Abstract Number: 1817 • 2013 ACR/ARHP Annual Meeting
The Clinical Burden Of Generalized Osteoarthritis Represented By Activity Limitations and Health Related Quality Of Life: A Cross-Sectional Study
Background/Purpose: A growing body of evidence shows that generalized osteoarthritis (GOA) is fairly common, however research and clinical practice recommendations are mainly focused on a…Abstract Number: 1818 • 2013 ACR/ARHP Annual Meeting
Automated Telephone-Linked Communication: A Novel Approach To Enhance Long-Term Adherence To Resistance Training Exercise Among People With Knee Osteoarthritis
Background/Purpose: Knee Osteoarthritis (OA) is one of the most common chronic musculoskeletal conditions and is a leading cause of disability. Strengthening exercise is well known…Abstract Number: 1819 • 2013 ACR/ARHP Annual Meeting
Effectiveness Of Pilates Method For The Treatment Of Chronic Mechanical Neck PAIN
Background/Purpose: The neck pain comes from multifactorial origin and affects approximately 70% of individuals at some point in their lives being considered a frequent problem…Abstract Number: 1820 • 2013 ACR/ARHP Annual Meeting
Assessing 24-Hour Physical (In)Activity and Sleep In People With Early Rheumatoid Arthritis
Background/Purpose: For people with inflammatory arthritis, the health benefits of physical activity (PA) and negative impact of sedentary lifestyle are clear. However, it is unclear…Abstract Number: 1821 • 2013 ACR/ARHP Annual Meeting
Benefits Of Progressive Muscle Strengthening Using a Swiss Ball In Patients With Ankylosing Spondylitis: A Randomized Controlled Trial
Background/Purpose: Ankylosing spondylitis (AS) is a systemic inflammatory disease that affects the physical capacity of patients globally. Exercises are recommended to the management of patients…Abstract Number: 1822 • 2013 ACR/ARHP Annual Meeting
Oleanolic Acid Acetate Inhibits Osteoclast Differentiation By Downregulating Phospholipase Cγ2 –calcium ion oscillation-Nuclear Factor Of Activated T Cell c1 Signaling, and Suppresses Bone Loss In Mice
Background/Purpose: we first isolated oleanolic acid acetate (OAA), a triterpenoid compound, from Vigna angularis(azuki bean) to discover anti-bone resorptive agents. Many studies have identified and…Abstract Number: 1823 • 2013 ACR/ARHP Annual Meeting
IL-6 Suppresses Osteoblast Differentiation Through The SHP2/MEK2 and SHP2/Akt2 Pathways In Vitro
Background/Purpose: Interleukin-6 (IL-6), a potent inflammatory cytokine, plays a key role in the pathogenesis of rheumatoid arthritis (RA), including osteoporosis not only in inflamed joints…Abstract Number: 1826 • 2013 ACR/ARHP Annual Meeting
Immune Complex Formation By Adalimumab Contributes Significantly To Its Inhibitory Effect On TNF-Enhanced Human Osteoclast Development Even In The Absence Of Fc Receptor Binding
Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast development. …Abstract Number: 1824 • 2013 ACR/ARHP Annual Meeting
ONO-4059 – A Novel Small Molecule Dual Inhibitor Of Bruton’s Tyrosine Kinase (Btk) and Tec Kinase- Suppresses Osteoclastic Bone Resorption and Inflammation
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by leukocyte infiltration, synoviocyte hyperplasia and osteoclastogenesis, leading to erosion of the joints and cartilage,…Abstract Number: 1825 • 2013 ACR/ARHP Annual Meeting
Osteoclast Progenitors, Fibroblast-Like Cells and Draining Lymph Node Cells Induce Catecholaminergic-To-Cholinergic Transition Of Sympathetic Nerve Fibers Under Healthy Conditions But Not In Highly Inflamed Arthritic Tissue
Background/Purpose: Sympathetic nerve fibers innervate bone and tissue adjacent to joints. They play an important role in bone and tissue homeostasis. Under certain conditions, sympathetic…Abstract Number: 1827 • 2013 ACR/ARHP Annual Meeting
The Intraarticular Injection Of An Inhibitor Of Complex V Of Mitochondrial Respiratory Chain Induces a Pathological Response In Rat Knee Joints
Background/Purpose: A decline of mitochondrial function has been described in OA chondrocytes and RA synoviocytes. Recent ex vivo findings support a connection between mitochondrial dysfunction…Abstract Number: 1805 • 2013 ACR/ARHP Annual Meeting
Hydroxychloroquine Levels Identify Four Distinct Subsets of Systemic Lupus Erythematosus Patients
Background/Purpose: Hydroxychloroquine is used for both its effect on SLE disease activity (cutaneous and arthritis) and for its preventive roles (reduction in flares, renal damage,…Abstract Number: 1788 • 2013 ACR/ARHP Annual Meeting
The Multi-Biomarker Disease Activity Test (Vectra® DA) Estimates Risk Of Radiographic Progression For Patients With Rheumatoid Arthritis From The Leiden Early Arthritis Clinic
Background/Purpose: The multi-biomarker disease activity (MBDA) blood test assesses disease activity in patients with rheumatoid arthritis (RA) using a validated algorithm to provide a score…Abstract Number: 1789 • 2013 ACR/ARHP Annual Meeting
In Early Rheumatoid Arthritis, The 12 Individual Biomarkers That Comprise The Multiple Biomarker Disease Activity Score Relate Differentially To Clinical Response and Radiographic Progression: Results From a Randomized Trial
Background/Purpose: In early rheumatoid arthritis (eRA), clinical and radiographic predictors would be very useful for optimizing available therapies. Individual biomarkers and their combinations, such as…Abstract Number: 1790 • 2013 ACR/ARHP Annual Meeting
Serum Amyloid A Levels Model Rheumatoid Arthritis Disease Activity Better Than C-Reactive Protein Levels Especially During Treatment With Anti-Tumor Necrosis Factor α Therapy (Etanercept)
Background/Purpose: C reactive protein (CRP) levels have been used extensively to model disease activity in rheumatoid arthritis (RA). However, TNF antagonist therapy (and likely therapy…