Abstracts Archive - Page 2055 of 2425 - ACR Meeting Abstracts

Abstract Number: 146 • 2013 ACR/ARHP Annual Meeting
The Arthritis Severity Locus Cia4 Is An Early Regulator of IL-6, IL-1β, and NFκB activators’ Expression in Pristane-Induced Arthritis
Max Brenner^1,2, Teresina Laragione^1,2 and Percio Gulko^1,2, ¹Center for Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ²Molecular Medicine, Hosftra North Shore-LIJ School of Medicine, Manhasset, NY
Background/Purpose: Cia4 is a quantitative trait locus on rat chromosome 7 that regulates disease severity and joint damage in three models of rheumatoid arthritis including…
Abstract Number: 147 • 2013 ACR/ARHP Annual Meeting
Modular Analysis Of In Peripheral Blood Gene Expression In Rheumatoid Arthritis Captures Reproducible Gene Expression Changes In TNF Responders
Mark Curran¹, Michaela Oswald², Sarah Lamberth¹, Carrie Brodmerkel¹, Zhenya Cherkas¹ and Peter K. Gregersen³, ¹Janssen Research & Development, LLC., Spring House, PA, ²Laboratory of Genomics and Human Genetics, The Feinstein Institute for Medical Research, Manhasset, NY, ³Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: The use of whole blood gene expression to predict and follow the response to TNF inhibition therapy in RA has been challenging due to…
Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting
Microarray Analysis Of Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology
Arjen B. Blom¹, Peter L. van Lent², Martijn H. van den Bosch¹, Hans Cats³, Frank H.J. van den Hoogen⁴, Peter M. van der Kraan⁵ and Wim B. van den Berg⁶, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology, Rheumatology Centre Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
Abstract Number: 149 • 2013 ACR/ARHP Annual Meeting
Comparative Proteomic Analysis Of Neutrophils From Patients With Microscopic Polyangiitis and Granulomatosis With Polyangiitis
Teisuke Uchida¹, Kohei Nagai², Toshiyuki Sato³, Nobuko Iizuka³, Mitsumi Arito³, Yukiko Takakuwa⁴, Hiromasa Nakano⁴, Seido Ooka⁴, Manae Kurokawa³, Naoya Suematsu³, Kazuki Okamoto³, Shoichi Ozaki⁵ and Tomohiro Kato³, ¹Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, kawasaki, Japan, ²Department of Genetic Engineering, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan, ³Clinical Proteomics and Molecular Medicine, St. Marianna University Graduate School of Medicine, Kawasaki, Japan, ⁴Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, St. Marianna University School of Medicine, Kawasaki, Japan
Background/Purpose: Both microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) belong to ANCA-associated vasculitis (AAV), in which neutrophils are thought to be involved in their…
Abstract Number: 150 • 2013 ACR/ARHP Annual Meeting
A Subset Of Osteoarthritis Individuals Has Elevated IL-6 Pathway Activation Associated With Worse Symptoms
Michael Kuziora¹, Zheng Liu², Brandon W. Higgs², Philip Brohawn², Kim Lehmann², Fernanda Pilataxi², Katie Streicher², Lydia Greenlees¹, Meina Liang³, Rozanne Lee⁴, Amy Schneider⁴, Raffaella Faggioni⁴, Yihong Yao² and Koustubh Ranade², ¹Translational Science, MedImmune, LLC, Gaithersburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³Dmpk, MedImmune, LLC, Hayward, CA, ⁴DMPK, MedImmune, LLC, Hayward, CA
Background/Purpose: Elevated levels of the pro-inflammatory cytokine IL-6 have been found in the affected joint of patients with osteoarthritis (OA), although the prevalence of OA…
Abstract Number: 151 • 2013 ACR/ARHP Annual Meeting
The mtDNA Haplogroups Influence The Cartilage Integrity In Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Ignacio Rego-Pérez¹, Angel Soto-Hermida², Mercedes Fernández-Moreno², Sonia Pértega-Díaz³, Juan Fernández-Tajes², María Eugenia Vázquez-Mosquera², Estefanía Cortés-Pereira², Sara Relaño-Fernández², Natividad Oreiro-Villar², Carlos Fernández-López² and Francisco J. Blanco^4,5,6, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain, ⁶CIBER-BBN-ISCIII, Madrid, Spain
Background/Purpose: Magnetic resonance imaging (MRI) is ideally suited for detect structural changes and degradation in cartilage against the limitations of radiographic common methods. Changes in…
Abstract Number: 152 • 2013 ACR/ARHP Annual Meeting
The Uncoupling mtDNA Haplogroup T Associates With Better Radiographic Progression Of Osteoarthritis. Data From The Osteoarthritis Initiative (OAI)
Angel Soto-Hermida¹, Ignacio Rego-Pérez², Mercedes Fernández-Moreno¹, Sonia Pértega-Díaz³, Juan Fernández-Tajes¹, María Eugenia Vázquez-Mosquera¹, Estefanía Cortés-Pereira¹, Sara Relaño-Fernández¹, Natividad Oreiro-Villar¹, Carlos Fernández-López¹ and Francisco J. Blanco^1,4,5, ¹INIBIC-Hospital Universitario A Coruña. Rheumatology Division. Genomic Group, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ³Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴CIBER-BBN-ISCIII, Madrid, Spain, ⁵Proteo-Red/ISCIII, Madrid, Spain
Background/Purpose: The Osteoarthritis Initiative (OAI) is a multicentre study focused on identifying and evaluating risk factors of knee osteoarthritis (OA). Previous studies carried out by…
Abstract Number: 153 • 2013 ACR/ARHP Annual Meeting
Identification Of Autoimmune Disease Risk Alleles That Are Under Recent Selection In The Sea Island Gullah African Americans
Carl D. Langefeld¹, Satria Sajuthi¹, Jasmin Divers¹, Yiqi Huang², Uma Nayak³, Wei-Min Chen³, Kelly J. Hunt⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁶, Jyotika K. Fernandes⁷, Ida J. Spruill⁷, W. Timothy Garvey⁸, Michèle M. Sale² and Paula S. Ramos⁵, ¹Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ²Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ³Public Health Sciences, University of Virginia, Charlottesville, VA, ⁴Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁷Medical University of South Carolina, Charleston, SC, ⁸Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The reasons for the ethnic disparities in rheumatic and autoimmune diseases (AIDs) are largely unknown. Given the increasing evidence of selection at loci associated…
Abstract Number: 154 • 2013 ACR/ARHP Annual Meeting
Identification Of Autoimmune Disease Genes In Regions Under Selection In The Gullah African American Population Of South Carolina
Paula S. Ramos¹, Nathan Titus², Satria Sajuthi³, Jasmin Divers³, Yiqi Huang⁴, Uma Nayak⁵, Wei-Min Chen⁵, Kelly J. Hunt⁶, Diane L. Kamen⁷, Gary S. Gilkeson⁷, Jyotika K. Fernandes⁸, Ida J. Spruill⁸, W. Timothy Garvey⁹, Michèle M. Sale⁴ and Carl D. Langefeld³, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁵Public Health Sciences, University of Virginia, Charlottesville, VA, ⁶Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁷Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁸Medical University of South Carolina, Charleston, SC, ⁹Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Most autoimmune diseases (ADs) are more prevalent in specific ethnic groups. We hypothesize that one reason for the ethnic disparity may be an effect…
Abstract Number: 155 • 2013 ACR/ARHP Annual Meeting
Exome Sequencing For Identification Of Potential Causal Variants For Diffuse Cutaneous Systemic Sclerosis
Angel CY Mak¹, M Kari Connolly², Tamiko Katsumoto^3,4, Paul Wolters⁵, Clare Cleveland^3,4, Blanca M Herrera¹, Paul LF Tang¹, Simi Mathauda¹, Richard Lao¹, Pui-Yan Kwok^1,2 and Lindsey A. Criswell^3,4, ¹University of California, San Francisco, Institute for Human Genetics, San Francisco, CA, ²University of California, San Francisco, Department of Dermatology, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, ⁴University of California, San Francisco, Department of Medicine, San Francisco, CA, ⁵University of California, San Francisco, Department of Medicine, Pulmonary Division, San Francisco, CA
Background/Purpose: Scleroderma is a genetically complex autoimmune disease with substantial phenotypic heterogeneity. Previous genome-wide association studies (GWAS) have identified a large number of gene regions…
Abstract Number: 156 • 2013 ACR/ARHP Annual Meeting
Cartilage Peptide Profiling: Identifying Novel OA Biomarkers For Early Disease Detection
Valentina Calamia¹, Lucía Lourido¹, Diego López¹, Jesus Mateos¹, Patricia Fernández-Puente¹, Carolina Fernández-Costa², Beatriz Rocha², Cristina Ruiz-Romero³ and Francisco J. Blanco¹, ¹Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ²Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ³Grupo de Proteomica-PBR2-ProteoRed/ISCIII Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006 A Coruña, Spain, A Coruña, Spain
Background/Purpose: Cartilage secretome contains a complex matrix of proteolytically derived peptides that may provide useful information of the biological events occurring in the articular joint…
Abstract Number: 157 • 2013 ACR/ARHP Annual Meeting
Application Of a Multiplex Gene Polymorphism Assay For Variants Associated With Rheumatoid Arthritis Susceptibility: Results Of 168 Single Nucleotide Polymorphisms In The Optima Study
Jeffrey F. Waring¹, Viswanath Devanarayan², Kenneth Idler¹, Feng Hong², Josef S. Smolen³, Arthur Kavanaugh⁴, Hartmut Kupper⁵, Hendrik Schulze-Koops⁶ and Alla Skapenko⁷, ¹AbbVie Inc., North Chicago, IL, ²AbbVie Bioresearch Center, Worchester, MA, ³Medical University of Vienna and Hietzing Hospital, Vienna, Austria, ⁴University of California San Diego, La Jolla, CA, ⁵AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁶Division of Rheumatology, University of Munich, Munich, Germany, ⁷Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany
Background/Purpose: Genetic factors have been identified that may be associated with the development and severity of rheumatoid arthritis (RA), disease progression, or response to treatment.…
Abstract Number: 158 • 2013 ACR/ARHP Annual Meeting
The Use Of “Autoantigenomics” To Rapidly Identify Targets Of Human Autoantibodies
Wei-Hong Yang¹, Emily G. Bloch², Daniel F. Berenson³, Rita L. Galdos³, Pankaj Arora⁴, Connie Wu² and Donald B. Bloch⁵, ¹Rheumatology, allergy and immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ³The Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁴3the Center for Human Genetic Research and Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁵Rheumatology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA
Background/Purpose: The messenger RNA (mRNA) processing body (P-body) is a cellular structure that regulates the stability of cytoplasmic mRNA. Approximately 5% of patients with the…
Abstract Number: 159 • 2013 ACR/ARHP Annual Meeting
Transcriptomic Blood Markers and Molecular Stratification In Sarcoidosis
Robert Su¹, Michael Li², Nirav Bhakta², Misha Agarwal², Prescott Woodruff² and Laura Koth², ¹Rheumatology, University of California San Francisco, San Francisco, CA, ²University of California San Francisco, San Francisco, CA
Background/Purpose: Sarcoidosis is a heterogeneous disease with diverse manifestations and varied clinical courses. Currently there are no reliable non-invasive biomarkers of disease activity or severity.…
Abstract Number: 120 • 2013 ACR/ARHP Annual Meeting
The Symptom Severity In Korean Patients With Fibromyalgia Is Associated With Socioeconomic Status, But Not With Obesity
Dong-Jin Park¹, Shin-Seok Lee², Seong-Ho Kim³, Seong-Su Nah⁴, Ji Hyun Lee⁵, Seong-Kyu Kim⁶, Yeon-Ah Lee⁷, Seung-Jae Hong⁷, Hyun-Sook Kim⁸, Hye-Soon Lee⁹, Hyoun Ah Kim¹⁰, Chung-Il Joung¹¹ and Sang-Hyon Kim¹², ¹Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, ²Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, South Korea, ³Internal Medicine, Division of Rheumatology, Inje University College of Medicine, Haeundae Paik Hospital, Busan, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Maryknoll Medical Center, Busan, South Korea, ⁶Catholic University of Daegu School of Medicine, Daegu, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, ⁸Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University of Korea, Seoul, South Korea, ⁹Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ¹⁰Ajou University Hospital, Suwon, South Korea, ¹¹Department of Internal Medicine, Konyang university hospital, Daejeon, South Korea, ¹²Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea
Background/Purpose: Fibromyalgia (FM) is a chronic pain disorder characterized by widespread pain, tenderness, and various associated symptoms including sleep disturbances, chronic fatigue, depression, and other…

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