Abstract Number: 2846 • 2014 ACR/ARHP Annual Meeting
CaMK4 Inhibition Ameliorates the Development of Th17 Driven Inflammatory Diseases By Preventing Recruitment of IL-17 Producing Cells to Target Organs
Background/Purpose: IL-17 producing T helper (Th17) cells have been closely associated with the development of organ damage in inflammatory and autoimmune diseases. We have previously…Abstract Number: 2847 • 2014 ACR/ARHP Annual Meeting
Survivin Co-Ordinates Formation of Follicular T-Cells in Rheumatoid Arthritis
Background/Purpose Survivin is a proto-oncogene that regulates cell division and apoptosis. Recently, survivin has emerged as a biomarker of persistently active and joint destructive rheumatoid…Abstract Number: 2848 • 2014 ACR/ARHP Annual Meeting
T-Cell Signaling Defects Can be Corrected By Manipulating ‘TCR Signal Fine-Tuning Molecules’ That Are Altered Due to Increased Ubiquitination in Systemic Autoimmune Disease
Background/Purpose . T-cell selection in the thymus is primarily determined by the avidity of T cell receptor (TCR) for self-ligand-MHC. Since this process is dependent…Abstract Number: 2849 • 2014 ACR/ARHP Annual Meeting
Involvement of CD8+ T Cells in the Pathogenesis of Giant Cell Arteritis and Polymyalgia Rheumatica
Background/Purpose Previous studies have demonstrated the implication of CD4+ T cells, especially T helper (Th1) and Th17 cells, in the pathogenesis of giant cell arteritis (GCA)…Abstract Number: 2850 • 2014 ACR/ARHP Annual Meeting
MiR-125a Is Critical Regulator for Controlling Autoimmunity in Multiple Autoimmune Diseases through Stabilizing Treg Mediated Immune Homeostasis
Background/Purpose Although different autoimmune diseases show distinct clinical phenotypes, common cellular and molecular immune pathways have been shown to be intimately involved in the autoimmune…Abstract Number: 2851 • 2014 ACR/ARHP Annual Meeting
The Relationship of ARMS2 Genotype with Idiopathic Inflammatory Vasculitis
Background/Purpose: Patients with age-related macular degeneration (AMD), a leading cause of irreversible blindness, have a 10-fold increased prevalence of abdominal aortic aneurysms. Single nucleotide polymorphisms…Abstract Number: 2852 • 2014 ACR/ARHP Annual Meeting
Evaluation of KIR3DL1/KIR3DS1 Association with Behçet’s Disease in Turkish Individuals
Background/Purpose: The Behçet’s disease (BD)-associated HLA-B type, HLA-B*51 (B*51), is a ligand for a pair of allelic killer immunoglobulin-like receptors (KIR) present on cytotoxic cells…Abstract Number: 2853 • 2014 ACR/ARHP Annual Meeting
Comparative Study of Infliximab Versus Adalimumab in Patients with Refractory Uveitis Due to Behçet´s Disease. Multicenter Study of 125 Cases
Background/Purpose: To compare the efficacy of infliximab (IFX) versus adalimumab (ADA) as first biologic drug in refractory uveitis due to Behçet's disease (BD) for 1-year…Abstract Number: 2854 • 2014 ACR/ARHP Annual Meeting
Effect of Apremilast on Quality of Life and Physical Function in Patients with Behçet’s Syndrome
Background/Purpose: The oral ulcers in Behçet’s syndrome (BS) can be painful, causing difficulty in eating and speaking, and can impair the quality of life. Apremilast…Abstract Number: 2815 • 2014 ACR/ARHP Annual Meeting
Better Functional Ability with Less Biologicals 2 years after Induction with Combination DMARD Therapy versus methotrexate Monotherapy
Background/Purpose: To assess differences in frequency of biological therapy use and functional ability in early RA patients two years after starting induction therapy according to…Abstract Number: 2816 • 2014 ACR/ARHP Annual Meeting
Distinctive DNA Methylome Signatures in Early Rheumatoid Arthritis (RA) Synoviocytes Compared with Longstanding (RA) and Other Inflammatory Arthritides
Background/Purpose: Epigenetics influences pathogenic mechanisms in autoimmunity. Recently, a stable RA DNA methylation signature in fibroblast-like synoviocytes (FLS) was defined in 2375 genes. The…Abstract Number: 2817 • 2014 ACR/ARHP Annual Meeting
Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis
Background/Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS)…Abstract Number: 2818 • 2014 ACR/ARHP Annual Meeting
SH2 Domain-Containing Phosphatase 2 Promotes Aggressiveness of Rheumatoid Fibroblast-like Synoviocytes
Background/Purpose In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. Although this cell…Abstract Number: 2819 • 2014 ACR/ARHP Annual Meeting
The YAP Pathway Regulates Fibroblast-like Synoviocyte Invasion
Background/Purpose: Fibroblast like synoviocytes (FLS) in RA possesses unique transformed phenotype, such as cartilage invasion that is maintained independent of cytokines and other inflammatory cells.…Abstract Number: 2820 • 2014 ACR/ARHP Annual Meeting
Dual Role for B Cells in Promoting Bone Erosion in Rheumatoid Arthritis Via Effects on Osteoclast and Osteoblast Differentiation
Background/Purpose Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage, a process mediated by an imbalance between bone resorption and…
ACR Meeting Abstracts