Abstracts Archive - Page 2057 of 2607 - ACR Meeting Abstracts

Abstract Number: 2664 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Hematological Malignancies in Children Born to Women with SLE
Evelyne Vinet¹, Ann E. Clarke², Christian A. Pineau³, Susan Scott⁴, Robert W. Platt⁵ and Sasha Bernatsky⁶, ¹McGill University Health Center, Montreal, QC, Canada, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose Patients with SLE have an increased risk of hematological malignancies, particularly non-Hodgkin lymphoma, compared to the general population. Recently, in utero exposures, such as…
Abstract Number: 2663 • 2014 ACR/ARHP Annual Meeting
Sense of Smell, Anti-Ribosomal P Antibodies and Neuropsychiatric Manifestations in Systemic Lupus Erythematosus
Fernando Augusto Peres¹, Karina Oliveira Peliçari², Nailu A. Sinicato¹, Mariana Postal¹, Aline T. Lapa¹, Lilian Costallat³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, United Kingdom, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Neuropsychiatric manifestations occur in 12-95% of SLE patients. Recent studies have demonstrated the high specificity of antiribosomal P antibodies for SLE. Antiribosomal P antibodies…
Abstract Number: 2662 • 2014 ACR/ARHP Annual Meeting
Attribution Protocol and Clinical Significance of Neuropsychiatric Manifestations in Childhood-Onset Systemic Lupus Erythematosus
Renata Barbosa¹, Karina Oliveira Peliçari², Aline T. Lapa³, Nailu A. Sinicato³, Mariana Postal³, Roberto Marini⁴, Marcelo Govoni Sr.⁵ and Simone Appenzeller⁶, ¹Medicine, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Germany, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Department of Clinical medicine and Experimental, University of Ferrara, Ferrara, Italy, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is caused by an imbalance of the immune system and may lead to injury and dysfunction of various systems and…
Abstract Number: 2661 • 2014 ACR/ARHP Annual Meeting
Serum Neuronal Biomarkers and Brain Atrophy in Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Renata Barbosa², Fernando Cendes³, Roberto Marini⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Medicine, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Germany, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose We aimedto investigate the association of serum biomarkers and regional and diffuse brain atrophy in cSLE. Methods We included consecutive cSLE patients (disease-onset before…
Abstract Number: 2659 • 2014 ACR/ARHP Annual Meeting
Neurofilament H Is Associated with White Matter Lesions in Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Lucas Ferreti Silveira², Fernando Cendes³, Roberto Marini⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Imaging findings in systemic lupus erythematosus (SLE) patients are diverse; and diffuse or regional atrophy and white matter hyperintensities (WMH) have been described in…
Abstract Number: 2660 • 2014 ACR/ARHP Annual Meeting
Metabolic Syndrome Features Can Influenciate Cognitive Functions and Brain Lesions in Childhood-Onset Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Aline T. Lapa¹, Mariana Postal¹, Bruna Bellini¹, Paula T Fernandes², Roberto Marini³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculty of Physical Education, State University of Campinas, Campinas, Brazil, ³Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: The underlying factor for an association between the metabolic syndrome (MetS) and cognitive decline might be a subclinical inflammation. Inflammatory mechanisms are hypothesized to…
Abstract Number: 2658 • 2014 ACR/ARHP Annual Meeting
Cognitive Symptoms and Associated Disease and Non-Disease Related Factors in Patients with Systemic Lupus Erythematosus : A Longitudinal Study
Yang Gao, Yi Lo and Mo Yin Mok, Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE). Its associated disease and non-disease related factors have been inconsistently reported. Objective:…
Abstract Number: 2657 • 2014 ACR/ARHP Annual Meeting
Brain Gray and White Matter Volume Losses and Their Associations with Glucocorticoid Use in Patients with Newly Diagnosed Systemic Lupus Erythematosus (SLE) – a Prospective MR Study
Anselm Mak¹, Roger CM Ho², Hanying Tng³ and Juan Zhou³, ¹Medicine, National University of Singapore, Singapore, Singapore, ²Psychological Medicine, National University of Singapore, Singapore, Singapore, ³Center for Cognitive Neuroscience, Duke-NUS Graduate Medical School, Singapore, Singapore
Background/Purpose Data suggest that cerebral atrophy occurs in patients with SLE as early as within 9 months after disease onset. We aimed to address (1)…
Abstract Number: 2656 • 2014 ACR/ARHP Annual Meeting
The Burden of Neuropsychiatric Symptoms in Systemic Lupus Erythematosus: Physician’s and Patient’s Perspectives
Chiara Tani¹, Maria Francisca Moraes-Fontes², Ana Carolina Araújo², Linda Carli³, Manuel Pereira Gonçalves⁴, Francesca Querci⁵, Alexandra Mendes⁶, Viola Signorini⁷, Sabrina Vagnani⁵, Rosaria Talarico⁸, Céu Mateus⁹, Stefano Bombardieri¹⁰, Nuno Riso² and Marta Mosca¹¹, ¹Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Serviço de Medicina 2, Hospital de Curry Cabral, Centro Hospitalar Lisboa Central, Lisbon, Portugal, ³GenOMeC PhD, University of Siena, Siena, Italy, ⁴Mental Health Unit, Universidade Nova de Lisboa (UNL), Portugal, Lisboa, Portugal, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Clinical Psychology Unit, CHLC, Portugal, Lisboa, Portugal, ⁷Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁸Rheumatology Unit, Pisa, Italy, ⁹Health Economy, National School of Public Health (UNL), Portugal, Lisboa, Portugal, ¹⁰Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ¹¹Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Neuropsychiatric symptoms (NPS) are observed in SLE with a variable prevalence depending on patient selection and assessment methods. In 2010, a 27-item questionnaire was…
Abstract Number: 2637 • 2014 ACR/ARHP Annual Meeting
Assessment of Plaque Thickness and Area in Patients with SLE As Measures of Atherosclerosis – Associations with Disease Activity
Sara Croca¹, Maura Griffin², David Isenberg³, Andrew Nicolaides⁴ and Anisur Rahman⁵, ¹5 University Street, University College London, London, United Kingdom, ²Vascular Screening and Diagnostic Centre, London, United Kingdom, ³Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁴St Georges London/Nicosia Medical School, University of Nicosia, Cyprus, Nicosia, Cyprus, ⁵Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose SLE is an independent risk factor for cardiovascular disease (CVD). Traditional risk stratification tools underestimate CVD risk in patients with SLE. Previous vascular ultrasound…
Abstract Number: 2636 • 2014 ACR/ARHP Annual Meeting
Vitamin D Improves Endothelial Function in Patients with Clinically Stable Systemic Lupus Erythematosus (SLE)
John A. Reynolds¹, David W. Ray², Terence O'Neill³, Yvonne Alexander⁴ and Ian N. Bruce^5,6, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom
Background/Purpose SLE patients have an increased risk of cardiovascular disease (CVD). Vitamin D deficiency has been associated with both CVD risk factors and subclinical CVD…
Abstract Number: 2635 • 2014 ACR/ARHP Annual Meeting
Noncalcified Plaque Progression in Systemic Lupus Erythematosus
Adnan Kiani¹, Armin Zadeh², Joao Lima², Laurence S. Magder³ and Michelle Petri⁴, ¹1830 E Monument St, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Coronary atherosclerosis is a major cause of morbidity and mortality in SLE. New technology, computed tomoangiography (CTA) can measure non-calcified coronary plaque (NCP),…
Abstract Number: 2634 • 2014 ACR/ARHP Annual Meeting
A Signal of Improvement in Lupus Disease Activity at 3 Months Predicts Further Valid Improvement at 6 Months
Zahi Touma¹, Dafna D. Gladman², Dominique Ibanez¹ and Murray B. Urowitz², ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: In patients with active disease, physicians look for an early signal in response to treatment to guide their therapeutic decisions. Systemic Lupus…
Abstract Number: 2653 • 2014 ACR/ARHP Annual Meeting
Clinical Features in Patients with Anti-Triosephosphate Isomerase Antibody-Positive Neuropsychiatric Systemic Lupus Erythematosus
Shuzo Sato¹, Hiroshi Watanabe², Tomoyuki Asano², Hiroko Kobayashi³, Hiromasa Ohira² and Makiko Yashiro², ¹Gastroenterology and Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan, ³Gastroenterlogy and Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan
Background/Purpose: Although several autoantibodies of Neuropsychiatric Systemic Lupus Erythematosus (NPSLE) have been reported, none of these autoantibodies were conclusively established as pathogenic. We have reported…
Abstract Number: 2652 • 2014 ACR/ARHP Annual Meeting
Headache in Patients with Systemic Lupus Erythematosus Is Associated with Reduced Cerebral Grey Matter Volume, but not with Measures of Glial Activation, Anti-NR2-, or Anti-P Antibodies
Anne B Tjensvoll¹, Maria B Lauvsnes², Shunsei Hirohata³, Jan T Kvaløy⁴, Mona K Beyer⁵, Erna Harboe⁶, Lasse G Gøransson⁶, Ole J Greve⁷ and Roald Omdal⁸, ¹Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ²Department of Internal Medicine, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ³Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ⁴Research Department, Stavanger University Hospital, Stavanger, Norway, ⁵Department of Radiology and Nuclear medicine, Oslo University Hospital, National Hospital, Oslo, Norway, ⁶Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁷Department of Radiology, Stavanger University Hospital, Stavanger, Norway, ⁸Department of Internal Medicin, Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway
Background/Purpose: Headache, especially migraine, is frequent and one of the most common neuropsychiatric manifestations in systemic lupus erythematosus (SLE). A possible mechanism for this is…

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