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  • Abstract Number: 1752 • 2013 ACR/ARHP Annual Meeting

    Behçet´s Disease Activity: An Important Factor For Immunogenicity Of Unadjuvanted Influenza A/H1N1 Vaccine

    Leandro L. Prado1, Carla G.S. Saad2, Julio C. B. Moraes1, Ana Cristina Medeiros Ribeiro1, Nadia E. Aikawa1, Clovis A. Silva3, Claudia G Schainberg1, Percival D Sampaio-Barros1, Alexander R. Precioso4, Maria A. Ishida5, Eloisa Bonfa6 and Celio Goncalves1, 1Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 4Instituto Butantan, São Paulo, Brazil, 5Instituto Adolfo Lutz, São Paulo, Brazil, 6University of Sao Paulo, Rheumatology Division, São Paulo, Brazil

    Background/Purpose: Routine annual influenza vaccination is the most effective method for preventing influenza virus infection and its complications. Influenza vaccine is recommended for all persons…
  • Abstract Number: 1753 • 2013 ACR/ARHP Annual Meeting

    An Outcome Survey Of 40 Patients With Budd-Chiari Syndrome Due To BEHÇET’S Syndrome Followed By A Single Center

    Emire Seyahi1, SerdaL Ugurlu2, Erkan Caglar3, Fatih Kantarci4, Abdullah Sonsuz5, Sebahattin Yurdakul2 and Hasan Yazici2, 1Division of Rheumatology,Department of Medicine,Cerrahpasa Medical Faculty, University of Istanbul, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Division of Gastroenterology, Department of Internal Medicine, Bakirkoy Research and Training Hospital, Istanbul, Turkey, 4Department of Radiology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 5Division of Gastroenterology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose: Budd-Chiari syndrome is a rare complication of BS with a frequency of < 1 %, and carries a high mortality rate. In a previous…
  • Abstract Number: 1754 • 2013 ACR/ARHP Annual Meeting

    Safety and Efficacy Of Peg-IFNa/Ribavirin/Protease Inhibitor Combination In 34 Patients With HCV-Mixed Cryoglobulinemia Vasculitis

    David Saadoun1, Stanislas Pol2, Vincent Thibault3, Gilles Pialoux4, François Blanc5, Lucile Musset6, Alexandre Karras7, Olivier Decaux8, Jean-Marc Ziza9, Olivier Lambotte10 and Patrice Cacoub Sr.11, 1Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 2Hepatology, Cochin Hospital, Paris, France, 3Virology, Pitié-Salpétrière, Paris, France, 4hôpital Tenon, Paris, France, 5hôpital Montpellier, Montpellier, France, 6Laboratoire d'immunochimie, Pitié- Salpêtrière, Paris, France, 7Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, 8Department of Internal Medicine, Rennes University Hospital, Rennes, France, 9Refferal center for bone and joint infections, Croix Saint Simon Hospital, Paris, France, 10Internal Medicine, Hopital Kremlin Bicêtre, Kremlin Bicêtre, France, 11Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France

    Background/Purpose: The standard of care treatment of patients presenting a HCV-mixed cryoglobulinemia (MC) vasculitis includes Peg-IFNaplus Ribavirin, w/wo Rituximab. Thirty to 40% of patients are…
  • Abstract Number: 1755 • 2013 ACR/ARHP Annual Meeting

    Genetic Association Of Mitochondrial DNA Polymorphisms With Behçet’s Disease In a Korean Population

    Mi-Hye Kwon1, Chung-Il Joung2 and Jiwon Hwang3, 1Department of Internal medicine, Konyang university hospital, Daejeon, South Korea, 2Department of Internal Medicine, Konyang university hospital, Daejeon, South Korea, 3Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose: Behcet’s disease (BD) is an inflammatory multisystemic disorder. Although precise etiopathogenesis should be elucidated, BD is known to be multifactorial and accumulating data suggest…
  • Abstract Number: 1756 • 2013 ACR/ARHP Annual Meeting

    Trends In Incidence and Mortality In Rheumatoid Arthritis and Systemic Autoimmune Rheumatic Diseases In Quebec, Canada: A Population-Based Study

    Sonia Jean1, Philippe Gamache2, Marie Hudson3, Louis Bessette4, Paul R. Fortin5, Gilles Boire6 and Sasha Bernatsky7, 1Chronic disease surveillence division, National Institute of public health of Quebec, Quebec, QC, Canada, 2Chronic disease surveillance division, National institute of public health of Quebec, Quebec, QC, Canada, 3Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, 4Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, 5Medicine, Centre de Recherche du Chu de Québec et Université Laval, Quebec City, QC, Canada, 6Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, 7Clinical Epidemiology, Research Institute of the McGill University Health Ctre, Montreal, QC, Canada

    Background/Purpose: Health administrative data (HAD) are a potentially efficient to conduct population-based research and are increasingly used to develop chronic disease surveillance indicators. Examining trends…
  • Abstract Number: 1757 • 2013 ACR/ARHP Annual Meeting

    Does Foot Pain Mediate The Effect Of Knee Osteoarthritis and Risk Of Indoor and Outdoor Falls In Older Men and Women?

    Uyen Sa D.T. Nguyen1, Yuqing Zhang2, Jingbo Niu3, Robert H. Shmerling4, Douglas P. Kiel5, Suzanne G. Leveille6, Carol A. Oatis7 and Marian T. Hannan8, 1Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, 2Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 3Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 4Beth Israel Deaconess Medical Center, Boston, MA, 5Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 6University of Massachusetts-Boston, Boston, MA, 7Physical Therapy, Arcadia University, Glenside, PA, 8Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose:  Knee osteoarthritis (OA), foot pain, and falls are common in older adults and limit mobility. We previously showed that knee OA increases the risk…
  • Abstract Number: 1759 • 2013 ACR/ARHP Annual Meeting

    The Effect Of Knee Replacement On Self-Reported Participation and Gait Speed:  The Multicenter Osteoarthritis Study and The Osteoarthritis Initiative

    Jessica L. Maxwell, Physical Therapy & Athletic Training, Boston Univ Sargent College, Boston, MA

    The Effect of Knee Replacement on Self-Reported Participation and Gait Speed:  The MOST Study and the Osteoarthritis InitiativeBackground/Purpose: Little research has explored participation outcomes, defined…
  • Abstract Number: 1758 • 2013 ACR/ARHP Annual Meeting

    Low Literacy Decision Aid Enhances Knowledge and Reduces Decisional Conflict Among Diverse Population Of Adults With Rheumatoid Arthritis: Results Of a Pilot Trial

    Jennifer Barton1, Laura Trupin2, Gina Evans-Young3, John B. Imboden4, Dean Schillinger5, Victor M. Montori6 and Edward H. Yelin7, 1Medicine, University of California, San Francisco, San Francisco, CA, 2Medicine, UC San Francisco, San Francisco, CA, 3Rheumatology, UCSF, San Francisco, CA, 4Department of Medicine, Division of Rheumatology, UCSF, San Francisco, CA, 5Medicine and Center for Vulnerable Populations, UCSF, San Francisco, CA, 6Divisions of Endocrinology and Diabetes and Health Care and Policy Research, Mayo Clinic, Rochester, MN, 7Arthritis Research Group, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Vulnerable populations with rheumatoid arthritis (RA) have poorer outcomes and report suboptimal shared decision-making communication. Patient involvement in the choice of disease modifying anti-rheumatic…
  • Abstract Number: 1760 • 2013 ACR/ARHP Annual Meeting

    Relationships Between Driving Distance, Rheumatoid Arthritis Diagnosis, and Disease-Modifying Anti-Rheumatic Drug Receipt

    Jennifer M. Polinski1, M. Alan Brookhart2, John Z. Ayanian3, Jeffrey N. Katz4, Seo Young Kim5, Chris Tonner6, Edward H. Yelin7 and Daniel H. Solomon8,9, 1Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, 2University of North Carolina, Chapel Hill, NC, 3Brigham and Women's Hospital, Boston, MA, 4Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, 5Division of Rheumatology; Division of Pharmacoepidemiology, Brigham and Women's Hospital, Boston, MA, 6Medicine, University of California, San Francisco, San Francisco, CA, 7Arthritis Research Group, University of California, San Francisco, San Francisco, CA, 8Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA, 9Division of Rheumatology, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) are recommended for all patients with rheumatoid arthritis (RA). Some studies estimate that almost half of patients with RA do…
  • Abstract Number: 1761 • 2013 ACR/ARHP Annual Meeting

    The Link Of Foot Structure and Foot Function With Falls: The Johnston County Osteoarthritis Project

    Yvonne M. Golightly1, Marian T. Hannan2, Howard J. Hillstrom3, Alyssa B. Dufour4, Amanda E. Nelson5, Adam Dore6 and Joanne M. Jordan7, 1Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC, 2Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Rehabilitation, Hospital Special Surgery (HSS), New York, NY, 4Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, 5University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, 6Rheumatology, Allergy and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC

    Background/Purpose:   Nearly 1/3 of older adults experience at least one fall annually in the United States.  Foot type (static and dynamic arch height) is…
  • Abstract Number: 1762 • 2013 ACR/ARHP Annual Meeting

    Endogenous IL-22 Regulates Th1 Responses and Plays a Pathogenic Role After the Onset of Arthritis

    Shivali Justa1, Xiaoqun Zhou2 and Sujata Sarkar3, 1Rheumatology & Arizona Arthritis Center, University of Arizona, Tucson, AZ, 2Rheumatology, University of Arizona, Tucson, AZ, 3Rheumatology and Arizona Arthritis Center, University of Arizona, Tucson, AZ

    Background/Purpose: IL-22,belongs to the IL-10 family of cytokines and is primarily produced by CD4 T, NK and LTi cells. IL-22 plays a dual role depending…
  • Abstract Number: 1763 • 2013 ACR/ARHP Annual Meeting

    IL4-10 Synerkine: A Novel Immunoregulatory Drug To Prevent Immunopathology In Rheumatic Diseases

    Sarita Hartgring1, Cristine Steen-louws2, C.E. Hack3, Martin De Smet4, Floris Lafeber5 and J.A.G. van Roon6, 1Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2Rheumatology & Clinical Immunology/Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 3Immunology, UMC Utrecht, Utrecht, Netherlands, 4Lab Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 5Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, 6Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: A considerable percentage of patients shows a limited response to biologics targeting one specific inflammatory mediator, largely because of redundancy of these mediators. An…
  • Abstract Number: 1764 • 2013 ACR/ARHP Annual Meeting

    Binding Of Apoptotic Fetal Cardiocytes By Anti-Ro Antibodies Stimulates uPA/uPAR- Dependent Macrophage Infiltration and M2 Type Phenotype

    Paraskevi Briasouli1, Savvas Pavlides2, Leslie Gold3, Mark Halushka4 and Jill P. Buyon5, 1Rheumatology, New York University Medical Center, New York, NY, 2New York University Medical Center, new York, NY, 3new York University Medical Center, new York, NY, 4Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, 5Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Organ injury induced by antibodies characteristic of Sjogren's Syndrome and Systemic Lupus Erythematosus, while varied in the adult and fetus, may share in common…
  • Abstract Number: 1765 • 2013 ACR/ARHP Annual Meeting

    Complement Component C5a Permits The Co-Existence Of Pathogenic Th17 Cells and Type I Interferon In Lupus

    Marc C. Levesque1, Sudesh Pawaria2, Kelly Maers2 and Partha Biswas3, 1Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Dept. of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a type I interferon (IFN-I)-driven autoimmune disorder with exaggerated B and T-helper (Th) cell responses.  Th17 cells, a recently…
  • Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting

    Role Of IL33 In The Inflammation Of Takayasu Arteritis

    David Saadoun1, Marlène Garrido2, Julien Gaudric3, Cloé Comarmond4, Michele Rosenzwacjg5 and Patrice Cacoub6, 1Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, 2I3 laboratory, Pitié-Salpétrière, Paris, France, 3Department of Vascular surgery GHPS, Paris, France, 4Internal Medicine and Clinical Imunology, Referal Center for Autoimmune diseases, Internal Medicine and Clinical Imunology, Hôpital Pitié Salpétrière, Paris, France, 5Department of Immunology GHPS, Paris, France, 6Médecine Interne 2, Hopital Pitié-Salpétrière, Paris, France

    Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…
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