Abstracts Archive - Page 2058 of 2425 - ACR Meeting Abstracts

Abstract Number: 2902 • 2013 ACR/ARHP Annual Meeting
Key Roles For Interferon and Macrophage Activation In Progressive Lung Fibrosis Associated With Systemic Sclerosis
Romy Christmann¹, Giuseppina Stifano², Claudia Borges³, Carlos Carvalho⁴, Ronaldo Kairalla⁴, Edwin R. Parra⁵, Avrum Spira⁶, Robert W. Simms¹, Percival Sampaio-Barros⁷, Vera L. Capelozzi⁵ and Robert Lafyatis¹, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, ⁴Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁵Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁶Computational Biomedicine, Boston University School of Medicine, Boston, MA, ⁷Rheumatology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Background/Purpose: Interstitial lung disease associate with Systemic Sclerosis(SSc-ILD) is one of the leading causes of mortality. We analyzed the gene expression of lung tissue in…
Abstract Number: 2903 • 2013 ACR/ARHP Annual Meeting
Perturbed Response To Experimental Renal Injury In a TGFβ Dependent Mouse Model Of Scleroderma
Emma Derrett-Smith¹, Mark Neal², David J. Abraham³, Alan Salama⁴, Mark A. Little² and Christopher P. Denton³, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²UCL Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁴Centre for Nephrology, University College London, London, United Kingdom
Background/Purpose: Scleroderma renal pathology is predominantly vascular and fibrotic without major inflammatory features. Accelerated hypertension and rapidly progressive renal dysfunction are hallmarks of scleroderma renal…
Abstract Number: 2904 • 2013 ACR/ARHP Annual Meeting
Gadolinium-Based Compounds Induce NLRP3-Dependent IL-1β Production and Peritoneal Inflammation
Jonathan Kay^1,2, Lukas Bossaller³, Christian Schmidt-Lauber^1,4, Hani H. Abujudeh⁵, Gregory Vladimer³, Eicke Latz^3,6, Katherine A. Fitzgerald³, Ann Marshak-Rothstein¹ and Ellen M. Gravallese^1,7, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁴Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ⁵Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nephrogenic systemic fibrosis (NSF) is a progressive iatrogenic fibrosing disorder that develops in patients with chronic kidney disease following administration of gadolinium (Gd)-based contrast…
Abstract Number: 2905 • 2013 ACR/ARHP Annual Meeting
Demethylation of ITGAL (CD11a) regulatory sequences in CD4+T lymphocytes of Systemic Sclerosis
Yaoyao Wang¹, Ye Shu², Qing Wang¹, Ming Zhao¹, Gongping Liang¹, Qianjin Lu¹ and Rong Xiao¹, ¹Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Hunan Children's Hospital, Changsha, China

Background/Purpose: Systemic sclerosis (SSc) is an autoimmune connective tissue disease epitomized numerous cellular and humoral immunological abnormalities. The immune system undoubtedly plays a pivotal…
Abstract Number: 2906 • 2013 ACR/ARHP Annual Meeting
Peripheral Blood Mononuclear Cells Co-Cultured With Autologous Skin Fibroblasts Up-Regulate IL-17A and Play Anti-Fibrotic Effects In Systemic Sclerosis
Serena Vettori¹, Giuseppe Pasquale², Michele Iudici³, Giovanna Cuomo³, Giusi Barra², Barbara Russo⁴, Raffaele De Palma² and Gabriele Valentini¹, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Clinical and Experimental Medicine, Immunology Unit, Second University of Naples, Naples, Italy, ³Department of Internal and Experimental Medicine, Second University of Naples, Naples, Italy, ⁴Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: IL-17A has been recently implicated in the pathogenesis of systemic sclerosis (SSc). Therefore, we explored its expression and effects in peripheral blood mononuclear cells…
Abstract Number: 2907 • 2013 ACR/ARHP Annual Meeting
D1398G Variant Of Hepatocyte Growth Factor Receptor – A Potential Biomarker Of Severe Interstitial Lung Disease In African American Scleroderma Patients
Ilia Atanelishvili¹, Tanjina Akter², Richard M. Silver³ and Galina S. Bogatkevich², ¹Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ²Department of Rheumatology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ³Div Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC
Background/Purpose: Interstitial lung disease (ILD) is a major complication and leading cause of mortality in scleroderma (SSc, systemic sclerosis). The morbidity and mortality rates in…
Abstract Number: 2908 • 2013 ACR/ARHP Annual Meeting
The Roles Of Nurse Practitioners and Physician Assistants In Rheumatology Practices In The United States
Erika Brown¹, Asaf Bitton², Liana Fraenkel³, Hsun Tsao⁴, Jeffrey N. Katz⁵ and Daniel H. Solomon^1,6, ¹Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Medicine, Brigham and Women's Hospital, Boston, MA, ³Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ⁴Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, ⁶Division of Pharmacoepidemiology, Harvard Medical School, Brigham and Women's Hospital, Division of Rheumatology, Division of Pharmacoepidemiology, Boston, MA
Background/Purpose: A recent workforce study of rheumatology in the US suggests that during the next several decades the demand for rheumatology services will outstrip the…
Abstract Number: 2909 • 2013 ACR/ARHP Annual Meeting
2010 Medical Care Expenditures Among US Adults With Arthritis
Miriam Cisternas¹, Louise Murphy², David Pasta³, Edward H. Yelin⁴ and Charles G. Helmick⁵, ¹MGC Data Services, Carlsbad, CA, ²Division of Population Health, CDC, Atlanta, GA, ³DMA Corporation, Palo Alto, CA, ⁴Medicine, UC San Francisco, San Francisco, CA, ⁵National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Using data from the 2010 Medical Expenditure Panel Survey (MEPS), we estimated total and arthritis-attributable medical care expenditures among US adults age 18 years…
Abstract Number: 2910 • 2013 ACR/ARHP Annual Meeting
Differences In Abatacept Use In Rheumatoid Arthritis Patients Across Europe: A Pan-European Database Analysis Of Abatacept In European RA Registries
David Neto¹, Axel Finckh², Florenzo Iannone³, Estíbaliz Loza⁴, Elisabeth Lie⁵, Piet L.C. Van Riel⁶, Merete L. Hetland⁷, Karel Pavelka⁸, Jacques-Eric Gottenberg⁹, Xavier Mariette¹⁰ and Carl Turesson¹¹, ¹University of Geneva, Geneva, Switzerland, ²Rheumatology, Geneva University Hospital, Geneva, Switzerland, ³D.I.M.I.M.P, Rheumatology Unit - University of Bari, Bari, Italy, ⁴Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ⁵Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁷Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ⁸Department of Clinical and Experimental Rheumatology, Charles University, Prague, Czech Republic, ⁹Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹⁰Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ¹¹Department of Rheumatology, Skåne University Hospital, Malmö, Sweden
Background/Purpose: Several European registries have pooled data of patients (pts) who received Abatacept (ABA) for rheumatoid arthritis (RA) to acquire new knowledge about performance of…
Abstract Number: 2911 • 2013 ACR/ARHP Annual Meeting
The Challenge To Develop a Multidimensional Computerized Adaptive Test For Fatigue In Rheumatoid Arthritis
Stephanie Nikolaus¹, Christina Bode², Erik Taal³, Cees A.W. Glas⁴ and Mart A.F.J. van de Laar⁵, ¹Behavioral Sciences, University of Twente, Enschede, Netherlands, ²Faculty of Behavioral Sciences, University of Twente, Enschede, Netherlands, ³Psychology, Health and Technology, University of Twente, Enschede, Netherlands, ⁴Research Methodology, Measurement and Data Analysis, University of Twente, Enschede, Netherlands, ⁵Rheumatology, Medisch Spectrum Twente & University of Twente, Enschede, Netherlands
Background/Purpose: Computerized adaptive testing (CAT) provides the possibility to measure patient reported outcomes precisely at individual level. As items are selected based on the previous…
Abstract Number: 2912 • 2013 ACR/ARHP Annual Meeting
Integrating Patient Electronic Health Records With An Electronic Data Capture System In a Biologics Registry For Inflammatory Arthritides
Inge C. Olsen¹, Espen A. Haavardsholm², Tore K. Kvien³, Ellen Moholt³ and Elisabeth Lie³, ¹Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Diakonhjemmet Hospital, Oslo, Norway, ³Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: The NORwegian Disease Modifying Anti-Rheumatic Drugs (NOR-DMARD) registry has since 2000 been registering DMARD use and response in five different Norwegian rheumatology departments (ref).…
Abstract Number: 2913 • 2013 ACR/ARHP Annual Meeting
The Validity Of Patient-Reported Short-Term Complications Following Total Hip and Knee Arthroplast
Leslie R. Harrold¹, David Ayers², Regis O'Keefe³, Courtland Lewis⁴, Vincent Pellegrini⁵ and Patricia D. Franklin², ¹University of Massachusetts Medical School, Worcester, MA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³University of Rochester Medical Center, Rochester, NY, ⁴Hartford Hospital, Hartford, CT, ⁵Medical University of South Carolina, Charleston, SC
Background/Purpose: Given the absence of national longitudinal data on patients who undergo total joint arthroplasty (TJA) and the limitations of hospital databases to capture information…
Abstract Number: 2914 • 2013 ACR/ARHP Annual Meeting
Serum Proteins and Whole Blood Transcripts Suppressed By An Anti-Type I Interferon Receptor Monoclonal Antibody In Subjects With Systemic Sclerosis
Xiang Guo¹, Brandon W. Higgs², Christopher Kane³, Chris, A. Morehouse², Zheng Liu², Liangwei Wang⁴, Stephen Yoo⁵, Yihong Yao², Lorin Roskos⁶ and Wendy White⁷, ¹Translational Sciences, MedImmune LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³MedImmune, LLC, Gaithersburg, MD, ⁴Biostatistics, MedImmune, LLC, Gaithersburg, MD, ⁵Clinical Development, MedImmune, LLC, Gaithersburg, MD, ⁶One MedImmune Way, Medimmune, Gaithersburg, MD, ⁷Translational Sciences, MedImmune, Gaithersburg, MD
Background/Purpose: To identify serum markers that are modulated by an investigational human IgG1κ monoclonal antibody directed against subunit 1 of the type I interferon receptor…
Abstract Number: 2915 • 2013 ACR/ARHP Annual Meeting
Effect Of Menopause On Skin Thickening In Systemic Sclerosis
Evelyne Vinet¹, Sasha Bernatsky², Christian A. Pineau³, Marie Hudson⁴, Murray Baron⁵ and the Canadian Scleroderma Research Group⁶, ¹McGill University Health Center, Montreal, QC, Canada, ²Division of Clinical Epidemiology, McGill University Health Center, Montreal, QC, Canada, ³Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁴Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Menopause, characterized by a low estrogenic state, is associated with skin thinning, due to decreased extracellular matrix protein deposition by fibroblasts. Although systemic sclerosis…
Abstract Number: 2916 • 2013 ACR/ARHP Annual Meeting
Anti-Fibrillarin Antibodies Are Associated With More Severe Gastrointestinal Involvement and Poorer Survival
Shervin Assassi¹, Marie Hudson², Maureen D. Mayes³, Jennifer Walker⁴, Murray Baron^5,6, Wendy Stevens⁷, Karen Patterson⁸, Tiffany Graham¹, Solene Tatibouet⁹, James Wick¹⁰, Matt Stephenson¹¹ and Marvin J. Fritzler¹¹, ¹Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³University of Texas Health Science Center at Houston, Houston, TX, ⁴Flinders Medical Centre, Adelaide, Australia, ⁵McGill University, Montreal, QC, Canada, ⁶MCGill University, Montreal, QC, Canada, ⁷Rheumatology, St Vincent's Hospital, Melbourne, Australia, ⁸Institute of Medical and Veterinary Science, North Adelaide, Australia, ⁹Jewish General Hospital, McGill University, Montreal, QC, Canada, ¹⁰Department of medicine, Faculty of Medicine, University of Calgary, Calgary, AB, Canada, ¹¹Medicine, University of Calgary, Calgary, AB, Canada
Background/Purpose: Anti-fibrillarin (U3-RNP) antibodies (AFA) are a relatively specific biomarker for systemic sclerosis (SSc). Previous studies have indicated a higher prevalence of AFA among African…

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