Abstracts Archive - Page 2104 of 2607 - ACR Meeting Abstracts

Abstract Number: 1955 • 2014 ACR/ARHP Annual Meeting
Disparity in Internalisation of Monoclonal Antibodies Targeting B Cell Antigens and Regulation By Fc Gamma Receptor IIb: Implications for Targeted Therapy in SLE
Venkat Reddy¹, Geraldine Cambridge², David A. Isenberg³, Mark Cragg⁴ and Maria J. Leandro², ¹Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Antibody and Vaccine group, Cancer Sciences Unit, Faculty of Medicine, Southampton University, Southampton, United Kingdom
Background/Purpose Monoclonal antibodies (mAbs) targeting B cell antigens CD20 and CD22 are used to treat patients with SLE either in the clinic or in clinical…
Abstract Number: 1954 • 2014 ACR/ARHP Annual Meeting
Successfull Long-Term Depletion of Memory Plasma Cells Requires a Combined Depletion of Plasma Cells and Their Precurors in NZB/W Mice
Adriano Taddeo¹, Laleh Khodadadi¹, Qingyu Cheng², Andreas H. Radbruch¹, Falk Hiepe³ and Bimba F. Hoyer², ¹Deutsches Rheumaforschungszentrum, Berlin, Germany, ²Charité University Medicine, Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Germany, Berlin, Germany, ³Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany
Background/Purpose: Autoantibodies contribute significantly to the pathogenesis of systemic lupus erythematosus (SLE). The long-lived plasma cells (LLPC) secreting such autoantibodies are unfortunately refractory to conventional…
Abstract Number: 1953 • 2014 ACR/ARHP Annual Meeting
Circulating Plasmablasts from Patients with Systemic Lupus Erythematosus Produce Autoantibodies Reactive to Epstein-Barr Virus
Yangsheng Yu¹, Song Li¹, Run Fan², Yinshi Yue¹, Hongyan Liao¹, Zhixin Wang¹, Lin Huang¹, Qin Wang³, Michelene Hearth-Holmes⁴, Amy Cannella⁵, W. Winn Chatham⁶, Robert Kimberly^2,7, James O'Dell⁸, Lynell Klassen⁵, Robert Carter⁷, Zhixin Zhang^9,10 and Kaihong Su^1,5,10, ¹Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ²Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, ³Shanghai Fengxian District Central Hospital, Shanghai Jiao Tong University, Shanghai, China, ⁴Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE, ⁵Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁸University of Nebraska Medical Center, Omaha, NE, ⁹Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ¹⁰Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by the over-production of high affinity autoantibodies. It is not clear how such autoantibodies are generated during the…
Abstract Number: 1952 • 2014 ACR/ARHP Annual Meeting
Elucidation of Molecular Mechanisms of Breg Induction in Autoimmune Diseases
Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Yuri Hirosaki, Hirofumi Tsuzuki, Kumiko Noda, Siamak Jabbarzadeh-Tabrizi, Atsushi Tanaka, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto and Koichi Akashi, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose The advent of B-cell depletion therapy in autoimmune diseases identifies a novel B cell population, referred to as regulatory B cells (Bregs), that exerts…
Abstract Number: 1934 • 2014 ACR/ARHP Annual Meeting
Examing Why Minority Women Are Risk Averse : A Qualitative Study
Sonal Bhalla¹, Kristin Mattocks² and Liana Fraenkel³, ¹Yale-New Haven Hospital, New Haven, CT, ²VA Central Western Massachusetts Healthcare System, University of Massachusetts Medical School, Leeds, MA, ³Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Systems, New Haven, CT
Background/Purpose: Prior research has shown that when making choices about the risks and benefits of medications, women from minority ethnic groups tend to be more…
Abstract Number: 1933 • 2014 ACR/ARHP Annual Meeting
Getting a Grip on Arthritis Online: Web-Based Continuing Education Supports the Dissemination of Arthritis Clinical Practice Guidelines Among Rural/Remote Primary Care Providers
Sydney Lineker¹, Mary Bell², Lisa Fleet³, Elizabeth M. Badley⁴, Vernon Curran⁵, Marlene Del Pino⁶, Fran Kirby³, Anne Lyddiatt⁷, Lynn Moore⁸, Karla Simmons³, Raquel Sweezie¹, Peter Tugwell⁹ and Ed Ziesmann¹, ¹Arthritis Rehabilitation and Education Program, The Arthritis Society, Toronto, ON, Canada, ²Rheum Div/Univ of Toronto, Sunnybrook Health Sciences Ctr, Toronto, ON, Canada, ³Professional Development and Conferencing Services, Memorial University, St. John's, NF, Canada, ⁴Division of Health Care and Outcomes Research, Toronto Western Research Institute; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁵Centre for Collaborative Health Professional Education, Memorial University, St. John's, NF, Canada, ⁶First Nations and Inuit Health Branch, Health Canada, Regina, SK, Canada, ⁷Patient Partners in Arthritis, Toronto, ON, Canada, ⁸Programs and Services, The Arthritis Society, Toronto, ON, Canada, ⁹Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada
Background/Purpose Primary care providers (physiotherapists, occupational therapists, nurses, family physicians) are often challenged with accessing relevant up-to-date arthritis information to enable delivery of optimal care.…
Abstract Number: 1932 • 2014 ACR/ARHP Annual Meeting
Increasing Access to Inflammatory Arthritis Education in Rural and Remote Communities Using Telemedicine
Carol Kennedy¹, Kelly Warmington², Carol Flewelling³, Rachel Shupak⁴, Angelo Papachristos⁵, Caroline Jones⁶, Dorcas Beaton⁷, Sydney Brooks⁸ and Denise Linton⁹, ¹Mobility Program Clinical Research Unit, St. Michael's Hospital, Toronto, ON, Canada, ²Learning Institute, The Hospital for Sick Children, Toronto, ON, Canada, ³St. Michael's Hospital, Toronto, ON, Canada, ⁴Rheumatology, St. Michael's Hospital, Toronto, ON, Canada, ⁵Physiotherapy, St Michael's Hospital, Toronto, ON, Canada, ⁶Mobility Program, St. Michael's Hospital, Aurora, ON, Canada, ⁷Research, Mobility Program Clinical Research Unit, Li Ka Shing Knowledge Institute, St. Michaels Hospital, Toronto, ON, Canada, ⁸The Arthritis Society, Ontario Division, Toronto, ON, Canada, ⁹Mobility Clinical Research Unit, St. Michael's Hospital, Toronto, ON, Canada
Background/Purpose: Telemedicine-based approaches to healthcare service delivery improve access to care. It was recognised that people with inflammatory arthritis living in rural areas had limited…
Abstract Number: 1931 • 2014 ACR/ARHP Annual Meeting
Mycophenolate Mofetil (MMF) Use in Scleroderma Patients with Pulmonary Hypertension: Observations from the Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma Cohort
Lesley Ann Saketkoo¹, Matthew R. Lammi², Aryeh Fischer³, Jerry A. Molitor⁴ and Virginia D. Steen⁵, ¹Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, ²Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, ³Rheumatology / ILD Program, National Jewish Health, Denver, CO, ⁴Rheumatology, University of Minnesota, Minneapolis, MN, ⁵Department of Rheumatology, Georgetown University Medical Center, Washington, DC
Background/Purpose: Systemic sclerosis (SSc) related pulmonary hypertension (PH) carries a high mortality and patients with SSc-PH related to restrictive lung disease having an even worse…
Abstract Number: 1930 • 2014 ACR/ARHP Annual Meeting
The Value of Repeated Nailfold Capillaroscopy in Raynaud’s Phenomenon in Daily Practice: A Follow-up Study in the Netherlands
B. de Boer¹, J. Meijs¹, J. van Aken², T.W.J. Huizinga¹, A.a. Schouffoer³ and J.K. de Vries-Bouwstra⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Spaarne Ziekenhuis, Hoofddorp, Netherlands, ³Rheumatology, Haga Hospital, The Hague, Netherlands, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose Nailfold capillaroscopy is an important tool to differentiate primary Raynaud's phenomenon (PRP) from secondary Raynaud's phenomenon (SRP). Based on possible transition from PRP to…
Abstract Number: 1929 • 2014 ACR/ARHP Annual Meeting
Echocardiographic Phenomics for Novel Classification of Cardiac Involvement in Systemic Sclerosis
Monique Hinchcliff¹, Vistasp Daruwalla², Lauren Beussink-Nelson³, Sofia Podlusky⁴, Mary A. Carns⁴, John Varga⁵ and Sanjiv J. Shah⁶, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Internal Medicine, Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Traditional studies of systemic sclerosis (SSc) cardiac involvement have examined one or a few echocardiographic (echo) variables; however, cardiac involvement in SSc can be…
Abstract Number: 1928 • 2014 ACR/ARHP Annual Meeting
A Multicenter, Prospective Cohort Study Using Nailfold Videocapillaroscopy and Other Clinical Characteristics to Determine the Risk of Developing New Digital Ulcers in Patients with Systemic Sclerosis
Vanessa Smith¹, Maurizio Cutolo², Ariane Herrick³, Oliver Distler⁴, Mike Becker⁵, Emma Beltran⁶, Patrick Carpentier⁷, Clodoveo Ferri⁸, Murat Inanc⁹, Panayiotis Vlachoyiannopoulos¹⁰, Harbajan Chadha-Boreham¹¹, Emmanuelle Cottreel¹¹, Thomas Pfister¹¹, Daniel Rosenberg¹¹ and Juan Torres, on behalf of the CAP study investigators¹², ¹Ghent University Hospital, Ghent, Belgium, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ³Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany, ⁶Hospital La Fe, Valencia, Spain, ⁷Vascular Medicine, La Tronche Hospital, Grenoble, France, ⁸Rheumatology, University of Modena & Reggio E, Moderna, Italy, ⁹Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey, ¹⁰Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ¹¹Actelion Pharmaceuticals Ltd, Allschwil, Switzerland, ¹²Syntax for Science SL, Basel, Switzerland
Background/Purpose Digital ulcers (DU) are painful and disabling and affect almost 50% of systemic sclerosis (SSc) patients. Nailfold videocapillaroscopy (NVC) non-invasively assesses SSc-related micro-angiopathy and…
Abstract Number: 1947 • 2014 ACR/ARHP Annual Meeting
Prolactin Promotes Survival of Immature B Cells from MRL/Lpr Mice
Karina Chavez-Rueda¹, Rocio Flores-Fernández¹, Francisco Blanco-Favela¹, María Legorreta-Haquet², Luis Chávez-Sánchez², Rafael Hernández-González³ and Emiliano Tesoro-Cruz³, ¹UIM en Inmunologia, IMSS, Mexico DF, Mexico, ²IMSS, Mexico DF, Mexico, ³Departamento de Investigación Experimental y Bioterio, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico DF, Mexico
Background/Purpose Prolactin (PRL) plays an important role in modulating the immune response. PRL is secreted by the pituitary gland as well as many other organs…
Abstract Number: 1946 • 2014 ACR/ARHP Annual Meeting
CD22 Is Required for Formation of Memory B Cell Precursors within Germinal Centers
Craig Chappell, Kevin Draves and Edward Clark, Immunology, University of Washington, Seattle, WA
Background/Purpose CD22 is a sialic-acid binding co-receptor expressed primarily on B cells that has a number of functions including adhesion, regulation of B cell homeostasis and…
Abstract Number: 1945 • 2014 ACR/ARHP Annual Meeting
Pharmacodynamic Effects of the CD22-Targeted Monoclonal Antibody Epratuzumab on B Cells in Patients with Systemic Lupus Erythematosus
Anthony Shock¹, Brian Kilgallen², Willem Koetse², Christian Stach³, Sabine Bongardt³ and Catrinel Galateanu⁴, ¹UCB Pharma, Slough, United Kingdom, ²UCB Pharma, Raleigh, NC, ³UCB Pharma, Monheim, Germany, ⁴UCB Pharma, Brussels, Belgium
Background/Purpose Epratuzumab is a humanized monoclonal antibody (mAb) that targets the B cell-specific protein CD22 and is currently in Phase 3 clinical trials in patients…
Abstract Number: 1944 • 2014 ACR/ARHP Annual Meeting
Targeting CD22 with Epratuzumab Impacts Cytokine Production By B Cells
Vanessa Fleischer^1,2, Julia Sieber^1,2, Sarah J. Fleischer^3,4, Anthony Shock⁵, Guido Heine⁶, Capucine Daridon^1,2 and Thomas Dörner^1,2, ¹CC12, Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ²German Rheumatism Research Centre Berlin, Berlin, Germany, ³Charité University Medicine, Dept. Medicine/Rheumatology and Clinical Immunology/German Rheumatism Research Center (DRFZ), Berlin, Germany, ⁴Department of Medicine/Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany, ⁵UCB Pharma, Slough, United Kingdom, ⁶Department of Dermatology, Venerology and Allergology, Charité University Medicine Berlin, Berlin, Germany
Background/Purpose CD22 is a negative co-receptor of the B-cell receptor (BCR) and, when targeted by epratuzumab, partially inhibits BCR signaling, for example by reducing Syk…

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