Abstracts Archive - Page 2090 of 2607 - ACR Meeting Abstracts

Abstract Number: 2156 • 2014 ACR/ARHP Annual Meeting
Persistent Arthralgia Following Chikungunya Fever
Anna Kristina Gutierrez-Rubio and Ester Penserga, Section of Rheumatology, Philippine General Hospital, Manila, Philippines
Background/Purpose: Chikungunya fever is a reemerging viral infection in the Philippines and neighboring countries. Persistent arthralgia following Chikungunya infection has been observed during previous epidemics,…
Abstract Number: 2157 • 2014 ACR/ARHP Annual Meeting
Tuberculosis Reactivation Risk in Patients Treated with Tumor Necrosis Factor Alpha Inhibitors: A Turkish Experience with Higher Mortality and Different Background Diseases
Bunyamin Kisacik¹, Omer Pamuk², Ahmet Mesut Onat³, B. Erer⁴, Gulen Hatemi⁵, Yesim Ozguler⁶, Yavuz Pehlivan⁷, Levent Kilic⁸, Ihsan Ertenli⁸, Meryem Can⁹, Haner Direskeneli⁹, Gökhan Keser¹⁰, Fahrettin Oksel¹⁰, Ediz Dalkilic¹¹, Sedat Yilmaz¹², Salih Pay¹³, Ayse Balkarli¹⁴, Veli Cobankara¹⁵, Gozde Yildirim Cetin¹⁶, Mehmet Sayarlioglu¹⁷, Ayse Cefle¹⁸, Ayten Yazici¹⁸, Ali Berkant Avci¹⁹, Ender Terzioglu²⁰, Suleyman Ozbek²¹, Servet Akar²² and Ahmet Gül²³, ¹Rheumatology, Gaziantep University, School of Medicine, Gaziantep, Turkey, ²Trakya Üniversitesi, edirne, Turkey, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Istanbul Faculty of Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁵Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁶University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ⁷Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, ⁸Hacettepe Üniversity, Ankara, Turkey, ⁹Marmara Üniversitesi, Ýstanbul, Turkey, ¹⁰Ege Üniversitesi, Ýzmir, Turkey, ¹¹Uludað Üniversitesi, Bursa, Turkey, ¹²GATA, ANKARA, Turkey, ¹³GATA, Ankara, Turkey, ¹⁴Pamukkale Üniversitesi, Denizli, Turkey, ¹⁵Denizli Üniversitesi, Denizli, Turkey, ¹⁶Deparment of Rheumatology, Sutcu Imam University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey, ¹⁷Rheumatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey, ¹⁸Department of Rheumatology, Kocaeli University, Kocaeli, Turkey, ¹⁹Antalya University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Antalya, Turkey, ²⁰School of Medicine, Akdeniz University, Antalya, Turkey, ²¹Cukurova Üniversitesi, Adana, Turkey, ²²Katip Çelebi Üniversitesi, Ýzmir, Turkey, ²³Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose Tumor necrosis factor alpha inhibitors (anti-TNF) are a breakthrough for the treatment of inflammatory rheumatic diseases and tuberculosis (TB) is the prevailing and vitally…
Abstract Number: 2158 • 2014 ACR/ARHP Annual Meeting
Severe Neutropenia in Patients with Rheumatic Diseases at a Tertiary Care Hospital in South Korea
Chang-Nam Son¹, Ji-Min Kim¹, Sang-Hyon Kim¹, Soo-Kyung Cho², Yoon-Kyoung Sung², Tae-Hwan Kim³, Jae-Bum Jun², Sang-Cheol Bae⁴ and Dae-Hyun Yoo⁴, ¹Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea, ²Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose: Neutropenia is relatively common in patients with rheumatic diseases. Neutropenia is characterized by an absolute neutrophil count (ANC) of less than 1,500/µL. It is…
Abstract Number: 2159 • 2014 ACR/ARHP Annual Meeting
Human T-Lymphotropic Virus Type 1 Biomarkers in Patients with Rheumatoid Arthritis
Akihiko Okayama¹, Masako Iwanaga², Yasuko Sagara³, Toshihiko Hidaka⁴, Kunihiko Umekita⁵, Kazumi Nakano⁶, Toshiki Watanabe⁶, Yoshihisa Yamano⁷, Yoshiro Horai⁸, Hideki Nakamura⁹ and Atsushi Kawakami⁹, ¹Department of Rheumatology, Infectious Diseases and Laboratory Medicine, University of Miyazaki, Miyazaki, Japan, ²The Jikei University of School of Medicine, Tokyo, Japan, ³Japanese Red Cross Kyushu Block Blood Center, Fukuoka, Japan, ⁴Zenjinkai Shimin-No-Mori Hospital, Miyazaki, Japan, ⁵University of Miyazaki, Miyazaki, Japan, ⁶Laboratory of Tumor Cell Biology, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan, ⁷Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ⁸Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). It has been debated recently whether or not immunosuppressive…
Abstract Number: 2161 • 2014 ACR/ARHP Annual Meeting
Interest of Systematic Lyme Serology in Context of Recent Onset Arthritis
Dewi Guellec¹, Valérie Narbonne², Divi Cornec³, Thierry Marhadour⁴, Maxime Dougados⁵, Jean-Pierre Daures⁶, Sandrine Jousse-Joulin¹, Valerie Devauchelle⁷ and Alain Saraux⁸, ¹Rheumatology, CHU Brest, Brest, France, ²Microbiology, CHU Brest, Brest, France, ³Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, ⁴Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁵INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ⁶Biostatistic, INSERM, Montpellier, France, ⁷Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France, ⁸Rhumatologie, CHU Brest and EA 2216, UBO, Brest, France
Background/Purpose Lyme arthritis is a late manifestation of a tick-transmitted spirotechal infection, mainly caused by Borrelia burdorgferi. Lyme arthritis typically presents as a mono- or…
Abstract Number: 2162 • 2014 ACR/ARHP Annual Meeting
Immunological Abnormalities in Adult Patients with Parvovirus B19 Infection : A study of 23 Cases
Edouard Pertuiset, Farid Kemiche, Mehdi Yahia and Isabelle Cerf-Payrastre, Rheumatology, Centre Hospitalier René Dubos, Pontoise, France
Background/Purpose In adults, parvovirus B19 infection can induce joint symptoms and cutaneous manifestations which are known to be transient most of the time. It has…
Abstract Number: 2163 • 2014 ACR/ARHP Annual Meeting
Genetic Variants of TNFAIP3 in Patients with HCV Related Lymphoma Are Associated with the Presence of Rheumatoid Factor (RF)
Gaetane Nocturne¹, Saida Boudaoud², Caroline Besson³, Frederic Davi⁴, Danielle Canioni⁵, Patrice Cacoub⁶, Olivier Hermine⁷ and Xavier Mariette⁸, ¹INSERM U1012, Paris sud university, Le Kremlin Bicetre, France, ²Université Paris-Sud, INSERM U1012, Le Kremlin Bicêtre, France, ³Paris Sud University, Le Kremlin Bicêtre, France, ⁴Department of Pathology, Hôpital de la Pitié Salepetrière, Paris, France, ⁵Service d'anatomo-pathologie, Hôpital Necker,, Paris, France, ⁶Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ⁷Service d'hématologie, Centre de référence des mastocytoses, Hôpital Necker Enfants malades, Université Paris V, IFR Necker,, Paris, France, ⁸rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France
Background/Purpose: HCV chronic infection is associated with an increased risk of non-Hodgkin lymphoma (NHL) occurrence. HCV-associated NHL share homologies with primary Sjögren Syndrome (pSS)-associated NHL,…
Abstract Number: 2164 • 2014 ACR/ARHP Annual Meeting
Self-Phospholipids Regulate Inflammation Via Activation of CD1d-Restricted T-cells and Induction of ‘anti-inflammatory’ Myeloid-Derived Suppressor Cells (MDSC)
Ram Raj Singh^1,2,3,4, Cynthia Tran¹, Priti Prasad¹, Jing Wang⁵, Dirk Zajonc⁵ and Ramesh Halder¹, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA, ³Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ⁴Department of Pathology and Laboratory Medicine, UCLA, Los Angeles, CA, ⁵La Jolla Institute of Allergy and Immunology, La Jolla, CA
Background/Purpose Self-lipids play an increasingly appreciated role in immunity and inflammation. Lipid antigens are presented by CD1d and CD1a-d molecules in mouse and human, respectively,…
Abstract Number: 2165 • 2014 ACR/ARHP Annual Meeting
Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis: Friend or Foe?
Fanlei Hu¹, Chunqing Guo², Xiang-Yang Wang² and Zhanguo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA
Background/Purpose Although myeloid-derived suppressor cells (MDSCs) have been linked to T-cell tolerance, their role in rheumatoid arthritis (RA) remains exclusive. Here, we investigated the potential…
Abstract Number: 2166 • 2014 ACR/ARHP Annual Meeting
Bim Suppresses the Development of Glomerulonephritis By Inhibiting M2 Polarization
Fu-Nien Tsai, Northwestern University, Chicago, IL
Background/Purpose Only recently have monocytes and macrophages been accepted as critical players in the pathogenesis of SLE. However, very little is known regarding the molecular…
Abstract Number: 2167 • 2014 ACR/ARHP Annual Meeting
Snapin Is Critical for Cathepsin D Activation and the Normal Lysosomal Function
Bo Shi¹, Qi Quan Huang², Robert Birkett², Renee E. Koessler¹, Andrea Dorfleutner¹, Christian Stehlik¹ and Richard M. Pope¹, ¹Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Our recent data indicates that Snapin, a SNAP associated protein, is critical for maintaining healthy autophagy and monocytes to macrophage (MFs) differentiation which requires…
Abstract Number: 2168 • 2014 ACR/ARHP Annual Meeting
Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Many rheumatic diseases are driven by chronic, repeated activation of Toll-like receptors (TLR) causing the initiation and perpetuation of disease. However, TLR-activated innate immune…
Abstract Number: 2169 • 2014 ACR/ARHP Annual Meeting
Targeting ITGAM+ Cells Successfully Treats a Model of Anti-RNP-Associated Pulmonary Hypertension
Vineet Gupta¹, Yunjuan Zang², Karen Young³, Jian Huang³, Irina Fernandez² and Eric L. Greidinger^2,4, ¹Drug Discovery Center, Rush University Medical Center, Chicago, IL, ²Rheumatology, University of Miami, Miami, FL, ³Pediatrics, University of Miami, Miami, FL, ⁴Miami VAMC, Miami, FL
Background/Purpose: Aggressive immunotherapy has shown modest effectiveness for pulmonary hypertension in anti-RNP Autoimmunity, but with high morbidity. We studied the ability of an ITGAM-targeted therapy…
Abstract Number: 2170 • 2014 ACR/ARHP Annual Meeting
Human Tolerogenic Dendritic Cells Generated with Protein Kinase C Inhibitor Are Optimal for Regulatory T Cell Induction-a Comparative Study
Endy Adnan¹, Hitoshi Hasegawa², Takuya Matsumoto¹, Jun Ishizaki¹, Sachiko Onishi¹, Koichiro Suemori¹ and Masaki Yasukawa¹, ¹Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan, ²Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan
Background/Purpose Tolerogenic dendritic cells (tDCs) are a promising tool for autoimmune diseases, transplantation and allergy. Actually, tDCs have been tried for the therapy of rheumatoid…
Abstract Number: 2130 • 2014 ACR/ARHP Annual Meeting
Bone Microstructure in Patients with Cutaneous Psoriasis and No History of Psoriatic Arthritis Shows Bone Anabolic Changes at a Greater Extent Than in Healthy Controls
David Simon¹, Francesca Faustini¹, Matthias Englbrecht¹, Arnd Kleyer¹, Roland Kocijan², Judith Haschka³, Stephanie Finzel¹, Sebastian Kraus³, Axel J. Hueber¹, Michael Sticherling⁴, Georg Schett¹ and Jürgen Rech³, ¹Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medical Department II, St. Vincent Hospital, Vienna, Austria, ³Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose Psoriasis (PSO) is a frequent disease which affects about 1-2% of the population and can be associated to arthritis (PsA). Skin disease often predates…

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