Abstracts Archive - Page 2054 of 2425 - ACR Meeting Abstracts

Abstract Number: 171 • 2013 ACR/ARHP Annual Meeting
Effects Of Chondroitin Sulfate On The Gene Expression Profile In The Inflamed Synovial Membrane
Cécile Lambert¹, Jean-Emile Dubuc², Eulalia Montell³, Josep Verges³ and Yves Henrotin¹, ¹University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, ²Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium, ³Pre-Clinical R&D Area, Pharmascience Division, BIOIBERICA S.A., Barcelona, Spain
Background/Purpose: Chondroitin sulfate (CS) is one the most used molecules in the management of OA. Its mechanism of action remains to be detailed. The aim…
Abstract Number: 172 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Kidney Biopsies From Chinese Patients With Lupus Nephritis Suggests a Prevalence Of Infiltrating CD8+ T Cells, Monocytes/Macrophages, and B Cells In ISN/RPS Class IV Disease
Zheng Liu¹, Chris Morehouse¹, Xinfang Huang², Philip Brohawn¹, Nan Shen³, Gabor G. Illei⁴, Yihong Yao¹ and Brandon W. Higgs¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ³Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, cincinnati, OH, ⁴Clinical Development, MedImmune, LLC, Gaithersburg, MD
Transcript profiling of kidney biopsies from Chinese patients with lupus nephritis suggests a prevalence of infiltrating CD8+ T cells, monocytes/macrophages, and B cells in ISN/RPS…
Abstract Number: 173 • 2013 ACR/ARHP Annual Meeting
HLA-DRB1*08:02 Is Associated With Bucillamine-Induced Proteinuria In Japanese Rheumatoid Arthritis Patients: A Case-Control Study
Hiroshi Furukawa¹, Shomi Oka¹, Kota Shimada², Shoji Sugii², Atsushi Hashimoto³, Akiko Komiya¹, Naoshi Fukui¹, Taiichiro Miyashita⁴, Kiyoshi Migita⁴, Akiko Suda⁵, Shouhei Nagaoka⁶, Naoyuki Tsuchiya⁷ and Shigeto Tohma¹, ¹Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ³Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁴Clinical Research Center, Nagasaki Medical Center, National Hospital Organization, Omura, Japan, ⁵Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan, ⁶Department of Rheumatology, Yokohama Minami Kyousai Hospital, Yokohama, Japan, ⁷Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Bucillamine (Buc) is one of the commonly used disease-modifying anti-rheumatic drugs (DMARDs) in Japan. Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated…
Abstract Number: 174 • 2013 ACR/ARHP Annual Meeting
Genetic Association On Disease Severity In Rheumatoid Arthritis: A Validation Study In Japanese Patients
Shinji Yoshida¹, Katsunori Ikari¹, Koichiro Yano¹, Yoshiaki Toyama², Atsuo Taniguchi³, Hisashi Yamanaka¹ and Shigeki Momohara³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: The disease severity of rheumatoid arthritis (RA) is objectively measured by radiographic joint destruction, which is reflective of the cumulative burden of inflammation. Recently,…
Abstract Number: 175 • 2013 ACR/ARHP Annual Meeting
Dynamics Of The Inflammatory Response In Rheumatoid Arthritis Patients Following Traumatic Injury: Insights From In Vivo,In Silico, and Single Nucleotide Polymorphism Studies
Rajaie Namas¹, Rami Namas², Harpreet Sagar³, Felix Fernandez-Madrid³, Timothy Billiar² and Yoram Vodovotz⁴, ¹Rheumatology, Wayne State University/ Henry Ford Health System, Detroit, MI, ²Surgery, University of Pittsburgh, Pittsburgh, PA, ³Internal Medicine/Rheumatology, Wayne State University, Detroit, MI, ⁴Surgery, Immunology, Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Both traumatic injury/hemorrhagic shock (T/HS) and rheumatoid arthritis (RA) are inflammatory diseases that are major sources of morbidity worldwide. We hypothesize that RA modifies…
Abstract Number: 176 • 2013 ACR/ARHP Annual Meeting
Identification Of Major Histocompatibility Complex Class II Alleles Associated With Systemic Sclerosis Through Imputation Strategy
Jose Ezequiel Martin¹, Carmen P. Simeón², Norberto Ortego-Centeno³, Patricia Carreira⁴, Miguel A. Gonzalez-Gay^5,6, Nicolas Hunzelmann⁷, Shervin Assassi⁸, Filemon K. Tan⁸, Frank C. Arnett⁸, Xiaodong Zhou⁸, T.R.D.J. Radstake^9,10, Maureen D. Mayes¹¹, Paul de Bakker^12,13, Javier Martin^1,14 and B. P. C. Koeleman¹³, ¹Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ²Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, ³Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ⁴Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain, ⁶Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, ⁷Department of Dermatology, University of Cologne, Cologne, Germany, ⁸Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁹Laboratory for Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ¹⁰Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹¹University of Texas Health Science Center at Houston, Houston, TX, ¹²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ¹³Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁴Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain
Background/Purpose: Different alleles of MHC class II molecules have been associated either with risk to systemic sclerosis (SSc) or its subphenotypes. Due to the high…
Abstract Number: 177 • 2013 ACR/ARHP Annual Meeting
Differences and Overlap Of Immunological Pathways Implicated In The Aetiology Of Anti-Citrullinated Peptide Antibody Positive and Negative Rheumatoid Arthritis
Sebastien Viatte¹, Paul Martin², Andrew Brass³, Mark Lunt⁴, Anne Barton⁵ and Stephen Eyre⁵, ¹Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ²Arthritis Research UK Epidemiology Unit, Manchester Academic Health Sciences Centre, Institute of Inflammation and Repair, The University of Manchester, Manchester, United Kingdom, ³School of Computer Science, University of Manchester, Manchester, United Kingdom, Manchester, United Kingdom, ⁴Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ⁵Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose: Genome-wide association studies have been successful in identifying single nucleotide polymorphisms (SNPs) associated with disease. However, previous studies have been under-powered to detect differences…
Abstract Number: 178 • 2013 ACR/ARHP Annual Meeting
Fc-Gamma Receptor Genetic Variation In Kawasaki Disease
Carline E. Tacke^1,2, Willemijn B. Breunis^3,4, Long T. Hoang¹, Eileen Png¹, Judy Geissler⁵, Sietse Nagelkerke⁴, Justine Ellis^6,7, Sonia Davila⁸, Chiea Chuen Khor⁸, Michael Levin⁹, David Burgner^10,11, Chisato Shimizu¹², Jane C. Burns¹², Martin L. Hibberd¹ and Taco W. Kuijpers^4,13, ¹Infectious Diseases, Genome Institute of Singapore, Singapore, Singapore, ²Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands, ³Pediatric rheumatology and immunology, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands, ⁴Blood cell research, Sanquin Resarch and Landsteiner Laboratory (AMC), Amsterdam, Netherlands, ⁵Sanquin Resarch and Landsteiner Laboratory (AMC), Amsterdam, Netherlands, ⁶Murdoch Childrens Research Institute, Parkville, Australia, ⁷Department of Paediatrics, The University of Melbourne, Parkville, Australia, ⁸Human Genetics, Genome Institute of Singapore, Singapore, Singapore, ⁹Department of Pediatrics, Imperial College London, London, United Kingdom, ¹⁰The royal Children's Hospital, Murdoch Childrens Research Institute, Parkville, Australia, ¹¹Department of Paediatrics, The University of Melbourne, Melbourne, Australia, ¹²Pediatrics, UC San Diego, School of Medicine, La Jolla, CA, ¹³Pediatric Rheumatology and Immunology, Emma Children's Hospital/Academic Medical Center (AMC), Amsterdam, Netherlands
Abstract on behalf of the International Kawasaki Disease Genetics Consortium. Background/Purpose: Kawasaki disease (KD) is a pediatric vasculitis of unknown etiology with a substantial genetic…
Abstract Number: 179 • 2013 ACR/ARHP Annual Meeting
The Association Between Single Nucleotide Polymorphism ABCG2 rs2231142 and Hyperuricemia: A Case-Control Study
Bingqing Zhang¹, Weigang Fang², Yun Zhang^3,4, Shufen Liu³, Yuanjie Li³ and Xuejun Zeng², ¹Peking Union Medical College, Beijing, China, ²Medicine, Peking Union Medical College Hospital, Beijing, China, ³Peking Union Medical College Hospital, Beijing, China, ⁴Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China
Background/Purpose: The prevalence of hyperuricemia and gout in China increased markedly in the past decades. Genome-wide association studies in Caucasian population have identified multiple…
Abstract Number: 140 • 2013 ACR/ARHP Annual Meeting
Fibromyalgia and Pregnancy: Challenges Of The Savella^® (Milnacipran) Pregnancy Registry
Damien Hirsch¹, Denise Leclair¹, Robert H. Palmer¹, Vikki Brown², Susan Sinclair Roberts^2,3 and Janice McLean², ¹Forest Research Institute, Inc., Jersey City, NJ, ²INC Research, LLC, Wilmington, NC, ³University of North Carolina Wilmington, Wilmington, NC
Background/Purpose: During pregnancy, women with fibromyalgia (FM) often experience worsening of symptoms, which include widespread pain, fatigue, sleep disturbances, cognitive difficulties, and reduced daily functioning.…
Abstract Number: 141 • 2013 ACR/ARHP Annual Meeting
Skin Disease and Fibromyalgia: Dermatologic Diagnoses Encountered In a Series Of 845 Patients With Fibromyalgia At Mayo Clinic In 2008
Valerie Laniosz¹, David Wetter² and Desiree Godar², ¹Dermatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN
Background/Purpose: To determine the common dermatological diagnoses and skin-related complaints in a cohort of patients with fibromyalgia seen in a tertiary referral center. Methods: A…
Abstract Number: 142 • 2013 ACR/ARHP Annual Meeting
Home Tender Point Measurement In Fibromyalgia Patients
Robert S. Katz¹, Hannah Bond² and Jessica L. Polyak², ¹Rush Medical College, Chicago, IL, ²Rheumatology Associates, Chicago, IL
Background/Purpose: To determine whether: 1) patients with the fibromyalgia syndrome (FMS) can accurately evaluate their own tender points, similar to self-administered testing for other purposes…
Abstract Number: 143 • 2013 ACR/ARHP Annual Meeting
Rapid Infrared Microscopy (IRMS) For Differential Diagnosis Of Fibromyalgia and Other Central Sensitivity Syndromes
Kevin V. Hackshaw¹, Luis Rodriguez-Saona², Irving L. Rosenberg³, Marcal Plans² and C.A. Tony Buffington⁴, ¹Immunology/Rheumatology, The Ohio State University, Columbus, OH, ²Food Sciences, The Ohio State University, Columbus, OH, ³Immunology/ Rheumatology, The Ohio State University, Columbus, OH, ⁴Veterinary Biological Sciences, The Ohio State University, Columbus, OH
Background/Purpose: Background/Purpose: The aim of this study was to investigate the ability of a rapid blood-spot-based method for diagnosis of Fibromyalgia (FM) using mid-infrared microspectroscopy (IRMS)…
Abstract Number: 144 • 2013 ACR/ARHP Annual Meeting
Cytokines, Oxidative Stress Markers and Brain-Derived Neurotrophic Factor In Fibromyalgia Syndrome
Aline Ranzolin^1,2, Claudio Antônio da C. Neto³, Bruna Maria Ascoli⁴, Bianca Wollenhaupt-Aguiar⁵, Angela Luzia B. Pinto Duarte³, Markus Bredemeier⁶, Flávio Kapczinski⁴ and Ricardo M. Xavier⁷, ¹Rheumatology, Hospital das Clínicas - Universidade Federal de Pernambuco, Recife, Brazil, ²Programa de Pós-Graduação em Ciências Médicas da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ³Faculdade de Medicina, Universidade Federal de Pernambuco - Hospital das Clínicas de Pernambuco, Recife, Brazil, ⁴Programa de Pós-Graduação em Ciências Médicas da Universidade Federal do Rio Grande do Sul: Psiquiatria, Porto Alegre, Brazil, ⁵Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, ⁶Rheumatology, Hospital Nossa Senhora da Conceição - Grupo Hospitalar Conceição, Porto Alegre, Brazil, ⁷Rheumatology Division, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil
Background/Purpose: The pathophysiology of Fibromyalgia Syndrome (FMS) is incompletely understood. An imbalance of pro- and anti-inflammatory cytokines is assumed to play a role in the…
Abstract Number: 145 • 2013 ACR/ARHP Annual Meeting
Autonomic Nervous System “Decomplexification” In Fibromyalgia. A Proof Of Concept Study Looking At The Fractality Of Heart Rhythms
Manuel Martinez-Lavin¹, Claudia Lerma², Laura Aline Martinez-Martinez³, Oscar Infante² and Angelica Vargas³, ¹Chief Rheumatology, National Institute of Cardiology, Mexico City, Mexico, ²National Institute of Cardiology, Mexico City, Mexico, ³Rheumatology, National Institute of Cardiology, Mexico City, Mexico
Background/Purpose: Prevailing linear-reductionist medical model seems unable to explain complex diseases like fibromyalgia (FM) and similar maladies. As consequence of this divorce, some physicians disparage…

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