Abstract Number: 1980 • 2014 ACR/ARHP Annual Meeting
Thrombospondin-1 Is Elevetad in the Plasma of Patients with Antiphospholipid Syndrome and Is Correlated with Soluble Fas Ligand and Free Active TGF-B levels
Background/Purpose Antiphospholipid syndrome (APS) is an acquired thombophillia characterized by recurrent thromboembolism and pregnancy morbidity. Thrombospondin (TSP-1) is a matricellular glycoprotein with antiangiogenic and proapoptotic…Abstract Number: 1979 • 2014 ACR/ARHP Annual Meeting
Pseudostarvation By AMPK Activator Therapy Is Associated with Reduced Disease Activity and Downregulation of Pro-Inflammatory Responses in Rheumatoid Arthritis (RA)
Background/Purpose AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…Abstract Number: 1977 • 2014 ACR/ARHP Annual Meeting
The Proangiogenic Function of the Epigenetic Regulator EZH2 in Synovial Tissue Is Mediated By Fibroblasts in Rheumatoid Arthritis
Background/Purpose The histone methyltransferase Enhancer of Zeste 2 (EZH2) is overexpressed in solid tumors and is associated with invasion, malignancy and tumor angiogenesis. EZH2 expression…Abstract Number: 1976 • 2014 ACR/ARHP Annual Meeting
Elevation and Functional Activity of Interferon Omega in Human Systemic Lupus Erythematosus
Background/Purpose IFNα is emerging as a clinically validated target in SLE yet it is currently unclear if other type I IFNs are contributing to the…Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting
Profiling 14-3-3η in Human Primary Cell Based BioMAP® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology
Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions. The 14-3-3 eta…Abstract Number: 1974 • 2014 ACR/ARHP Annual Meeting
Sex Steroids, Interleukin-1, and Interleukin-10 Inhibit interferon–gamma (IFN-γ) Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Human Synovial Fibroblasts
Background/Purpose B cell activating factor of the tumor necrosis factor family (BAFF) is a cytokine important for the stimulation and survival of autoreactive B cells…Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting
Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis
Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…Abstract Number: 1972 • 2014 ACR/ARHP Annual Meeting
Analysis of Anakinra in Primary Human Cell Systems Reveals an in Vitro Signature for Skin-Related Side Effects
Background/Purpose The therapeutic options for treatment of rheumatic diseases have grown and now include a variety of inflammatory pathway inhibitors, with diverse mechanisms, but having…Abstract Number: 1971 • 2014 ACR/ARHP Annual Meeting
The Role of the Proinflammatory Mediator High-Mobility Group Box Protein 1 (HMGB1) in Anti-Collagen-Antibody-Induced Arthritis Is Dependent on Vascular Endothelial Growth Factor (VEGF)
Background/Purpose High-mobility group box 1 (HMGB1) is a non-histone nuclear protein that is released extracellulary and has been implicated in rheumatoid arthritis (RA) and angiogenesis.…Abstract Number: 1970 • 2014 ACR/ARHP Annual Meeting
TH17 Inflammatory Responses Occur in a Subset of Patients with Erythema Migrans or Lyme Arthritis, but Are Not Predominant Responses in Joints
Background/Purpose Lyme disease usually begins with an expanding skin lesion, erythema migrans (EM), whereas arthritis is a late disease manifestation. The infection usually resolves with…Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting
Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential
Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…Abstract Number: 1968 • 2014 ACR/ARHP Annual Meeting
Highly activated IL-23/Th17 axis and JAK2/STAT3 signal pathway in PBMC of active AS patients involve in pathogenesis of AS
Background/Purpose: T helper cell(Th17), the third lineage of CD4+T cells, has been determined its important role in pathogenesis of AS, and its main effector, IL-17,…Abstract Number: 1982 • 2014 ACR/ARHP Annual Meeting
Final Year Medical Students Prefer E-Reading Content to Interactive Case-Based Quizzes in a Pediatric Rheumatology E-Learning Module
Background/Purpose: Traditional medical student learning and teaching methods, such as lectures and bedside teaching, maybe inadequate for providing core knowledge and clinical skills in rheumatology,…Abstract Number: 1978 • 2014 ACR/ARHP Annual Meeting
Role of Monocytes Subsets in the Pathology of Rheumatoid Arthritis: Involvement in Endothelial Dysfunction and Proinflammatory Profile
Background/Purpose Different frequency of monocytes subsets has been reported in rheumatoid arthritis (RA).Human monocytes are divided into three main subpopulations according to expression of the…Abstract Number: 1951 • 2014 ACR/ARHP Annual Meeting
A Novel CD27(-) Spleen Tyrosine Kinase (Syk) Bright Memory B-Cell Subset Is Expanded in SLE
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease known to be associated with a breakdown of self-tolerance, B-cell hyperactivity and disturbed B-cell homeostasis of…
ACR Meeting Abstracts