Abstract Number: 1872 • 2013 ACR/ARHP Annual Meeting
Gene-Body Mass Index Interactions Are Associated With Methotrexate Toxicity in Rheumatoid Arthritis
Background/Purpose: Response to methotrexate (MTX) therapy in rheumatoid arthritis (RA) is highly heterogeneous, with both genetic and environmental factors contributing to the efficacy and toxicity…Abstract Number: 1873 • 2013 ACR/ARHP Annual Meeting
Use Of Mendelian Randomization Associates Increased Serum Urate Caused By Genetic Variation In Uric Acid Transporters With Improved Renal Function
Background/Purpose: Hyperuricemia is the central risk factor for gout. In observational studies hyperuricemia also predicts the development and progression of chronic kidney disease independent of…Abstract Number: 1874 • 2013 ACR/ARHP Annual Meeting
Genome-Wide Profiling Identifies Significant Differences Between The T-Lymphocyte and B-Lymphocyte Methylomes In Healthy Individuals
Background/Purpose: Multiple reports now describe changes to the DNA methylome in a variety of autoimmune disorders, such as rheumatoid arthritis. In many cases, these studies…Abstract Number: 1875 • 2013 ACR/ARHP Annual Meeting
A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…Abstract Number: 1876 • 2013 ACR/ARHP Annual Meeting
Potential Chondrogenic Biomarkers For Cell-Based Therapy Monitoring In Osteoarthritis
Background/Purpose: Chondrogenesis occurs as a result of mesenchymal stem cells (MSCs) condensation and chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain as resting cells to…Abstract Number: 1877 • 2013 ACR/ARHP Annual Meeting
A Neutrophil Signature Comprised Of Low Density Granulocyte (LDG)-Enriched Genes Is Associated With Organ-Specific Disease Activity In Systemic Lupus Erythematosus
Background/Purpose: The neutrophil gene signature (NGS) has recently gained interest due to new understanding of the role of neutrophils and NETosis in SLE pathogenesis. We…Abstract Number: 1878 • 2013 ACR/ARHP Annual Meeting
Proteomics Analysis Of Cartilage Secretome: A Powerful Tool For The Discovery Of OA Biomarkers
Background/Purpose: Osteoarthritis (OA) is characterized by the progressive loss of cartilage structural extracellular matrix (ECM) components, mainly collagenous and non-collagenous proteins. The release of these…Abstract Number: 1879 • 2013 ACR/ARHP Annual Meeting
Major Histocompatibility Complex Class I Molecules Contribute To Behçet’s Disease Risk Through Both Innate and Adaptive Immune Interactions
Background/Purpose: Behçet's Disease (BD) is a complex genetic disease of unknown etiology that is characterized by inflammatory lesions of the eyes, skin, and oro-genital mucosa.…Abstract Number: 1880 • 2013 ACR/ARHP Annual Meeting
Global Gene Expression Profiles Reveal Genetic Signatures Of Kawasaki Disease and Disease Outcome
Background/Purpose: Kawasaki Disease (KD) is a self-limited vasculitis of unknown etiology that predominantly affects children younger than 5 years. The inflammation associated with KD affects…Abstract Number: 1881 • 2013 ACR/ARHP Annual Meeting
HLA-DRB1 Rheumatoid Arthritis Susceptibility Amino Acids Define Haplotypes Associated With Radiological Outcome
Background/Purpose: Rheumatoid arthritis (RA) is a systematic autoimmune disease caused by the interplay between environmental and genetic risk factors. The major genetic determinants of RA…Abstract Number: 1882 • 2013 ACR/ARHP Annual Meeting
Characterizing The C-Type Lectin Domain Family 4, Member C Gene (CLEC4C) Expression In Peripheral Blood From Rheumatoid Arthritis Patients
Background/Purpose: A previous hypothesis-seeking study examining baseline phenotypic expression of mRNA in a Phase 2 clinical trial of tabalumab (also known as LA294 or LY2127399)…Abstract Number: 1883 • 2013 ACR/ARHP Annual Meeting
Fine Mapping and Expression Of a Locus Overlapping 3 Types Of Inflammatory Arthritis
Background/Purpose: In a recent fine-mapping study using the Immunochip array, the RUNX1 region was strongly associated with rheumatoid arthritis (RA p=5x10-10), juvenile idiopathic arthritis (JIA…Abstract Number: 1884 • 2013 ACR/ARHP Annual Meeting
Autoantibody Specificities and Type I Interferon Pathway Activation In Idiopathic Inflammatory Myopathies
Background/Purpose: Idiopathic inflammatory myopathies (IIM) are rare autoimmune diseases characterized by proximal muscle weakness and muscle inflammation. IIM are associated with several autoantibodies, which are…Abstract Number: 1885 • 2013 ACR/ARHP Annual Meeting
A Weighted Genetic Risk Score Using All Known Susceptibility Variants To Predict Rheumatoid Arthritis Risk
Background/Purpose: Recent advances in the identification of loci associated with susceptibility to complex disease have led to methods being developed that incorporate this information into…Abstract Number: 1886 • 2013 ACR/ARHP Annual Meeting
Differential Methylation Related To Response To Etanercept In Patients With Rheumatoid Arthritis
Background/Purpose: The introduction of biologic drug therapies targeting specific components of the inflammatory response represents a huge advance in the treatment of rheumatoid arthritis (RA).…
ACR Meeting Abstracts