ACR Meeting Abstracts

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  • Abstract Number: 137 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Metalloproteinase-3 As a Soluble Biomarker of Synovitis Using Weighted Joint Counts Assessed Clinically and on Ultrasound Imaging

    Agata Burska1,2, Elizabeth Hensor2,3, Jackie L. Nam3, Lukasz Kozera4, Richard J. Wakefield3, Paul Emery3 and Ann W Morgan5, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., Leeds, United Kingdom, 2joint first authorship, Leeds, United Kingdom, 3NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 4Faculty of Pharmacy and Laboratory Diagnostics, Wroclaw Medical University, Wroclaw, Poland, Wroclaw, Poland, 5NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Synovial inflammation is known to play a central role in articular cartilage degradation in rheumatoid arthritis (RA); it could be a passive marker of…
  • Abstract Number: 156 • 2014 ACR/ARHP Annual Meeting

    Colchicine and the Risk of Acute Cardiovascular (CV) Events Among Gout Patients: The New York Department of Veterans Affairs Retrospective Cohort Study

    Daria B. Crittenden1,2, Jessica N. Kimmel1,2, Virginia C. Pike1,2, Rebecca Boas1,2, Daniel Diaz1,2, Cilian J. White1,2, Michael DeBerardine1,2, Grace Kim1,2, Pajazit Morina1,2, Avni Shah1,2, Binita Shah2,3, Steven P. Sedlis2,3, Jeffrey D. Greenberg2,4, Craig T. Tenner2,5, Christopher J. Swearingen1,6, Svetlana Krasnokutsky Samuels1,2, Bruce N. Cronstein1 and Michael H. Pillinger1,2, 1NYU School of Medicine, Division of Rheumatology, New York, NY, 2VA New York Harbor Health Care System, New York, NY, 3NYU School of Medicine, Division of Cardiology, New York, NY, 4NYU School of Medicine, New York, NY, 5NYU School of Medicine, Department of Medicine, New York, NY, 6Department of Pediatrics and Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR

    Background/Purpose: Gout patients are at increased risk for CV disease, possibly owing to chronic inflammation. Colchicine is commonly used in gout, and inhibits inflammatory cell…
  • Abstract Number: 155 • 2014 ACR/ARHP Annual Meeting

    Cost-Effectiveness Analysis of HLA-B5801 Genotyping in the Treatment of Gout Patients with Chronic Renal Insufficiency in Korea

    Dong-Jin Park1, Kyung-Eun Lee1, Sung-Hwan Park2 and Shin-Seok Lee3, 1Rheumatology, Chonnam National University Medical School, Gwangju, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 3Dept of Int Med/Rheumatology, Chonnam National University Medical School, Gwangju, South Korea

    Background/Purpose Allopurinol-induced severe cutaneous adverse reactions (SCARs) are relatively rare, but cause high rates of morbidity and mortality. Studies have shown that the HLA-B5801 allele…
  • Abstract Number: 154 • 2014 ACR/ARHP Annual Meeting

    Cimt in Individuals with Rheumatoid Arthritis Compared to Individuals with Type2 Diabetes

    Helen Pahau Sr.1,2, Leanne Short3, Brian Haluskas4, Vibeke Videm5 and Ranjeny Thomas6, 1Diamantina Institute, The University of Queensland, Woolloongabba, Australia, 2Diamantina Institute, University of Queensland Diamantina Institute, Brisbane, Australia, 3Cardiovascular Imaging Research Centre, University of Queensland, Woolloongabba, Australia, 4Cardiovascular Imaging Research Centre, the University of Queensland, Woolloongabba, Australia, 5Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, and Department of Immunology and Transfusion Medicine, Trondheim University Hospital,, Trondheim, Norway, 6University of Queensland Diamantina Institute, Brisbane, Australia

    Background/Purpose It is well known that patients with RA or Type 2 diabetes (T2DM) have increased risk of atherosclerosis and CVD. Carotid ultrasound measurement of…
  • Abstract Number: 153 • 2014 ACR/ARHP Annual Meeting

    Musculoskeletal Ultrasound of Finger and Foot Joints in a Population of Volunteers: Is Osteoarthritis an Underestimated Problem? Results from the German “Rheuma-Truck” Cohort

    Dr. Philipp Sewerin1, Dr. Stefan Vordenbäumen2, Aiko Liedmann3, Sarah Ohrndorf4, Marina Backhaus4, Dr. Oliver Sander2, Prof. Dr. Matthias Schneider5 and Prof. Dr. Benedikt Ostendorf1, 1Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, 2Department for Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, 3Univ. Duesseldorf, Düsseldorf, Germany, 4Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, 5Department of Rheumatology, Univ. Duesseldorf, Duesseldorf, Germany

    Background/Purpose To investigate the frequency of osteoarthritis (OA) in musculoskeletal ultrasound of the MCP, MTP and PIP joints in a volunteer population using the US-7…
  • Abstract Number: 152 • 2014 ACR/ARHP Annual Meeting

    Subclinical Synovial Inflammation in Gout

    Priya Chowalloor1,2, Patrick Cheah3 and Helen I. Keen1,2, 1Rheumatology, Royal Perth Hospital, Perth, Australia, 2School of Medicine and Pharmacology, The University of Western Australia, Crawley, Australia, 3Rheumatology, Sir Charles Gairdner Hospital, Nedlands, Australia

    Background/Purpose Gout is poorly managed in the community. Long standing poorly controlled gout can lead into progressive destructive arthropathy, decreased quality of life and increased…
  • Abstract Number: 138 • 2014 ACR/ARHP Annual Meeting

    Can Ultrasonography of Peripheral Entheses Play a Role in the Diagnosis and Understanding of Diffuse Idiopathic Skeletal Hyperostosis (DISH)?

    Reuven Mader1,2, Irina Novofastovski3, Salvatore Iervolino4, Alex Pavlov5, Leonid Chervinsky6, Naama Schwartz7 and Nicola Pappone4, 1Rheumatology, Ha Emek Medical Ctr, Afula, Israel, 2B.Rappaport Facuklty of Medicine, Technion Institute of Technology, Haifa, Israel, 3Rheumatology Unit Haemek Medical center, Ha Emek Medical Ctr, Afula, Israel, 4Rheumatology, "Salvatore Maugeri” Foundation, IRCCS Scientific Institute, Telese Terme, Italy, 5Radiology, Bnai Zion Medical Center, Haifa, Israel, 6Radiology, Ha'Emek Medical Center, Afula, Israel, 7Biostatistics, Ha'Emek Medical Center, Afula, Israel

    Background/Purpose to investigate musculoskeletal ultrasound (MSUS) as a diagnostic modality in DISH and to explore if it might help in elucidating its pathogenesis and events…
  • Abstract Number: 143 • 2014 ACR/ARHP Annual Meeting

    Detailed Anatomical Distribution of Synovial Inflammation Revealed By Ultrasound in Patients with Blau Syndrome

    Kei Ikeda1, Naotomo Kambe2, Syuji Takei3,4, Taiji Nakano5, Yuzaburo Inoue5, Minako Tomiita6, Natsuko Oyake7, Takashi Satoh8, Tsuyoshi Yamatou3, Tomohiro Kubota3, Ikuo Okafuji9, Nobuo Kanazawa10, Ryuta Nishikomori11, Naoki Shimojo5, Hiroyuki Matsue8 and Hiroshi Nakajima1, 1Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 2Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, 3Department of Pediatrics, Kagoshima University Hospital, Kagoshima, Japan, 4School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, 5Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba, Japan, 6Department of Allergy and Rheumatology, Chiba Children’s Hospital, Chiba, Japan, 7Department of Pediatrics, Hitachinaka General Hospital, Hitachinaka, Japan, 8Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan, 9Department of Pediatrics, Kobe City Medical Center General Hospital, Kobe, Japan, 10Department of Dermatology, Wakayama Medical University, Wakayama, Japan, 11Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Background/Purpose Arthritis is the most frequent manifestation of Blau syndrome, an autoinflammatory disorder caused by the genetic mutation of NOD2. However, the detailed information on…
  • Abstract Number: 118 • 2014 ACR/ARHP Annual Meeting

    Difficult to Treat Gouty Arthritis Associated with Poor Health Related Quality of Life and High Resource Utilization: Post- Hoc Analysis

    Louis Bessette1, Frédéric Lioté2, Carmen Moragues3, Rüdiger Moericke4, Zhang Zhiyi5, Alberto Ferreira6, Pascal Lecomte6, Sophia Kessabi6, Haijun Tian7 and Jasvinder A. Singh8,9, 1CHUL, Quebec, QC, Canada, 2Hôpital Lariboisière & University Paris Diderot, Paris, France, 3Hospital Platón, Barcelona, Italy, 4Institut für Präventive Medizin & Klinische Forschung GbR, Magdeburg, Germany, 5The First Affiliated Hospital of Haerbin Medical University, Haerbin, China, 6Novartis Pharma AG, Basel, Switzerland, 7Novartis Pharmaceuticals Corporation, East Hanover, NJ, 8Mayo Clinic, Rochester, MN, 9University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Difficult-to-treat (DTT) group in the MOTION study included symptomatic refractory gouty arthritis (RGA) patients with ≥3 flares, refractory to NSAIDs/colchicine/steroids or to uric acid…
  • Abstract Number: 117 • 2014 ACR/ARHP Annual Meeting

    Predictors of Gout Flares in a US Managed Care Setting

    Robert Jackson1, Aki Shiozawa2, Erin Buysman3, Aylin Altan3, Stephanie Korrer3 and Hyon K. Choi4, 1Global Medical Office, Takeda Pharmaceuticals International, Inc, Deerfield, IL, 2One Takeda Parkway, Takeda Pharmaceuticals International, Inc, Deerfield, IL, 3Health Economics and Outcomes Research, Optum, Eden Prairie, MN, 4Boston University School of Medicine, Boston, MA

    Background/Purpose Gout is the most common inflammatory arthritis in the US, and acute gout flares are among the most painful events experienced by humans. The…
  • Abstract Number: 136 • 2014 ACR/ARHP Annual Meeting

    Serum Calprotectin (S100A8/9) Is an Independent Predictor of Ultrasound Synovitis in Patients with Rheumatoid Arthritis

    Jana Hurnakova1, Jakub Zavada1, Petra Hanova2, Hana Hulejova1, Martin Klein1, Herman F. Mann1, Olga Sleglova1, Martina Olejarova1, Sarka Forejtova3, Olga Ruzickova1, Martin Komarc4, Karel Pavelka1 and Ladislav Senolt3, 1Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 2Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 3Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Institute of biophysics and informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose Serological biomarkers specifically reflecting pathological processes may have added value in assessing joint inflammation in rheumatoid arthritis (RA). Calprotectin (S100A8/9 protein) has been demonstrated…
  • Abstract Number: 135 • 2014 ACR/ARHP Annual Meeting

    Comparison of the Ultrasonography Images and Synovial Pathology of the Joints in Patients with Rheumatoid Arthritis Treated with Biological Agents

    Asami Abe1, Hajime Ishikawa1 and Akira Murasawa2, 1Rheumatology, Niigata Rheumatic Center, Shibata, Japan, 2Niigata Rheumatic Center, Shibata, Japan

    Background/Purpose: An early diagnosis and tight disease control have increased in importance in the era of biological therapy for rheumatoid arthritis (RA).  Ultrasonography (US) of…
  • Abstract Number: 134 • 2014 ACR/ARHP Annual Meeting

    Histopathological  Correlation of Ultrasound-Defined Active Synovitis in Patients with Rheumatoid Arthritis in Clinical Remission. Preliminary Results

    Julio Ramirez1, Virginia Ruiz-Esquide1, Raquel Celis2, Alicia Usategui3, Regina Faré4, Andrea Cuervo1, Sonia Cabrera-Villalba5, Maria Victoria Hernández6, Jose Inciarte-Mundo1, Jose L. Pablos4, Raimon Sanmarti7 and Juan D. Cañete5, 1Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 2Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, 3Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (i+12), Madrid, Spain, 4Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 5Rheumatology, Hospital Clinic, Barcelona, Spain, 6Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain, 7Rheumatology, Clinic Hospital, Barcelona, Spain

    Background/Purpose We recently demonstrated that 45.4% of patients with RA in clinical remission have ultrasound (US)-defined active synovitis (synovial hypertrophy (HS) grade 2 or higher…
  • Abstract Number: 133 • 2014 ACR/ARHP Annual Meeting

    On-Demand Ultrasonography Assessment in the Most Affected Joint Is Efficient for Management of RA Patients in Daily Practice

    Ryusuke Yoshimi1, Takeno Mitsuhiro2, Yukihiro Toyota1, Naomi Tsuchida1, Yumiko Sugiyama1, Yosuke Kunishita1, Daiga Kishimoto1, Reikou Kamiyama1, Kaoru Minegishi-Takase1, Maasa Hama3, Yohei Kirino1, Atsuhisa Ueda1 and Yoshiaki Ishigatsubo1, 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan, 3Yokohama City University Graduate School of Medicine, Yokohama, Japan

    Background/Purpose: Musculoskeletal ultrasonography (US) is recognized as a useful tool for the diagnosis and monitoring of rheumatoid arthritis (RA). Although several sets of power Doppler…
  • Abstract Number: 132 • 2014 ACR/ARHP Annual Meeting

    Do Ultrasound (PDUS) and DAS28 Measure Different Aspects of Disease Activity? Analyses from the First Prospective International Phase IIIb Study of PDUS Response in Abatacept-Treated Patients with Rheumatoid Arthritis (RA)

    Maria-Antonietta d'Agostino1, M Boers2, R Wakefield3, H Berner Hammer4, O Vittecoq5, M Galeazzi6, P Balint7, I Möller8, A Iagnocco9, E Naredo10,11, M Ostergaard12, C Gaillez13, E Barre14, M Le Bars15 and On behalf of the OMERACT-EULAR-Ultrasound Task Force, 1AP-HP Ambroise Paré Hospital, Boulogne-Billancourt, France, 2VU University Medical Center, Amsterdam, Netherlands, 3University of Leeds, Leeds, United Kingdom, 4Diakonhjemmet Hospital, Oslo, Norway, 5University Hospital, Rouen, France, 6University of Siena, Siena, Italy, 7Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, 8Instituto Poal, Barcelona, Spain, 9Sapienza Università di Roma, Roma, Italy, 10Hospital Universitario Severo Ochoa, Madrid, Spain, 11Hospital GU Gregorio Marañón, Madrid, Spain, 12Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, 13Formerly of Bristol-Myers Squibb, Rueil-Malmaison, France, 14Bristol-Myers Squibb, Braine-L’Alleud, Belgium, 15Bristol-Myers Squibb, Rueil-Malmaison, France

    Background/Purpose: A composite (power Doppler/grayscale ultrasound [PDUS]) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, was shown to be responsive in RA patients with inadequate…
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