Abstract Number: 1902 • 2013 ACR/ARHP Annual Meeting
Characterization Of HLA-DRB1 Distribution By 3rd Hypervariable Region Sequence In Systemic Sclerosis and Control Populations
Background/Purpose: HLA class II genes are associated with a wide spectrum of autoimmune diseases. Specific alleles at the DRB1, DQA1 and DQB1 loci are associated…Abstract Number: 1903 • 2013 ACR/ARHP Annual Meeting
PIK3CD Overexpression In The Synovial Membrane Of Rheumatoid Arthritis Patients Is Associated With Response To Anti-TNF Therapy
Background/Purpose: The mechanisms by which Rheumatoid Arthritis (RA) patients do not respond to TNF blockade are still poorly characterized. The goal of this study is…Abstract Number: 1904 • 2013 ACR/ARHP Annual Meeting
Gene Expression In Whole Blood Predicts The Abatacept–Methotrexate Combination Responsiveness In Rheumatoid Arthritis: Preliminary Results From The Power Doppler Ultrasonography IM101-179 Study
Background/Purpose: The overall response rate (defined as low disease activity [LDA] related to DAS28[CRP]) to abatacept associated with MTX was 57.1% at 6 months in…Abstract Number: 1905 • 2013 ACR/ARHP Annual Meeting
Protein Profiles Of Peripheral Blood Mononuclear Cells As a Biomarker For Behcet’s Disease
Background/Purpose: To investigate the pathophysiology of Behcet’s disease (BD) and find biomarker candidates for the disease, we analyzed protein profiles of peripheral blood mononuclear cells…Abstract Number: 1906 • 2013 ACR/ARHP Annual Meeting
Comparison Of Decision Rules For Identifying Patients With Systemic Lupus Erythematosus (SLE) In Administrative Healthcare Databases
Background/Purpose: Identification of SLE cases in administrative healthcare databases is used to estimate disease frequency, healthcare utilization and cost. The optimal methodology for achieving this…Abstract Number: 1907 • 2013 ACR/ARHP Annual Meeting
Acceptability Of Various Technology-Based Communication Modalities In a Rheumatology Clinic
Background/Purpose: Technological advances have diversified the communication modalities of patients and healthcare providers. These include conveying information through telephone, internet portals, short-message service (SMS, “texting”),…Abstract Number: 1868 • 2013 ACR/ARHP Annual Meeting
Chemokine Expression In Systemic Lupus Erythematosus
Background/Purpose: Systemic lupus erythematosus(SLE) is a systemic autoimmune disease characterised by the deregulated activation of T and B lymphocytes, production of autoantibodies and the formation…Abstract Number: 1869 • 2013 ACR/ARHP Annual Meeting
Serum Cytokine/Chemokine Profiles Are Useful For Evaluating Pathological Conditions Of Rheumatoid Arthritis and Diagnosing Anti-CCP Antibody-Negative Patients
Background/Purpose: The diagnosis of anti-CCP antibody (ACPA) negative rheumatoid arthritis (RA) are known to be difficult and delayed as compared with ACPA-positive RA. This study…Abstract Number: 1870 • 2013 ACR/ARHP Annual Meeting
B-Cell Activating Factor (BAFF) and Pregnancy Outcomes
Background/Purpose: Pregnancy often exacerbates systemic rheumatic diseases, and systemic rheumatic diseases often lead to adverse obstetric outcomes. Both rheumatic disease activity and adverse obstetrical outcomes…Abstract Number: 1871 • 2013 ACR/ARHP Annual Meeting
Progranulin Directly Binds To The CRD 2 and CRD3 Of TNFR Extracellular Domains
Background/Purpose: We previously reported that Progranulin (PGRN) bound to TNF receptors (TNFR) and was therapeutic in inflammatory arthritis (Tang, W., et al, Science, 2011). PGRN…Abstract Number: 1872 • 2013 ACR/ARHP Annual Meeting
Gene-Body Mass Index Interactions Are Associated With Methotrexate Toxicity in Rheumatoid Arthritis
Background/Purpose: Response to methotrexate (MTX) therapy in rheumatoid arthritis (RA) is highly heterogeneous, with both genetic and environmental factors contributing to the efficacy and toxicity…Abstract Number: 1873 • 2013 ACR/ARHP Annual Meeting
Use Of Mendelian Randomization Associates Increased Serum Urate Caused By Genetic Variation In Uric Acid Transporters With Improved Renal Function
Background/Purpose: Hyperuricemia is the central risk factor for gout. In observational studies hyperuricemia also predicts the development and progression of chronic kidney disease independent of…Abstract Number: 1874 • 2013 ACR/ARHP Annual Meeting
Genome-Wide Profiling Identifies Significant Differences Between The T-Lymphocyte and B-Lymphocyte Methylomes In Healthy Individuals
Background/Purpose: Multiple reports now describe changes to the DNA methylome in a variety of autoimmune disorders, such as rheumatoid arthritis. In many cases, these studies…Abstract Number: 1875 • 2013 ACR/ARHP Annual Meeting
A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…Abstract Number: 1876 • 2013 ACR/ARHP Annual Meeting
Potential Chondrogenic Biomarkers For Cell-Based Therapy Monitoring In Osteoarthritis
Background/Purpose: Chondrogenesis occurs as a result of mesenchymal stem cells (MSCs) condensation and chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain as resting cells to…