Abstracts Archive - Page 2103 of 2607 - ACR Meeting Abstracts

Abstract Number: 1950 • 2014 ACR/ARHP Annual Meeting
Circulating CD19⁺CD38⁺CD43⁺ B Cell Subset in SLE Patients Have More Cell Cycle Related Genes Than Healthy Controls
Hiroshi Fujii¹, Tomoaki Machiyama¹, Kanae Akita², Yukiko Kamogawa¹, Ryu Watanabe¹, Yoko Fujita³, Yuko Shirota⁴, Shinichiro Saito⁵, Tomonori Ishii⁶ and Hideo Harigae¹, ¹Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ²Department of Heatology and Rheumatology, Tohoku University, Sendai, Japan, ³Department of Hematolgy and rheumatolgy, Tohoku University, Sendai, Japan, ⁴Department of Hematology and Rheumatolgy, Tohoku University, Sendai, Japan, ⁵Department of hematology and rheumatology, Tohoku University, Sendai, Japan, ⁶Seiryouchou Aobaku, Tohoku University, Sendai, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with deposition of autoantibodies such as anti DNA antibody. After activation of B cells…
Abstract Number: 1949 • 2014 ACR/ARHP Annual Meeting
Defective PTEN Regulation and Function Contributes to B Cell Hyper-Responsiveness in Systemic Lupus Erythematosus
Xiangni Wu¹, Yanxia Ye², Jingwen Niu¹, Yang Li¹, Xin Li¹, Xin You³, Hua Chen¹, Lidan Zhao¹, Xiaofeng Zeng⁴, Fengchun Zhang¹, Fulin Tang¹, Wei He¹, Xuetao Cao⁵, Xuan Zhang⁶ and Peter E. Lipsky⁷, ¹Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ²Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ³Division of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁴Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁵School of Basic Medicine, Peking Union Medical College, and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, ⁶Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, ⁷NIH, Charlottesville, VA

Background/Purpose: PTEN regulates normal signaling through the B cell receptor (BCR). In systemic lupus erythematosus(SLE), enhanced BCR signaling contributes to increased B cell activity. We, therefore,…
Abstract Number: 1948 • 2014 ACR/ARHP Annual Meeting
A Dual Role for IFN-γ in Development of Peripheral B Cells in Lupus-Prone MRL/Lpr Mice
Takeshi Machida¹, Natsumi Sakamoto¹, Gary S. Gilkeson² and Hideharu Sekine¹, ¹Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: It had been reported previously that IFN-gamma and IFN-gamma-receptor-1 (IFNGR1) were required for auto-Ab production and development of renal disease in lupus-prone MRL/lpr mice.…
Abstract Number: 1967 • 2014 ACR/ARHP Annual Meeting
Transforming Growth Factor Beta Is a Major Regulator of Micro-RNA Synthesis in Rheumatoid Arthritis Synovial Fibroblasts
Anna Engler¹, Emmanuel Karouzakis¹, Christoph Kolling², Renate E. Gay³, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland
Background/Purpose Transforming growth factor beta (TGFβ) modulates microRNA (miRNA) biogenesis in a variety of cell types. The expression of miRNAs is deregulated in the synovial…
Abstract Number: 1966 • 2014 ACR/ARHP Annual Meeting
CTLA4-Ig (abatacept) Modulate in Vitro the ICAM1 and VEGFR-2 Expression in Human Endothelial Cells
Maurizio Cutolo¹, Paola Montagna², Stefano Soldano², Paola Contini³, Barbara Villaggio⁴, Alberto Sulli¹, Sabrina Paolino¹, Carmen Pizzorni¹, Bruno Seriolo¹, Giuseppe Zampogna², Marco A. Cimmino¹ and Renata Brizzolara², ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁴Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose CTLA4-Ig (abatacept) is employed as biological agent in rheumatoid arthtritis (RA) treatment and interacts with the costimulatory molecule CD86 expressed by different cells involved…
Abstract Number: 1965 • 2014 ACR/ARHP Annual Meeting
Characterization of the Thyroid Hormone System in Rheumatoid Arthritis
Anna-Sophia Pörings¹, Torsten Lowin², Luise Rauch¹, Tanja Späth¹, Angelika Graeber² and Rainer Straub³, ¹Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Regensburg, Germany, ²Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: Chronic inflammation is characterized by an energy appeal reaction supporting high energy demand of the activated immune system. Thyroid hormones are strongly associated with…
Abstract Number: 1964 • 2014 ACR/ARHP Annual Meeting
Changes in Soluble CD18 Reflect Latency in the Immune System and Predict Radiographic Progression in Early Rheumatoid Arthritis
Tue Wenzel Kragstrup¹, Babak Jalilian¹, Kresten Krarup Keller², Kristian Stengaard-Pedersen³, Merete Lund Hetland⁴, Kim Hørslev-Petersen⁵, Peter Junker⁶, Mikkel Østergaard⁴, Ellen Margrethe Hauge^7,8, Malene Hvid¹, Thomas Vorup-Jensen¹ and Bent Deleuran^1,3, ¹Department of Biomedicine, Aarhus University, Aarhus, Denmark, ²Aarhus University Hospital, Aarhus, Denmark, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Glostrup University Hospital, Glostrup, Denmark, ⁵Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, ⁶Odense University Hospital, Odense, Denmark, ⁷Dept. of Anatomi, Aarhus University, Aarhus, Denmark, ⁸Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose In early rheumatoid arthritis (RA), clinical disease characterized by swollen and painful joints is caused by synovitis. However, presence of autoantibodies may precede the…
Abstract Number: 1963 • 2014 ACR/ARHP Annual Meeting
Hierarchical Role of PI3K/Akt/mTOR Signaling Cascade on: Tissue Inflammation, Organization and Angiogenesis in Autoimmune Arthritis
Siba Raychaudhuri¹, Anupam Mitra², Ananya Datta Mitra³, Christine Abria⁴ and Smriti K. Raychaudhuri³, ¹Med/Rheumatology, Univ California Davis/VA Sac, Davis, CA, ²Dermatology, VA Sacramento Medical Center, Mather, CA, ³Rheumatology, VA Sacramento Medical Center, Mather, CA, ⁴Research, VA Sacramento Medical Center, Mather, CA
Background/Purpose: The PI3K/Akt/mTOR signaling proteins are pro-growth/pro-survival and thus likely to regulate inflammatory cascades in autoimmune diseases (1). The key pathologic outcome in psoriatic arthritis…
Abstract Number: 1962 • 2014 ACR/ARHP Annual Meeting
Inflammatory Properties of Inhibitor of DNA Binding 1 As a Unique Fibroblast Derived Nuclear Protein
Gautam Edhayan¹, Christine M. Ha¹, Ray A. Ohara¹, Takeo Isozaki¹, M. Asif Amin¹, Ali Arbab², Pei-Suen Tsou³, Phillip L. Campbell⁴, Elena Schiopu³, Dinesh Khanna³, Rachel Morgan¹, Sean C. Friday¹, David A. Fox¹ and Jeffrey Ruth¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Georgia Regents University, Augusta, GA, ³University of Michigan Scleroderma Program, Ann Arbor, MI, ⁴Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Inhibitor of DNA binding 1 (Id1) is a nuclear protein containing a basic helix-loop-helix (bHLH) domain that regulates cell growth by selective binding and…
Abstract Number: 1961 • 2014 ACR/ARHP Annual Meeting
Chemokine-like Receptor 1 (CMKLR1) is Expressed on Synoviocytes and Proinflammatory Monocytes in Arthritis and is Predominantly Regulated By β arrestin 2 and G Protein Coupled Receptor Kinase (GRK) 6
D. Stephen Serafin¹, Maria F. Sassano², Daniel Mattox¹, Roman Timoshchenko¹, Matthew J. Billard¹, David P. Siderovski³, Bryan Roth⁴ and Teresa K. Tarrant⁵, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Pharmacology, Dept. of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, ⁴Dept. of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose Chemokine-like receptor 1 (CMKLR1) is a G protein-coupled receptor (GPCR) expressed by inflammatory monocytes and up-regulated in fibroblast-like synoviocytes (FLSs), both of which are…
Abstract Number: 1960 • 2014 ACR/ARHP Annual Meeting
NF-κB-Inducing Kinase (NIK) Is Expressed in Synovial Endothelial Cells in Early Arthritis Patients and Correlates with Local Disease Activity and Systemic Markers of Inflammation
Karen I. Maijer¹, Ae-Ri Noort², Maria J. H. de Hair¹, Christiaan van der Leij³, Katinka P.M. van Zoest⁴, Danielle M. Gerlag^5,6, Mario Maas³, Paul-Peter Tak^1,7,8 and Sander W. Tas², ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁶GlaxoSmithKline, Cambridge, United Kingdom, ⁷University of Cambridge, Cambridge, United Kingdom, ⁸GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose The NF-κB family of transcription factors is strongly involved in synovial inflammation. We have previously shown that NF-κB-inducing kinase (NIK) is a key regulator…
Abstract Number: 1959 • 2014 ACR/ARHP Annual Meeting
Interaction of PDE4 and β-Arrestin Reverses Anti-Inflammatory Effects of Catecholamine-Producing Cells in Chronic Arthritis Via Adrenoceptor Switching from Gαs to GαI Signalling
Zsuzsa Jenei-Lanzl¹, Janika Zwingenberg², Torsten Lowin³ and Rainer Straub², ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ³Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose In recent studies, we confirmed the anti-inflammatory effects of tyrosine-hydroxylase (TH)-positive catecholamine producing synovial cells in chronic arthritis. Other studies described that inhibitors of…
Abstract Number: 1958 • 2014 ACR/ARHP Annual Meeting
Pyrrolopyrimidine Derivatives That Inhibit Binding of BAFF to Its Receptor, BR3, Are Drug Candidates for Primary Sjögren’s Syndrome
Keiko Yoshimoto¹, Eriko Ishioka², Katsuya Suzuki¹, Takahiro Itou³, Tomohiro Sugano³, Hajime Yamada³, Ayumu Okuda³, Hiroyuki Ishiwata³, Takeshi Doi³, Takatsugu Hirokawa⁴ and Tsutomu Takeuchi⁵, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ³Tokyo New Drug Research Laboratories, Kowa Co., Ltd., Higashimurayama-City, Japan, ⁴Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), Koto-ku, Japan, ⁵Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: We have been investigating the possible involvement of BAFF (B cell activating factor of TNF family) in the pathogenesis of primary Sjögren's syndrome (pSS).…
Abstract Number: 1957 • 2014 ACR/ARHP Annual Meeting
Dysregulation of CC Chemokines at Microvascular Endothelial Cells of Blood and Lymphatic Vessels Under Inflammatory Conditions
Lisa Rump-Goodrich¹, Ayman Askari², Derek Mattey³ and Jim Middleton⁴, ¹Arthritis Research centre, Keele University, Gobowen, United Kingdom, ²Rheumatology, Robert Jones and Agnes Orthopaedic Hospital, Gobowen, United Kingdom, ³Keele University, Stoke-on-Trent, United Kingdom, ⁴Bristol university, Bristol, United Kingdom
Background/Purpose: Inflammation in the rheumatoid arthritis (RA) synovium is directly associated with inflammatory cell migration across microvasculature endothelial cells (ECs), and their persistence within the…
Abstract Number: 1956 • 2014 ACR/ARHP Annual Meeting
Increased IL-6 Production By Effector B Cells in Giant Cell Arteritis and Polymyalgia Rheumatica
Kornelis S.M. van der Geest¹, Wayel H. Abdulahad², Gerda Horst³, Abraham Rutgers², Annemieke M.H. Boots⁴ and Elisabeth Brouwer⁵, ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Hanzeplein 1, UMCG, Groningen, Netherlands
Background/Purpose: The role of B cells in auto-immunity may extend beyond the production of auto-antibodies. B cells can influence T cell responses via antigen presentation…

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