Abstracts Archive - Page 2046 of 2425 - ACR Meeting Abstracts

Abstract Number: 87 • 2014 ACR/ARHP Annual Meeting
Association of TRIM21 (RO52) Polymorphisms with Systemic Lupus Erythematosus in a Japanese Population
Misaki Hidaka¹, Aya Kawasaki¹, Hiroshi Furukawa², Yuya Kondo³, Satoshi Ito⁴, Isao Matsumoto⁵, Makio Kusaoi⁶, Hirofumi Amano⁶, Akiko Suda⁷, Keigo Setoguchi⁸, Tatsuo Nagai⁹, Kota Shimada¹⁰, Shoji Sugii¹⁰, Akira Okamoto¹¹, Noriyuki Chiba¹², Eiichi Suematsu¹³, Masao Katayama¹⁴, Akiko Okamoto¹⁵, Hajime Kono¹⁵, Shigeru Ohno⁷, Shunsei Hirohata¹⁶, Shouhei Nagaoka¹⁷, Yoshinari Takasaki¹⁸, Hiroshi Hashimoto¹⁹, Shigeto Tohma², Takayuki Sumida³ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁴Department of Rheumatology, Niigata Rheumatic Center, Shibata, Japan, ⁵Department of Interenal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁶Department of Rheumatology and Internal Medicine, Juntendo University, Tokyo, Japan, ⁷Center for Rheumatic Diseases, Yokohama City University Medical Center, Yokohama, Japan, ⁸Allergy and Immunological Diseases, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan, ⁹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan, ¹⁰Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ¹¹Department of Rheumatology,, Himeji Medical Center, National Hospital Organization, Himeji, Japan, ¹²Department of Rheumatology, Morioka Hospital, National Hospital Organization, Morioka, Japan, ¹³Department of Internal Medicine and Rheumatology, Clinical Research Institute, Kyushu Medical Center, National Hospital Organization, Fukuoka, Japan, ¹⁴Division of Rheumatology, Department of Internal Medicine, Nagoya Medical Center, National Hospital Organization, Nagoya City, Aichi, Japan, ¹⁵Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ¹⁶Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan, ¹⁷Department of Rheumatology, Yokohama Minami Kyousai Hospital, Yokohama, Japan, ¹⁸Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ¹⁹Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose TRIM21, also referred to as Ro52 or SS-A1, belongs to the tripartite motif-containing (TRIM) family. TRIM21 is not only important as an autoantigen, but…
Abstract Number: 86 • 2014 ACR/ARHP Annual Meeting
Association of Leukocyte Immunoglobulin-like Receptor A3 (LILRA3) with Systemic Sclerosis
Yuki Hachiya¹, Aya Kawasaki¹, Takashi Matsushita², Hiroshi Furukawa³, Shouhei Nagaoka⁴, Kota Shimada⁵, Shoji Sugii⁵, Takayuki Sumida⁶, Shigeto Tohma³, Minoru Hasegawa⁷, Manabu Fujimoto⁸, Shinichi Sato⁹, Kazuhiko Takehara¹⁰ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Deramtology, Kanazawa University, Kanazawa, Japan, ³Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁴Department of Rheumatology, Yokohama Minami Kyousai Hospital, Yokohama, Japan, ⁵Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ⁶Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁷Dermatology, University of Fukui, Yoshida-gun, Fukui, Japan, ⁸Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁹Department of Dermatology, The University of Tokyo, Tokyo, Japan, ¹⁰Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: The leukocyte immunoglobulin-like receptors (LILRs) are a gene family located in leukocyte receptor complex at 19q13.4. LILRs are expressed mainly in immune cells as…
Abstract Number: 85 • 2014 ACR/ARHP Annual Meeting
Protective Association of HLA-DRB1*13:02 Against MPO-ANCA Positive ANCA-Associated Vasculitis in a Japanese Population
Naoyuki Tsuchiya¹, Narumi Hasebe¹, Ken-ei Sada², Shigeto Kobayashi³, Hidehiro Yamada⁴, Hiroshi Furukawa⁵, Kunihiro Yamagata⁶, Takayuki Sumida⁷, Nobuyuki Miyasaka⁸, Seiichi Matsuo⁹, Shigeto Tohma⁵, Shoichi Ozaki¹⁰, Hiroshi Hashimoto¹¹, Hirofumi Makino², Masayoshi Harigai¹² and Aya Kawasaki¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ³Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, ⁴Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁵Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁶Department of Internal Medicine (Nephrology), Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁷Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁸Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ⁹Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹⁰Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ¹¹Juntendo University School of Medicine, Tokyo, Japan, ¹²Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose Epidemiology of antineutrophil cytoplasmic antibody (ANCA) – associated vasculitis (AAV) is substantially different between European and Asian populations. In the Japanese population, the majority…
Abstract Number: 83 • 2014 ACR/ARHP Annual Meeting
Whole Exome Sequencing Analysis Performed on a Patient with Fibroblastic Rheumatism
Michal Feldon MD¹, Keith A. Sikora², John B. Harley³, Jennifer L. Huggins¹, Hermine I. Brunner⁴ and Kenneth M. Kaufman³, ¹Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴PRCSG, Cincinnati, OH
Background/Purpose Fibroblastic Rheumatism is a rare disease, first described in 1980 with almost 30 cases reported thus far. One-third of the patients are children. The…
Abstract Number: 82 • 2014 ACR/ARHP Annual Meeting
HLA-DPB1^*04:01 Confers Risk for PR3-ANCA Positive ANCA-Associated Vasculitis (AAV), but Protects Against MPO-ANCA Positive AAV, in a Japanese Population
Aya Kawasaki¹, Misaki Hidaka², Narumi Hasebe², Ken-ei Sada³, Shigeto Kobayashi⁴, Hidehiro Yamada⁵, Hiroshi Furukawa⁶, Kunihiro Yamagata⁷, Takayuki Sumida⁸, Nobuyuki Miyasaka⁹, Shigeto Tohma⁶, Shoichi Ozaki¹⁰, Seiichi Matsuo¹¹, Hiroshi Hashimoto¹², Hirofumi Makino³, Masayoshi Harigai¹³ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁴Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, ⁵Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁶Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ⁷Department of Internal Medicine (Nephrology), Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁸Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁹Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ¹⁰Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ¹¹Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹²Juntendo University School of Medicine, Tokyo, Japan, ¹³Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose Epidemiologic difference between European and Asian populations is observed in antineutrophil cytoplasmic antibody (ANCA) – associated vasculitis (AAV). Granulomatosis with polyangiitis (GPA) is prevalent…
Abstract Number: 81 • 2014 ACR/ARHP Annual Meeting
Elevated Peripheral Blood Leukocyte Inflammatory Gene Expression in Radiographic Progressors with Symptomatic Knee Osteoarthritis: NYU and OAI Cohorts
Mukundan Attur¹, Alexander Statnikov², Svetlana Krasnokutsky Samuels¹, Virginia B. Kraus³, Joanne Jordan⁴, Braxton D. Mitchell⁵, Michelle Yau⁶, Jyoti Patel¹, Constantin F. Aliferis², Marc C. Hochberg⁷, Jonathan Samuels¹ and Steven B. Abramson⁸, ¹Rheumatology, NYU Langone Medical Center, New York, NY, ²Center for Health Informatics and Bioinformatics, NYU Langone Medical Center, New York, NY, ³Medicine/Rheumatology, Duke University Medical Center, Durham, NC, ⁴Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, ⁶Epidemiology and Public Health, University of Maryland, Baltimore,, MD, ⁷Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁸Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: We and others have demonstrated low grade inflammation exists in OA joint tissues, where it may contribute to disease pathogenesis. In the current studies…
Abstract Number: 84 • 2014 ACR/ARHP Annual Meeting
Amerindian Ancestry Influences Polyautoimmunity
Nicolás Molano-González¹, John Castiblanco¹, Ruben-Dario Mantilla¹, Adriana Rojas-Villarraga^1,2 and Juan-Manuel Anaya^1,2, ¹Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ²Mederi, Hospital Universitario Mayor, Bogota, Colombia
Background/Purpose Polyautoimmunity [i.e., the presence of two or more autoimmune diseases (ADs) in a single patient] is a frequent phenomenon in autoimmunity, ranging from 10%…
Abstract Number: 90 • 2014 ACR/ARHP Annual Meeting
Genetic Variants in IL-6, IL-10, C5-TRAF1 and FCRL3 and Progression of Joint Damage in Rheumatoid Arthritis; A Study on Six Cohorts
H.W. van Steenbergen¹, L. Rodriguez-Rodriguez², E. Berglin³, A. Zhernakova⁴, R. Knevel¹, J. Ivorra-Cortes⁵, T.W.J. Huizinga¹, B. Fernández-Gutiérrez⁶, P.K. Gregersen⁷, S. Rantapää-Dahlqvist⁸ and A.H.M. van der Helm-van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ³Rheumatology, Institution of Public health and clinical medicine/ Rheumatology, University of Umeå, Umeå, Sweden, ⁴Genetics, University Medical Center Groningen, Groningen, Netherlands, ⁵Rheumatology, University Hospital la Fe, Valencia, Spain, ⁶Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁷The Feinstein Institute for Medical Research, Manhasset, NY, ⁸Department of Public Health and Clinical Medicine/Rheumatology, Umeå University Hospital, Umeå, Sweden
Background/Purpose Understanding the mechanisms underlying the inter-individual differences in radiographic progression is relevant and heritability studies have shown that genetic factors explain part of these…
Abstract Number: 61 • 2014 ACR/ARHP Annual Meeting
Advocating for Pediatric Rheumatology Care in the Mid-Canadian Provinces: Large Geographic Area, Large Pediatric Population, Low Number of Pediatric Rheumatologists and Allied Health Workers Identified As Unique Challenges
Paivi Miettunen¹, Nadia Luca², Susanne Benseler², Janet Ellsworth³, Tommy Gerschman⁴, Nicole Johnson², Heinrike Schmeling² and Natalie J. Shiff⁵, ¹Department of Pediatrics/Alberta Children's Hospital, Department of Pediatrics/University of Calgary, Calgary, AB, Canada, ²Pediatrics/Alberta Children's Hospital, Department of Pediatrics/University of Calgary, Calgary, AB, Canada, ³Department of Pediatrics, University of Alberta, Edmonton, AB, Canada, ⁴Alberta Children's Hospital, Calgary, AB, Canada, ⁵Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada
Background/Purpose Advocacy for pediatric rheumatology care for Mid-Canadian (MC) provinces (Alberta, Manitoba, Northwest Territories, Nunavut and Saskatchewan) represents a challenge. Although these provinces comprise a…
Abstract Number: 60 • 2014 ACR/ARHP Annual Meeting
Epidemiology of Polymyalgia Rheumatica in Korea
In young Kim¹, Seulkee Lee¹, Hemin Jeong¹, Hyungjin Kim¹, Jiwon Hwang¹, Jaejoon Lee², Eun-mi Koh¹ and Hoon-Suk Cha¹, ¹Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose Polymyalgia rheumatica (PMR) is a chronic inflammatory disease affecting people older than 50 years. Diagnosis is made based on clinical features and the current…
Abstract Number: 59 • 2014 ACR/ARHP Annual Meeting
Assessing Dietary Habits in a Large Cohort of Rheumatoid Arthritis and Psoriatic Arthritis Patients: Results of the Spanish Imid Consortium
Maria López Lasanta¹, Jesús Tornero², Juan D. Cañete³, Antonio Fernandez Nebro⁴, Francisco Blanco⁵, Jesus Rodriguez⁶, Isidoro González-Alvaro⁷, Jordi Gratacós⁸, Joan Maymo⁹, Rubén Queiro¹⁰, Mercedes Alperi-López¹¹, Carlos Montilla-Morales¹², Benjamin Fernandez Gutierrez¹³, Juan Carlos Torre-Alonso¹⁴, Alejandro Olive¹⁵, Jose Javier Perez Venegas¹⁶, Hector Corominas¹⁷, Alba Erra¹⁸, Santiago Muñoz¹⁹, Carlos M. Gonzalez²⁰, Daniel Roig²¹, Gabriela Avila¹, Arnald Alonso¹, Toni Julia¹, Raül Tortosa¹, Andrés Garcia Montero²² and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Hospital Universitario Guadalajara, Guadalajara, Spain, ³Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ⁴Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, ⁵Complejo Hospitalario Juan Canalejo, A Coruña, Spain, ⁶Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ⁷Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁸Hospital Parc Taulí, Sabadell, Spain, ⁹Rheumatology, Hospital del Mar, Barcelona, Spain, ¹⁰Rheumatology Department. Hospital Universitario Central de Asturias, Oviedo, Spain, ¹¹Rheumatology Department, Hospital Universitario Central de Asturias, Oviedo, Spain, ¹²H. de Salamanca, Salamanca, Spain, ¹³Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ¹⁴Rheumatology Department, H. Monte Naranco, Oviedo, Spain, ¹⁵Rheumatology Service, Germans Trias Pujol Hospital, Barcelona, Spain, ¹⁶Rheumatology Department, Hospital del SAS Jerez de la Frontera, Cadiz, Spain, ¹⁷Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, ¹⁸Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain, ¹⁹Rheumatology Department, Hospital Infanta Sofia, Madrid, Spain, ²⁰Rheumatology Department, Gregorio Marañon Hospital, Madrid, Spain, ²¹Rheumatology Service, Hospital Moisès Broggi,, Barcelona, Spain, ²²Banco Nacional de ADN, Salamanca, Spain
Background/Purpose: Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) are complex diseases of unknown etiology and its pathogenesis results from the combination of genetic susceptibility and…
Abstract Number: 58 • 2014 ACR/ARHP Annual Meeting
What Does the Patient Global Assessment Mean for Patients with Psoriatic Arthritis? A Post-Hoc Analysis of 223 Patients with Psoriatic Arthritis
Sandra Tälli¹, Adrien Etcheto², Bruno Fautrel³, Andra Balanescu⁴, Jürgen Braun⁴, Juan D. Cañete⁵, Kurt de Vlam⁴, Maarten de Wit⁴, Turid Heiberg⁴, Philip S. Helliwell⁴, Umut Kalyoncu⁴, Uta Kiltz⁶, Mara Maccarone⁴, Dora Niedermayer⁴, Kati Otsa⁴, Rossana Scrivo⁴, Josef Smolen⁴, Tanja Alexandra Stamm⁴, Douglas J. Veale⁷, Tore K. Kvien⁴ and Laure Gossec³, ¹Rheumatology, GRC UPMC Paris 06 University, Pitie-Salpétriere hospital, Paris, France, ²Cochin Hospital, Paris Descartes University, Paris, France, ³Rheumatology, UPMC GRC08, Paris 06 University, Pitié Salpétrière Hospital, Paris, France, ⁴PsAID taskforce, EULAR, Zurich, Switzerland, ⁵Rheumatology, Hospital Clinic, Barcelona, Spain, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany, ⁷Translational Rheumatology Research Group, St. Vincent's University Hospital, Dublin 4, Ireland
Background/Purpose Patient global assessment (PGA) is one of the most widely used patient reported outcomes (PROs) in psoriatic arthritis (PsA). PGA should reflect the global…
Abstract Number: 57 • 2014 ACR/ARHP Annual Meeting
Risk of Hospitalized Infection in a Psoriasis/Psoriatic Arthritis Cohort
Kevin L. Winthrop¹, Lang Chen², John Baddley², Allison Taylor³, Benjamin Chan⁴, Huifeng Yun⁵, Sarah Siegel⁶ and Jeffrey R. Curtis⁷, ¹Dept of Infectious Disease, Oregon Health & Science University, Portland, OR, ²Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Clinical Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Oregon Health and Science University, Portland, OR, ⁵Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ⁶Oregon Health & Science University, Portland, OR, ⁷The University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Psoriasis (PsO)/Psoriatic arthritis (PsA) often requires treatment with systemic immunosuppressive agents, some of which may increase hospitalized infection risk. Few population-based studies to date…
Abstract Number: 76 • 2014 ACR/ARHP Annual Meeting
Identification of Synovial Genes and Pathways Associated with Disease Progression in a Cohort of Early Symptomatic Osteoarthritis Patients Using a Transcriptomic Approach
Arjen B. Blom¹, Peter L. van Lent¹, Martijn H. van den Bosch², Hans Cats³, Frank H.J. van den Hoogen⁴, Floris P.J.G. Lafeber⁵, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ³Hengstdal 3, Sint Maartenskliniek, Ubbergen, Netherlands, ⁴Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ⁵Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: If and how the synovial activation that is observed in over 50% of osteoarthritis (OA) patients contributes to irreversible joint pathology, is not known.…
Abstract Number: 75 • 2014 ACR/ARHP Annual Meeting
Robust Identification of Anti-TNF Non-Responders in RA from Blood
Ty Thomson, Reynald Lescarbeau, David Drubin, David Fryburg, David de Graaf, Renée Deehan, Daphna Laifenfeld and Aaron Van Hooser, Selventa, Cambridge, MA
Background/Purpose: The number of biologic therapies approved for use in treating rheumatoid arthritis (RA) has grown steadily over the past 15 years. While many patients…

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