Abstract Number: 2735 • 2014 ACR/ARHP Annual Meeting
Association of a-Kinase Anchoring Protein-79 (AKAP79) to PKC Mediates Inhibition of IL2 Transcription and Erk Activation in T Cells
Background/Purpose A-Kinase anchoring Protein AKAP79 associates to and regulates the activity of PKA, PKC and calcineurin, key regulators of T cell activation. We have previously…Abstract Number: 2734 • 2014 ACR/ARHP Annual Meeting
B55β Regulates T Cell Survival through the Modulation of AKT during Cytokine Deprivation
Background/Purpose . The abundance of cytokines controls the length of immune responses through poorly defined mechanisms. B55β is a molecule that triggers apoptosis in activated…Abstract Number: 2737 • 2014 ACR/ARHP Annual Meeting
Microrna-155 Suppresses IL-21 Signaling and Production in Systemic Lupus Erythematosus
Background/Purpose IL-21 is a key regulator of B cells functions and autoantibody production and is mainly produced by follicular T helper cells. The purpose of…Abstract Number: 2738 • 2014 ACR/ARHP Annual Meeting
Shk-186, a Kv1.3 channel inhibitor That Targets Effector Memory T Cells: Safety and Tolerability in Humans and Its Evaluation in a Model of Rapidly Progressive Glomerulonephritis
Background/Purpose: The voltage-gated potassium channel Kv1.3 is a novel target for the treatment of autoimmune disorders including psoriatic and rheumatic diseases. ShK-186 is an exquisitely specific,…Abstract Number: 2739 • 2014 ACR/ARHP Annual Meeting
SHP-1 Regulates the Activation Threshold of iNKT Cells
Background/Purpose Autoreactive invariant Natural Killer T (iNKT) cells have been implicated in several rheumatic diseases, including Systemic lupus erythematosus and Rheumatoid arthritis. iNKT cells are…Abstract Number: 2740 • 2014 ACR/ARHP Annual Meeting
Microbiota Modulate Intraepithelial Lymphocyte Presence and Function
Background/Purpose: Microbiome studies in autoimmune diseases including rheumatoid arthritis and inflammatory bowel disease demonstrate alterations in relative abundance of specific bacterial species (dysbiosis). The immunologic…Abstract Number: 2741 • 2014 ACR/ARHP Annual Meeting
The Role of Fli1 in Lupus T Cell Function and Nephritis
Background/Purpose: The Ets factor Fli1 is implicated as a key modulator of lupus disease expression. Over-expressing Fli1 in healthy mice, results in the development of…Abstract Number: 2742 • 2014 ACR/ARHP Annual Meeting
Polymorphisms in the Slam Family of Molecules Play a Role in the Development and Function of Invariant Natural Killer T Cells in New Zealand Black Mice
Background/Purpose: The family of signaling lymphocyte activating molecules (SLAM) have been shown to play a key role in the development of autoimmunity in spontaneous and…Abstract Number: 2743 • 2014 ACR/ARHP Annual Meeting
CD27 Is a Key Regulator of T Cell Responses
Background/Purpose: CD27 is a member of the TNF superfamily of receptors that is expressed on a majority of natural killer (NK) cells, T cells, memory…Abstract Number: 2744 • 2014 ACR/ARHP Annual Meeting
Mi-RNA Profile of Active Vascular BEHÇET’S Patients
Background/Purpose Behçet’s Disease (BD) is a systemic vasculitis that predominantly presented with oral aphtous ulcers and additionally at least two of the following findings like…Abstract Number: 2745 • 2014 ACR/ARHP Annual Meeting
Plasma of Patients with Active Behçet´s Disease (BD) Increases Neutrophil Extracellular Trap Formation, Oxidative Metabolism and NADPH-Oxidase Expression in Normal and BD Neutrophils, and Carries Several Neutrophil Stimulating Factors
Background/Purpose Plasma factors seem to play a role in Behçet’s disease (BD) pathogenesis, especially by increasing phagocyte oxidative profile. No data exists regarding neutrophil extracellular…Abstract Number: 2746 • 2014 ACR/ARHP Annual Meeting
The Importance of the Serum Visfatin Levels in Behcet’s Disease Patients
Background/Purpose: It’s a known fact that serum levels of the tumor necrosis factor Alfa (TNF-α) interleucin-6 (IL-6) and other proinflammatory cytokines which are released from…Abstract Number: 2747 • 2014 ACR/ARHP Annual Meeting
Identification of Potential Serum Biomarkers for Behcet Disease By High Resolution Quantitative Proteomic Analysis
Background/Purpose: Behcet’s disease (BD) is a chronic, multisystemic vasculitis, pathogenesis of BD remains enigmatic. Diagnosis of BD is sometimes difficult, and until now, no specific…Abstract Number: 2748 • 2014 ACR/ARHP Annual Meeting
Microparticles May Play a Role in Causing Thrombosis in Behçet’s Syndrome and Act As a Biomarker for Risk Management
Background/Purpose Thrombosis occurs in 20% of patients with Behçet’s Syndrome (BS) and leads to significant morbidity. There is no robust association between thrombosis in BS…Abstract Number: 2749 • 2014 ACR/ARHP Annual Meeting
The Clinical Course of Acute Deep Vein Thrombosis of the Legs in Behçet’s Syndrome
Background/Purpose To determine the prospective clinical course of lower extremity deep vein thrombosis (LEDVT) in patients with Behçet’s syndrome (BS). Methods Consecutive BS patients with…
ACR Meeting Abstracts