Abstract Number: 42 • 2014 ACR/ARHP Annual Meeting
The Prevalence of Ankylosing Spondylitis in Sweden – a Nationwide Register Study
Background/Purpose: Reported Ankylosing Spondylitis (AS) prevalence estimates vary considerably, and there is a lack of nationwide estimates. Previous studies by our group support the validity…Abstract Number: 41 • 2014 ACR/ARHP Annual Meeting
The Impact of Ankylosing Spondylitis on Work Impairment: Data from the Scotland Registry for Ankylosing Spondylitis
Background/Purpose: The impact of ankylosing spondylitis (AS) on work status is substantial. While the majority of studies focus on the prevalence of absenteeism in this…Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting
Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men
Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…Abstract Number: 22 • 2014 ACR/ARHP Annual Meeting
Adenosine a2A Receptor (A2AR) Stimulation Inhibits Osteoclast Differentiation and Promotes Osteoblast Formation By Regulation of Axon Guidance Proteins
Background/Purpose Semaphorins (Sema), axonal guidance proteins, play a role in communication between osteoclast and osteoblast. Thus, sema4D, secreted by osteoclasts, binds to its receptor PlexinB1…Abstract Number: 21 • 2014 ACR/ARHP Annual Meeting
Mendelian Randomization Analysis to Examine for Causal Relationships Between Serum Urate Levels and Bone Mineral Density
Background/Purpose: In observational studies, serum urate is positively associated with bone mineral density (BMD) and reduced risk of fragility fractures. However, the possibility of unmeasured…Abstract Number: 20 • 2014 ACR/ARHP Annual Meeting
High Systemic LDL Cholesterol Levels during Experimental Osteoarthritis Lead to Increased Synovial Activation and Ectopic Bone Formation at End-Stage Osteoarthritis, While Excessive Levels Accelerate Development of Joint Pathology Already at Early-Stage Osteoarthritis
Background/Purpose: A relation between osteoarthritis (OA) and the metabolic syndrome has long been established. One of the characteristics of the metabolic syndrome is increased cholesterol…Abstract Number: 19 • 2014 ACR/ARHP Annual Meeting
Adenosine Receptors Stimulate Bone Regeneration
Background/Purpose Such orthopedic procedures as spinal fusion and repair of bone defects due to trauma, infection or metastatic disease, require formation of new bone. Adenosine,…Abstract Number: 18 • 2014 ACR/ARHP Annual Meeting
The Effect of Clinically Significant Antiphospholipid Antibody Positivity on Organ Damage in Systemic Lupus Erythematosus
Background/Purpose: The effect of antiphospholipid antibodies (aPL) on organ damage in Systemic Lupus Erythematosus (SLE) patients remains unclear as there are limited number of studies…Abstract Number: 17 • 2014 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Following Infection: A Systematic Review of Case Reports
Background/Purpose The occurrence of antiphospholipid syndrome (APS) following an infection has been increasingly reported in the literature. We conducted a systematic review of case reports…Abstract Number: 36 • 2014 ACR/ARHP Annual Meeting
The Use of Three-Dimensionally Printed β-Tricalcium Phosphate/Hydroxyapatite to Further Understand the Regulation of Adenosine Receptors in Osteoclast Formation and Promotion in Bone Regeneration
Background/Purpose Bone defects resulting from trauma or infection need timely and effective treatments to restore damaged bone. Using specialized three-dimensional (3-D) printing technology, combined with…Abstract Number: 35 • 2014 ACR/ARHP Annual Meeting
Hydrogen Sulfide Inhibits Human Osteoclast Differentiation in Vitro By Triggering Sustained Antioxidant Response and Inhibiting the RANKL/OPG Ratio
Background/Purpose Hydrogen sulfide (H2S) has been recently appreciated as a novel gasotransmitter with an important role in the regulation of tissues and organs. H2S is…Abstract Number: 34 • 2014 ACR/ARHP Annual Meeting
Pro-Nerve Growth Factor (ProNGF) Stimulates Bone Growth By Stimulating Osteoblasts and Inhibiting Osteoclast Differentiation, an Explanation for Anti-NGF-Mediated Osteonecrosis; Prongf Is a Novel Therapeutic Target for Treatment of Osteonecrosis and Charcot’s Arthropathy
Background/Purpose Neurotrophins (Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF)) are initially synthesized as pro-neurotrophins (proNGF and proBDNF), which are hydrolyzed to produce the…Abstract Number: 33 • 2014 ACR/ARHP Annual Meeting
Stimulation of the Adenosine a2A receptor (A2AR) Regulates the Expression of Netrin1 and Their Receptors (Unc5b, DCC) and Inhibits Osteoclast Differentiation and Inflammatory Bone Destruction
Background/Purpose A variety of molecules mediate communication between osteoclasts and osteoblasts during bone remodeling. Netrin1 is a member of the family of axonal guidance proteins,…Abstract Number: 32 • 2014 ACR/ARHP Annual Meeting
Regulation of Senescence and Inflammatory Mediators By N- and C-Terminal Parathyroid Hormone-Related Protein in Osteoarthritic Human Osteoblasts
Background/Purpose In osteoarthritis (OA), there is an abnormal remodeling process in subchondral bone associated with an altered osteoblast metabolism. Inflammatory mediators participate in bone remodeling…Abstract Number: 31 • 2014 ACR/ARHP Annual Meeting
Interaction of FGF-8 and TNF-a in the Regulation of BMP-Induced Osteoblast Differentiation
Background/Purpose: Osteoblasts and osteoclasts play important roles in the bone remodeling. When the balance between these cells is disrupted, bone loss or aberrant bone…
ACR Meeting Abstracts