Abstracts Archive - Page 2069 of 2425 - ACR Meeting Abstracts

Abstract Number: 2743 • 2013 ACR/ARHP Annual Meeting
Targeted Activation Of The Metabolic Super-Regulator AMP-Activated Protein Kinase (AMPK) Blunts Gouty Inflammation
Ru L. Bryan¹, Robert Terkeltaub² and Yun Wang³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA
Background/Purpose: Gout is associated with both multiple dietary triggers and metabolic co-morbidities, including obesity, metabolic syndrome, and diabates. AMP-activated protein kinase (AMPK) is a master…
Abstract Number: 2744 • 2013 ACR/ARHP Annual Meeting
Caspase 8 Modulates The Polarisome To Prevent Lung Fibrosis In a Murine Ssc-Like Disease Model
Carla M. Cuda¹, Alexander Misharin², Gokhan Mutlu³, Luisa Morales-Nebreda⁴, GR Scott Budinger⁴ and Harris R. Perlman³, ¹Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ³Northwestern University, Chicago, IL, ⁴Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Pulmonary fibrosis has emerged as the leading cause of death in patients with Systemic Sclerosis (SSc). Currently available therapies are only marginally effective in…
Abstract Number: 2745 • 2013 ACR/ARHP Annual Meeting
Reshaping Inflammatory Macrophage Development and Functions by a Monosaccharide Analogue In Rheumatoid Arthritis
Jun Li¹, Hui-Chen Hsu^2,3, PingAr Yang¹, Qi Wu¹, Bao Luo¹, Amber L Rowse⁴, David M. Spalding⁵, James A Mobley⁶, S. Louis Bridges Jr.⁷ and John D. Mountz^3,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Birmingham VA Medical Center, Birmingham, AL, ⁴Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁶University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Inflammatory macrophages (MΦs) play key roles in pathogenesis of rheumatoid arthritis (RA). Fucosylation, comprising the transfer of a fucose (6-Deoxy-L-galactose) to proteins, is regulated…
Abstract Number: 2748 • 2013 ACR/ARHP Annual Meeting
Safety Results From The Beta Confident Registry In Canakinumab-Treated Patients With Cryopyrin-Associated Periodic Syndrome
Hal Hoffman¹, Jasmin B. Kuemmerle-Deschner², Philip N. Hawkins³, T. van der Poll⁴, Ulrich A. Walker⁵, Michael Nebesky⁶, Ken Abrams⁷ and Hugh Tilson⁸, ¹University of California at San Diego, San Diego, CA, ²University Hospital Tuebingen, Tuebingen, Germany, ³University College London Medical School, London, United Kingdom, ⁴Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology, Universitäts-Poliklinik, Felix-Platter Spital, Basel, Switzerland, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC
Background/Purpose: Cryopyrin-associated periodic syndrome (CAPS) comprises s extremely rare auto-inflammatory disorders, including familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease/chronic…
Abstract Number: 2749 • 2013 ACR/ARHP Annual Meeting
Amyloidosis and Its Related Factors In Patients With Familial Mediterranean Fever: A Nationwide Multicenter Study
Timucin Kasifoglu¹, Sule Yasar¹, Ismail Sari², Dilek Solmaz², Soner Senel³, Hakan Emmungil⁴, Levent Kilic⁵, Sibel Yilmaz Oner⁶, Fatih Yildiz⁷, Sedat Yilmaz⁸, Muhammet Cinar⁹, Duygu Ersozlu Bakirli¹⁰, Muge Aydin Tufan¹¹, Sema Yilmaz¹², Veli Yazisiz¹³, Yavuz Pehlivan¹⁴, Cemal Bes¹⁵, Gozde Yildirim Cetin¹⁶, Sukran Erten¹⁷, Emel Gonullu¹, Tuncer Temel¹⁸, Servet Akar², Kenan Aksu⁴, Umut Kalyoncu⁵, Haner Direskeneli¹⁹, Eren Erken¹¹, Bunyamin Kisacik²⁰, Mehmet Sayarlioglu²¹ and Cengiz Korkmaz²², ¹Rheumatology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey, ²Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, ³Rheumatology, Kayseri Erciyes University School of Medicine, Kayseri, Turkey, ⁴Rheumatology, Ege University School of Medicine, Izmir, Turkey, ⁵Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey, ⁶Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ⁷Rheumatology, Cukurova University, School of Medicine, Adana, Turkey, ⁸Gulhane School of Medicine, Ankara, Turkey, ⁹Rheumatology, Gulhane School of Medicine, Ankara, Turkey, ¹⁰Rheumatology, Adana Numune Training and Research Hospital, Adana, Turkey, ¹¹Rheumatology, Cukurova University School of Medicine, Adana, Turkey, ¹²Department of Rheumatology, Selcuk University School of Medicine, Konya, Turkey, ¹³Rheumatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹⁴Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, ¹⁵Rheumatology, Bolu Izzet Baysal School of Medicine, Bolu, Turkey, ¹⁶Rheumatology, Kahramanmaras University School of Medicine, Kahramanmaras, Turkey, ¹⁷Rheumatology, Ataturk Training and Research Hospital, Ankara, Turkey, ¹⁸Gastroenterology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey, ¹⁹Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ²⁰Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ²¹Rheumatology, Ondokuz Mayis University School of Medicine, Samsun, Turkey, ²²Eskisehir Osmangazi University, Eskisehir, Turkey
Background/Purpose: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease that occurs worldwide and predominantly affects the populations arising from the Mediterranean origin. Secondary…
Abstract Number: 2750 • 2013 ACR/ARHP Annual Meeting
Long-Term Efficacy and Safety Of IL1 Receptor Antagonist In Schnitzler’s Syndrome : A French Multicenter Study
Antoine Néel¹, Agathe Masseau¹, Sebastien Barbarot², Benoit Henry³, Pierre-Jean Weiller⁴, Olivier Decaux⁵, Xavier Kyndt⁶, Xavier Puechal⁷, Arnaud Hot⁸, Pierre Pottier¹, Amar Smail⁹, David Launay¹⁰, Jean-Marie Berthelot¹¹, Eric Hachulla¹², Leonardo Astudillo¹³, Pierre-Yves Hatron¹², Laurent Sailler¹³, Aurelien Lorleac'h¹⁴, Achille Aouba¹⁵, Bérangère Cador¹⁶, Renato Fior¹⁷, Robin Dhote¹⁸, Fabrice Bonnet¹⁹, Jean-Dominique de Korwin²⁰ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Dermatology, Nantes University Hospital, Nantes, France, ³Infectious and Tropical Diseases, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Internal Medicine Department, La Timone University Hospital, Marseille, France, ⁵Department of Internal Medicine, Rennes University Hospital, Rennes, France, ⁶Department of Nephrology and Internal Medicine, CH, Valenciennes, Valenciennes, France, ⁷Internal Medicine, Hôpital Cochin, Paris, France, ⁸Internal Medicine, Edouard Herriot University Hospital, Lyon, France, ⁹Internal Medicine Department, CHU Amiens Nord, Amiens, France, ¹⁰Internal Medicine, Claude Huriez University Hospital, Lille, France, ¹¹Rheumatology Unit, Nantes University Hospital, Nantes, France, ¹²Department of Internal Medicine, Claude Huriez University Hospital, Lille, France, ¹³Department of Internal Medicine, Toulouse University Hospital, Toulouse, France, ¹⁴Internal Medicine Department, Lorient Hospital, Lorient, France, ¹⁵Hematology, Necker University Hospital, Paris, France, ¹⁶Internal Medicine Department, Rennes University Hospital, Rennes, France, ¹⁷Internal Medicine Department, Antoine Béclère University Hospital, Clamart, France, ¹⁸Internal Medicine, Avicenne University Hospital, Bobigny, France, ¹⁹Internal Medicine, Bordeaux University Hospital, Bordeaux, France, ²⁰Internal Medicine Department, Nancy University Hospital, Nancy, France
Background/Purpose: Schnitzler's syndrome is a rare late onset auto-inflammatory disease which associates a chronic/recurrent urticarial skin rash, a monoclonal gammopathy (mostly IgM kappa), and a…
Abstract Number: 2751 • 2013 ACR/ARHP Annual Meeting
Recurrent Pericarditis In Children and Adolescents: Etiology, Presentation, Therapies, and Outcomes In a Multicenter Retrospective Cohort Of 100 Patients
Antonio Brucato¹, Massimo Imazio², Marco Gattorno³, Antonella Insalaco⁴, Chiara Di Blasi Lo Cuccio¹, Simona Marcora⁵, Rolando Cimaz⁶, Luca Cantarini⁷, Luciana Breda⁸, Manuela Marsili⁹, Fabrizia Corona¹⁰ and Alberto Martini¹¹, ¹Internal Medicine, USC Internal Medicine, Ospedale Papa Giovanni XXIII, Bergamo, Italy, ²Cardiology, Maria Vittoria Hospital, Torino, Italy, ³Second Division of Paediatrics, G. Gaslini Institute, Genova, Italy, ⁴Department of Pediatric Rheumatology, Ospedale Pediatrico Bambino Gesù, Roma, Italy, ⁵Paediatric Cardiology, Ospedale Papa Giovanni XXIII, Bergamo, Italy, ⁶Rheumatology Unit, A. Meyer Children's Hospital, Florence, Italy, ⁷University of Siena, Siena, Italy, ⁸Department of Paediatrics, University of Chieti G. D'Annunzio, Chieti, Italy, ⁹Paediatrics Department, University of Chieti G. D'Annunzio, Chieti, Italy, ¹⁰Reumatologia Pediatrica, Paediatric Department University of Milano, Milano, Italy, ¹¹Pediatria, Istituto G Gaslini, Pediatria II, Reumatologia, Genova, Italy
Background/Purpose: Acute pericarditis is defined as at least 2 of the following criteria: typical chest pain (sharp and pleuritic, improved by sitting up and leaning…
Abstract Number: 2752 • 2013 ACR/ARHP Annual Meeting
Good, Moderate and Poor Outcome Trajectories Of Pain Severity In Early Symptomatic Knee Osteoarthritis; 5 Year Follow-Up Of Check study
Janet Wesseling¹, Alex N. Bastick², Sita M.A. Bierma-Zeinstra³ and Johannes W.J. Bijlsma⁴, ¹Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ³Orthopaedics and General Practice, Erasmus MC - University Medical Center, Rotterdam, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Knee pain is often the first sign of knee OA (osteoarthritis) and it is known that its course can be very different between patients over…
Abstract Number: 2753 • 2013 ACR/ARHP Annual Meeting
Relationship Of Pre-Radiographic MRI Lesions With Prevalent Frequent Knee Symptoms and Incident Persistent Knee Symptoms In Persons At Higher Risk For Knee Osteoarthritis
Leena Sharma¹, Joan S. Chmiel¹, Orit Almagor¹, Dorothy D. Dunlop², Marc C. Hochberg³, Charles Eaton⁴, C. Kent Kwoh⁵, Rebecca D. Jackson⁶, Joan M. Bathon⁷, Ali Guermazi⁸, Frank Roemer⁹, Michel Crema⁸, W. Jerry Mysiw⁶ and Michael C. Nevitt¹⁰, ¹Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Ohio State University, Columbus, OH, ⁷Columbia University, New York, NY, ⁸Boston University, Boston, MA, ⁹Klinikum Augsburg, Augsburg, Germany, ¹⁰Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA
Background/Purpose: The clinical significance of pre-radiographic MRI lesions in persons at risk for knee OA is unclear. Understanding whether such lesions are inconsequential or early…
Abstract Number: 2754 • 2013 ACR/ARHP Annual Meeting
Trajectory Of Cartilage Thickness Change During The Years Prior To Knee Replacement: Data From The Osteoarthritis Initiative
Felix Eckstein¹, Robert M. Boudreau², Zhijie Wang³, Michael J. Hannon³, Wolfgang Wirth¹, Sebastian Cotofana⁴, Ali Guermazi⁵, Frank Roemer⁶, Michael C. Nevitt⁷, Markus John⁸, Christoph Ladel⁹, David J. Hunter¹⁰ and C. Kent Kwoh¹¹, ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Musculoskeletal Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁵Boston University, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Merck KG, Darmstadt, Germany, ¹⁰Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ¹¹School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Knee replacement (KR) represents a clinically important and cost-effective endpoint of knee osteoarthritis (OA). We have shown previously that, in a year prior to…
Abstract Number: 2755 • 2013 ACR/ARHP Annual Meeting
The Clinical Significance and Natural History Of Knee Bone Marrow Lesions Over 8 Years
Yi Chao Foong¹, Hussain Ijaz Khan¹, Dawn Aitken¹, Changhai Ding², Flavia Cicuttini³ and Graeme Jones², ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart, 7000, Australia, ²Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Department of Epidemiology and Preventive Medicine, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, 3004, Australia
Background/Purpose: There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of OA. Whilst many studies have…
Abstract Number: 2726 • 2013 ACR/ARHP Annual Meeting
A Polymorphism In The Mif Gene Is Associated With Cardiovascular Morbidity In Systemic Lupus Erythematosus – a Pilot Study
Eric F. Morand, Kathryn Connelly and Alberta Y. Hoi, Centre for Inflammatory Diseases, Monash University, Melbourne, Australia
Background/Purpose: Chronic inflammation is believed to be responsible for accelerated atherosclerotic cardiovascular disease (CVD) in patients with SLE. Macrophage migration inhibitory factor (MIF) is a…
Abstract Number: 2716 • 2013 ACR/ARHP Annual Meeting
Support For Psychological State May Be Effective to Attain Remission Of Boolean-Based Definition Of Patient Global Assessment In Patients With Rheumatoid Arthritis
Mie Fusama¹, Kumiko Yukioka², Takanori Kuroiwa³, Chikako Yukioka⁴, Miyako Inoue², Tae Nakanishi², Norikazu Murata⁴, Noriko Takai⁵, Kayoko Higashi⁶, Taro Kuritani⁷, Keiji Maeda⁷, Yasushi Miura¹, Hajime Sano⁸, Masao Yukioka⁴ and Hideko Nakahara⁹, ¹Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ²Division of Clinical Psychology, Yukioka Hospital, Osaka, Japan, ³Department of Rheumatology, Yukioka Hospital, Osaka, Japan, ⁴Department of Orthopaedic Surgery, Yukioka Hospital, Osaka, Japan, ⁵Division of Clinical Psychology, Yukioka College of Health Science, Osaka, Japan, ⁶Division of nursing, NTT West Osaka Hospital, Osaka, Japan, ⁷Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan, ⁸Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya-city, Japan, ⁹Division of Allergy, Rheumatology and Connective Tissue Diseases, Department of Internal Medicine, NTT West Osaka Hospital, Osaka, Japan
Background/Purpose: The patients with rheumatoid arthritis (RA) often do not meet patient global assessment (PGA) remission criterion despite a good clinical disease state and, therefore,…
Abstract Number: 2717 • 2013 ACR/ARHP Annual Meeting
Fatigue in Rheumatoid Arthritis Is Associated With Modifiable Lifestyle Factors
Patricia P. Katz¹, Vladimir Chernitskiy² and David I. Daikh², ¹Medicine, University of California, San Francisco, San Francisco, CA, ²Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Fatigue has been identified as a major concern for individuals with rheumatoid arthritis (RA) and has been endorsed as a core outcome measure. However,…
Abstract Number: 2718 • 2013 ACR/ARHP Annual Meeting
Exploring E-Health Ethics and Multi-Morbidity: A Qualitative Study Of Patient and Clinician Experiences Using Digital Media For Health Purposes
Anne F. Townsend^1,2,3,4, Paul M Adam⁵, Linda C. Li^6,7, Jenny Leese¹, Michael McDonald⁸, Sheila Kerr⁹, Gordon Whitehead¹⁰ and Catherine L. Backman¹¹, ¹Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada, ³Qualitative Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology Liaison, Mary Pack Arthritis Centre, Vancouver, BC, Canada, ⁶Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ⁷Physical Therapy, Arthritis Centre of Canada, Richmond, BC, Canada, ⁸Maurice Young Centre for Applied Ethics, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ⁹Arthritis Patient Advisory Board, Richmond, BC, Canada, ¹⁰Consumer Advisory Board, Vancouver, BC, Canada, ¹¹Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: E-Health can potentially transform and enhance health care delivery and empower patients. E-health includes a spectrum of digital health services and information communicated through…

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