Abstracts Archive - Page 2139 of 2425 - ACR Meeting Abstracts

Abstract Number: 1705 • 2013 ACR/ARHP Annual Meeting
Genetic Associations In Anterior Uveitis Implicate T-Cell Co-Stimulation and Other Immune Pathways
Philip Robinson¹, Dorith Claushuis², Paul Leo¹, Pamela Mukhopadhyay³, P. Wordsworth^4,5, Michael H. Weisman⁶, Walter P. Maksymowych⁷, Proton Rahman⁸, Robert Inman⁹, Alex Hewitt¹⁰, Tammy M. Martin¹¹, James T. Rosenbaum¹², Dennis Wakefield¹³, John D. Reveille¹⁴ and Matthew A. Brown¹⁵, ¹Human Genetics Group, University of Queensland Diamantina Insititute, Brisbane, Australia, ²Human Genetics Group, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ⁴Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ⁵Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Medicine, University of Alberta, Edmonton, AB, Canada, ⁸Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁹Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada, ¹⁰Lions Eye Institute, University of Western Australia, Perth, Australia, ¹¹Ophthalmology/L467AD, Oregon Health & Science Univ, Portland, OR, ¹²Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR, ¹³Faculty of Medicine, University of New South Wales, Sydney, Australia, ¹⁴Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹⁵University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Anterior uveitis (AU) complicates a number of autoimmune diseases including ankylosing spondylitis (AS), Behcet’s disease and sarcoidosis. It is highly heritable and HLA-B27 is…
Abstract Number: 1681 • 2013 ACR/ARHP Annual Meeting
Assessment of Patients With Takayasu’s Arteritis in Routine Clinical Follow-Up With Indian Takayasu Clinical Activity Score 2010(ITAS2010)
Fatma Alibaz-Oner and Haner Direskeneli, Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey
Background/Purpose: ITAS2010 (Indian Takayasu Clinical Activity Score) is a new composite index developed to assess clinical activity in Takayasu’s arteritis (TAK), which is weighted for…
Abstract Number: 1665 • 2013 ACR/ARHP Annual Meeting
B Cells Revisited In Giant Cell Arteritis
Kornelis S.M. van der Geest¹, Wayel H. Abdulahad², Gerda Horst², Caroline Roozendaal³, Abraham Rutgers², Annemieke M.H. Boots² and Elisabeth Brouwer², ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Giant cell arteritis (GCA) is a primary vasculitis affecting large to medium-sized arteries. Ample evidence suggests that dendritic cells, T cells and monocytes/macrophages contribute…
Abstract Number: 1666 • 2013 ACR/ARHP Annual Meeting
Negative Temporal Artery Biopsies: Pathologic Findings Of Patients With Biopsy-Negative Giant Cell Arteritis Compared To Those Of Patients Without Arteritis
Francesco Muratore¹, Alberto Lo Gullo¹, Alberto Cavazza², Giuseppe Germanò¹, Luigi Boiardi¹ and Carlo Salvarani³, ¹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Pathology Unit, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ³Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Temporal artery biopsy (TAB) showing transmural inflammation is considered the gold standard for the diagnosis of giant cell arteritis (GCA). A negative TAB does…
Abstract Number: 1667 • 2013 ACR/ARHP Annual Meeting
Serum S100A8/S100A9 and S100A12 As a Marker Of Disease Activity In Giant Cell Arteritis
Jason Springer¹, Dirk Holzinger², Gary S. Hoffman³, Paul A. Monach⁴, Thomas Hamilton⁵, Carol A. Langford⁶, Dirk Foell⁷, David Cuthbertson⁸, Colin O'Rourke⁹, Simon Carette¹⁰, Nader A. Khalidi¹¹, Carol McAlear¹², Christian Pagnoux¹⁰, Philip Seo¹³, Kenneth J. Warrington¹⁴, Steven R. Ytterberg¹⁵, Thomas Vogl¹⁶, Peter A. Merkel¹⁷, Johannes Roth¹⁸ and Rula Hajj-Ali¹⁹, ¹Division of Allergy, Clinical Immunology and Rheumatology, University of Kansas Medical Center, Kansas City, KS, ²Institute of Immunology, University Muenster, Muenster, Germany, ³Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁴Rheumatology, Boston University, Boston, MA, ⁵Cleveland Clinic, Cleveland, OH, ⁶Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁷Department of Pediatric Rheumatology and Immunology, University of Münster, Münster, Germany, ⁸Department of Biostatistics, University of South Florida, Tampa, FL, ⁹Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ¹⁰Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ¹¹Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ¹²University of Pennsylvania, Philadelphia, PA, ¹³Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹⁴Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹⁵Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁶Institute of Immunology, University of Muenster, Muenster, Germany, ¹⁷Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, ¹⁸Immunology, Institute of Immunology University of Muenster, Muenster, Germany, ¹⁹Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: The S100 proteins (S100A8/9 complex and S100A12) are calcium binding proteins expressed during myeloid differentiation. S100 proteins are phagocyte-specific proteins that have been demonstrated…
Abstract Number: 1668 • 2013 ACR/ARHP Annual Meeting
Does Fibrinogen Have a Role In The Assessment Of Patients With Giant Cell Arteritis?
Lorraine O' Neill¹, Eoghan M. McCarthy², Anne M. Madigan³, Geraldine M. McCarthy⁴, Eamonn S. Molloy⁵, Ursula Fearon⁶, Douglas J. Veale⁵ and Conor Murphy⁷, ¹Rheumatology, Dublin Academic Medical Centre, St. Vincent's University Hospital, Dublin, Ireland, ²Rheumatology, Beaumont Hospital, Dublin, Ireland, ³Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ⁴Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland, ⁵Rheumatology, St. Vincent's University Hospital, Dublin 4, Ireland, ⁶Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ⁷Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland
Background/Purpose: Giant cell arteritis (GCA) in the most common systemic vasculitis in patients over 50 years of age. Considerable difficulties exist in the evaluation of…
Abstract Number: 1669 • 2013 ACR/ARHP Annual Meeting
The Birmingham Vasculitis Activity Score As a Measure Of Disease Activity In Patients With Giant Cell Arteritis
Tanaz A. Kermani¹, David Cuthbertson², Simon Carette³, Gary S. Hoffman⁴, Nader A. Khalidi⁵, Curry L. Koening⁶, Carol A. Langford⁷, Kathleen McKinnon-Maksimowicz⁸, Carol McAlear⁹, Paul A. Monach¹⁰, Philip Seo¹¹, Kenneth J. Warrington¹², Steven R. Ytterberg¹³, Peter A Merkel¹⁴ and Eric L. Matteson¹⁵, ¹Rheumatology, University of California Los Angeles, Los Angeles, CA, ²Department of Biostatistics, University of South Florida, Tampa, FL, ³Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁴Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ⁵Internal Medicine/Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Internal Medicine, Salt Lake City Veterans Administration, Salt Lake City, UT, ⁷Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ⁸Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁹University of Pennsylvania, Philadelphia, PA, ¹⁰Rheumatology, Boston University, Boston, MA, ¹¹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹²Division of Rheumatology, Mayo Clinic, Rochester, MN, ¹³Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁴Division of Rheumatology, University of Pennsylvania and VA Medical Center, Philadelphia, PA, ¹⁵Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS), a validated tool for assessment of vasculitis disease activity, in a cohort…
Abstract Number: 1670 • 2013 ACR/ARHP Annual Meeting
Large Vessel Vasculitis: Estimating Disease Activity In Patients With Inflammatory Thoracic Aortic Aneurysms
Alison Clifford¹, Tiffany M. Clark², Douglas Johnston³, Gosta Pettersson³, Eric Roselli⁴, E. Rene Rodriguez⁵, Edward Soltesz³, Lars Svensson⁴, Carmela Tan⁶ and Gary S. Hoffman¹, ¹Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ²Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, ³Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁴Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ⁵Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH, ⁶Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Thoracic aortic aneurysms due to large vessel vasculitis may be a sign of ongoing inflammation or the sequelae of previous damage to the arterial…
Abstract Number: 1671 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Risk At Incidence Of Giant Cell Arteritis: A Population Based Retrospective Cohort Study
P. Deepak Udayakumar¹, Arun K. Chandran¹, Cynthia S. Crowson², Kenneth J. Warrington³ and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Many systemic inflammatory rheumatic conditions are associated with increased cardiovascular (CV) risk. We aimed at assessing the CV risk at incidence of giant cell…
Abstract Number: 1672 • 2013 ACR/ARHP Annual Meeting
Serious Cardiovascular Events Risk Factors In Giant Cell Arteritis. A Population-Based Study In The French Apogee Cohort
Grégory Pugnet¹, Laurent Sailler², Guillaume Moulis³, Jean-Pascal Fournier⁴, Robert Bourrel⁵, Jean-Louis Montastruc⁶ and Maryse lapeyre-Mestre⁶, ¹Department of Internal Medicine, Toulouse University Hospital, University of Toulouse, INSERM UMR 1027, Toulouse, France, ²Department of Internal Medicine, Toulouse University Hospital, Toulouse, France, ³Clinical Pharmacology Department, Toulouse University Hospital, University of Toulouse, UMR INSERM-UPS 1027, Toulouse, France, ⁴Toulouse University, INSERM UMR 1027, Toulouse, France, ⁵Service Médical, Caisse Nationale de l'Assurance Maladie échelon régional, Midi-Pyrénées, Toulouse, France, ⁶Department of Clinical Pharmacology, Toulouse University Hospital, INSERM U1027, University of Toulouse, France, Toulouse, France
Background/Purpose: No population-based study has assessed serious cardiovascular events (sCVE) risk factors in Giant Cell Arteritis (GCA). The aim of our study was to identify…
Abstract Number: 1673 • 2013 ACR/ARHP Annual Meeting
Risk Of Myocardial Infarction In Patients With Giant Cell Arteritis: A Population-Based Study
Neda Amiri¹, Hyon K. Choi^2,3, Eric C. Sayre³, Kamran Shojania^3,4 and J. Antonio Avina-Zubieta^5,6, ¹University of British Columbia, Vancouver, BC, Canada, ²Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Richmond, BC, Canada, ⁶Rheumatology, Arthritis Research Centre of Canada, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Involvement of large arteries leading to stenosis is well-documented in giant cell arteritis (GCA), but limited data are available on the risk of coronary…
Abstract Number: 1674 • 2013 ACR/ARHP Annual Meeting
Acute Coronary Syndromes In Patients With Giant Cell Arteritis: A Population Based Retrospective Cohort Study
P. Deepak Udayakumar¹, Arun K. Chandran¹, Cynthia S. Crowson², Kenneth J. Warrington³ and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Acute coronary syndrome (ACS) is one of the leading causes of death in the general population. We aimed at assessing the occurrence of ACS…
Abstract Number: 1675 • 2013 ACR/ARHP Annual Meeting
Infections Requiring Or Acquired During Hospitalizations In Patients With Giant Cell Arteritis – a Population Based Retrospective Cohort Study
P. Deepak Udayakumar¹, Arun K. Chandran¹, Cynthia S. Crowson², Kenneth J. Warrington³ and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: There is a general impression that the patients with giant cell arteritis (GCA) on glucocorticoid therapy are at higher risk for infections. We aimed…
Abstract Number: 1676 • 2013 ACR/ARHP Annual Meeting
Statins Do Not Influence Occurrence Or Prednisone Requirement Of Giant Cell Arteritis. A French Population-Based Cohort Study
Grégory Pugnet¹, Laurent Sailler², Robert Bourrel³, Jean-Louis Montastruc⁴ and Maryse Lapeyre-Mestre⁴, ¹Toulouse University Hospital, Department of Internal Medicine, University of Toulouse, INSERM UMR 1027, Toulouse, France, ²Department of Internal Medicine, Toulouse University Hospital, Toulouse, France, ³Service Médical, Caisse Nationale de l'Assurance Maladie échelon régional, Midi-Pyrénées, Toulouse, France, ⁴Department of Clinical Pharmacology, Toulouse University Hospital, INSERM U1027, University of Toulouse, France, Toulouse, France
Background/Purpose: Statins are widely prescribed to reduce the risk of cardiovascular ischemic events, but also present immunoregulatory effects promoting a shift from a TH-1 to…
Abstract Number: 1677 • 2013 ACR/ARHP Annual Meeting
May Giant Cell Arteritis Be Characterized By Different Clinical Entity and Long-Term Outcome?
Rosaria Talarico¹, Chiara Stagnaro², Claudia Ferrari³, Anna d'Ascanio⁴, Chiari Tani², Chiara Baldini², Marta Mosca³ and Stefano Bombardieri², ¹Rheumatology Unit, Pisa, Italy, ²University of Pisa, Rheumatology Unit, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy
Background/Purpose: Giant cell arteritis (GCA) represents the most common primary vasculitis of the elderly, that affect large and medium-sized arterial vessels. Growing data shown that…

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