ACR Meeting Abstracts

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  • Abstract Number: 1811 • 2013 ACR/ARHP Annual Meeting

    Validation Of The ICD-CM-9 Code For Systemic Sclerosis Using Updated ACR/EULAR Classification Criteria

    Aaliya Yaqub1, Lorinda Chung2, David Fiorentino3 and Eswar Krishnan4, 1Stanford Univ Medical Center, Stanford, CA, 2Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 3Dermatology, Stanford University School of Medicine, Redwood City, CA, 4Medicine, Stanford University, Palo Alto, CA

    Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease associated with substantial morbidity.  Epidemiologic studies using large administrative databases often rely on the accuracy of…
  • Abstract Number: 1812 • 2013 ACR/ARHP Annual Meeting

    Adverse Events In Connective Tissue Disease-Associated Pulmonary Arterial Hypertension Compared To Idiopathic Pulmonary Arterial Hypertension

    Rennie L. Rhee1, Nicole B. Gabler2, Amy Praestgaard2, Peter A Merkel3 and Steven M. Kawut4, 1Rheumatology, University of Pennsylvania, Philadelphia, PA, 2Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 3Division of Rheumatology, University of Pennsylvania and VA Medical Center, Philadelphia, PA, 4Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Whether the risk of treatment-related adverse events (AEs) in patients with pulmonary arterial hypertension (PAH) differs based on diagnosis, either connective tissue disease (CTD-PAH)…
  • Abstract Number: 1814 • 2013 ACR/ARHP Annual Meeting

    The Risk Of Pulmonary Embolism and Deep Venous Thrombosis In Systemic Sclerosis: A Population-Based Cohort Study

    J. Antonio Avina-Zubieta1, Iman Hemmati2, Eric C. Sayre3, Kamran Shojania3,4 and Hyon Choi3,5,6, 1Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, 2Deparment of Medicine and Rheumatology, University of British Columbia, Vancouver, BC, Canada, 3Arthritis Research Centre of Canada, Richmond, BC, Canada, 4Rheumatology, University of British Columbia, Vancouver, BC, Canada, 5Section of Rheumatology and the Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 6Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Data on the risk of pulmonary embolism (PE) and deep venous thrombosis (DVT) in patients with systemic sclerosis (SSc) is lacking. To fill this…
  • Abstract Number: 1815 • 2013 ACR/ARHP Annual Meeting

    Asymmetric Dimethylarginine Levels In The Early Detection Of Systemic Sclerosis-Related Pulmonary Arterial Hypertension

    Vivek Thakkar1, Wendy Stevens2, David Prior3, Joanne Sahhar4, Janet E. Roddy5, Jane Zochling6, Peter Nash7, Peter Youssef8, Susanna Proudman9 and Mandana Nikpour10, 1St Vincent's Hospital, Melbourne, Australia, 2Rheumatology, St Vincent's Hospital, Melbourne, Australia, 3Cardiology, St Vincent's Hospital, Melbourne, Australia, 4Rheumatology Unit, Monash Medical Centre, Clayton, Australia, 5Royal Perth Hospital, Perth, Australia, 6Menzies Research Institute Tasmania, Hobart, Australia, 7Rheumatology Research Unit, Nambour Hospital, Sunshine Coast, Australia, 8Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, Australia, 9Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, 10Department of Medicine (St Vincent's Hospital), University of Melbourne, Fitzroy, Australia

    Background/Purpose: Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc), and alterations in nitric oxide (NO) metabolism and endothelial cell…
  • Abstract Number: 1816 • 2013 ACR/ARHP Annual Meeting

    Exercise Therapy Reduces Pain Sensitivity In Patients With Knee Osteoarthritis: A Randomized Controlled Trial

    Marius Henriksen1, Louise Klokker2, Thomas Graven-Nielsen3, Cecilie Bartholdy2, Tanja Schjoedt Joergensen4, Elisabeth Bandak1, Bente Danneskiold-Samsøe5, Robin Christensen6 and Henning Bliddal1, 1Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark, 2The Parker Institute, Copenhagen, Denmark, 3Center for Sensori-Motor Interaction, Aalborg University, Aalborg, Denmark, 4The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen F, Denmark, 5Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark, 6Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark

    Background/Purpose: Exercise has beneficial effects on pain in patients with knee osteoarthritis (OA), yet the underlying analgesic mechanisms are ambiguous. A deeper understanding of the…
  • Abstract Number: 1817 • 2013 ACR/ARHP Annual Meeting

    The Clinical Burden Of Generalized Osteoarthritis Represented By Activity Limitations and Health Related Quality Of Life: A Cross-Sectional Study

    Nienke Cuperus1, Thea Vliet Vlieland2, Elien Mahler1, Clarinda Kersten1, Thomas Hoogeboom3 and Els van den Ende1, 1Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Department of Orthopaedics, University Medical Center Leiden, Leiden, Netherlands, 3Department of Epidemiology, CAPHRI school for public health and primary care, CCTR centre for Care Technology Research, Maastricht University, Maastricht, Netherlands

    Background/Purpose: A growing body of evidence shows that generalized osteoarthritis (GOA) is fairly common, however research and clinical practice recommendations are mainly focused on a…
  • Abstract Number: 1818 • 2013 ACR/ARHP Annual Meeting

    Automated Telephone-Linked Communication: A Novel Approach To Enhance Long-Term Adherence To Resistance Training Exercise Among People With Knee Osteoarthritis

    Kristin Baker1, Aileen Ledingham1, Michael P. Lavalley2, Julie J. Keysor1 and David T. Felson3, 1Physical Therapy, Boston University Sargent College, Boston, MA, 2Biostatistics, Boston University, Boston, MA, 3Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom

    Background/Purpose: Knee Osteoarthritis (OA) is one of the most common chronic musculoskeletal conditions and is a leading cause of disability.  Strengthening exercise is well known…
  • Abstract Number: 1819 • 2013 ACR/ARHP Annual Meeting

    Effectiveness Of Pilates Method For The Treatment Of Chronic Mechanical Neck PAIN

    Luciana A. Cazotti1, Anamaria Jones1, Diego Roger Silva2, Luiza H. C. Ribeiro1 and Jamil Natour3, 1Unifesp-EPM, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 3Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil

    Background/Purpose: The neck pain comes from multifactorial origin and affects approximately 70% of individuals at some point in their lives being considered a frequent problem…
  • Abstract Number: 1820 • 2013 ACR/ARHP Annual Meeting

    Assessing 24-Hour Physical (In)Activity and Sleep In People With Early Rheumatoid Arthritis

    Christopher Feehan1, Eric C. Sayre2, Erin Carruthers2 and Lynne M. Feehan3, 1Medicine, University of British Columbia, Vancouver, BC, Canada, 2Arthritis Research Centre of Canada, Richmond, BC, Canada, 3Physical Therapy, Arthritis Research Centre of Canada and University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: For people with inflammatory arthritis, the health benefits of physical activity (PA) and negative impact of sedentary lifestyle are clear. However, it is unclear…
  • Abstract Number: 1821 • 2013 ACR/ARHP Annual Meeting

    Benefits Of Progressive Muscle Strengthening Using a Swiss Ball In Patients With Ankylosing Spondylitis: A Randomized Controlled Trial

    Marcelo Souza1, Fabio Jennings2, Hisa Morimoto1 and Jamil Natour3, 1Division of Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 3Rheumatology, Universidade Federal de São Paulo, São Paulo, Brazil

    Background/Purpose: Ankylosing spondylitis (AS) is a systemic inflammatory disease that affects the physical capacity of patients globally. Exercises are recommended to the management of patients…
  • Abstract Number: 1822 • 2013 ACR/ARHP Annual Meeting

    Oleanolic Acid Acetate Inhibits Osteoclast Differentiation By Downregulating Phospholipase Cγ2 –calcium ion oscillation-Nuclear Factor Of Activated T Cell c1 Signaling, and Suppresses Bone Loss In Mice

    Chang-Hoon Lee1, Myeung Su Lee1, Won Seok Lee2, Wan-Hee Yoo3, Ju-Young Kim4, Jae-Min Oh4 and Yong-Geun Jeong5, 1Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, Chonbuk, South Korea, 2Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 3Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, South Korea, 4Department of Anatomy, School of Medicine, Wonkwang University, Iksan, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Changwon Fatima Hospital, Changwon, South Korea

    Background/Purpose: we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis(azuki bean) to discover anti-bone resorptive agents. Many studies have identified and…
  • Abstract Number: 1823 • 2013 ACR/ARHP Annual Meeting

    IL-6 Suppresses Osteoblast Differentiation Through The SHP2/MEK2 and SHP2/Akt2 Pathways In Vitro

    Shoichi Kaneshiro1, Kosuke Ebina1, Kenrin Shi1, Chikahisa Higuchi2, Hideki Yoshikawa1, Jun Hashimoto3 and Makoto Hirao4, 1Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan, 2Osaka University Graduate School of Medicine, Suita, Japan, 3Dept of Rheumatology, Osaka-Minami Medical Center, Kawachinagano City, Japan, 4Orthopaedic Surgery, Osaka Minami Medical Center, Osaka, Japan

    Background/Purpose: Interleukin-6 (IL-6), a potent inflammatory cytokine, plays a key role in the pathogenesis of rheumatoid arthritis (RA), including osteoporosis not only in inflamed joints…
  • Abstract Number: 1826 • 2013 ACR/ARHP Annual Meeting

    Immune Complex Formation By Adalimumab Contributes Significantly To Its Inhibitory Effect On TNF-Enhanced Human Osteoclast Development Even In The Absence Of Fc Receptor Binding

    Bohdan P. Harvey and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast development. …
  • Abstract Number: 1824 • 2013 ACR/ARHP Annual Meeting

    ONO-4059 – A Novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase- Suppresses Osteoclastic Bone Resorption and Inflammation

    Yuko Ariza1, Toshio Yoshizawa1, Yoshiko Ueda1, Shingo Hotta1, Tomoko Yasuhiro1, Masami Narita1, Yutaka Shichino2 and Kazuhito Kawabata1, 1Discovery Research Laboratories 3, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 2Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., Osaka, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by leukocyte infiltration, synoviocyte hyperplasia and osteoclastogenesis, leading to erosion of the joints and cartilage,…
  • Abstract Number: 1825 • 2013 ACR/ARHP Annual Meeting

    Osteoclast Progenitors, Fibroblast-Like Cells and Draining Lymph Node Cells Induce Catecholaminergic-To-Cholinergic Transition Of Sympathetic Nerve Fibers Under Healthy Conditions But Not In Highly Inflamed Arthritic Tissue

    Hubert Stangl1, Dominique Muschter2, Susanne Graessel3 and Rainer H. Straub4, 1Department of Internal Medicine 1, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, 2Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital Regensburg, Regensburg, Germany, 3Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital of Regensburg, Regensburg, Germany, 4Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany

    Background/Purpose: Sympathetic nerve fibers innervate bone and tissue adjacent to joints. They play an important role in bone and tissue homeostasis. Under certain conditions, sympathetic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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