Abstract Number: 1862 • 2013 ACR/ARHP Annual Meeting
Target-Directed Development Of a Proposed Biosimilar Etanercept, GP2015: Comparability Of In Vitro Target Binding and Pre-Clinical Efficacy and Pharmacokinetics
Background/Purpose: Biosimilars are copy versions of existing biologic medicines that have lost patent exclusivity and are approved via stringent regulatory pathways. Biosimilars are designed to…Abstract Number: 1863 • 2013 ACR/ARHP Annual Meeting
SLE Disease Activity In The Mucocutaneus, Vascular and Hematologic Systems Is Associated With An Increase In Plasma Type I Interferon Activity
Background/Purpose: Type I interferon (IFN-I) has been implicated in SLE pathogenesis, and cross-sectional studies have shown that IFN-I pathway activation is associated with multiple disease…Abstract Number: 1864 • 2013 ACR/ARHP Annual Meeting
Immunologic Markers and Molecular Mechanisms Associated With Increased Systemic Lupus Erythematosus Activity In Patients Not Taking Immunosuppressive Medications
Background/Purpose: The course of systemic lupus erythematosus (SLE) is characterized by exacerbations (or flares) and remissions of disease activity. Predicting which patients are likely to…Abstract Number: 1865 • 2013 ACR/ARHP Annual Meeting
Complement Activation and Anaphylatoxin Generation In Response To Staphylococcal Protein A Exposure: Ex Vivo and In Vivo Human Studies
Background/Purpose: PRTX-100, a highly-purified GMP staphylococcal protein A (SpA), is currently in clinical trials treating patients with active rheumatoid arthritis (RA). It has been reported…Abstract Number: 1866 • 2013 ACR/ARHP Annual Meeting
Primary Human Cell BioMAP® Profiling Of Methotrexate, Tocilizumab, Adalimumab, and Tofacitinib Reveals Different Mechanisms Of Action With Distinct Phenotypic Signatures
Background/Purpose: Proinflammatory cytokines cause joint inflammation and destruction in patients with rheumatoid arthritis, as exemplified by the therapeutic success of inhibiting tumor necrosis factor alpha…Abstract Number: 1867 • 2013 ACR/ARHP Annual Meeting
Profiling Cytokine Production Of B Cells From SLE Patients Upon TLR9 Stimulation
Background/Purpose: Beyond their antibody producing function, B cells have been shown to be potent antigen-presenting and cytokine-producing cells. In systemic lupus erythematosus (SLE), B cells…Abstract Number: 1833 • 2013 ACR/ARHP Annual Meeting
Combination Of TNF and IL-6 Induces Osteoclast-Like Cells With Bone-Resorption Activity Both In Vitro and In Vivo
Background/Purpose: Although TNF inhibitors suppress bone destruction in patients with rheumatoid arthritis (RA), TNFα stimulation alone does not directly induce osteoclasts, bone-resorbing cells. With the…Abstract Number: 1828 • 2013 ACR/ARHP Annual Meeting
In Vivo Cartilage-Specific Deletion Of Ephrin-B2 In Mice Results In Developmental Locomotory Defects Associated With Hip Bone Abnormality
Background/Purpose: The ephrins and their related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events. We have…Abstract Number: 1829 • 2013 ACR/ARHP Annual Meeting
Carboxypeptidase B2 Down-Regulates Osteoclast Activation In Inflammation
Background/Purpose: Carboxypeptidase B2 (CPB2) is well established to play an anti-fibrinolytic role by removing C-terminal lysine residues from fibrin, thereby preventing its cleavage by plasmin.…Abstract Number: 1830 • 2013 ACR/ARHP Annual Meeting
Adenosine A2A Receptor (A2AR) Diminishes Wear Particle (UHMWPE)-Mediated Osteolysis, Increases Bone Formation and Regulates Expression Of Axonal Guidance Proteins (AGP) By Macrophages, Osteoclasts (OC) and Osteoblasts (OB)
Background/Purpose: Communication between OC and OB is critical for maintenance of bone homeostasis; both OC and OB release regulatory messengers. Among these signaling molecules are…Abstract Number: 1831 • 2013 ACR/ARHP Annual Meeting
Study Of Serum Levels Of Osteocalcin (s-OC) On Patients With Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Ankylosing Spondilitis (AS)
Background/Purpose: Osteocalcin (bone Gla protein), one of the basic markers for bone matabolism, has not been thoroughly studied on patients with DISH and AS. It…Abstract Number: 1832 • 2013 ACR/ARHP Annual Meeting
Discovery of MicroRNAs in the Regulation of Inflammation and Bone Erosion in Rheumatoid Arthritis
Background/Purpose: Focal articular bone erosion in rheumatoid arthritis (RA) is mediated by osteoclasts and repair of erosion by osteoblasts is uncommon, despite the use of…Abstract Number: 1834 • 2013 ACR/ARHP Annual Meeting
Abnormal Collagen Fibers Deposition In The Synovial Joints Is a Characteristic Of The Temporal Evolution Of The Diabetic rats’ Model Induced By Streptozotocin
Background/Purpose: Diabetes is a causative factor in joint diseases and amplifies the damage induced by other agents as well. According to an accepted hypothesis, damaged…Abstract Number: 1835 • 2013 ACR/ARHP Annual Meeting
Dynamic Visualization Of Monocyte Migration In 3D Synovial Micromass Tissue Cultures
Background/Purpose: Monocytes (Mo) are among the first hematopoietic cells to migrate into the inflamed synovial tissue of arthritic joints. Monocyte migration appears to be associated…Abstract Number: 1836 • 2013 ACR/ARHP Annual Meeting
Suppression Of HDAC5 Expression By Inflammatory Cytokines Is Required To Promote CXCL Chemokine Production In RA FLS
Background/Purpose: Histone deacetylases (HDACs) are important regulators of gene expression and protein function in the immune system. HDAC inhibitors (HDACi) display anti-inflammatory properties in animal…
ACR Meeting Abstracts