Abstracts Archive - Page 2088 of 2607 - ACR Meeting Abstracts

Abstract Number: 2207 • 2014 ACR/ARHP Annual Meeting
Decreased Bone Mineral Density in Patients with Ehler-Danlos Syndrome
Narender Annapureddy¹, Joel A. Block² and Sonali Khandelwal¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Ehler-Danlos Syndrome (EDS) constitutes a heterogeneous group of inherited connective tissue disorders characterized by abnormalities of collagen I, III, V, or fibronectin, and primarily…
Abstract Number: 2208 • 2014 ACR/ARHP Annual Meeting
Ovarian Reserve Alterations in Premenopausal Women with Rheumatoid Arthritis, Behcet’s Disease and Spondyloarthritis – Impact on Anti-Muellerian Hormone Levels
Joerg C. Henes¹, Julia Froeschlin², Andre Taran³, Theodoros Xenitidis⁴ and Melanie Henes⁵, ¹Department of Internal Medicine II, Rheumatology Division, University Hospital Tuebingen, Tuebingen, Germany, ²University Tuebingen, Tuebingen, Germany, ³University Hospital for Women Tuebingen, Tuebingen, Germany, ⁴Internal Medincine II, devision for Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁵University Hospital for Women, Tuebingen, Germany
Background/Purpose: Recent publications showed a negative influence of systemic lupus erythematosus and antiphospholipid antibody syndrome on female ovarian reserve (OR). Other authors did not find…
Abstract Number: 2209 • 2014 ACR/ARHP Annual Meeting
Novel Biomarkers of Extracellular Matrix Remodeling in Inflammatory Bowel Disease: Different Patterns of Gut Injury in UC and CD
Joachim Høg Mortensen¹, Line Elberg Godskesen², Michael Dam Jensen², Lone Gabriels Klinge², Jens Kjeldsen², Aleksander Krag², Morten Karsdal³ and Anne C. Bay-Jensen⁴, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Købehavn, Denmark, ²Odense University Hospital, Odense, Denmark, ³Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ⁴Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark
Background/Purpose: About 10 % of patients with IBD have symptoms that match both Crohn's disease (CD) and ulcerative colitis (UC), termed inflammatory bowel disease unclassified…
Abstract Number: 2210 • 2014 ACR/ARHP Annual Meeting
Redefining Dermatomyositis: Description of New Diagnostic Criteria That Differentiate Pure Dermatomyositis from Overlap Myositis with Dermatomyositis Features
Marie-Pier Payette¹, Yves Troyanov¹, Ira N. Targoff², Jean-Pierre Raynauld¹, Suzanne Chartier³, Jean-Richard Goulet¹, Josiane Bourré-Tessier¹, Eric Rich¹, Tamara Grodzicky¹, Marvin J. Fritzler⁴, France Joyal⁵, Martial Koenig⁵ and Jean-Luc Senécal¹, ¹Department of Medicine, Division of Rheumatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ²Veterans Affairs Medical Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Division of Dermatology, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada, ⁴Mitogen Advanced Diagnostics Laboratory, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ⁵Department of Medicine, Division of Internal Medicine, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada
Background/Purpose: Dermatomyositis (DM) is a major form of autoimmune myositis (AIM). The characteristic DM rash (Gottron's papules, heliotrope rash) and perifascicular atrophy (PFA) at muscle…
Abstract Number: 2188 • 2014 ACR/ARHP Annual Meeting
Incidence and Mortality of Relapsing Polychondritis in the United Kingdom: A Population-Based Cohort Study
Nisha Hazra¹, Alex Dregan¹, Judith Charlton¹, Martin C Gulliford¹ and David P. D'Cruz², ¹Division of Primary Care and Public Health Research, King's College London, London, United Kingdom, ²Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom
Background/Purpose: To estimate the incidence, prevalence and mortality of Relapsing Polychondritis (RP), and to describe the clinical features of RP, in a large population. Methods:…
Abstract Number: 2189 • 2014 ACR/ARHP Annual Meeting
Multicentric Reticulohistiocytosis- Case Series from a Tertiary Care Center
Namrata Singh¹, Karolyn A Wanat², Mary Stone², Zuhair K. Ballas³ and Jacob W. Ijdo⁴, ¹Medicine, University of Iowa, Iowa City, IA, ²Dermatology, University of Iowa, Iowa City, IA, ³Internal Medicine, Iowa City VA and the University of Iowa, Iowa City, IA, ⁴Internal Medicine, University of Iowa, Iowa City, IA
Background/Purpose Multicentric Reticulohistiocytosis (MRH) is a rare systemic inflammatory disease with skin nodules and arthritis. On skin or joint biopsy the hallmark is the presence…
Abstract Number: 2190 • 2014 ACR/ARHP Annual Meeting
Features of Interstitial Lung Disease Associated with Connective Tissue Disease in a Spanish Southwest Cohort
Adela Gallego Flores¹, Carmen Carrasco Cubero², Raul Veroz Gonzalez¹, Luz Maria Mellado Narciso¹, Tamara Libertad Rodriguez Araya¹, Juan Jose Aznar Sánchez¹ and Eugenio Chamizo Carmona¹, ¹Rheumatology, Hospital de Mérida, Mérida, Spain, ²Rheumatology, Hospital de Merida, Mérida, Spain
Background/Purpose Diffuse interstitial lung disease (ILD) can be associated with connective tissue diseases (CTD), and can increase morbidity and mortality significantly. The predominant patterns of…
Abstract Number: 2171 • 2014 ACR/ARHP Annual Meeting
Polymorphisms in theÂ FCN1Â Gene Coding for M-Ficolin Are Associated with Disease Activity, Radiographic Damage and Are the Strongest Predictors of DAS28 Remission in 180 DMARD naÃ¯ve Early Rheumatoid Arthritis Patients
Christian G. Ammitzbøll¹, Rudi Steffensen², Steffen Thiel³, Jens Christian Jensenius³, Kim Horslev-Petersen⁴, Torkell Ellingsen^5,6, Merete Lund Hetland⁷, Peter Junker⁸, Mikkel Ostergaard⁹ and Kristian Stengaard-Pedersen¹⁰, ¹Arhus University Hospital, Aarhus, Denmark, ²Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark, ³Biomedicine, Aarhus University, Aarhus, Denmark, ⁴Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Graasten, Denmark, ⁵Reumatology, Odense University Hospital, Odense, Denmark, ⁶Diagnostic Center, Regional Hospital Silkeborg, Silkeborg, Denmark, ⁷DANBIO, Department of Rheumatology, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ⁸Department of Rheumatology, Odense University Hospital, Odense, Denmark, ⁹Dept of Rheumatology RM, Copenhagen University Hospital, Glostrup, Denmark, ¹⁰Rheumatology, Arhus University Hospital, Aarhus, Denmark
Background/Purpose: M-ficolin is a pattern recognition molecule that collaborates with associated serine proteases as an activator of the complement system. High M-ficolin levels are strongly…
Abstract Number: 2172 • 2014 ACR/ARHP Annual Meeting
PTPN22 Promotes TLR-Induced Amelioration of Arthritis
David Ewart¹, Erik J. Peterson¹ and Yaya Wang², ¹University of Minnesota, Minneapolis, MN, ²Center for Immunology, University of Minnesota, Minneapolis, MN
Background/Purpose: Rheumatoid arthritis (RA) synovial fluid exhibits high levels of type 1 interferons (IFN). Type 1 IFN may exert potent anti-inflammatory effects, since a TLR3…
Abstract Number: 2173 • 2014 ACR/ARHP Annual Meeting
Role of Natural Killer Cells and Gamma Delta T Cells in Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis
Priyanka Gaur¹, Ramnath Misra² and Amita Aggarwal², ¹Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Enthesitis Related Arthritis (ERA) is the most common form of Juvenile Idiopathic Arthritis (JIA) in India. ERA is associated with increased frequency of Th17…
Abstract Number: 2174 • 2014 ACR/ARHP Annual Meeting
MicroRNA-146a in Salivary Gland Epithelial Cells Inhibits Co-Stimulatory Molecule CD80 Expression and Increases Autoreactive T Cell Activation in Sjögren’s Syndrome
Adrienne Gauna¹, Jun-O Jin^2,3, Qing Yu², Carol Stewart¹ and Seunghee Cha¹, ¹Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, FL, ²Department of Immunology and Infectious Diseases, The Forsyth Institute, Cambridge, MA, ³Shanghai Public Health Clinical Center, Fudan University Shanghai Medical College, Shanghai, China
Background/Purpose: Sjögren’s syndrome (SS) causes severe dry mouth and eyes. The presence of immune cell infiltration in the salivary (SG) and lacrimal glands suggests a…
Abstract Number: 2175 • 2014 ACR/ARHP Annual Meeting
Macrophages from the Synovium of Active Rheumatoid Arthritis Exhibit an Activin a- Dependent Pro-Inflammatory Profile
Elena Izquierdo¹, Blanca Soler Palacios², Lizbeth Estrada-Capetillo², Gabriel Criado³, Concha Nieto¹, Cristina Municio², Isidoro González-Álvaro⁴, Paloma Sánchez-Mateos², Jose L. Pablos⁵, Ángel L. Corbí¹ and Amaya Puig-Kröger², ¹Microbiología Molecular y Biología de las Infecciones, Centro de Investigaciones Biologicas (CSIC), Madrid, Spain, ²Laboratorio de Inmuno-Metabolismo, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, ³Servicio de reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, ⁴Rheumatology Department, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria Hospital Universitario La Princesa, Madrid, Spain, ⁵Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Background/Purpose: Synovial macrophages are key effector cells in rheumatoid arthritis (RA), where they are a major source of pro-inflammatory cytokines and contribute to the cartilage…
Abstract Number: 2176 • 2014 ACR/ARHP Annual Meeting
Macrophages-Mediated Response to Uric Acid Crystals Is Modulated By Their Functional Polarization
Emma Garcia-Melchor¹, Monica Guma², Jordi Yagüe¹, Manel Juan¹ and Jacquie Harper³, ¹Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Arthritis and Inflammation Group, Malaghan Institute of Medical Research, Wellington, New Zealand
Background/Purpose: Macrophages have been involved in both initiation and resolution of gout flares. Accordingly, these cells are characterized by their plasticity as the environment modulates…
Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting
Class a Scavenger Receptor（SR-a）Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis
Yingni Li¹, Fanlei Hu², Li Zheng¹, Linchong Su³, Lianjie Shi², Pei Song¹ and Zhanguo Li², ¹Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ³Hubei Minzu University, Enshi, China
Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
Abstract Number: 2178 • 2014 ACR/ARHP Annual Meeting
Extensive Natural Killer Cell Receptor Phenotyping on NK and T Cells Discloses Differences in RA and Psa, Potentially Mirroring Diverse Immunoregulatory Functions
Marta Cossu¹, Sandra TA van Bijnen², Mieke Roeven², Tim Jansen³, Frank Preijers⁴, Harry Dolstra⁴ and Timothy Radstake⁵, ¹Department of Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Hematology, Radboud University Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁴Laboratory Medicine-Laboratory of Hematology, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are immune-mediated diseases, which share clinical features, but differ in the mechanisms, leading to aberrant immune responses.…

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