ACR Meeting Abstracts

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  • Abstract Number: 2535 • 2013 ACR/ARHP Annual Meeting

    Rare Autoantibodies To Cellular Antigens In Systemic Lupus Erythematosous

    Micaela Fredi1, Ilaria Cavazzana2, Marzia Quinzanini3, Mara Taraborelli4, Stefania Cartella3, Angela Tincani5 and Franco Franceschini3, 1Rheumatology Chair, Rheumatology Chair, University of Brescia and Pavia, Brescia, Italy, 2Rheumatology and Clinical Immunology Unit, AO Spedali Civili, Brescia, Italy, 3Rheumatology Unit, Spedali Civili, Brescia, Italy, 4Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, 5Rheumatology Unit, University of Brescia, Brescia, Italy

    Background/Purpose: a high number of antinuclear antibody specificities can be detected in Systemic Lupus Erythematosous (SLE). Some of them are related to a distinct clinical…
  • Abstract Number: 2536 • 2013 ACR/ARHP Annual Meeting

    Lupus Impact Tracker Is Responsive To Changes In Physician Assessed Disease Status By Systemic Lupus Erythematosus Responder Index

    Hervé Devilliers1,2, Mark Kosinski3, Cindy Garris4 and Meenakshi Jolly5, 1Clinical investigation and clinical epidemiology center (INSERM CIE01), Dijon, France, 2Internal medicine and systemic disease unit, Dijon University Hospital, Dijon, France, 3QualityMetric Inc, Lincoln, RI, 4US Health Outcomes, GlaxoSmithKline R&D, Research Triangle Park, NC, 5Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: Lupus Impact Tracker (LIT) is a 10-item patient reported outcome tool to measure the impact of Systemic Lupus Erythematosus (SLE) or its treatment on…
  • Abstract Number: 2537 • 2013 ACR/ARHP Annual Meeting

    Inactive Systemic Lupus Erythematosus: Cytokines and Soluble Tumor Necrosis Factor Receptors Response To Moderate/Intense Exercise

    Luiz A. Perandini1, Diego Sales-de-Oliveira1, Suzana B.V. Mello2, Niels O Camara3, Fernanda R. Lima1, Eduardo F. Borba2, Eloisa Bonfa2, Ana Lucia Sá-Pinto1, Hamilton Roschel4 and Bruno Gualano5, 1University of Sao Paulo, Rheumatology Division, Sao Paulo, Brazil, 2University of Sao Paulo, Rheumatology Division, São Paulo, Brazil, 3Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil, 4Universidade de São Paulo, Faculdade de Educação Física e Esporte, São Paulo, Brazil, 5University of Sao Paulo, School of Physical Education and Sport, Sao Paulo, Brazil

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterized by a chronic inflammation associated with worse cardiovascular outcome. Although a few studies have…
  • Abstract Number: 2538 • 2013 ACR/ARHP Annual Meeting

    Impact Of Omega-3 Fatty Acids On Quality Of Life In Systemic Lupus Erythematosus

    Cristina Arriens1, Chandra Mohan2 and David R. Karp3, 1Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 2University of Houston, Houston, TX, 3Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: A comprehensive metabolomic screen of sera from patients with Systemic Lupus Erythematosus (SLE) has shown that the concentrations of many substrates for energy generation,…
  • Abstract Number: 2539 • 2013 ACR/ARHP Annual Meeting

    The Reliability Of a Novel Automated System For ANA Immunofluorescence Analysis In Daily Clinical Practice

    Mohammed Alsuwaidi1, Margit Dollinger1, Martin Fleck1,2 and Boris P. Ehrenstein1, 1Rheumatology & Clinical Immunology, Asklepios Clinic Bad Abbach, Bad Abbach, Germany, 2Internal Medicine I, University Medical Center of Regensburg, Regensburg, Germany

    Background/Purpose:  Recently, automated interpretation (AI) systems for anti-nuclear antibody (ANA) analysis have been introduced based on assessment of indirect immunofluorescence (IIF) patterns. However, the reliability…
  • Abstract Number: 2540 • 2013 ACR/ARHP Annual Meeting

    Serum Mercury Level and Disease Activity Of Systemic Lupus Erythematosus (SLE): A Case-Control Study

    Chi Chiu Mok1, Becky Fong1 and Chris Wong2, 1Medicine, Tuen Mun Hospital, Hong Kong, Hong Kong, 2Biology, Baptist University Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Environmental contamination with mercury (Hg) is linked to autoimmune diseases.  Exposure to low-dose non-organic mercury has been reported to exacerbate murine SLE.  The aim of…
  • Abstract Number: 2542 • 2013 ACR/ARHP Annual Meeting

    Validation Of The Revised Selena Flare Index In Systemic Lupus Erythematosus

    Michelle Petri1, Joan T. Merrill2, R. Maciuca3, John C. Davis Jr.3 and William P. Kennedy3, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Genentech, Inc, South San Francisco, CA

    Background/Purpose: The SELENA flare index (SFI) has been used in clinical and clinical trial settings since 2005 (1), but has the limitation that it classifies…
  • Abstract Number: 2543 • 2013 ACR/ARHP Annual Meeting

    Patients’ Perception Of Their Lupus Disease Activity, But Not Overall Health, Correlates With Physician Assessments

    Anca Askanase1, Samrawit Abraha1, Ummara Shah2, Aleks Merkovich1 and Jill P. Buyon3, 1Rheumatology, New York University School of Medicine, New York, NY, 2Division of Rheumatology, New York University School of Medicine, NYC, NY, 3Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: The Physician Global Assessment represents the average assessment of a patient’s disease activity based on physical examination and laboratory data while the Patient Global…
  • Abstract Number: 2544 • 2013 ACR/ARHP Annual Meeting

    Serum Mediated Phagocytosis Of Necrotic Material By Polymorphonuclear Leukocytes May Be Used As a Tool To Predict Clinical Manifestations In Systemic Lupus Erythematosus

    Michele Compagno1, Birgitta Gullstrand2, Andreas Jönsen3, Lennart Truedsson2, Gunnar Sturfelt4 and Anders A. Bengtsson3, 1Department of clinical sciences - Rheumatology, Lund University, Lund, Sweden, 2Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden, 3Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, 4Department of Clinical Sciences Lund, Section of Rheumatology, Lund University, Lund, Sweden

    Background/Purpose: Polymorphonuclear (PMNs) leukocytes with engulfed necrotic cell material (NCM), as formerly used in the LE-cell test, are frequently seen in SLE and associated to…
  • Abstract Number: 2545 • 2013 ACR/ARHP Annual Meeting

    Active Systemic Lupus Erythematosus: Cytokines and Soluble Tumor Necrosis Factor Receptors Response To Moderate/Intense Exercise

    Luiz A. Perandini1, Diego Sales-de-Oliveira1, Suzana B.V. Mello2, Niels O Camara3, Fernanda R. Lima1, Eduardo F. Borba2, Eloisa Bonfa2, Ana Lucia Sá-Pinto1, Hamilton Roschel4 and Bruno Gualano5, 1University of Sao Paulo, Rheumatology Division, Sao Paulo, Brazil, 2University of Sao Paulo, Rheumatology Division, São Paulo, Brazil, 3Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil, 4Universidade de São Paulo, Faculdade de Educação Física e Esporte, São Paulo, Brazil, 5University of Sao Paulo, School of Physical Education and Sport, Sao Paulo, Brazil

    Background/Purpose: Systemic lupus erythematosus (SLE) is a rheumatic autoimmune condition characterized by altered lipoprotein profile, physical dysfunction and increased risk of cardiovascular disease. Exercise is,…
  • Abstract Number: 2546 • 2013 ACR/ARHP Annual Meeting

    Anti-Nucleosome Antibodies As a Predictor Factor For Relapses In Clinically Quiescent Systemic Lupus Erythematosus: Results Of a Prospective Cohort Study

    Dalia Sanchez-Mosco1, Nadia Alejandra Gandarilla-Martinez2, Nicte Selene Fajardo-Robledo3, Valeria Diaz-Rizo4, Soraya Amali Zavaleta-Muñiz5, Miguel Huerta6, Xochitl Trujillo6, Arnulfo Nava7, Ernesto German Cardona-Muñoz8, Jose Francisco Muñoz-Valle9, Jorge Ivan Gamez-Nava10 and Laura Gonzalez-Lopez11, 1Centro Universitario de Investigación Biomédica, Universidad de Colima; Hospital General Regional 110 IMSS, Guadalajara, Jalisco, Mexico, 2Departamento de Medicina Interna/Reumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico, 3Fisiología, Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, 4Doctorado en Ciencias Médicas, Centro Universitario de Investigación Biomédica, Universidad de Colima; UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, 5UMAE, Hospital de Especialidades Centro Médico Nacional de Occidente, IMSS; Doctorado en Ciencias con orientación en Inmunología, Guadalajara, Jalisco, Mexico, 6Centro Universitario de Investigación Biomédica, Universidad de Colima, Colima, Mexico, 7UMAE, Hospital de Especialidades Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, 8Unidad de Investigación Cardiovascular, CUCS, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, 9Doctorado en Ciencias Biomédicas. Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, 10UMAE, Centro Médico Nacional de Occidente, IMSS; Doctorado en Farmacología, Universidad de Guadalajara, Jalisco, Mexico, 11Departamento de Medicina Interna/Rheumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico

    Background/Purpose: A significant number of studies have identified a correlation between anti-nucleosome antibodies (AN-ab) and disease activity in SLE; nevertheless, there is a lack of…
  • Abstract Number: 2547 • 2013 ACR/ARHP Annual Meeting

    Anti-Ribosomal P Antibody Has a Protective Role In The Development Of Chronic Kidney Disease In Patients With Lupus Nephritis

    Kyung-Eun Lee1, Dong-Jin Park1, Tae-Jong Kim2, Yong-Wook Park1 and Shin-Seok Lee2, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea

    Background/Purpose: Anti-ribosomal P antibody (anti-P) in patients with systemic lupus erythematosus (SLE) is associated with neuropsychiatric manifestation. Of interest, recent studies have suggested that anti-P…
  • Abstract Number: 2548 • 2013 ACR/ARHP Annual Meeting

    Assessment Of Worsening In Lupus Clinical Trials: Do The Endpoints Reflect Medical Judgement?

    Aikaterini Thanou1, Eliza Chakravarty2, Stan Kamp3, Fredonna C. Carthen3 and Joan T. Merrill4, 1Arthritis and Clinical Immmunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Discrimination between treatment and placebo is problematic in lupus trials. Recently, composite endpoints have evolved which define response by both improvement in baseline findings…
  • Abstract Number: 2549 • 2013 ACR/ARHP Annual Meeting

    Can Biomarkers Provide An Objective Standard Against Which To Assess Lupus Clinical Endpoint Measures?

    Aikaterini Thanou1, Melissa E. Munroe2, Stan Kamp3, Joel M. Guthridge4, Judith A. James5 and Joan T. Merrill6, 1Arthritis and Clinical Immmunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Despite the heterogeneity of SLE, specific pathways of immune dysregulation characterize significant subsets of patients. We examined cytokines reflecting IL6-TH17 pathology in lupus as…
  • Abstract Number: 2550 • 2013 ACR/ARHP Annual Meeting

    Predictive Markers Of Preeclampsia During Pregnancy In Patients With Systemic Erithematosus LUPUS and / Or Antiphospholipid Syndrome

    Esther Rodriguez-Almaraz1, Elena Gonzalo-Gil2, Ignacio Herráiz3, Paula I Gómez-Arriaga3, Paloma Vallejo3, Elena A López-Jiménez4, María Galindo Izquierdo1 and Alberto Galindo Izquierdo3, 1Department of Rheumatology. Hospital Universitario 12 de Octubre, Madrid, Spain, 2Grupo de Investigación en Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 3Fetal Medicine Unit, Department of Obstetrics and Gynecology. Hospital Universitario 12 de Octubre., Madrid, Spain, 4Department of Biochemistry. Hospital Universitario 12 de Octubre., Madrid, Spain

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of preeclampsia (PE), which can be confused with lupus nephritis. Our objective was to…
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