Abstract Number: 1757 • 2013 ACR/ARHP Annual Meeting
Does Foot Pain Mediate The Effect Of Knee Osteoarthritis and Risk Of Indoor and Outdoor Falls In Older Men and Women?
Background/Purpose: Knee osteoarthritis (OA), foot pain, and falls are common in older adults and limit mobility. We previously showed that knee OA increases the risk…Abstract Number: 1759 • 2013 ACR/ARHP Annual Meeting
The Effect Of Knee Replacement On Self-Reported Participation and Gait Speed: The Multicenter Osteoarthritis Study and The Osteoarthritis Initiative
The Effect of Knee Replacement on Self-Reported Participation and Gait Speed: The MOST Study and the Osteoarthritis InitiativeBackground/Purpose: Little research has explored participation outcomes, defined…Abstract Number: 1758 • 2013 ACR/ARHP Annual Meeting
Low Literacy Decision Aid Enhances Knowledge and Reduces Decisional Conflict Among Diverse Population Of Adults With Rheumatoid Arthritis: Results Of a Pilot Trial
Background/Purpose: Vulnerable populations with rheumatoid arthritis (RA) have poorer outcomes and report suboptimal shared decision-making communication. Patient involvement in the choice of disease modifying anti-rheumatic…Abstract Number: 1760 • 2013 ACR/ARHP Annual Meeting
Relationships Between Driving Distance, Rheumatoid Arthritis Diagnosis, and Disease-Modifying Anti-Rheumatic Drug Receipt
Background/Purpose: Disease-modifying antirheumatic drugs (DMARDs) are recommended for all patients with rheumatoid arthritis (RA). Some studies estimate that almost half of patients with RA do…Abstract Number: 1761 • 2013 ACR/ARHP Annual Meeting
The Link Of Foot Structure and Foot Function With Falls: The Johnston County Osteoarthritis Project
Background/Purpose: Nearly 1/3 of older adults experience at least one fall annually in the United States. Foot type (static and dynamic arch height) is…Abstract Number: 1762 • 2013 ACR/ARHP Annual Meeting
Endogenous IL-22 Regulates Th1 Responses and Plays a Pathogenic Role After the Onset of Arthritis
Background/Purpose: IL-22,belongs to the IL-10 family of cytokines and is primarily produced by CD4 T, NK and LTi cells. IL-22 plays a dual role depending…Abstract Number: 1763 • 2013 ACR/ARHP Annual Meeting
IL4-10 Synerkine: A Novel Immunoregulatory Drug To Prevent Immunopathology In Rheumatic Diseases
Background/Purpose: A considerable percentage of patients shows a limited response to biologics targeting one specific inflammatory mediator, largely because of redundancy of these mediators. An…Abstract Number: 1764 • 2013 ACR/ARHP Annual Meeting
Binding Of Apoptotic Fetal Cardiocytes By Anti-Ro Antibodies Stimulates uPA/uPAR- Dependent Macrophage Infiltration and M2 Type Phenotype
Background/Purpose: Organ injury induced by antibodies characteristic of Sjogren's Syndrome and Systemic Lupus Erythematosus, while varied in the adult and fetus, may share in common…Abstract Number: 1765 • 2013 ACR/ARHP Annual Meeting
Complement Component C5a Permits The Co-Existence Of Pathogenic Th17 Cells and Type I Interferon In Lupus
Background/Purpose: Systemic lupus erythematosus (SLE) is a type I interferon (IFN-I)-driven autoimmune disorder with exaggerated B and T-helper (Th) cell responses. Th17 cells, a recently…Abstract Number: 1766 • 2013 ACR/ARHP Annual Meeting
Role Of IL33 In The Inflammation Of Takayasu Arteritis
Background/Purpose: Interleukin (IL)-33, a member of the IL-1 cytokine family, is a recently described novel activator of endothelial cells, which promotes adhesion molecules and proinflammatory…Abstract Number: 1767 • 2013 ACR/ARHP Annual Meeting
Gender, Race, and Soluble Mediators Distinguish Blood Relatives Who Develop Incomplete Lupus Or Classified SLE In The Lupus Autoimmunity In Relatives (LAUREL) Study
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and identify individuals for prevention trials. Healthy blood relatives (FDRs) of lupus…Abstract Number: 1728 • 2013 ACR/ARHP Annual Meeting
Amelioration Of Collagen-Induced Arthritis By Modulation Of Inhibitory Apoptosis Stimulating Protein Of p53 To Activate Transcription Factor p73
Background/Purpose: Our previous studies have demonstrated p53 mutations competent for the inactivation of wild type p53 in synovial fibroblasts (SF) from either rheumatoid arthritis patients…Abstract Number: 1729 • 2013 ACR/ARHP Annual Meeting
Cell Cycle Regulation Therapy Combined With Cytokine Blockade Enhances Anti-Arthritic Effects Without Increase Of Immune Suppression
Background/Purpose: The pathogenesis of rheumatoid arthritis (RA) is characterized by infiltration of immune cells to the synovial tissues and their hyperplasia. Aim of the current…Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting
Novel Role For Ly6C– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis
Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…Abstract Number: 1731 • 2013 ACR/ARHP Annual Meeting
Treatment Of Innate Immune Arthritis With a Toll-Like Receptor 7 Agonist Requires Type I Interferon
Background/Purpose: We previously demonstrated that repeated administration of the low molecular weight Toll-like receptor (TLR) 7 agonist (1V136) substantially reduces arthritic inflammation in mice. Here…