Abstracts Archive - Page 2103 of 2425 - ACR Meeting Abstracts

Abstract Number: 2249 • 2013 ACR/ARHP Annual Meeting
What Proportion Of Patients With Rheumatoid Arthritis Fail To Achieve Remission Based On The Patient Global? An Analysis From The Prospective, Observational Biologic Treatment Registry Across Canada
Andrew Chow¹, Philip Baer², William G. Bensen³, Isabelle Fortin⁴, Majed M. Khraishi⁵, Dalton E. Sholter⁶, May Shawi⁷, Allen J. Lehman⁸, Susan M. Otawa⁸, Emmanouil Rampakakis^9,10 and John S. Sampalis^9,10, ¹University of Toronto, McMaster University, Credit Valley Rheumatology, Mississauga, ON, Canada, ²Private Practice, Scarborough, ON, Canada, ³Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, ⁴Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada, ⁵Nexus Clinical Research, St John's, NF, Canada, ⁶Rheumatology Associates, Edmonton, AB, Canada, ⁷Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada, ⁸Medical Affairs, Janssen Inc., Toronto, ON, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Jewish General Hospital, McGill University, Montreal, QC, Canada
Background/Purpose: According to the latest ACR/EULAR guidelines, Boolean remission in RA is defined as achievement of patient global assessment (PtGA) ≤1, 28-swollen joint count (SJC)…
Abstract Number: 2222 • 2013 ACR/ARHP Annual Meeting
Positive Allosteric Modulation Of The Adenosine A_2a Receptor Alters Inflammatory Cytokine Production and Alleviates Chronic Arthritis In Rats
Ajith A. Welihinda, Jordan A. Mechanic and Edward P. Amento, Molecular Medicine Research Institute, Sunnyvale, CA
Background/Purpose: Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation and joint destruction; a consequence of which is the high local concentration of…
Abstract Number: 2225 • 2013 ACR/ARHP Annual Meeting
COVA322: A Novel, Bispecific Tumor-Necrosis-Factor-Alpha / Interleukin-17A (TNF/IL-17A) Inhibitor With Excellent Pharmacokinetic Properties In Mice and Cynomolgus Monkeys
Mathias Locher, Dragan Grabulovski, Isabella Attinger-Toller, Susann Koenig-Friedrich, Ulrike von der Bey and Julian Bertschinger, Covagen AG, Schlieren, Switzerland
Background/Purpose: The generation of bispecific antibody molecules with excellent biophysical and pharmacokinetic properties has been a challenging task in the past. We present here COVA322,…
Abstract Number: 2210 • 2013 ACR/ARHP Annual Meeting
Involvement In Leisure Activities Among Children and Youth With Juvenile Idiopathic Arthritis
Sabrina Cavallo¹, Annette Majnemer², Ciaran M. Duffy³ and Debbie Ehrmann Feldman⁴, ¹Public Health-Epidemiology, Université de Montréal, Montreal, QC, Canada, ²School of Physical and Occupational therapy, McGill university, Montreal, QC, Canada, ³Rheumatology, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁴Rehabilitation, Université de Montréal, Montreal, QC, Canada
Background/Purpose: Children with arthritis may be at greater risk for adopting a more sedentary lifestyle compared to their healthy peers in part due to disease…
Abstract Number: 2211 • 2013 ACR/ARHP Annual Meeting
Hospital For Special Surgery’s Charla De Lupus ( Lupus Chat)® Teen/Young Adult/ Parent Group: Holistic Support For Lupus Patients and Their Families
Erica Sandoval¹, Lillian Mendez², Roberta Horton³, Josephine Isgro⁴ and Shawn Rose⁵, ¹Social Work Programs, Hospital For Special Surgery, New York, NY, ²Social Work Programs, Hospital for Speical Surgery, New York, NY, ³Department of Social Work Programs, Hospital for Special Surgery, New York, NY, ⁴Pediatric Rheumatology, Morgan Stanley Children's Hospital of New-York Presbyterian, Columbia University Medical Center, New York, NY, ⁵Cardiovascular and Pulmonary Branch, NIAMS, NHLBI, Bethesda, MD
Background/Purpose: Teens with chronic illnesses are faced with challenges to their identity, peer relationships, self-esteem, and developmental milestones, which can have a lasting impact on…
Abstract Number: 2212 • 2013 ACR/ARHP Annual Meeting
Development Of Tools To Facilitate Shared Decision Making About Medications For Juvenile Idiopathic Arthritis – A Project Of The Pediatric Rheumatology Care and Outcomes Improvement Network
Esi Morgan DeWitt¹, Ellen A. Lipstein², Katie Staun³, Linda Scherer⁴, Janalee Taylor⁵, Carole M. Lannon⁴ and William B. Brinkman⁶, ¹Department of Pediatrics, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Cincinnati, Cincinnati, OH, ⁴James M. Anderson Center for Health Systems Excellence, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵William S. Rowe Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Medication options for juvenile idiopathic arthritis (JIA) are increasing. Medications differ on a variety of attributes, including mechanisms of action, dosing intervals, modes of…
Abstract Number: 2213 • 2013 ACR/ARHP Annual Meeting
Anti-IL-6 Receptor Antibody Normalizes Both DKK-1 and Sclerostin As Wnt Inhibitors In a Mouse Model Of Collagen-Induced Arthritis
Hiroto Yoshida¹, Mika Yagoto¹, Miho Suzuki¹, Keisuke Tanaka¹, Isao Matsumoto², Takayuki Sumida³ and Yoshihiro Matsumoto¹, ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Department of Internal Medicine, Faculty of Medicine,, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: The Wnt pathway plays an important role in bone formation and regeneration. This pathway is regulated by several soluble inhibitors such as Dickkopf-1 (DKK-1)…
Abstract Number: 2214 • 2013 ACR/ARHP Annual Meeting
STAT3 Blockade Suppresses Autoimmune Arthritis In Mice Via The Reciprocal Regulation Of Treg and Th17 Cells
Jennifer Lee¹, Jae Ho Lee¹, Seung Min Jung², Young Sun Suh¹, Jung Hee Koh¹, Soo Young Lee³, Dae Chul Jeong⁴, Mi-La Cho⁵, Seung-Ki Kwok¹, Ji Hyeon Ju¹, Kyung-Su Park¹ and Sung-Hwan Park⁶, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, ³Department of Pediatrics, School of Medicine, The Catholic University of Korea, Incheon St. Mary's Hospital, Incheon, South Korea, ⁴Division of Rheumatology, Department of Pediatrics, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁵Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁶Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: IL-6-mediated STAT3 signaling which is essential to Th17 differentiation plays the central role in the pathogenesis of rheumatoid arthritis. To investigate the molecular mechanism…
Abstract Number: 2215 • 2013 ACR/ARHP Annual Meeting
Apoptotic Cell-Based Therapy To Treat Collagen-Induced Experimental Arthritis. Rationale For The Use Of Apoptotic Cells In The Treatment Of Rheumatoid Arthritis
Sylvain Perruche¹, Amandine Clauzon¹, Francis Bonnefoy¹, Eric Toussirot² and Philippe Saas³, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, ³Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France
Background/Purpose: Most of the currently available biological agents used in the treatment of rheumatoid arthritis (RA) target a cellular or soluble factor involved in the…
Abstract Number: 2216 • 2013 ACR/ARHP Annual Meeting
Tubastatin A, a Selective Histone Deacetylase-6 Inhibitor, Suppresses Synovial Inflammation and Joint Destruction In a Collagen Antibody-Induced Arthritis Mouse Model
Joong Kyong Ahn¹, Jaejoon Lee², Hyemin Jeong², Jiwon Hwang², Seulkee Lee², Ji Young Chai³, Inyoung Kim^2,4, Eun Chung Hong⁵, Eun-Kyung Bae⁵, Hoon-Suk Cha² and Eun-Mi Koh², ¹Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Division of Rheumatology, Jesang Hospital, Seongnam-si Gyeonggi-do, South Korea, ⁴MD, Seoul, South Korea, ⁵Samsung Biomedical Research Institute, Seoul, South Korea
Background/Purpose: Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylasing histones, and HDAC inhibitors induce various cellular effects, including apoptosis, cell…
Abstract Number: 2217 • 2013 ACR/ARHP Annual Meeting
Experimental Arthritis Exacerbates Periodontal Disease But Periodontal Infection Does Not Exacerbated Experimental Arthritis
John Butcher¹, Jessica Oliver-Bell¹, Robert Benson¹, James Brewer², Paul Garside¹, Iain B. McInnes¹ and Shauna Culshaw³, ¹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ²Immunology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: There is a proposed link between periodontal disease (PD) and rheumatoid arthritis (RA). A substantial, although not unanimous, body of epidemiological evidence indicates a…
Abstract Number: 2218 • 2013 ACR/ARHP Annual Meeting
Gingival Stem Cells Suppress Osteoclast Formation and Bone Erosion In CIA Through CD39 Signal
Song Guo Zheng¹, Jian Gu², Maogeng Chen¹ and Yi Shen³, ¹Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Medcine, University of Southern California Keck School of Medicine, Los Angeles, CA, ³Medicine, Shanghai East Hospital at Tongji University, Shanghai, China
Background/Purpose: We recently have reported that human-derived gingival mesenchymal stem cells (GMSC) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis, however,…
Abstract Number: 2219 • 2013 ACR/ARHP Annual Meeting
Active Immunization Against VEGF-Derived Oligopeptides Improves Joint Inflammation and Destruction In Collagen-Induced Arthritis
Emilie Duvallet¹, Laure Foulboeuf¹, Luca Semerano², Nadia Belmellat¹, Marc Lecouvey³, Eric Assier¹, Sylviane Muller⁴ and Marie-Christophe Boissier⁵, ¹EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, EA4222, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ³CSPBAT Paris 13 University, Bobigny, France, ⁴Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France, ⁵INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose: We have demonstrated in experimental models the efficacy of vaccination against cytokines, using a heterocomplex of keyhole limpet hemocyanin (KLH) and human TNF, called…
Abstract Number: 2220 • 2013 ACR/ARHP Annual Meeting
The Role Of CD11c+ Dendritic Cells In Inflammatory Arthritis
Antonia Puchner¹, Stephan Blüml¹, Victoria Saferding², Harald Leiss¹, Josef S. Smolen³ and Kurt Redlich⁴, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose: Dendritic cells (DCs) play an important role in bridging the innate and the adaptive immune response by serving as antigen presenting cells and are…
Abstract Number: 2221 • 2013 ACR/ARHP Annual Meeting
The Histamine H₄ Receptor Drives Inflammation In Preclinical Models Of Arthritis
Paul J. Dunford¹, Jeffery Cowden², Fuqu Yu², Homayon Banie², Mandana Farahani², Ping Ling², Steven Nguyen², Jason Riley², Mai Zhang², Jian Zhu² and Robin L. Thurmond², ¹Immunology, Janssen R&D, LLC, San Diego, CA, ²Janssen R&D, LLC, San Diego, CA
Background/Purpose: The histamine H4 receptor (H4R) has been shown to drive inflammatory responses in models of asthma, colitis and dermatitis and in these models it…

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