Illei2, Stephen Yoo2, Liangwei Wang3 and Warren Greth2, 1Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, 2Clinical Development, MedImmune, LLC, Gaithersburg, MD, 3Biostatistics, MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: Anti-dsDNA autoantibodies are highly specific for SLE. Anti-dsDNA positivity is an important eligibility criterion in many SLE studies, and decreases in anti-dsDNA levels are…
  • Abstract Number: 1579 • 2013 ACR/ARHP Annual Meeting

    Novel Risk Factors For Thrombotic Thrombocytopenic Purpura In Systemic Lupus Erythematosus  patients

    Javier Merayo-Chalico1, Diana Gómez-Martín2, Roberta Demichelis-Gómez3, Sandra Rajme-Lopez2, Luis Aparicio-Vera2 and Jorge Alcocer-Varela2, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico, 3Haematology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico

    Background/Purpose: Thrombotic thrombocytopenic purpura (TTP) is an uncommon disease characterized by thrombocytopenia and microangiopathic hemolytic anemia and, in some cases, fever, neurologic and/or renal abnormalities.…
  • Abstract Number: 1580 • 2013 ACR/ARHP Annual Meeting

    Drug-Resistant Bloodstream Infections In Systemic Lupus Erythematosus Patients: A Clinical Perspective

    Ana Barrera-Vargas1, Diana Gómez-Martín1, Alfredo Ponce de León2 and Jorge Alcocer-Varela1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Infectology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Infections are an important cause of mortality and morbidity in Systemic Lupus Erythematosus (SLE) patients. Different risk factors have been described for the development…
  • Abstract Number: 1581 • 2013 ACR/ARHP Annual Meeting

    Lipid Lowering Medication Use Is Associated With Reduced Muscle Strength In Systemic Lupus Erythematosus

    James S. Andrews1 and Patricia P. Katz2, 1Rheumatology, University of California San Francisco, San Francisco, CA, 2Medicine, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Premature atherosclerotic coronary artery disease is a major source of morbidity for women with systemic lupus erythematosus (SLE).  Lipid lowering medications (LLM) are among…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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