Abstracts Archive - Page 2104 of 2425 - ACR Meeting Abstracts

Abstract Number: 2223 • 2013 ACR/ARHP Annual Meeting
Monitoring Of Active Matrix Metalloproteinase-3 Using
Sung Jae Choi¹, Young Ho Seo², Young Ho Lee³, Jong Dae Ji¹, Gwan Gyu Song⁴, Aeju Lee² and Jae-Hoon Kim⁴, ¹Rheumatology, Korea University Medical Center, Seoul, South Korea, ²Rheumatology, Korea University Medical center, Seoul, South Korea, ³Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, ⁴Div of Rheum, Dept of Int Med, Korea Univ College of Med, Seoul, South Korea
Background/Purpose: Active matrix metalloproteinase-3 (MMP-3) is a prognostic marker of rheumatoid arthritis (RA). Recently, we developed the MMP-3 probe which can specifically detect an active…
Abstract Number: 2224 • 2013 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Alpha Induces Anti-Citrullinated Protein Antibodies and Arthritis In Part Through Peptidyl Arginine Deiminase 4
Miriam A. Shelef¹, Jeremy Sokolove², Catriona Wagner³, Eric Sackmann⁴, Thomas Warner⁵, David Beebe⁴, William H. Robinson⁶ and Anna Huttenlocher⁷, ¹Medicine, Univ of Wisconsin Schl of Med, Madison, WI, ²VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ³VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁴Materials Science Program and Department of Biomedical Engineering, University of Wisconsin, Madison, WI, ⁵Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Dept of Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI
Background/Purpose: Rheumatoid arthritis is an autoimmune, destructive arthritis characterized by anti-citrullinated protein antibodies (ACPAs) and high levels of inflammatory cytokines like tumor necrosis factor alpha…
Abstract Number: 2226 • 2013 ACR/ARHP Annual Meeting
Involvement Of Suppressor Of Cytokine Signaling In Anti-Arthritic Effect Induced By Anti-IL-6 Receptor Antibody
Miho Suzuki¹, Hiroto Yoshida¹, Keisuke Tanaka¹, Isao Matsumoto², Takayuki Sumida³ and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: In the treatment of rheumatoid arthritis (RA), biologics such as IL-6 and TNF inhibitors have high therapeutic efficacy with extended duration of effect [“LITHE…
Abstract Number: 2227 • 2013 ACR/ARHP Annual Meeting
The Anti-Proliferative Function of RSK2 in Synovial Fibroblasts Protects Against TNF-á-Induced Joint Destruction in Inflammatory Arthritis
Anja Derer¹, Christina Boehm¹, Bettina Groetsch¹, Michael Stock¹, Kirsten Neubert², Sybille Boehm³, Bettina Sehnert¹, Georg Schett¹, Axel J. Hueber⁴ and Jean-Pierre David⁵, ¹Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Clinical Research Group, Nikolaus-Fiebiger Center, University of Erlangen-Nuremberg, Erlangen, Germany, ³Institute of Genetics, Department of Biology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Group Genes and Transcription, Institute of Osteology and Biomechanics (IOBM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Background/Purpose: The pro-inflammatory cytokine Tumor Necrosis Factor alpha (TNF-α) directly activates the ribosomal S6 kinase RSK2 in vitro. We recently demonstrated the protective effect of…
Abstract Number: 2228 • 2013 ACR/ARHP Annual Meeting
FMS-Like Tyrosine Kinase 3 Ligand -Dependent CD103+DC Are Crucial For The Initiation Of Collagen-Induced Arthritis
Maria Ines Ramos¹, Samuel Garcia², Saïda Aarrass¹, Boy Helder³, Kris A. Reedquist⁴, Paul-Peter Tak⁵ and Maria C. Lebre¹, ¹Clinical Immunology and Rheumatology & Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Clinical Immunology and Rheumatology & Experiemental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Dendritic cells (DCs) are a heterogeneous cell population that plays an important role for the initiation of protective and pathogenic immunity. Flt3L is a…
Abstract Number: 2229 • 2013 ACR/ARHP Annual Meeting
Alleviation Of Collagen-Induced Arthritis By Multifunctional Nanoparticle Containing Methotrexate
You-Jung Ha¹, Sun-Mi Lee², Ji-Hee Lim¹, Hyung-Joon Kim², Sang-Won Lee³, Soo Kon Lee⁴, Kyung-Hwa Yoo² and Yong-Beom Park⁵, ¹Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Nanomedical Graduate Program, Department of Physics, Yonsei University, Seoul, South Korea, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, NV, South Korea, ⁴Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁵Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea
Background/Purpose: Methotrexate (MTX) is the most widely used disease-modifying anti-rheumatic drugs for the treatment of rheumatoid arthritis (RA). Despite of its efficacy, the continuous use…
Abstract Number: 2196 • 2013 ACR/ARHP Annual Meeting
Aberrant IgG Glycosylation Is Associated With Active Disease In Juvenile Idiopathic Arthritis Patients
Esperanza Cleland, Brooke Gilliam and Terry L. Moore, Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: Aberrant glycosylation of IgG is an abnormality of humoral immunity in patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) that is not…
Abstract Number: 2197 • 2013 ACR/ARHP Annual Meeting
High Titer IgG Anti-Cyclic Citrullinated Peptide Antibodies Are Associated With Joint Destruction In Juvenile Idiopathic Arthritis Patients
Brooke Gilliam, Lance Feller and Terry L. Moore, Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO
Background/Purpose: IgG anti-cyclic citrullinated peptide (anti-CCP) antibodies have been identified as an important indicator of destructive disease in juvenile idiopathic arthritis (JIA), as is the…
Abstract Number: 2190 • 2013 ACR/ARHP Annual Meeting
Clinical and Immunologic Description Of Pediatric Conditions With Interferon-Regulated Gene Signatures (Chronic Atypical Neutrophilic Dermatosis Lipodystrophy Elevated Tempature, Aicardi Goutieres Syndrome, Juvenile Dermatomyositis, Juvenile Systemic Lupus Erythematosus)
Hanna Kim¹, Adriana Almeida de Jesus², Yin Liu³, Yan Huang¹, Gina Montealegre⁴, Dawn Chapelle⁵, Nicole Plass¹, Wanxia Tsai⁶, Massimo Gadina⁷, Lisa G. Rider⁸, Adeline Vanderver⁹ and Raphaela Goldbach-Mansky¹, ¹Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ²Translational Autoinflammatory Disease Section, NIAMS/NIH, Bethesda, MD, ³Translational Autoinflammatory Disease Section, Office of the Clinical Director, NIAMS/NIH, Bethesda, MD, ⁴Office of the Clinical DIrector, NIAMS / NIH, Bethesda, MD, ⁵Office of the Clinical Director, NIAMS / NIH, Bethesda, MD, ⁶Translational Immunology Section, NIAMS / NIH, Bethesda, MD, ⁷Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, ⁸Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁹Pediatric Neurology, Children's National Medical Center, Washington, DC
Background/Purpose: Increased interferon (IFN) regulated gene (IRG) expression has been reported in juvenile systemic lupus (JSLE)1 and juvenile dermatomyositis (JDM)2. Recently, two monogenic conditions chronic…
Abstract Number: 2191 • 2013 ACR/ARHP Annual Meeting
Intestinal Microbiome In Polyarticular Juvenile Idiopathic Arthritis: A PILOT Study
Petra C.E. Hissink Muller^1,2, A.E. Budding³, Cornelia F. Allaart⁴, Danielle M.C. Brinkman^1,5, Taco W. Kuijpers⁶, Michiel Westedt¹, J. Merlijn van den Berg⁷, Lisette W.A. Van Suijlekom-Smit⁸, Marion A.J. Van Rossum⁹, Tim G.J. de Meij¹⁰ and Rebecca Ten Cate¹, ¹Pediatric Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Pediatric Rheumatology, Reade Institute, Amsterdam, Netherlands, ³Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Pediatric Rheumatology, Rijnland Hospital, Leiderdorp, Netherlands, ⁶Pediatric Rheumatology and Immunology, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands, ⁷Department of Pediatric Rheumatology and Immunology, Emma Children's Hospital / Academic Medical Center (AMC), Amsterdam, Netherlands, ⁸Pediatric Rheumatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands, ⁹Department of Pediatric Rheumatology and Immunology, Emma Children's Hospital / Academic Medical Center and Reade Institute, Amsterdam, Netherlands, ¹⁰Pediatric Gastroenterology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: The intestinal microbiome may play a role in the pathogenesis of Juvenile Idiopathic Arthritis (JIA). In IBD patients an overall decrease in microbial diversity of…
Abstract Number: 2192 • 2013 ACR/ARHP Annual Meeting
Vitamin D Receptor Polymorphisms In A Cohort Of Italian Patients With Juvenile Idiopathic Arthritis
Fernanda Falcini¹, Francesca Marini², Donato Rigante³, Federico Bertini⁴, Gemma Lepri⁵, Stefano Stagi⁶, Marco Matucci Cerinic⁷ and Maria Luisa Brandi⁸, ¹Department of Biomedicine, Division of Rheumatology AOUC, Excellence Centre for Research, Florence, Italy, ²Surgery and Translational Medicine, University of Florence, Firenze, Italy, ³Pediatrics, Università Cattolica Sacro Cuore, Rome, Italy, ⁴Department of Internal Medicine, Rheumatology Section, University of Florence, Florence, Italy, ⁵Department of Internal Medicine, Section of Rheumatology, Transition Clinic, University of Florence, Florence, Italy, ⁶Pediatric Endocrinology Unit, Anna Meyer Children’s Hospital, University of Florence, Firenze, Italy, ⁷Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy, ⁸Surgery and Translational Medicine, University of Florence, Florence, Italy
Background/Purpose: A role for vitamin D has been hypothesized in generating disease activity for patients with juvenile idiopathic arthritis (JIA): specific polymorphisms of vitamin D…
Abstract Number: 2193 • 2013 ACR/ARHP Annual Meeting
Altered Apoptosis Profile and Associated Soluble Factors In Patients With Juvenile-Onset Systemic Lupus Erythematosus
Bernadete Liphaus¹, Maria H. B. Kiss¹, Solange Carrasco² and Cláudia Goldenstein-Schainberg³, ¹Pediatria, Instituto da Criança, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²University of São Paulo, São Paulo, Brazil, ³Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Apoptosis has been demonstrated to be involved in immune dysregulation and development of adult systemic lupus erythematosus (SLE) but less is known about its…
Abstract Number: 2194 • 2013 ACR/ARHP Annual Meeting
RNA-Sequencing In Peripheral Blood Mononuclear Cells Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts In Juvenile Idiopathic Arthritis
Kaiyu Jiang¹, Xiaoyun Sun², Yanmin Chen¹, Yufeng Shen² and James N. Jarvis¹, ¹Pediatrics, The University at Buffalo, Buffalo, NY, ²Center for Computational Biology & Bioinformatics, Columbia University, New York, NY
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. The aetiology of JIA remains largely unknown, but the interplay between genes…
Abstract Number: 2195 • 2013 ACR/ARHP Annual Meeting
Expanding The Spectrum Of Recombination Activating Gene-1 Deficiency To Include Early Onset Autoimmunity
Lauren A. Henderson¹, Francesco Frugoni¹, Gregory Hopkins², Helen de Boer², Sung-Yun Pai^2,3, Yu Nee Lee¹, Jolan E. Walter⁴, Melissa M. Hazen¹ and Luigi D Notarangelo^5,6, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, ³Division of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, ⁴Division of Allergy/Immunology, Massachusetts General Hospital for Children, Boston, MA, ⁵Division of Immunology and The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, MA, ⁶Harvard Stem Cell Institute, Boston, MA
Background/Purpose: We sought to identify the etiology of early onset autoimmunity and T cell lymphopenia in two siblings through genetic and functional studies. Newborn screening…
Abstract Number: 2198 • 2013 ACR/ARHP Annual Meeting
Genome Wide Association Meta-Analysis Implicates HLA-DRB1, The BTNL2/HLA-DRA region, and a Novel Susceptibility Locus On Chromosome 1 In Systemic Juvenile Idiopathic Arthritis
Michael J. Ombrello¹, Elaine F. Remmers², Ioanna Tachmazidou³, Alexei A. Grom⁴, Dirk Föll⁵, Alberto Martini⁶, Marco Gattorno⁷, Seza Ozen⁸, Sampath Prahalad⁹, John F. Bohnsack¹⁰, Norman T. Ilowite¹¹, Elizabeth D. Mellins¹², Ricardo A. G. Russo¹³, Claudio A. Len¹⁴, Sheila K. Oliveira¹⁵, Rae SM Yeung¹⁶, Lucy R. Wedderburn¹⁷, Jordi Anton¹⁸, Carl D. Langefeld¹⁹, Susan D. Thompson²⁰, Eleftheria Zeggini³, Wendy Thomson²¹, Daniel L. Kastner²², Patricia Woo²³ and on Behalf Of the International Childhood Arthritis Genetics Consortium²⁴, ¹Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³The Wellcome Trust Sanger Institute, Cambridge, United Kingdom, ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Pediatric Rheumatology and Immunology, University Children's Hospital Muenster, Muenster, Germany, ⁶Pediatria II, Istituto Giannina Gaslini, Genova, Italy, ⁷Second Division of Paediatrics, G. Gaslini Institute, Genova, Italy, ⁸Hacettepe University, Ankara, Turkey, ⁹Emory University School of Medicine, Atlanta, GA, ¹⁰Pediatriacs, University of Utah, Salt Lake City, UT, ¹¹Pediatrics, Albert Einstein College of Medicine, Bronx, NY, ¹²Dept of Pediatrics CCSR, Stanford University Medical Center, Stanford, CA, ¹³Immunology & Rheumatology, Hospital de Pediatria Garrahan, Buenos Aires, Argentina, ¹⁴Universidade Federal de São Paulo/Escola Paulista de Medicina, São Paulo, Brazil, ¹⁵PRINTO-Istituto Gaslini, Genova, Italy, ¹⁶Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁷Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ¹⁸Rheumatology, Hospital Sant Joan de Deu, Barcelona, Spain, ¹⁹Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²⁰Division and Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ²²Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD, ²³University College London, London, United Kingdom, ²⁴INCHARGE, London, United Kingdom
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory disease of childhood characterized by periods of daily spiking fever, evanescent skin rash, arthritis, serositis,…

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