Abstracts Archive - Page 2069 of 2607 - ACR Meeting Abstracts

Abstract Number: 2486 • 2014 ACR/ARHP Annual Meeting
Patient-Reported Outcomes Following 12 Months of Therapy with Abatacept (Plus Methotrexate or as Monotherapy) or Methotrexate and up to 6 Months after Treatment Withdrawal in Patients with Early Rheumatoid Arthritis
Daniel E. Furst¹, Vivian P. Bykerk², Gerd Burmester³, B Combe⁴, T W J Huizinga⁵, E Alemao⁶, D Wong⁶, C S Karyekar⁶ and P Emery⁷, ¹University of California at Los Angeles, Los Angeles, CA, ²Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ³Charité – University Medicine Berlin, Berlin, Germany, ⁴Monpellier University Hospital, Montpellier, France, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶Bristol-Myers Squibb, Princeton, NJ, ⁷University of Leeds, Leeds, United Kingdom
Background/Purpose: Early biologic use can improve long-term control of RA,1,2 potentially leading to improved physical function and reduced pain. Recent EULAR recommendations support shared decisions…
Abstract Number: 2485 • 2014 ACR/ARHP Annual Meeting
Predictors of Drug-Free Remission Following Treatment with Abatacept (in Combination with Methotrexate or as Monotherapy) in Early Rheumatoid Arthritis
P Emery¹, Gerd Burmester², Vivian P. Bykerk³, B Combe⁴, Daniel E. Furst⁵, E Barre⁶, C S Karyekar⁷, D Wong⁷ and T W J Huizinga⁸, ¹University of Leeds, Leeds, United Kingdom, ²Charité – University Medicine Berlin, Berlin, Germany, ³Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁴Monpellier University Hospital, Montpellier, France, ⁵University of California at Los Angeles, Los Angeles, CA, ⁶Bristol-Myers Squibb, Braine-L’Alleud, Belgium, ⁷Bristol-Myers Squibb, Princeton, NJ, ⁸Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: In the Phase IIIb, randomized, double-blind, active-controlled AVERT study, abatacept (ABA) + MTX and ABA monotherapy induced protocol-defined DAS remission (DAS28 [CRP]
Abstract Number: 2484 • 2014 ACR/ARHP Annual Meeting
Adding an Initial Six-Month Course of Infliximab to an Active Combination Treatment Is Cost Saving in Working-Aged Early Rheumatoid Arthritis Patients
Vappu Rantalaiho¹, Kari Puolakka², Janne Martikainen³, Hannu Kautiainen^4,5,6 and Marjatta Leirisalo-Repo^7,8, ¹Department of Internal Medicine, Centre for Rheumatic Diseases, Tampere University Hospital, Tampere, Finland, ²Department of Medicine, South Karelia Central Hospital, Lappeenranta, Finland, ³Pharmacoeconomics and Outcomes Research Unit, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, ⁴Department of General Practice, University of Helsinki, Helsinki, Finland, ⁵Unit of Primary Health Care, Turku University Hospital, Turku, Finland, ⁶Unit of Primary Health Care, Helsinki University Central Hospital, Helsinki, Finland, ⁷Department of Clinical Medicine, University of Helsinki, Helsinki, Finland, ⁸Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland
Background/Purpose To study the cost-effectiveness of adding initial infliximab to a remission-targeted combination treatment with disease modifying antirheumatic drugs (DMARDs) in early rheumatoid arthritis (RA).…
Abstract Number: 2483 • 2014 ACR/ARHP Annual Meeting
Treatment Adjustment Strategy after Achieving Remission or Low Disease Activity in Rheumatoid Arthritis : A Systematic Review and Meta-Analysis
Sophie Henaux¹, Thomas Barnetche², Adeline Ruyssen Witrand³, Bruno Fautrel⁴, Alain G. Cantagrel⁵ and Arnaud Constantin⁶, ¹Centre de Rhumatologie, Hopital Purpan, Toulouse, France, ²Rheumatology, Bordeaux University Hospital, Bordeaux, France, ³Rheumatolgy, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France, ⁴GRC-UPMC 08; AP-HP, Rheumatology dépt, Pitié Salpêtrière Hospital, Paris, France, ⁵Centre Hospitalier Universitaire de Toulouse, Toulouse, France, ⁶Rheumatology, CHU Purpan - Hôpital Pierre-Paul Riquet, Toulouse, France
Conflict of interest : NONE.Background/Purpose Attaining remission or at least low-disease activity (LDA) is a goal achieved in a significant proportion of rheumatoid arthritis (RA) patients…
Abstract Number: 2482 • 2014 ACR/ARHP Annual Meeting
Use of Biologic Therapy As Monotherapy in Patients with Rheumatoid Arthritis
Antonio Gómez-Centeno¹, Olga Martínez², Francisco Javier Ballina³, José Manuel Rodríguez⁴, Jenaro Graña⁵, Manuel Brito⁶, Juana Sampedro⁷, Gerardo Iglesias⁸, Concepción Delgado⁹ and Indalecio Monteagudo¹⁰, ¹Hospital Parc Taulí, Sabadell, Spain, ²Hospital Virgen de la Concha, Zamora, Spain, ³Hospital Central de Asturias, Oviedo, Spain, ⁴Hospital Getafe, Getafe, Spain, ⁵Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, ⁶Hospital Nuestra Señora Candelaria, Santa Cruz de Tenerife, Spain, ⁷Hospital Virgen de la Salud, Toledo, Spain, ⁸Complejo Hospitalario Palencia, Palencia, Spain, ⁹Hospital Clínico Lozano Blesa, Zaragoza, Spain, ¹⁰Hospital Gregorio Marañón, Madrid, Spain
Background/Purpose The treatment for Rheumatoid Arthritis (RA) is based on synthetic or biological disease-modifying drugs (DMARDs). Current guidelines recommend biologics in combination with methotrexate as…
Abstract Number: 2493 • 2014 ACR/ARHP Annual Meeting
Prediction of Remission and Low Disease Activity in DMARD-Refractory Patients with RA Treated with Golimumab
N Vastesaeger¹, P Durez², Bhaskar Dasgupta³, B Combe⁴, H Schulze-Koops⁵, I Louw⁶, J Wollenhaupt⁷, CAF Zerbini⁸, A Beaulieu⁹, K Pavelka¹⁰, M Lazaro¹¹, A Garcia Kutzbach¹², RJ Moots¹³, H Amital¹⁴, S Huyck¹⁵, B Fu¹⁵, M Govoni¹⁶ and HH Weng¹⁵, ¹MSD Belgium, Brussels, Belgium, ²Université Catholique de Louvain, Bruxelles, Belgium, ³Southend University Hospital, Essex, United Kingdom, ⁴Monpellier University Hospital, Montpellier, France, ⁵Division of Rheumatology, University of Munich, Munich, Germany, ⁶Panorama Medical Centre, Cape Town, South Africa, ⁷Schön Klinik Hamburg-Eilbek, Hamburg, Germany, ⁸Rheumatology, Centro Paulista de Investigação Clinica, Sao Paulo, Brazil, ⁹Bureau 360, Centre de Rhumatologie, St-Louis, QC, Canada, ¹⁰Revmatologicky Ustav, Praha, Czech Republic, ¹¹IARI Instituto de Asistencia Reumatologica Integral, Buenos Aires, Argentina, ¹²AGAR Francisco Marroquin University, Guatemala City, Guatemala, ¹³University Hospital Aintree, Liverpool, United Kingdom, ¹⁴Medicine B, Sheba Medical Center, Tel-Hashomer, Israel, ¹⁵Merck & Co., Inc., Whitehouse Station, NJ, ¹⁶MSD Italy, Rome, Italy
Background/Purpose EULAR recommendations for RA therapy suggest addition of a biologic only if poor prognostic factors such as high disease activity are present. However, low…
Abstract Number: 2481 • 2014 ACR/ARHP Annual Meeting
Which Factors Influence the Prescription of Tocilizumab Alone or in Combination with DMARDsÂ in Rheumatoid Arthritis Patients in a Real Life Setting?: An Interim Analysis of Safety and Efficacy at 6 Months
Jacques Tebib¹, Isabelle Idier², Mathieu Coudert³, David Pau⁴, Rene-Marc Flipo⁵ and Jean-Francis Maillefert⁶, ¹Rheumatology, University Hospital Lyon, Lyon, France, ²Chugai Pharma, La Defense, France, ³Statistics, Experis IT, Nanterre, France, ⁴Statistics, Roche, Boulogne-Billancourt, France, ⁵Rheumatology, University Hospital Lille, Lille, France, ⁶Rheumatology, University Hospital Dijon, Dijon, France
Background/Purpose Baseline factors influencing the use of tocilizumab (TCZ) in monotherapy (Mono) instead of combination with DMARDs (Combo) in real-life practice in RA patients (pts)…
Abstract Number: 2479 • 2014 ACR/ARHP Annual Meeting
Utility of Adjustment of Administration Interval in Tocilizumab in Rheumatoid Arthritis
Shuntaro Saito, Keisuke Izumi, Yuko Kaneko, Katsuya Suzuki and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose Interleukin-6 (IL-6) is considered a key cytokine in the pathogenesis of rheumatoid arthritis (RA). Tocilizumab (TCZ) is a monoclonal antibody which binds to membrane-bound…
Abstract Number: 2480 • 2014 ACR/ARHP Annual Meeting
Is there a Difference in the Effectiveness in the Treatment of Rheumatoid Arthritis with Rituximab when Using a Dose of 1 or 2 Grams per Cycle? a Systematic Review
Ana M. Ortiz¹, María Piedad Rosario², Carmen Martínez² and Isidoro González-Alvaro¹, ¹Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ²Research Unit, Spanish Society of Rheumatology, Madrid, Spain
Background/Purpose: Since the description of the efficacy of rituximab (RTX) in treating patients with rheumatoid arthritis (RA), the use of this drug has been extended.…
Abstract Number: 2472 • 2014 ACR/ARHP Annual Meeting
The First, Multicenter, Double-Blind, Randomized, Parallel-Group Study of Certolizumab Pegol in Early Rheumatoid Arthritis Demonstrates Inhibition of Joint Damage Progression
Tatsuya Atsumi¹, Kazuhiko Yamamoto², Tsutomu Takeuchi³, Hisashi Yamanaka⁴, Naoki Ishiguro⁵, Yoshiya Tanaka⁶, Katsumi Eguchi⁷, Akira Watanabe⁸, Hideki Origasa⁹, Toshiharu Shoji¹⁰, Osamu Togo¹¹, Toshiyuki Okada¹², Désirée M. van der Heijde¹³, Nobuyuki Miyasaka¹⁴ and Takao Koike^15,16, ¹Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, ³Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Kitakyushu, Japan, ⁴Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁵Department of orthopedics, Nagoya University Graduate School and Faculty of Medicine, Nagoya, Japan, ⁶The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ⁷Department of Rheumatology, Sasebo City General Hospital, Nagasaki, Japan, ⁸Division of Rheumatology, Department of Internal Medicine, School of Medicine, Tohoku University, Tokyo, Japan, ⁹Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine, Toyama, Japan, ¹⁰Department of Clinical Research and Development, UCB Pharma, Tokyo, Japan, ¹¹Biometrics Group, UCB Pharma, Tokyo, Japan, ¹²Astellas Pharma Inc, Tokyo, Japan, ¹³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ¹⁴Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ¹⁵NTT Sapporo Medical Center, Sapporo, Japan, ¹⁶Hokkaido University Graduate School of Medicine, Sapporo, Japan
Background/Purpose The efficacy and safety of certolizumab pegol (CZP)+methotrexate (MTX) therapy compared to MTX alone, in Japanese MTX-naïve early rheumatoid arthritis (RA) patients (pts) with…
Abstract Number: 2471 • 2014 ACR/ARHP Annual Meeting
Effect of Teriparatide in Patients with Osteoporosis and Rheumatoid Arthritis
Robin Dore¹, Kenneth G. Saag², Guillermo Valenzuela³, Kathleen Taylor⁴, Qiu He⁴, Jahangir Alam⁴ and Kelly D. Krohn⁵, ¹University of California, Los Angeles, CA, ²Immunology & Rheumatology, The University of Alabama at Birmingham, Birmingham, AL, ³Integral Rheumatology and Immunology Specialists, Plantation, FL, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵DC 5208, Eli Lilly and Company, LLC, Indianapolis, Indiana, Indianapolis, IN
Background/Purpose: A common complication in rheumatoid arthritis (RA) is osteoporosis (OP) with increased incidence of fragility fractures. RA is the only disease specifically included…
Abstract Number: 2470 • 2014 ACR/ARHP Annual Meeting
Treatment Strategy for Maximizating the Effect of Adalimumab in Japanese Patients with Rheumatoid Arthritis : Retrospective Analyses of Data Collected from the Patient Treated with Adalimumab in Routine Clinical Practice in Hamamatsu Area
Toshiaki Miyamoto, Rheumatology, SEIREI HAMAMATSU GENERAL HOSPITAL, Hamamatsu, Japan
Background/Purpose: Adalimumab (ADA) showed highly efficacious in rheumatoid arthritis (RA) in the clinical trials, although there is little evidence in daily clinical practice.The clinical usefulness…
Abstract Number: 2469 • 2014 ACR/ARHP Annual Meeting
The Efficacy and Safety of Tocilizumab Subcutaneous Q2W and Following Escalation from Q2W to QW Therapy in Combination with Traditional Dmards in Patients with Moderate to Severe Rheumatoid Arthritis at 96 Weeks
Alan Kivitz¹, Ewa Olech², Michael A. Borofsky³, Beatriz M. Zazueta⁴, Federico Navarro-Sarabia⁵, S. C. Radominski⁶, Joan T. Merrill⁷, Jinglan Pei⁸, Lucy Rowell⁹, Clare Nasmyth-Miller⁹, Sunethra Wimalasundera⁹ and Janet E. Pope¹⁰, ¹Altoona Arthritis & Osteoporosis Center, Duncansville, PA, ²Internal Medicine, Division of Rheumatology, University of Nevada School of Medicine, Las Vegas, NV, ³Clinical Research Center of Reading, Reading, PA, ⁴Reumatologia, Centro de Investigacion en Enfermedades Reumaticas, Mexicali, Mexico, ⁵Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, ⁶Universidade Federal do Paraná, Curitiba, Brazil, ⁷Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Genentech, South San Francisco, CA, ⁹Roche, Welwyn Garden City, United Kingdom, ¹⁰St Joseph Health Care, London, ON, Canada
Background/Purpose : The BREVACTA study assessed the efficacy and safety of subcutaneous tocilizumab (TCZ SC) in patients (pts) with RA who had an inadequate response…
Abstract Number: 2468 • 2014 ACR/ARHP Annual Meeting
Stringent Criteria for Low Disease Activity and Remission after 12 Months of Treatment, and after Treatment Withdrawal, with Abatacept Monotherapy, Abatacept with Methotrexate or Methotrexate Alone in Early Rheumatoid Arthritis
Gerd Burmester¹, Daniel E. Furst², B G Combe³, T W J Huizinga⁴, Vivian P. Bykerk⁵, D Wong⁶, C S Karyekar⁶ and P Emery⁷, ¹Charité – University Medicine Berlin, Berlin, Germany, ²University of California at Los Angeles, Los Angeles, CA, ³Montpellier University Hospital, Montpellier, France, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁶Bristol-Myers Squibb, Princeton, NJ, ⁷University of Leeds, Leeds, United Kingdom
Background/Purpose: Clinical remission is associated with better long-term outcomes1,2 and should be the goal of therapy in RA. In the Assessing Very Early Rheumatoid arthritis…
Abstract Number: 2467 • 2014 ACR/ARHP Annual Meeting
Effectiveness and Safety of Tocilizumab in Biologics NaÃ¯ve RA Patients – Interim Analysis of PMS for Investigating Success in Achieving Clinical and Functional Remission and Sustaining Efficacy with Tocilizumab in Biologics-NaÃ¯ve RA Patients Study
Naoki Ishiguro¹, Tatsuya Atsumi², Masayoshi Harigai³, Tsuneyo Mimori⁴, Norihiro Nishimoto⁵, Takayuki Sumida⁶, Tsutomu Takeuchi⁷, Yoshiya Tanaka⁸, Nobuhiro Takagi⁹, Kunihiko Tanaka¹⁰ and Hisashi Yamanaka¹¹, ¹Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Medicine II School of Medicine, Hokkaido University, Sapporo, Japan, ³Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Dept of Rheum & Clinical Immunology, Kyoto Univ Grad Schl of Med, Kyoto, Japan, ⁵Department of Molecular Regulation for Intractable Diseases, Institute of Medical Science, Tokyo Medical University, Osaka, Japan, ⁶Dept Internal Medicine, Univ of Tsukuba/Inst Clin Med, Tsukuba City, Japan, ⁷Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan, ⁸First Dept of Internal Med, U Occupa & Environ Hlth, Kitakyushu, Japan, ⁹Medical Science, Chugai Pharmaceutical, Tokyo, Japan, ¹⁰Pharmacovigilance, Chugai Pharmaceutical, Tokyo, Japan, ¹¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: The all-patient PMS study of tocilizumab (TCZ) followed 7901 RA patients for 28 wks. That study (hereafter, PMS7901) showed patients with a high probability…

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