Abstract Number: 1625 • 2014 ACR/ARHP Annual Meeting
Interferon Stimulates Transglutaminase Activity on Human Monocytes and Their Microparticles
Background/Purpose: Microparticles (MPs) are circulating membrane-bound vesicles derived from blood and endothelial cells via a highly regulated process. They are immunomodulatory and have been implicated…Abstract Number: 1624 • 2014 ACR/ARHP Annual Meeting
The Role of B Lymphocyte Stimulator in Monocyte Subpopulation Differentiation in SLE
Background/Purpose Monocytes are increasingly recognised to play a key role in the pathogenesis of SLE. Different subpopulations of monocytes contribute to the disease through dysregulated pro…Abstract Number: 1623 • 2014 ACR/ARHP Annual Meeting
Increased CD95 (Fas) Expression on Naive B Cells Is Associated with a Switch to Double Negative and Plasma Cells in the Peripheral Blood, and Correlates with Disease Activity in Systemic Lupus Erythematosus
Background/Purpose: systemic lupus erythematosus (SLE) is characterized by a break of tolerance to autoantigens, and polyclonal activation of B cells. We performed multicolor flow cytometry…Abstract Number: 1642 • 2014 ACR/ARHP Annual Meeting
A Prospective Study of Vitamin D Effects on T Cells Phenotype in Patients with Systemic Lupus Erythematosus Treated with Different Regimens of Supplementation for Two Years
Background/Purpose Vitamin D (VD) receptor is constitutively expressed on the membrane of multiple cells, including lymphocytes. Recent studies highlight that VD may have an action…Abstract Number: 1641 • 2014 ACR/ARHP Annual Meeting
Baseline Factors That Predict High BLyS Levels in Patients with Systemic Lupus Erythematosus (SLE) and High Disease Activity
Background/Purpose: Post hoc analyses from the BLISS trials demonstrated that patients with high baseline B-lymphocyte stimulator (BLyS) levels (≥2 ng/ml) had an increased risk of…Abstract Number: 1640 • 2014 ACR/ARHP Annual Meeting
Cyclophosphamide Diminishes Plasmablasts and Transitional B Cells and Suppresses Autocrine Production of B Cell Activating Factor of Tumor Necrosis Factor Family (BAFF) in These Cells in Patients with Systemic Lupus Erythematosus
Background/Purpose . B cell activating factor of tumor necrosis factor family (BAFF) is a positive regulator of B cell function and expressed in dendritic cells,…Abstract Number: 1639 • 2014 ACR/ARHP Annual Meeting
Serum Anti-Müllerian Hormone Levels in SLE Patients. the Disease Severity and Cyclophosphamide Reduce the Ovarian Reserve
Background/Purpose . Systemic lupus erythematosus (SLE) predominantly affects women of childbearing age, can lead to severe organ involvement and may require prolonged immunosuppressive therapy. Anti-Müllerian Hormone is produced by the granulosa ovary cells and…Abstract Number: 1638 • 2014 ACR/ARHP Annual Meeting
Anti-Dense Fine Speckled 70 Antibodies: Long-Term Followup Study of Clinical Associations in a US Laboratory Patient Population
Background/Purpose The recently recognized nuclear dense fine speckled immunofluorescence (IF) ANA pattern is associated with antibodies to the dense fine speckled 70 (DFS70) antigen. Presence…Abstract Number: 1637 • 2014 ACR/ARHP Annual Meeting
LACK of Association of ANTI CCP and Arthritis in SLE
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by multiplicity of auto antibodies, many of them play an unknown role in disease pathogenesis. Anti cyclic citrulinated…Abstract Number: 1616 • 2014 ACR/ARHP Annual Meeting
Functional Profiling of PBMC from SLE Patients Versus Healthy Controls Identifies Subgroups with Disease-Associated Dysfunctional Signaling
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a multi-system rheumatic disease with widely differing clinical manifestations and outcomes. Treatment is generally immunosuppressive, with no available…Abstract Number: 1615 • 2014 ACR/ARHP Annual Meeting
MiR-127-3p As a Novel Regulator of Type I Interferon Signaling Pathway in SLE
Background/Purpose Type I interferon(IFN) is a critical pathogenic factor in Systemic Lupus Erythematosus(SLE) and its associated nephritis, as elevated IFN inducible genes have been found…Abstract Number: 1614 • 2014 ACR/ARHP Annual Meeting
Functional Analysis of Interferon Responsiveness in PBMC from SLE Donors Identifies Subgroups with Higher and Lower Disease Activity
Background/Purpose: Interferons (IFN) reportedly are central to SLE pathogenesis and increased expression of IFN regulated genes (the ‘IFN signature') is associated with active disease. Clinical…Abstract Number: 1613 • 2014 ACR/ARHP Annual Meeting
Circulating microRNAs As Candidate Biomarkers of Diagnosis in Systemic Lupus Erythematosus
Background/Purpose : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. MicroRNAs (miRNAs) are short,…Abstract Number: 1612 • 2014 ACR/ARHP Annual Meeting
Deficient Repair of DNA Double-Strand Breaks and Increased Apoptosis in Patients with Lupus Nephritis
Background/Purpose: Accumulation of apoptotic cells leads to excessive autoantigen presentation and autoantibody formation in autoimmunity, whereas mandatory to avoid apoptosis is the efficient repair of…Abstract Number: 1611 • 2014 ACR/ARHP Annual Meeting
Modular Transcriptional Neutrophil Signature As Predictive of Nephritis and of Its Severity in SLE Patients
Background/Purpose: Lupus nephritis (LN) is a serious complication of SLE. Reliable biomarkers to assess and/or predict renal involvement in SLE patients are needed. The aim…
ACR Meeting Abstracts