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  • Abstract Number: 2649 • 2013 ACR/ARHP Annual Meeting

    Rituximab For The Treatment Of IgG4-Related Disease: A Prospective Clinical Trial

    Mollie Carruthers1, Mark Topazian2, Arezou Khosroshahi3, Thomas Witzig4, Judith Oakley5, Philip Hart6, Lauren Kelly5, Lori Bergstrom6, Suresh Chari6 and John Stone7, 1Rheumatology, Massachusetts General Hospital, Boston, MA, 2Gastroenterology, Mayo Clinic, Rochester, MA, 3Rheumatology, Emory University School of Medicine, Atlanta, GA, 4Hematology & Oncology, Mayo Clinic, Rochester, MN, 5Clinical Research Program, Massachusetts General Hospital, Boston, MA, 6Gastroenterology, Mayo Clinic, Rochester, MN, 7Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a multi-organ, fibro-inflammatory disorder. An open label pilot trial of rituximab (RTX) in IgG4-RD conducted at twocentershas enrolled 29 of…
  • Abstract Number: 2650 • 2013 ACR/ARHP Annual Meeting

    Silent Ischemic Heart Disease In Patients With Primary Antiphospholipid Syndrome

    Antonio R. Cabral1, Gregoria Gómez-Hernández2, Martha Morelos-Guzmán3, Tatiana Rodriguez-Reyna4, Carlos Alberto Núñez-Alvarez5 and Jorge Vazquez-Lamadrid3, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, 2Internal Medicine, Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, 3Radiology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, 4Immunology and Rheumatology, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico, 5Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose:   Premature atherosclerosis in PAPS is still a matter of debate Patients and Methods:   To determine the prevalence of ischemic heart disease in…
  • Abstract Number: 2651 • 2013 ACR/ARHP Annual Meeting

    The Association Between Antiphospolipid Antibodies and Related Clinical Outcomes: A Critical Review Of The Literature

    Cecilia B. Chighizola1, Laura Andreoli2, Alessandra Banzato3, Guilherme Ramires de Jesus4, Guillermo J. Pons-Estel5, Doruk Erkan6 and On Behalf of APS Action7, 1Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, 2Rheumatology Unit, University of Brescia, Brescia, Italy, 3Department of Cardiac Thoracic and Vascular Sciences, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy, 4Department of Obstetrics, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, 5Servicio de Enfermedades Autoinmunes, Department of Autoimmune Diseases, Institut Clìnic de Medicina i Dermatologia, Hospital Clìnic, Barcelona, Spain, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7APS ACTION, New York, NY

    Background/Purpose: AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) is an international network that has been created to design and conduct APS…
  • Abstract Number: 2652 • 2013 ACR/ARHP Annual Meeting

    Ovarian Reserve In Women With Primary Antiphospholipid Syndrome

    Lucas Yamakami1, Paulo Serafini2, Daniel B. Araujo3, Eloisa Bonfá4, Elaine P. Leon5, Edmund C. Baracat6 and Clovis A. Silva7, 1Gynecology Department, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 2MD; PhD, Sao Paulo, Brazil, 3Rheumatology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil, 4Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 6Gynecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 7Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil

    Background/Purpose: Aging, smoking, obesity and surgery have been found to influence the quantity and quality of primordial follicles in ovaries and, ultimately, the ovarian reserve.…
  • Abstract Number: 2653 • 2013 ACR/ARHP Annual Meeting

    Low Vitamin D Is Associated With Increased Risk of Venous Thrombosis in Systemic Lupus Erythematosus, Regardless of Lupus Anticoagulant Status

    Michelle Petri and Hong Fang, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Vitamin D deficiency is common in SLE. Vitamin D deficiency is also associated with activation of Tissue Factor. In cross-sectional studies, vitamin D deficiency…
  • Abstract Number: 2654 • 2013 ACR/ARHP Annual Meeting

    IgG Antibodies Directed Against Domain I Of ß2-Glycoprotein I Are Significant Predictors Of Thromboembolic Events In Patients With Antiphospholipid Antibodies. A Prospective Cohort Study

    Stephane Zuily1, Bas de Laat2, Francis Guillemin3, Pierre Kaminsky4, Hilde Kelchtermans5, Roger Albesa6, Gary L. Norman6, Anne-Christine Rat7, Philip de Groot8, Thomas Lecompte9, Veronique Regnault10 and Denis Wahl1, 1CHU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy, F-54000, France; Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France, Nancy, France, 2Biochemistry, CARIM, Maastricht University, The Netherlands; Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands; Synapse BV, Maastricht, The Netherlands; Sanquin Research, Amsterdam, The Netherlands, Maastricht, Netherlands, 3CHU Nancy, Clinical Epidemiology and Evaluation, Université de Lorraine, Paris Descartes University, APEMAC, EA 4360, Nancy, France, 4Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Orphan disease unit, Nancy, F-54000, France;, Nancy, France, 5Biochemistry, CARIM, Maastricht University, The Netherlands; Synapse BV, Maastricht, The Netherlands, Maastricht, Netherlands, 6Research, INOVA Diagnostics, San Diego, CA, 7Université de Lorraine, Nancy, F-54000, France; Inserm, CIC-EC CIE6, Nancy, F-54000, France; CHU de Nancy, Clinical Epidemiology and Evaluation Department, Nancy, F-54000, France; CHU de Nancy, Rheumatology department, Nancy, France, 8Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands, Utrecht, Netherlands, 9Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Haematology Laboratory, Nancy, F-54000, France; Division of Haematology, HUG, Geneva, Switzerland (current address), Geneva, Switzerland, 10Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Contrat d’interface, Nancy, F-54000, France, Nancy, France

    AbstractBackground/Purpose : Our objective was to prospectively determine the prognostic significance of laboratory variables regarding thrombotic events during follow-up, including novel assays IgG antibodies directed…
  • Abstract Number: 2615 • 2013 ACR/ARHP Annual Meeting

    Serum Beta 2 Microglobulin and Its Association With Disease Activity in Patients With Behcet’s Disease

    Meltem Alkan Melikoglu1 and Mehmet Melikoglu2, 1Rheumatology, Ataturk University Faculty of Medicine, Erzurum, Turkey, 2Dermatology, Health Ministry Erzurum Regional Training and Research Hospital, Dermatology, Erzurum, Turkey

    Background/Purpose: β2-microglobulin (β2M) is a low-molecular weight protein, that is a constant component of human leukocyte antigen (HLA), which is secreted from all nucleated cells.…
  • Abstract Number: 2616 • 2013 ACR/ARHP Annual Meeting

    Ischemia-Modified Albumin : A Novel Marker of Vascular Involvement in Behcet’s Disease ?

    Erhan Capkin1, Murat Karkucak2, Mehmet Kola3, Adem Karaca2, süleyman Caner Karahan4, Aysegul Sumer4, Arzu Aydin Capkin5, Ferhat Gokmen2 and Refik Ali Sari6, 1rheumatolgy, trabzon, Turkey, 2rheumatology, trabzon, Turkey, 3oftalmology, trabzon, Turkey, 4biochemistry, trabzon, Turkey, 5dermatology, trabzon, Turkey, 6immunology and allergy, trabzon, Turkey

    Background/Purpose: The etiology and pathogenesis of Behçet’s disease (BD) are not yet well understood, but immunoregulatory abnormalities have been proposed as pathogenic mechanisms. Ischemia-modified albumin…
  • Abstract Number: 2617 • 2013 ACR/ARHP Annual Meeting

    Clinical Features Of 127 Patients With Behcet’s Disease In Japan

    Keisuke Nishimura1, Jun Saegusa2, Sho Sendo3, Yoshinori Kogata1, Goichi Kageyama1, Seiji Kawano1, Shunichi Kumagai4 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 4Center of rheumatic diseases, Shinko hospital, Kobe, Japan

    Background/Purpose: Behcet’s disease (BD) is characterized by recurrent oral aphthae and any of several systemic manifestations including genital ulcer, ocular disease, skin lesions, gastrointestinal involvement,…
  • Abstract Number: 2618 • 2013 ACR/ARHP Annual Meeting

    Bipolar Disorders May Represent a Primary Feature Of Behçet’s Disease

    Rosaria Talarico1, Laura Palagini2, Elena Elefante3, Claudia Ferrari4, Chiara Stagnaro3, Chiara Baldini3, Chiari Tani3, Marta Mosca4 and Stefano Bombardieri3, 1Rheumatology Unit, Pisa, Italy, 2University of Pisa, Psychiatry Unit, Department of Neuroscience, Pisa, Italy, 3University of Pisa, Rheumatology Unit, Pisa, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Frequency of psychiatric disorders in BD is a debated issue: while some experts attribute their presence to the chronicity of the illness, others think…
  • Abstract Number: 2619 • 2013 ACR/ARHP Annual Meeting

    Suicidal Ideation Among Patients With Behcet’s Syndrome

    Didem Uzunaslan1, Caner Saygin1, Gulen Hatemi2, Koray Tascilar1, Hasan Yazici3 and Vedat Hamuryudan4, 1University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 2Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 3Cerrahpasa Medical Faculty University of Istanbul, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, 4Division of Rheumatology, Istanbul University, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey

    Background/Purpose:  An increased frequency of depression has been reported in Behcet’s syndrome (BS). While an increased suicidal ideation has been reported in other chronic rheumatologic conditions, this…
  • Abstract Number: 2620 • 2013 ACR/ARHP Annual Meeting

    Development Of De Novo Major Involvement During The Follow-Up In Behçet’s Disease

    Claudia Ferrari1, Rosaria Talarico2, Chiara Stagnaro3, Anna d'Ascanio4, Chiara Tani3, Chiara Baldini3, Marta Mosca1 and Stefano Bombardieri3, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Rheumatology Unit, Pisa, Italy, 3University of Pisa, Rheumatology Unit, Pisa, Italy, 4Malattie muscolo-scheletriche e cutanee, Rheumatology Unit, Pisa, Italy

    Background/Purpose: Behçet’s disease (BD) is globally characterized by a variable spectrum of disease profile: while prevalent muco-cutaneous lesions and arthritis represent the only clinical features…
  • Abstract Number: 2621 • 2013 ACR/ARHP Annual Meeting

    Venous Claudication Is A Severe and Frequent Symptom In BEHCET’S Syndrome

    SerdaL Ugurlu1, Emire Seyahi1, Veysel Oktay2, Zerrin Yigit2, Serdar Kucukoglu2 and Hasan Yazici1, 1Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Department of Cardiology, Cardiology Institute, University of Istanbul, Istanbul, Turkey

    Background/Purpose: In a previous cross-sectional questionnaire survey, we had shown that intermittent claudication was significantly more common among BS patients when compared to healthy controls,…
  • Abstract Number: 2622 • 2013 ACR/ARHP Annual Meeting

    Comparison Of Different Methods Of Skin Pathergy Test In Patients With Behçet’s Syndrome

    Aysegul Lacin1, Cigdem Atan Uzun1, Zafer Gunendi2 and Feride Gogus1, 1Physical Medicine and Rehabilitation, Division of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey, 2Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Skin pathergy test (SPT) has a diagnostic value in Behçet’s syndrome (BS). There are different descriptions of the test which may effect its positivity rate.…
  • Abstract Number: 2623 • 2013 ACR/ARHP Annual Meeting

    A CT Evaluation Of Pulmonary and Cardiac Lesions In BEHÇET’S Syndrome Patients Without Pulmonary Symptoms

    Emire Seyahi1, Deniz Cebi Olgun2, SerdaL Ugurlu1, Idil Hanci3, Reona Takahashi4 and Hasan Yazici1, 1Division of Rheumatology,Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 2Department of Radiology,, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, 3Department of Neurology, Krankrenhaus Nordwest, Frankfurt am Main, Frankfurt, Germany, 4Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey

    Background/Purpose:  In Behçet’s syndrome (BS) patients with symptomatic pulmonary artery involvement (PAI) varying and multiple pulmonary parenchymal and cardiac lesions can be seen in thorax CT…
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