Abstract Number: 1658 • 2013 ACR/ARHP Annual Meeting
Vessel Wall Characteristics Using High Resolution Magnetic Resonance Imaging In Reversible Cerebral Vasoconstriction Syndrome and Central Nervous System vasculitis
Background/Purpose: Distinguishing between reversible cerebral vasoconstriction syndrome (RCVS) and central nervous system (CNS) vasculitis is often a diagnostic dilemma. High-resolution-3-Tesla Magnetic Resonance Imaging with contrast…Abstract Number: 1660 • 2013 ACR/ARHP Annual Meeting
Primary Central Nervous System Vasculitis: Treatment and Course
Background/Purpose: To determine the response to therapy and long-term outcome of PCNSV we reviewed all cases of PCNSV seen over a 29-year period. Methods:…Abstract Number: 1661 • 2013 ACR/ARHP Annual Meeting
The Spectrum of childhood Inflammatory Brain Diseases; An Increasingly Recognised Field
Background/Purpose: Childhood Inflammatory Brain diseases are potentially life-threatening diseases leading to severe neurological deficits if not treated. The spectrum of childhood inflammatory brain diseases is…Abstract Number: 1662 • 2013 ACR/ARHP Annual Meeting
Developing Guideline For Polymyalgia Rheumatica: Prioritisation Of Outcome Measures – Perspective Of Patients, General Practitioners and Rheumatologists
Background/Purpose: To explore similarities and differences between rheumatologists (rheum), general practitioners (GP) and patients (pt) regarding the relevance of outcome parameters in polymyalgia rheumatica (PMR).Methods:…Abstract Number: 1663 • 2013 ACR/ARHP Annual Meeting
Obese Polymyalgia Rheumatica Patients Experience More Pain and Disability and Need Higher Doses Of Glucocorticoids
Background/Purpose: Obesity is not only a risk factor for osteoarthritis but also for rheumatoid arthritis (RA). In obese RA patients, disease incidence is higher and…Abstract Number: 1664 • 2013 ACR/ARHP Annual Meeting
Lower Tissue Expression Of IL 6 In Patients With Giant Cell Arteritis Presenting With a Cranial Ischaemic Compication
Background/Purpose: Giant Cell Arteritis (GCA) is a granulomatous systemic vasculitis with a prediliction for the aorta and it’s extracranial branches. The majority of the morbidity…Abstract Number: 1623 • 2013 ACR/ARHP Annual Meeting
Differential Methylation Of Interferon-Related Genes Is Associated With Anti-dsDNA Autoantibody Production In Systemic Lupus Erythematosus
Background/Purpose: DNA methylation studies in systemic lupus erythematosus (SLE) have shown that SLE patients have less methylation in genes regulating the immune response compared to…Abstract Number: 1624 • 2013 ACR/ARHP Annual Meeting
Lupus Risk Alleles With High Ethnic Variability Worldwide Are Associated With Renal Disease In Hispanic Patients
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects minority patients. Non-European ancestry is associated with more severe disease, and conversely, European ancestry is associated with a…Abstract Number: 1625 • 2013 ACR/ARHP Annual Meeting
Prolactin-Induced Interferon Regulatory Factor 1 Activation and Histone H4 Hyperacetylation In Monomac-6 Cells Correlating With Changes Seen In Monocytes From Systemic Lupus Erythematosus Patients
Background/Purpose: Epigenetic changes have been described in systemic lupus erythematosus (SLE) and offer a potential explanation for the chronicity of disease and missing heritability. Therapies…Abstract Number: 1626 • 2013 ACR/ARHP Annual Meeting
Genetic Alterations In Abnormal Neutrophils Isolated From Human Systemic Lupus Erythematosus Patients
Background/Purpose: Human SLE patients have an abnormal population of neutrophils called low density granulocytes (LDGs). LDGs express the surface markers of mature neutrophils, yet their…Abstract Number: 1627 • 2013 ACR/ARHP Annual Meeting
Typing TREX1 Gene In Patients With Systemic Lupus Erythematosus
Background/Purpose: An increased expression of type I interferon regulated genes (IFN signature) has been reported in patients (pts) with Systemic Lupus Erythematosus (SLE) and it…Abstract Number: 1628 • 2013 ACR/ARHP Annual Meeting
Decreased Levels Of Splicing Factor 2 / Alternative Splicing Factor (SF2/ASF) Correlate With Lower Transcript Levels Of The RasGRP1 Normal Isoform In Lupus T Cells
Background/Purpose: Down-regulation of MAP kinase pathway has been recognized in T cells from patients with SLE that results in hypo-methylation of DNA. RasGRP1 is an…Abstract Number: 1629 • 2013 ACR/ARHP Annual Meeting
Functional Effect Of NR1H3 (LXRA) Promoter Polymorphisms In Korean Patients With Systemic Lupus Erythematosus
Background/Purpose: Liver X receptor alpha (LXRA, NR1H3) and beta (LXRB, NR1H2) can influence macrophage biology by modulation of lipid metabolism and by effects on innate…Abstract Number: 1630 • 2013 ACR/ARHP Annual Meeting
Association Of TREM-Like Transcript-1 With Systemic Lupus Erythematosus
Background/Purpose: Recent studies suggest that a platelet α-granule protein named TREM-like transcript-1 (TLT-1) is a key molecule in modulating the inflammatory response. TLT-1 has been…Abstract Number: 1631 • 2013 ACR/ARHP Annual Meeting
Transcription Activation-Like Effector Nuclease-Mediated Enhancer Knockout Influences TNFAIP3 Gene Expression and Mimics a Functional Phenotype Associated With Systemic Lupus Erythematosus
Background/Purpose: Emerging technologies for precise, targeted genome editing provide new opportunities for the functional elucidation of causal genetic variants and genomic elements without the confounding…