ACR Meeting Abstracts

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  • Abstract Number: 2043 • 2013 ACR/ARHP Annual Meeting

    Perinatal Exposure To Traditional and Biologic Disease Modifying Antirheumatic Drugs In Rheumatic Diseases: A Systematic Review Of Congenital Outcomes

    Corisande Baldwin1, Sharan Rai2, J. Antonio Avina-Zubieta2,3 and Mary De Vera2,4, 1Division of Rheumatology, University of British Columbia, Vancouver, BC, Canada, 2Arthritis Research Centre of Canada, Richmond, BC, Canada, 3Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, 4Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose:  Despite the high incidence of rheumatic diseases during reproductive years, little is known about the perinatal impact of traditional and biologic disease modifying antirheumatic…
  • Abstract Number: 2044 • 2013 ACR/ARHP Annual Meeting

    Birth Outcomes In Childbearing Women Treated With Thiopurines: A Meta-Analysis

    Zeinab F. Saleh1, Raveendhara R. Bannuru2, William F. Harvey2 and Timothy E. McAlindon3, 1Adult Rheumatology, Tufts Medical Center, Boston, MA, 2Rheumatology, Tufts Medical Center, Boston, MA, 3Division of Rheumatology, Tufts Medical Center, Boston, MA

     Background/Purpose: The thiopurines azathioprine (AZA) and 6-mercaptopurine (6-MP) are effective treatments for many rheumatic and autoimmune conditions. These medications have a category D classification from…
  • Abstract Number: 2045 • 2013 ACR/ARHP Annual Meeting

    Long QT and Hydroxychloroquine; A Poorly Recognised Problem In Rheumatology Patients

    Andra Negoescu1, Andrew Thornback2, Eugene Wong2 and Andrew J. Ostor2, 1Rheumatology, Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, United Kingdom, 2Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, United Kingdom

    Background/Purpose:      Hydoxychloroquine (HCQ) is widely used for the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) with a side-effect profile including myopathy…
  • Abstract Number: 2046 • 2013 ACR/ARHP Annual Meeting

    Lower-Dose Indomethacin Submicron Particle Capsules’ Efficacy In Acute Pain: Results From Two Phase 3 Studies

    Roy D. Altman1, Allan Gibofsky2, Mark Jaros3 and Clarence Young4, 1David Geffen School of Medicine, UCLA, Los Angeles, CA, 2Medicine and Public Health, Hospital for Special Surgery, New York, NY, 3Summit Analytical, Denver, CO, 4Iroko Pharmaceuticals, Philadelphia, PA

    Background/Purpose: Indomethacin is used to treat acute gouty arthritis and other acute pain conditions but, like other NSAIDs, is associated with dose-related gastrointestinal, cardiovascular, and…
  • Abstract Number: 2047 • 2013 ACR/ARHP Annual Meeting

    Lower-Dose Indomethacin Submicron Particle Capsules’ Combined Safety From Two Phase 3 Studies In Patients With Acute Pain Following Elective Surgery

    Allan Gibofsky1, Roy D. Altman2, Clarence Young3, Daniel Solorio4 and Jennifer Nezzer5, 1Medicine and Public Health, Hospital for Special Surgery, New York, NY, 2David Geffen School of Medicine, UCLA, Los Angeles, CA, 3Iroko Pharmaceuticals, Philadelphia, PA, 4Iroko Pharmaceuticals, LLC, Philadelphia, PA, 5Premier Research, Philadelphia, PA

    Background/Purpose: Indomethacin is prescribed to treat acute pain and inflammation but, like other NSAIDs, is associated with dose-dependent gastrointestinal, cardiovascular, and renal adverse events (AEs).…
  • Abstract Number: 2048 • 2013 ACR/ARHP Annual Meeting

    Risk Factors For Glucocorticoids-Induced Diabetes In Patients With Rheumatic Diseases

    Takayuki Katsuyama1, Sayaka Aoki2, Ken-ei Sada3, Yuriko Yamamura1, Haruki Watanabe1, Eri Katsuyama1, Mariko Narazaki1, Noriko Tatebe1, Koichi Sugiyama1, Katsue S. Watanabe3, Hiroshi Wakabayashi1, Tomoko Kawabata1, Jun Wada4 and Hirofumi Makino3, 1Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, 2Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, 4Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Background/Purpose: Since the efficacy of glucocorticoids for various rheumatic diseases was reported, glucocorticoids are still one of the important therapeutic agents in the current treatment…
  • Abstract Number: 2009 • 2013 ACR/ARHP Annual Meeting

    Outcome Of Allopurinol Or Febuxostat Treatment In Gout Patients Naïve To Urate-Lowering Therapy

    Puja Khanna1, Hind Hatoum2,3, Swu-Jane Lin2,4, Aki Shiozawa5, Kasem Akhras6 and Dinesh Khanna1, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Hind T. Hatoum and Company, Chicago, IL, 3University of Illinois at Chicago, chicago, IL, 4University of Illinois at Chicago, Chicago, IL, 5Global Outcomes and Epidemiology Research, Takeda Pharmaceuticals International, Inc, Deerfield, IL, 6Global Outcomes Research, Formerly of Takeda Pharmaceuticals International, Inc, Deerfield, IL

    Background/Purpose: In the US, 3.9% (8.3 million) of the population have self-reported gout, and 21.4% (43.3 million) have hyperuricemia. The 2012 ACR guidelines recommend febuxostat…
  • Abstract Number: 2010 • 2013 ACR/ARHP Annual Meeting

    Erdheim-Chester Disease: A Monocentric Series Of 96 Patients

    Julien Haroche1, Laurent Arnaud1, Fleur Cohen-Aubart1, Baptiste Hervier1, David Saadoun1, Nathalie Costedoat-Chalumeau2, Sophie Besnard3, Kim Heang Ly4, Michel Pavic5, Jean-Gabriel Fuzibet6, Loic Raffray7, Laurent Aaron8, Pascal Bindi9, António Marinho10, Bjorn Blomberg11, Juan Salvatierra12, Claudia Dechant13, Aude Rigolet14, François Lifermann15, Jo Caers16, Catherine Veyssier-Belot17, Bertrand Wechsler18, Lucienne Michaux19, Giorgio Graziani20 and Zahir Amoura1, 1Internal Medicine, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, 2Internal Medicine, Hopital Cochin, Paris, France, 3Internal Medicine, Pontchaillou University Hospital, Rennes, Rennes, France, 4CHU Dupuytren, Limoges, Limoges, France, 5Internal Medicine, HIA Desgenettes, Lyon, France, Lyon, France, 6Internal Medicine, Internal Medicine, Hôpital de l'Archet 1, CHU de Nice, Nice, France, 7Internal Medicine, CHU de Bordeaux, Bordeaux, France, 8Internal Medicine, Hôpital Jacques Coeur, Bourges, Bourges, France, 9Internal Medicine, Department of medicine A, Centre Hospitalier de Verdun, Verdun, France, 10Unidade de Imunologia Clínica, Porto, Portugal, 11Internal Medicine, University of Bergen, Norway, Bergen, France, 12Rheumatology, University Hospital San Cecilio, Granada, Spain, 13Division of Rheumatology and Clinical Immunology, Med. Klinik und Poliklinik IV, University of Munich, Munich, Germany, 14Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, 15Internal Medicine, CH Côte d'Argent, Dax, Dax, France, 16Department of Clinical Hematology, Centre Hospitalier Universitaire de Liège Domaine Universitaire du Sart Tilman, Liège, Belgium, 17Internal Medicine, CHI Poissy Saint-Germain-en-Laye, Saint-Germain-en-Laye, France, 18Internal Medicine, DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 19Hematology, Cliniques Universitaires Saint-Luc UCL Bruxelles, Bruxelles, Belgium, 20Internal Medicine and Nephrology, Istituto Clinico Humanitas IRCCS, Rozzano-Milano, Italy, Milan, Italy

    Background/Purpose: Erdheim-Chester disease (ECD) is a rare non-Langerhans form of histiocytosis characterized by an infiltration of foamy CD68+ CD1a- histiocytes. More than 500 cases of…
  • Abstract Number: 2011 • 2013 ACR/ARHP Annual Meeting

    Osseous Sarcoidosis: Clinical Presentation, Treatment, and Outcomes. Experience From a Large Tertiary Care Academic Hospital

    Jeffrey A. Sparks1, Jakob I. McSparron2, Christopher H. Fanta2 and Jonathan S. Coblyn3, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, 3Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Sarcoidosis is a systemic inflammatory disease characterized by the formation of non-caseating granulomas. Osseous involvement in sarcoidosis is a rare manifestation and has infrequently…
  • Abstract Number: 2012 • 2013 ACR/ARHP Annual Meeting

    Gender Influences On Organ Manifestations In a New Orleans Sarcoidosis Population

    Adam Janot1, McCall Walker2, Mary Yu1, Harmanjot K. Grewal3, Matthew R. Lammi4,5 and Lesley Ann Saketkoo6,7, 1Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, 2LSUHSC School of Medicine, New Orleans, LA, 3Rheumatology, Lousiana State University Health Sciences Center, New Orleans, LA, 4Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 5Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, 6LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 7Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA

    Background/Purpose: Sarcoidosis is a multi-organ disease in which pulmonary manifestations predominate. The skin, eyes, heart, gastrointestinal tract (GI), reticuloendothelial, renal and nervous systems are also…
  • Abstract Number: 2013 • 2013 ACR/ARHP Annual Meeting

    Biologic Therapy In Refractory Uveitis Of Sarcoidosis. Multicenter Study Of 16 Patients

    Javier Loricera1, Vanesa Calvo-Río2, Ricardo Blanco3, Marina Mesquida4, Alfredo M. Adan4, JM Herreras5, A Aparicio6, MJ Moreno Ramos7, MJ Moreno Martínez7, LF Linares Ferrando7, M Hernández Martínez8, D Peitado-Lopez9, Miguel Cordero-Coma10, Jl García Serrano11, Norberto Ortego11, O Maíz12, A Blanco13, Juan Sánchez-Bursón14, S González-Suárez15, Alejandro Fonollosa16, Montserrat Santos-Gómez2, F. Ortiz-Sanjuán1 and Miguel Angel González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Hospital Marques de Valdecilla, Santander, Spain, 4Ophthalmology, Hospital Clínic of Barcelona, Barcelona, Spain, 5Hospital Universitario, IOBA. Valladolid, Valladolid, Spain, 6Rheumatology., Hospital de Toledo., Toledo, Spain, 7Rheumatology, Hospital Clínico Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 8Ophthalmology, Hospital Clínico Universitario Virgen de la Arrixaca. Murcia, Murcia, Spain, 9Rheumatology, Hospital Universitario La Paz Madrid, Madrid, Spain, 10Ophthalmology, Hospital de León. Spain, León, Spain, 11Hospital San Cecilio. Granada, Granada, Spain, 12Rheumatology, Hospital Donosti San Sebastian, San Sebastián, Spain, 13Ophthalmology., Hospital Donosti San Sebastian, San Sebastián, Spain, 14Hospital de Valme. Sevilla, Sevilla, Spain, 15Rheumatology., Hospital Cabueñes, Gijón, Gijón, Spain, 16Ophtalmology Service, Hospital de Cruces. Bilbao, Bilbao, Spain

    Background/Purpose: Uveitis related to sarcoidosis is a potentially severe complication. Corticosteroids are the first line of treatment. In refractory cases or in those with unacceptable…
  • Abstract Number: 2014 • 2013 ACR/ARHP Annual Meeting

    Cigarette Smoking and Male Sex Are Independent Risk Factors For Ocular Sarcoidosis

    Adam Janot1, Dörte Huscher2, McCall Walker3, Harmanjot K. Grewal4, Mary Yu1, Matthew R. Lammi5,6 and Lesley Ann Saketkoo7,8, 1Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, 2German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany, 3LSUHSC School of Medicine, New Orleans, LA, 4Rheumatology, Lousiana State University Health Sciences Center, New Orleans, LA, 5Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 6Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, 7LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 8Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA

    Background/Purpose: Sarcoidosis is a multi-organ system granulomatous disease of unknown origin with an incidence of 1-40/100,000.  Though pulmonary manifestations are predominant, ocular morbidity is characteristic. …
  • Abstract Number: 2015 • 2013 ACR/ARHP Annual Meeting

    Sarcoid Arthritis In World Trade Center Exposed New York City Firefighters Presenting As a Unique Clinical Subset

    Konstantinos Loupasakis1, Jessica Berman2, Michelle S Glaser3,4, Nadia Jaber4, Rachel Zeig-Owens3,4, Mayris P Webber4,5, Michael D Weiden4,6, Anna Nolan4,7, Kerry J Kelly4 and David J Prezant4,8, 1Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, 2Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 3Medicine, Montefiore Medical Center, Bronx, NY, 4Bureau of Health Services Fire Department of New York, Brooklyn, NY, 5Medicine and Epideiology and Population Health, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, 6Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY, 7Medicine, New York University School of Medicine, New York, NY, 8Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Sarcoidosis is a multisystem disease characterized by the formation of non-caseating granulomas with lungs being predominantly affected and the joints in up to 40%.…
  • Abstract Number: 2016 • 2013 ACR/ARHP Annual Meeting

    Inflamamatory Myositis-Increased Incidence In Fire Department Of New York Firefighters After World Trade Center Exposure

    Basit Qayyum1, Michelle S Glaser2,3, Nadia Jaber3, Rachel Zeig-Owens2,3, Mayris P Webber3,4, Anna Nolan3,5, Kerry J Kelly3 and David J Prezant3,6, 1New York University School of Medicine, New York, NY, 2Medicine, Montefiore Medical Center, Bronx, NY, 3Bureau of Health Services Fire Department of New York, Brooklyn, NY, 4Medicine and Epideiology and Population Health, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, 5Medicine, New York University School of Medicine, New York, NY, 6Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Inflammatory myositis (IM) is extremely rare in white middle-aged males. Incidence rates in males ranging from 0.25 to 5 per million. We describe a…
  • Abstract Number: 2017 • 2013 ACR/ARHP Annual Meeting

    Hyper Ferritinemia Suggests a High Frequency Of Macrophage Activation Syndrome In a Large Adult Severe Sepsis Cohort: A Role For Anakinra?

    Bita Shakoory1, Joseph A. Carcillo2 and Steven Opal3, 1Medicine/Rheumatology, Temple University, Philadelphia, PA, 2Pediatrics, University of Pittsburg Medical Center, Pittsburgh, PA, 3Medicine, Brown University, Providence, RI

    Background/Purpose: Inreased ferritin levels are protective during infection whereas but very very high level are associated with MAS in rheumatologic disease cTo determine frequency of…
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