Abstracts Archive - Page 2080 of 2425 - ACR Meeting Abstracts

Abstract Number: 2586 • 2013 ACR/ARHP Annual Meeting
Antinuclear Antibody Negative Systemic Sclerosis Patients Have Less Vasculopathic Disease Manifestations
Gloria Salazar¹, Shervin Assassi¹, Fredrick M. Wigley², Daniel Furst^3,4,5, Laura K. Hummers², Dinesh Khanna⁶, John Varga⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Murray Baron¹⁰, Marie Hudson¹¹, Janet E. Pope^12,13, Monique E. Hinchcliff¹⁴, Marvin J. Fritzler¹⁵, David B. Robinson¹⁶, Robert W. Simms¹⁷, Richard M. Silver¹⁸, Tracy M. Frech¹⁹, Barri J. Fessler²⁰, Jerry A. Molitor²¹, Sara Zamanian²², Niall Jones²³, John D. Reveille¹, Frank C. Arnett¹ and Maureen D. Mayes²⁴, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³David Geffen School of Medicine, Div of Rheumatology, University of California at Los Angeles, Los Angeles, CA, ⁴Div of Rheumatology, UCLA Medical School, Los Angeles, CA, ⁵Rheumatology, UCLA, Los Angeles, CA, ⁶University of Michigan Health System, Ann Arbor, MI, ⁷Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Rheumatology/Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, ⁹Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁰McGill University, Montreal, QC, Canada, ¹¹Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ¹²Univ of Western Ontario, London, ON, Canada, ¹³St Joseph Health Care, London, ON, Canada, ¹⁴Division of Rheumatology, Northwestern University Medical School, Chicago, IL, ¹⁵Medicine, University of Calgary, Calgary, AB, Canada, ¹⁶Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ¹⁷Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁸Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ¹⁹Internal Medicine-Division of Rheumatology, University of Utah School of Medicine, SLC, UT, ²⁰Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²¹Rheumatic/Autoimmune Diseases, Univ of MN MMC108, Minneapolis, MN, ²²Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²³Rheumatology Clinic at 124th Street Medical Clinic, Edmonton, AB, Canada, ²⁴University of Texas Health Science Center at Houston, Houston, TX
Antinuclear Antibody Negative Systemic Sclerosis Patients Have Less Vasculopathic Disease ManifestationsBackground/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal…
Abstract Number: 2588 • 2013 ACR/ARHP Annual Meeting
Pulmonary Hypertension In Patients With Anti-U1-RNP Antibodies
Vincent Sobanski¹, Bernadette Lynch², Benjamin E. Schreiber³, Svetlana I. Nihtyanova⁴, Jennifer Harvey⁵, Clive Handler⁶, Christopher P. Denton⁷ and John G. Coghlan⁸, ¹Department of Rheumatology, Royal Free Hospital, London, United Kingdom, ²Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, ³Royal Free Hospital NHS Foundation Trust, National Pulmonary Hypertension Service, London, United Kingdom, ⁴Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁵Clinical Immunology, Royal Free Hospital, London, United Kingdom, ⁶Department of Pulmonary Hypertension, The Royal Free Hospital, London, United Kingdom, ⁷Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁸National Pulmonary Hypertension Service, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom
Background/Purpose: Pulmonary hypertension (PH) is a leading cause of morbidity and mortality in patients with connective tissue diseases (CTD). Patients with anti-U1-RNP antibodies belong to…
Abstract Number: 2589 • 2013 ACR/ARHP Annual Meeting
Scleroderma Patients With Pulmonary Hypertension and Increased Pulmonary Capillary Wedge Pressure In The Pulmonary Hypertension Assessment and Recognition Of Outcomes In Scleroderma (PHAROS) Cohort
Matthew R. Lammi^1,2, Lesley Ann Saketkoo^3,4, Jessica K. Gordon⁵, Paula Lauto⁶ and Virginia D. Steen⁷, ¹Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ²Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, ³Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, ⁴LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ⁵Rheumatology, Hospital for Special Surgery, New York, NY, ⁶Pulmonary and Critical Care Medicine, LSU Health Sciences Center, New Orleans, LA, ⁷Department of Rheumatology, Georgetown University Medical Center, Washington, DC
Background/Purpose: Systemic sclerosis (SSc) commonly leads to pulmonary hypertension (PH), which may be associated with left heart disease and an elevated pulmonary capillary wedge pressure…
Abstract Number: 2590 • 2013 ACR/ARHP Annual Meeting
Laser Speckle Contrast Analysis A New Method To Evaluate Blood Perfusion in Different Skin Areas Of Systemic Sclerosis Patients: Comparison With Laser Doppler Flowmetry
Alberto Sulli¹, Barbara Ruaro², Giorgia Ferrari², Elena Bernero², Carmen Pizzorni², Vanessa Smith³ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Internal medicine, Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
Background/Purpose: In systemic sclerosis (SSc), blood perfusion (BP) may be evaluated by both laser speckle contrast analysis (LASCA) and laser Doppler flowmetry (LDF) techniques, as…
Abstract Number: 2591 • 2013 ACR/ARHP Annual Meeting
Scleroderma Renal Crisis and Pulmonary Arterial Hypertension Are Very Rare In The Same Patient
Bernadette Lynch¹, Vincent Sobanski^1,2, Clive Handler³, Benjamin E. Schreiber⁴, John G. Coghlan⁵, Voon H. Ong⁶, Aine Burns⁷ and Christopher P. Denton⁸, ¹Department of Rheumatology, The Royal Free Hospital, London, United Kingdom, ²Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ³Department of Pulmonary Hypertension, The Royal Free Hospital, London, United Kingdom, ⁴Royal Free Hospital NHS Foundation Trust, National Pulmonary Hypertension Service, London, United Kingdom, ⁵National Pulmonary Hypertension Service, The Royal Free Hospital NHS Foundation Trust, London, United Kingdom, ⁶Department of Rheumatology, The Royal Free and University College Medical School, London, United Kingdom, ⁷Department of Nephrology, The Royal Free Hospital, London, United Kingdom, ⁸Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is associated with occlusive vasculopathy resulting in digital ischaemia, telangiectasia, scleroderma renal crisis (SRC) and pulmonary arterial hypertension (PAH). SRC and…
Abstract Number: 2592 • 2013 ACR/ARHP Annual Meeting
Clinical Significance Of Endothelial Vasodilator Function Evaluated By Endopat In Patients With Systemic Sclerosis
Naohiko Aozasa¹, Yoshihide Asano¹, Masaru Hatano², Ryosuke Saigusa¹, Kouta Takakuwa¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Hayakazu Sumida¹, Atsushi Yao³, Koichiro Kinugawa⁴, Hisataka Maki², Toshiro Inaba², Hironori Muraoka², Shun Minatsuki², Issei Komuro² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Division for Health Service Promotion, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Department of Therapeutic strategy for heart failure, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resultant fibrosis of skin and certain internal organs. Evidence has…
Abstract Number: 2559 • 2013 ACR/ARHP Annual Meeting
Effect Of NOX4 Overexpression On The Levels Of Micro RNAs Relevant To Systemic Sclerosis Fibrotic Process
Sonsoles Piera-Velazquez, Alma Makul and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is characterized by the excessive deposition of collagen and other connective tissue components in skin and multiple internal organs. Although transforming…
Abstract Number: 2562 • 2013 ACR/ARHP Annual Meeting
Inhibition Of SOX9 Phosphorylation Abrogates The Increased Expression Of Profibrotic Genes In Systemic Sclerosis Dermal Fibroblasts
Sonsoles Piera-Velazquez, Alma Makul and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: SOX9, a high mobility group transcription factor is a master regulator of chondrogenesis and plays a crucial role in the regulation of chondrocyte gene…
Abstract Number: 2564 • 2013 ACR/ARHP Annual Meeting
Functional Activation Of The TRPV1 and TRPV2 Non-Selective Cation Channels Potentiates TGF-β1-Induced Endothelial-To-Mesenchymal Transition In Murine Pulmonary Endothelial Cells Suggest a Potential Role Of Trpv Channels In The Pathogenesis Of Systemic Sclerosis
Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Transient receptor potential (Trp) cation channel, subfamily V (TRPV) members can impact a diverse range of vascular functions, including vascular tone, vascular permeability, mechanosensing,…
Abstract Number: 2565 • 2013 ACR/ARHP Annual Meeting
Synergistic Effects Of Endothelin-1 On Transforming Growth Factor-β1 (TGF-β1) Induced Endothelial-To-Mesenchymal Transition. A Novel Mechanism For The Fibrogenic Effects Of Endothelin
Peter J. Wermuth, Zhaodong Li and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA
Background/Purpose: The process of endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in the generation of activated myofibroblasts, cells that play a pivotal role in…
Abstract Number: 2567 • 2013 ACR/ARHP Annual Meeting
Cadherin-11 Regulates Pulmonary Fibrosis In Bleomycin-Induced Lung Injury
Mesias Pedroza, Anuh T. George and Sandeep K. Agarwal, Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX
Background/Purpose: Pulmonary fibrosis (PF) is the leading cause of death in systemic sclerosis. Pathologically, PF is characterized by an aberrant wound healing repair mechanism leading…
Abstract Number: 2552 • 2013 ACR/ARHP Annual Meeting
Predictive Significance Of ANTI-Prothrombin Antibodies For Second and Third Trimester Obstetric Complications In Patients With Systemic LUPUS Erythematosus and ANTI-Phospholipid Syndrome
Marta Mosca¹, Chiara Tani², Martina Fabris³, Francesca Strigini⁴, Linda Carli¹, Sabrina Vagnani⁵, Rosaria Talarico⁶, Chiara Baldini⁷, Alessandra Della Rossa⁸, Elio Tonutti⁹ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Institute of Clinical Pathology, Udine, Italy, ⁴University of Pisa, Pisa, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Rheumatology Unit, Pisa, Italy, ⁷University of Pisa, Rheumatology Unit, Pisa, Italy, ⁸Clinical and Experimental Medicine, Rheumatology Unit, Pisa, Italy, ⁹Santa Maria Hospital, Udine, Italy
Background/Purpose: Anti-prothrombin antibodies (aPT) either alone or in association with other anti-phospholipid antibodies have been associated with an increased risk of thrombosis as well as…
Abstract Number: 2553 • 2013 ACR/ARHP Annual Meeting
The Clinical Value Of Testing For Aphl, a New ELISA Kit With a Unique Phospholipid Mixture In Patients With Systemic Lupus Erythematosus (SLE)
Savino Sciascia¹, Giovanni Sanna², Veronica Murru³, Munther A. Khamashta⁴ and Maria Laura Bertolaccini³, ¹Department of Rare, Immunologic, Hematologic and Immunohematologic Diseases, Centro di Immunopatologia e Documentazione su Malattie rare, Torino, Italy, ²Louise Coote Lupus Unit, St. Thomas' Hospital, London, United Kingdom, ³Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom, ⁴Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Antibodies directed to APhL (a mixture of phospholipids) have been reported to predict APS more reliably than aCL tests. We designed this study to…
Abstract Number: 2554 • 2013 ACR/ARHP Annual Meeting
In Vitro Fertilization In Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Series Of 82 Cycles
Pauline Orquevaux¹, Agathe Masseau², Véronique le Guern³, Vanessa Gayet⁴, Danièle Vauthier-Brouzes⁵, Du Boutin⁶, Bertrand Wechsler⁷, Nathalie Morel⁸, Jean Loup Pennaforte¹, Jean-Charles Piette⁹ and Nathalie Costedoat-Chalumeau¹⁰, ¹Hu Robert Debre, CHU Reims, Reims, France, ²Internal Medicine Department, Nantes University Hospital, Nantes, France, ³Department of Internal Medicine, Hôpital Cochin, Paris, France, ⁴Cochin Hospital, Paris, France, ⁵gynecology obstetrical, Pitié Salpétrière Hospital, Paris, France, ⁶Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, ⁷Internal Medicine, DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, ⁸Internal Medicine, COCHIN, Paris, France, ⁹Department of Internal Medicine 1., CHU Pitié-Salpêtrière, Paris, France, ¹⁰Internal Medicine, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) undergoing in vitro fertilization (IVF) are at increased risk of both hormone-associated flare and…
Abstract Number: 2555 • 2013 ACR/ARHP Annual Meeting
Development and Validation Of a Questionnaire To Screen For The Presence Of Autoimmune Disease
Alan Boroway¹, Aileen M. Davis², Carolina Landolt-Marticorena¹ and Joan E. Wither³, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Healthy family members of patients with systemic autoimmune rheumatic diseases (SARDs) are at higher risk of developing autoimmune disease than the general population. …

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