ACR Meeting Abstracts

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  • Abstract Number: 0620 • ACR Convergence 2023

    Physical and Mental Health in Early Systemic Sclerosis: Baseline Results for Patient-Reported Outcomes Measurement Information System-29 from the Collaborative National Quality and Efficacy Registry

    Isha Lamba1, Ashima Makol2, Dinesh Khanna3, John VanBuren4, Angela Child4, Jessica Alvey4, Shervin Assassi5, Elana Bernstein6, Flavia Castelino7, Lorinda Chung8, Luke Evnin9, Tracy Frech10, Faye Hant11, Laura Hummers12, Kimberly Lakin13, Dorota Lebiedz-Odrobina14, Yiming Luo15, Jerry Molitor16, Duncan Moore17, Carrie Richardson18, Nora Sandorfi19, Ami Shah20, Ankoor Shah21, Victoria Shanmugam22, Brian Skaug23, Virginia Steen24, Elizabeth Volkmann25 and Jessica Gordon13, 1New York Presbyterian Hospital/Weill Cornell Medical Centre, New York, NY, 2Mayo Clinic, Rochester, MN, Rochester, MN, 3University of Michigan, Ann Arbor, MI, 4University of Utah, Salt Lake City, UT, 5University of Texas McGovern Medical School at Houston, Houston, TX, 6Columbia University, New York, NY, 7Massachusetts General Hospital, Boston, MA, 8Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA, 9Scleroderma Research Foundation, Brisbane, CA, 10Vanderbilt University Medical Center, Nashville, TN, 11Medical University of South Carolina, Charleston, SC, 12Johns Hopkins University, Baltimore, MD, 13Hospital for Special Surgery, New York, NY, 14University of Utah, Cottonwood Heights, UT, 15Division of Rheumatology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 16University of Minnesota, Minneapolis, MN, 17Northwestern Memorial Hospital, Chicago, IL, 18Northwestern University, Riverside, IL, 19University of Pennsylvania, Philadelphia, PA, 20Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Ellicott City, MD, 21Duke University, Durham, NC, 22Victoria Shanmugam, MD, Great Falls, VA, 23Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, 24Georgetown University School of Medicine, Washington, DC, 25University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Patient-Reported Outcomes Measurement Information System-29 version 2.0 (PROMIS-29v2) is a patient-centered questionnaire used to assess health-related quality of life (HRQoL). PROMIS-29v2 has shown validity…
  • Abstract Number: 0466 • ACR Convergence 2023

    Impact of Postpartum on Patients with Inflammatory Rheumatic Diseases: The P2Rheum Study

    Marie Hornez1, Anna Molto2, Maxime Leroy3, beatrice banneville4, Rakiba Belkhir5, elodie chauvet6, Marion Couderc7, Emanuelle Dernis8, sandra Desouches9, Valerie Devauchelle10, Aline Frazier-Mironer11, Laure Gossec12, elisabeth Gervais13, Hubert Marotte14, Christophe Richez15, Jeremie SELLAM16, Raphaele Seror17, Véronique Le Guern18, Gaelle Guettrot-Imbert18, Nathalie Costedoat-Chalumeau19, Rene-Marc Flipo20 and Jean-Guillaume Letarouilly21, 1University of Lille, Lille, France, 2HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, 3CHU Lille - Department of Biostatistics, Lille, France, 4Sorbonne universite and Pitié Salpêtrière Hospital, la Garenne Colombes, France, 5Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicêtre, France, 6CH Perpignan, Perpignan, France, 7CHU Gabriel Montpied, Clermont Ferrand, France, 8CH Le Mans, Le Mans, France, 9Hôpital Saint Antoine, Assistance Publique Hôpitaux de Paris, Paris, France, 10UBO, Brest, France, 11APHP Lariboisiere Hospital, Paris, France, 12Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France, 13CHU Poitiers, Poitiers, France, 14CHU Saint-Etienne, Saint-Etienne, France, 15Université de Bordeaux, Bordeaux, France, 16Sorbonne Université APHP, Paris, France, 17University Hospital Paris Saclay, Le Kremlin-Bicêtre, France, 18APHP Hôpital Cochin, Paris, France, 19Inserm DR Paris 5, Paris, France, 20La Lettre du Rhumatologue, Paris, France, 21CHU Lille, Lille, France

    Background/Purpose: There are limited data on the impact of the postpartum period (PP) on the activity of inflammatory rheumatic disorders (IRD), and the data available…
  • Abstract Number: 0621 • ACR Convergence 2023

    Scleroderma Renal Crisis: A Large Single-center Experience

    Rushab Shah1, laura ross2, Kathleen Morrisroe3, Wendy Stevens4 and Mandana Nikpour5, 1St Vincent's Hospital Melbourne/ Alfred Hospital, Melbourne, Australia, 2St. Vincent's Hospital Melbourne, Fitzroy, Australia, 3The University of Melbourne at St Vincent’s Hospital Melbourne, Fitzroy, Australia, 4Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Australia, 5The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia

    Background/Purpose: Scleroderma renal crisis (SRC) is a life-threatening vascular manifestation of systemic sclerosis (SSc) occurring in up to 5% of SSc patients. This condition continues…
  • Abstract Number: 0387 • ACR Convergence 2023

    The Association Between Inflammation, High-Sensitivity Cardiac Troponin T, and Cardiovascular Events in Rheumatoid Arthritis

    Brittany Weber1, Dana Weisenfeld1, Mary Jeffway1, Jonathan Coblyn1, Michael Weinblatt2, Nancy Shadick3, Marcelo DiCarli1 and Katherine Liao1, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Waban, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Patients with rheumatoid arthritis (RA) have a 1.5x excess risk of cardiovascular (CV) disease compared to the general population, attributed to chronic inflammation. In…
  • Abstract Number: 0568 • ACR Convergence 2023

    Comparison of Plasma Protein Profiles and Endothelial Function in Patients with Pediatric-Onset Systemic Lupus Erythematosus and Healthy Controls

    Liyoung Kim1, Gabrielle Alonzi1, Marina Barguil Macedo2, Pamela F. Weiss3, Jane Newburger4, Karen Costenbader5, Christian Lood2 and Joyce Chang1, 1Boston Children's Hospital, Boston, MA, 2University of Washington, Seattle, WA, 3Children's Hospital of Philadelphia, Philadelphia, PA, 4Boston Children's Hospital, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: Patients with pediatric-onset systemic lupus erythematosus (pSLE) have elevated cardiovascular (CV) risk associated with accelerated atherosclerosis that begins in childhood. Endothelial dysfunction may be…
  • Abstract Number: 0504 • ACR Convergence 2023

    Burden of Disease of Psoriatic Arthritis in Latin America: A Systemic Review of Literature

    Wilson Bautista-Molano1, Linda Ibata2, Susan Martinez2 and Andrea Chacon2, 1University Hospital Fundación Santa Fe de Bogotá, Bogotá, Colombia, 2InValue Health Solutions, Bogotá, Colombia

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory pathology that generates a substantial and progressive deterioration of functionality and quality of life. It is associated…
  • Abstract Number: 0392 • ACR Convergence 2023

    Novel Diagnostic Markers for Rheumatoid Arthritis Including Anti-CarP (Carbamylated Protein), Anti-Sa (Citrullinated Vimentin) and Anti-CEP1 (Citrullinated Enolase Peptide1) Are Frequently Positive in Diagnostic Profiles

    Jane Yang1, Rubio Punzalan1, Lehrhoff Andrew1, Michael Nappi1, Vincent ricchiuti2, Michael Zikry1 and Kelly Chun1, 1Labcorp, Calabasas, CA, 2Labcorp, Dublin, OH

    Background/Purpose: Despite the diagnostic contribution of Anti-CCP3.1 (cyclic citrillunated peptide) antibody and RF (rheumatoid factor) as classified by the 2010 ACR/EULAR RA criteria, approximately one-third…
  • Abstract Number: 0582 • ACR Convergence 2023

    Evaluation of Anifrolumab Treatment Responses by the Short Form 36 Health Survey Version 2 in SLE: A Post Hoc Analysis of the Placebo-Controlled Phase 3 Long-Term Extension Trial

    Vibeke Strand1, Kenneth Kalunian2, Barnabas Desta3, Caroline Seo4, Gabriel Abreu5, Raj Tummala3, Catharina Lindholm5 and Hussein Al-Mossawi6, 1Stanford University, Palo Alto, CA, 2University of California San Diego, La Jolla, CA, 3BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 4BioPharmaceuticals Medical Evidence, AstraZeneca, Gaithersburg, MD, 5BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 6BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom

    Background/Purpose: SLE is a chronic disease that progressively reduces patients’ health-related quality of life.1 In a post hoc analysis of the TULIP trials, patients with…
  • Abstract Number: 0370 • ACR Convergence 2023

    Clinical Disease Manifestations Associated with TNF Inhibitor Non-Response in Juvenile Spondyloarthritis

    Melissa Oliver1, Kelly Mosesso2, Pamela F. Weiss3, Robert Colbert4, Matthew Stoll5 and Hemalatha Srinivasalu6, 1Indiana University, Indianapolis, IN, 2Indiana University School of Medicine, Indianapolis, IN, 3Children's Hospital of Philadelphia, Philadelphia, PA, 4NIH/NIAMS, Bethesda, MD, 5University of Alabama at Birmingham, Birmingham, AL, 6Children's National Hospital, Washington, DC

    Background/Purpose: Tumor necrosis factor inhibitors (TNFi) are effective in children with juvenile spondyloarthritis (JSpA) and generally represent the first-line choice for biologic therapy. However, not…
  • Abstract Number: 0616 • ACR Convergence 2023

    Does Systemic Sclerosis Affect the Interpretation of Mammograms? A Retrospective Cohort Study

    Lea Meir1, Tegveer Sandhu2, Weiwei Chi2 and Gabriela Santiago2, 1Icahn School of Medicine, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Systemic Sclerosis is an autoimmune disorder marked by thickened and hardened skin. Cutaneous cutis, the deposition of insoluble calcium salts in the skin and…
  • Abstract Number: 0402 • ACR Convergence 2023

    Automated Detection and Quantification of Hand Joint Swelling in Rheumatoid Arthritis: Computer Vision, Deep Neural Network Models, and a Potential Biomarker for Disease Activity Monitoring

    Marc Blanchard1, Jules Maglione2, Cinja Koller3, Patrick Hermann4, David Brüschweiler3, Arnd Kleyer5 and Thomas Hügle6, 1Dept. of Rheumatology, University Hospital Lausanne (CHUV) and University Lausanne, Lausanne, Switzerland, 2EPFL, Lausanne, Switzerland, 3Lausanne University Hospital, Lausanne, Switzerland, 4ATREON SA, Lausanne, Switzerland, 5University Hospital Erlangen, Erlangen, Germany, 6Dept. of Rheumatology, University Hospital Lausanne (CHUV) and University of Lausanne, Lausanne, Switzerland

    Background/Purpose: We have previously shown that automated detection and processing of dorsal finger fold patterns from hand photographs can be used as a digital biomarker…
  • Abstract Number: 0618 • ACR Convergence 2023

    Incident versus Prevalent Interstitial Lung Disease in Systemic Sclerosis in the EUSTAR Database: Different Disease Phenotypes and Prognosis

    liubov Petelytska1, Arthiha Velauthapillai2, Lorenzo Tofani3, Patricia Carreira4, Giovanna Cuomo5, Eric Hachulla6, Ivan Castellvi7, Radim Becvar8, Alexandra Balbir-Gurman9, Paolo Airò10, Irena Litinsky11, Lesley Ann Saketkoo12, Madelon Vonk13, Jeska de Vries-Bouwstra14, Anna Maria Hoffmann-Vold15, marco Matucci Cerinic16, Oliver Distler17 and Cosimo Bruni17, 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, 2Department of Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, 3Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy, 4Hospital Universitario 12 de Octubre, Madrid, Spain, 5Department of Precision Medicine, “Luigi Vanvitelli” University of Campania, Naples, Italy, 6University of Lille, Lille, France, 7Rheumatology, Hospital Universitari de la Santa Creu i Sant Pau, Sant Just Desvern, Spain, 8Institute of Rheumatology, Prague, Czech Republic, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Praha, Czech Republic, 9Rheumatology Institute, Rambam Health Care Campus and Rappaport Faculty of |Medicine, Technion, Haifa, Israel, 10Spedali Civili di Brescia, Scleroderma UNIT, UOC Reumatologia ed Immunologia Clinica, Piazzale Spedali Civili 1, 25123, Brescia, Italy, 11Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 12University Medical Center - Comprehensive Pulmonary Hypertension Center and ILD Clinic Programs // New Orleans Scleroderma and Sarcoidosis Patient Care & Research Centeris, New Orleans, LA, 13Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 14Leiden University Medical Center, Leiden, Netherlands, 15Oslo University Hospital, Department of Rheumatology, Oslo, Norway, 16Unit of Immunology, Rheumatology, Allergy and Rare diseases, IRCCS San Raffaele Hospital, Milan, Milan, Italy, 17Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

    Background/Purpose: Although 50% of patients with systemic sclerosis (SSc) present with interstitial lung disease (ILD) at baseline, new onset of ILD can also occur later…
  • Abstract Number: 0518 • ACR Convergence 2023

    Tofacitinib Efficacy and Safety in Patients with Ankylosing Spondylitis by Baseline C-Reactive Protein Levels: A Post Hoc Analysis

    Atul Deodhar1, Xenofon Baraliakos2, Marina Nighat Magrey3, Lianne Gensler4, Amit V. Thorat5, Surya Pemmaraju6, Mary Jane Cadatal7 and Peter Nash8, 1Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, 3Case Western Reserve University, University Hospitals, Cleveland, OH, 4University of California San Francisco, Department of Medicine, Division of Rheumatology, San Francisco, CA, 5Pfizer Australia, Sydney, Australia, 6Pfizer Inc., Chennai, Tamil Nadu, India, 7Pfizer Inc., Manila, Philippines, 8School of Medicine, Griffith University, Brisbane, Australia

    Background/Purpose: Elevated baseline (BL) CRP levels can predict treatment response in patients (pts) with AS. Tofacitinib is a Janus kinase inhibitor for the treatment of…
  • Abstract Number: 0535 • ACR Convergence 2023

    Pharmacologic Treatment of Ankylosing Spondylitis in a Large Urban Medical Center: Effects of Socioeconomic Status, Race/Ethnicity and Sex

    EA TROY1, ZT Chan1, WL GALLANTER2, EM Adams3, Mina Al-Awqati2 and Huan Chang1, 1University of Illinois at Chicago; Jesse Brown VA Medical Center, Chicago, IL, 2University of Illinois at Chicago, Chicago, IL, 3Jesse Brown VA Medical Center, Chicago, IL

    Background/Purpose: Ankylosing spondylitis (AS) is estimated to affect up to 1,647,500 Americans, resulting in significant disability and lost productivity for affected individuals. Biologic medications reduce…
  • Abstract Number: 0480 • ACR Convergence 2023

    Non-random Sampling in Rheumatology Randomized Controlled Trials: Evidence of Concerning Trial Conduct?

    Victoria Le1, Mats Junek2, Mike Putman3, Maximilian Casey1, Kenrick Manswell1, Jay Goldsher1, Elizabeth Nettleton1, Desh Nepal1 and Sanket Shah1, 1Medical College of Wisconsin, Milwaukee, WI, 2McMaster University, Hamilton, ON, Canada, 3Division of Rheumatology, Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Non-random sampling of baseline variables in randomized controlled trials (RCTs) may be due unintentional errors, stratified randomization strategies, or data fabrication. Prior studies have…
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