Abstracts Archive - Page 2125 of 2425 - ACR Meeting Abstracts

Abstract Number: 1897 • 2013 ACR/ARHP Annual Meeting
Algorithms Using Genome-Wide SNP Analysis For Prediction Of Progression Of Joint Space Narrowing Or Erosion In Rheumatoid Arthritis Patients Using Data From Multiple Medical Cohorts
Tsukasa Matsubara¹, Satoru Koyano², Yoshitada Sakai³, Keiko Funahashi², Takako Miura¹, Kosuke Okuda¹, Takeshi Nakamura¹, Akira Sagawa⁴, Takeo Sakurai⁵, Hiroaki Matsuno⁶, Tomomaro Izumihara⁷ and Eisuke Shono⁸, ¹Matsubara Mayflower Hospital, Kato, Japan, ²Research Institute of Joint Diseases, Kobe, Japan, ³Kobe University, Kobe, Japan, ⁴Sagawa Akira Rheumatology Clinic, Sapporo, Japan, ⁵Inoue Hospital, Takasaki, Japan, ⁶Matsuno Clinic for Rheumatic Diseases, Toyama, Japan, ⁷Izumihara Rheumatic and Medical Clinic, Kagoshima, Japan, ⁸Shono Rheumatology Clinic, Fukuoka, Japan
Background/Purpose: Although not yet fully possible, ideally, since patients with rapidly progressing joint space narrowing/erosion exist, predicting progression of joint space narrowing/erosion would be pivotal…
Abstract Number: 1898 • 2013 ACR/ARHP Annual Meeting
Repression Of Wolf-Hischhorn Syndrome Candidate-1 (WHSC1) Contributes To The Osteoarthritis-Inducing Cartilage Loss Of Functions
Francisco Espinoza¹, Yves-Marie Pers², Paul Chuchana³, Jean Marc Brondello⁴ and Christian Jorgensen², ¹INSERM U844, MONTPELLIER, France, ²Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, ³INSERM U844, Montpellier, France, ⁴Inserm U844, UM1, Montpellier, France
Background/Purpose: Accumulation of senescent p16INK4A-positive cells within numerous tissues through out life span contributes to the onset of several age-related disease such as intervertebral disc…
Abstract Number: 1899 • 2013 ACR/ARHP Annual Meeting
Interferon Regulatory Factor 5 Gene Variant rs2004640 Is Associated With Carotid Intimal Medial Thickness In Rheumatoid Arthritis Patients
Saskia Vosslamber¹, Alper M. van Sijl², Carina Bos¹, A.E. Voskuyl², Michael T. Nurmohamed² and Cornelis L. Verweij³, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease which is associated with an increased cardiovascular (CV) risk.. An important process in atherogenesis…
Abstract Number: 1900 • 2013 ACR/ARHP Annual Meeting
Mass Spectrometry-Based Salivary Proteomics For The Discovery Of Novel Diagnostic Biomarkers For Primary Sjögren’s Syndrome and Its Clinical Subsets
Camillo Giacomelli¹, Chiara Baldini¹, Francesca Sernissi¹, Daniela Martini¹, Pasquale Pepe², Nicoletta Luciano¹, Francesco Ferro¹, Chiara Tani¹, Marta Mosca³ and Stefano Bombardieri¹, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Institute of Clinical Physiology, National Research Council, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Nowadays, the advances of novel proteomic technologies are encouraging research projects for generating reliable diagnostic biomarkers for primary Sjögren’s syndrome (pSS) to be used…
Abstract Number: 1901 • 2013 ACR/ARHP Annual Meeting
Genetic Variants In OPG and ANKH Are Associated With Severity Ofankylosis In Ankylosing Spondylitis In a Korean Cohort
Il-Hoon Sung¹, Tae-Hwan Kim², Young Bin Joo³, So-Young Bang⁴, Seunghun Lee⁵, Kyung-Bin Joo⁶, Proton Rahman⁷, Darren D. O'Rielly⁷ and Robert Inman⁸, ¹Orthopaedic surgery, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Hanyang University Guri Hospital, Guri, South Korea, ⁵Department of Radiology, Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁶Department of Radiology, Department of Radiology, Hanynag University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁷Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁸Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Spinal ankylosis,which represents the most severe radiologic change in ankylosing spondylitis (AS),is associated with permanent work disability as well as decreased quality of life.…
Abstract Number: 1902 • 2013 ACR/ARHP Annual Meeting
Characterization Of HLA-DRB1 Distribution By 3rd Hypervariable Region Sequence In Systemic Sclerosis and Control Populations
Coline, A. Gentil¹, Hilary S. Gammill¹, Christine, T. Luu¹ and J. Lee Nelson², ¹Immunogenetics, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ²Immunogenetics D2-100, Fred Hutchinson Cancer Rsch, Seattle, WA
Background/Purpose: HLA class II genes are associated with a wide spectrum of autoimmune diseases. Specific alleles at the DRB1, DQA1 and DQB1 loci are associated…
Abstract Number: 1903 • 2013 ACR/ARHP Annual Meeting
PIK3CD Overexpression In The Synovial Membrane Of Rheumatoid Arthritis Patients Is Associated With Response To Anti-TNF Therapy
Antonio Julià¹, Gabriela Ávila¹, Raquel Celis², Raimon Sanmarti³, Julio Ramirez⁴, Sara Marsal¹ and Juan D. Cañete³, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain
Background/Purpose: The mechanisms by which Rheumatoid Arthritis (RA) patients do not respond to TNF blockade are still poorly characterized. The goal of this study is…
Abstract Number: 1904 • 2013 ACR/ARHP Annual Meeting
Gene Expression In Whole Blood Predicts The Abatacept–Methotrexate Combination Responsiveness In Rheumatoid Arthritis: Preliminary Results From The Power Doppler Ultrasonography IM101-179 Study
T Lequerré¹, C Derambure¹, Maria-Antonietta d'Agostino², M Hiron³, P Gaudin⁴, C Gaillez⁵, M Le Bars⁶ and O Vittecoq¹, ¹Rouen University Hospital & Inserm U905, Rouen, France, ²AP-HP Ambroise Paré Hospital, Boulogne-Billancourt, France, ³Rouen University Hospital & Inserm, Rouen, France, ⁴CHU Hôpital Sud, Grenoble, France, ⁵Bristol-Myers Squibb, Rueil Malmaison, France, ⁶Bristol-Myers Squibb, Rueil-Malmaison, France
Background/Purpose: The overall response rate (defined as low disease activity [LDA] related to DAS28[CRP]) to abatacept associated with MTX was 57.1% at 6 months in…
Abstract Number: 1905 • 2013 ACR/ARHP Annual Meeting
Protein Profiles Of Peripheral Blood Mononuclear Cells As a Biomarker For Behcet’s Disease
Manae Kurokawa¹, Takuya Yoshioka², Toshiyuki Sato¹, Kouhei Nagai¹, Nobuko Iizuka¹, Mitsumi Arito¹, Yukiko Takakuwa², Hiromasa Nakano², Seido Ooka², Naoya Suematsu¹, Kazuki Okamoto¹, HIroshi Nakamura³, Noboru Suzuki⁴, Shoichi Ozaki⁵ and Tomohiro Kato¹, ¹Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ²Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ³Department of Rheumatology, Nippon Medical School, Bunkyo-ku, Japan, ⁴Department of Immunology and Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: To investigate the pathophysiology of Behcet’s disease (BD) and find biomarker candidates for the disease, we analyzed protein profiles of peripheral blood mononuclear cells…
Abstract Number: 1906 • 2013 ACR/ARHP Annual Meeting
Comparison Of Decision Rules For Identifying Patients With Systemic Lupus Erythematosus (SLE) In Administrative Healthcare Databases
John G. Hanly¹, Kara Thompson² and Chris Skedgel¹, ¹Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, ²Department of Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada
Background/Purpose: Identification of SLE cases in administrative healthcare databases is used to estimate disease frequency, healthcare utilization and cost. The optimal methodology for achieving this…
Abstract Number: 1907 • 2013 ACR/ARHP Annual Meeting
Acceptability Of Various Technology-Based Communication Modalities In a Rheumatology Clinic
Lisa A. Davis^1,2,3, Phat Luong¹, Sushmitha Bobba⁴, Hannah Dischinger¹, Itziar Quinzanos^4,5,6 and Liron Caplan^4,7, ¹Denver Veterans Affairs Medical Center, Denver, CO, ²Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, ³Division of Rheumatology, Univ. of Colorado Sch. of Medicine, Aurora, CO, ⁴Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO, ⁵Department of Medicine, Division of Rheumatology, Denver Health and Hospital Authority, Denver, CO, ⁶Department of Medicine, Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Department of Medicine, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Technological advances have diversified the communication modalities of patients and healthcare providers. These include conveying information through telephone, internet portals, short-message service (SMS, “texting”),…
Abstract Number: 1868 • 2013 ACR/ARHP Annual Meeting
Chemokine Expression In Systemic Lupus Erythematosus
Eoghan M. McCarthy¹, Joan Ní Gabhann², Siobhán Smith², Ruth Lee³, Gaye Cunnane⁴, Michele Doran⁵, Donough G. Howard³, Paul G. O'Connell¹, Grainne M. Kearns⁶ and Caroline Jefferies², ¹Rheumatology, Beaumont Hospital, Dublin, Ireland, ²Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland, ³Rheumatology, Beaumont Hospital, Dublin 9, Ireland, ⁴Dept of Rheumatology, St James's Hospital, Dublin, Ireland, ⁵Rheumatology Dept, St James's Hospital, Dublin, Ireland, ⁶Rheumatology Department, Beaumont Hospital, Dublin, Ireland
Background/Purpose: Systemic lupus erythematosus(SLE) is a systemic autoimmune disease characterised by the deregulated activation of T and B lymphocytes, production of autoantibodies and the formation…
Abstract Number: 1869 • 2013 ACR/ARHP Annual Meeting
Serum Cytokine/Chemokine Profiles Are Useful For Evaluating Pathological Conditions Of Rheumatoid Arthritis and Diagnosing Anti-CCP Antibody-Negative Patients
Hitoshi Uga¹, Takahiro Okazawa¹, Yoshiaki Miyamoto¹, Takehiro Hasegawa¹, Jun Saegusa², Goh Tsuji³, Sho Sendo⁴, Akio Morinobu⁵, Shunichi Kumagai^6,7 and Hirokazu Kurata¹, ¹Sysmex Corporation, Kobe, Japan, ²Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ³Center for Rheumatic Diseases, Shinko Hospital, Kobe, Japan, ⁴Center of rheumatic diseases, Shinko Hospital, Kobe, Japan, ⁵Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁶Center of rheumatic diseases, Shinko hospital, Kobe, Japan, ⁷Department of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: The diagnosis of anti-CCP antibody (ACPA) negative rheumatoid arthritis (RA) are known to be difficult and delayed as compared with ACPA-positive RA. This study…
Abstract Number: 1870 • 2013 ACR/ARHP Annual Meeting
B-Cell Activating Factor (BAFF) and Pregnancy Outcomes
Hindi E. Stohl¹, Lisa Korst¹, Richard H. Lee¹ and William Stohl², ¹Obstetrics and Gynecology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: Pregnancy often exacerbates systemic rheumatic diseases, and systemic rheumatic diseases often lead to adverse obstetric outcomes. Both rheumatic disease activity and adverse obstetrical outcomes…
Abstract Number: 1871 • 2013 ACR/ARHP Annual Meeting
Progranulin Directly Binds To The CRD 2 and CRD3 Of TNFR Extracellular Domains
Jinlong Jian¹, Shuai Zhao¹, Qingyun Tian¹, Elena Gonzalez Gugel², Jyoti Mundra², Sardar MZ Uddin², Ben Liu³, Brendon Richbourgh², Ryan Brunetti², Gerald Chan⁴, Carolyn Green⁵ and Chuanju Liu¹, ¹Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY, ²NYU Hospital for Joint Diseases, New York, NY, ³NYU Hospital for Joint Diseases, New York Univerity, NY, ⁴Atreaon, Boston, MA, ⁵Atreaon, Boston, NY
Background/Purpose: We previously reported that Progranulin (PGRN) bound to TNF receptors (TNFR) and was therapeutic in inflammatory arthritis (Tang, W., et al, Science, 2011). PGRN…

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