Abstracts Archive - Page 2039 of 2607 - ACR Meeting Abstracts

Abstract Number: 2916 • 2014 ACR/ARHP Annual Meeting
Effects of Exercise on Body Composition, Cardiovascular Fitness, Muscle Strength, and Cognition in Patients with Rheumatoid Arthritis: A Randomised Controlled Trial of a Patient-Specific Exercise Programme
Maha Azeez¹, Ciara Clancy², Tom O'Dwyer³, Fiona Wilson³ and Gaye Cunnane⁴, ¹Rheumatology, St James's Hospital and Trinity College Dublin, Dublin, Ireland, ²Department of Physiotherapy, Trinity College Dublin, Dublin, Ireland, ³Physiotherapy, Trinity College Dublin, Dublin, Ireland, ⁴Dept of Rheumatology, St James's Hospital and Trinity College Dublin, Dublin, Ireland
Background/Purpose Rheumatoid Arthritis (RA) patients have lower levels of physical activity compared to their non-RA counterparts. Large proportions of patients with RA are overweight or…
Abstract Number: 2917 • 2014 ACR/ARHP Annual Meeting
Inhibition of PAD4 Activity and the Formation of Neutrophil Extracellular Traps Via PTPN22, but Not Its Rheumatoid Arthritis-Prone W620 Variant
I-Cheng Ho¹, Hui-Hsin Chang¹, Nishant Dwivedi¹, Hsiao-Wei Tsao¹ and Anthony Nicholas², ¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Neurology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: One unique feature of rheumatoid arthritis (RA) is the presence of anti-citrullinated protein antibody (ACPA). Protein citrullination, a process mediated by peptidyl arginine deiminases,…
Abstract Number: 2918 • 2014 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Associations in ACPA-Positive Rheumatoid Arthritis Identified Shared HLA Amino Acid Polymorphisms in Asian and European Populations
Yukinori Okada¹, Kwangwoo Kim², Buhm Han³, Nisha E. Pillai⁴, Rick T-H. Ong⁴, Woei-Yuh Saw⁴, Ma Luo⁵, Lei Jiang⁶, Jian Yin⁶, So-Young Bang⁷, Hye-Soon Lee⁷, Matthew A. Brown⁸, Sang-Cheol Bae², Huji Xu⁹, Yik-Ying Teo⁴, Paul IW. de Bakker¹⁰ and Soumya Raychaudhuri³, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁴National University of Singapore, Singapore, Singapore, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶The Second Military Medical University, Shanghai, China, ⁷Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ⁸University of Queensland Diamantina Institute, Brisbane, Australia, ⁹Shanghai Changzheng Hospital, Shanghai, China, ¹⁰Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) risk is strongly associated with variations within the major histocompatibility complex (MHC) region, and in particular to HLA-DRB1 alleles. We aimed…
Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting
The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes
Anna-Karin Ekwall¹, Deepa Hammaker², John W. Whitaker³, William Bugbee⁴, Wei Wang⁵ and Gary S. Firestein⁶, ¹Medicine, UC San Diego, La Jolla, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³860 island ave, UCSD, San Diego, CA, ⁴Orthopaedics, Scripps Clinic, La Jolla, CA, ⁵Chemistry, UCSD, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…
Abstract Number: 2921 • 2014 ACR/ARHP Annual Meeting
Contraceptive Factors Are Associated with Serum Antibodies to Citrullinated Protein Antigens in Women at Elevated Risk for Future Rheumatoid Arthritis
Sonia Khatter¹, Mark C. Parish², Marie L. Feser², Jason R. Kolfenbach², Ryan W. Gan³, Michael H. Weisman⁴, James R. O'Dell⁵, Ted R. Mikuls⁶, Richard M. Keating⁷, Peter K. Gregersen⁸, Jane H. Buckner⁹, V. Michael Holers¹⁰, Kevin D. Deane², Jill M. Norris³ and M. Kristen Demoruelle², ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Epidemiology, Colorado School of Public Health, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Division of Rheumatology, Scripps Clinic, La Jolla, CA, ⁸Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁹Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹⁰Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The preclinical period of rheumatoid arthritis (RA) development is characterized by elevations of serum RA-related autoantibodies (Abs) including Abs to citrullinated protein antigens (ACPA)…
Abstract Number: 2922 • 2014 ACR/ARHP Annual Meeting
Association of Single Nucleotide Polymorphisms of PADI4 Gene with Susceptibility to Rheumatoid Arthritis-Related Lung Disease
Seong-Wook Kang¹, Seung-Taek Song¹, Song Soo Kim², Ji Young Kim¹, So Young Lee¹, Su-Jin Yoo³, In-Seol Yoo¹, Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Department of Radiology, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Chungnam National University School of Medicine, Daejeon, South Korea
Background/Purpose Rheumatoid arthritis (RA) causes a myriad of pulmonary complications, including bronchiolitis and bronchiectasis, pleuritis, and interstitial lung disease (ILD). Recently, several studies have shown…
Abstract Number: 2923 • 2014 ACR/ARHP Annual Meeting
Protein Quantification Using Mass Spectrometry Methods to Predict Response to Abatacept and Methotrexate Combination Therapy in Rheumatoid Arthritis
A Obry^1,2, P Cosette², T Lequerré^1,3, Maria-Antonietta d'Agostino⁴, C Gaillez⁵, M Le Bars⁶ and O Vittecoq^1,3, ¹Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, ²UMR 6270 CNRS, PISSARO Proteomic Facility, IRIB, Normandy University, University of Rouen, Rouen, France, ³Department of Rheumatology, Rouen University Hospital, Rouen, France, ⁴AP-HP Ambroise Paré Hospital, Boulogne-Billancourt, France, ⁵Formerly of Bristol-Myers Squibb, Rueil-Malmaison, France, ⁶Bristol-Myers Squibb, Rueil-Malmaison, France
Background/Purpose: Targeted biologic therapies with different mechanisms of action are commonly used in RA. Abatacept is a recombinant fusion protein that inhibits T-cell co-stimulatory molecules…
Abstract Number: 2924 • 2014 ACR/ARHP Annual Meeting
Clinical Utility of Random Anti-TNF Drug Level Testing and Measurement of Anti-Drug Antibodies on Long-Term Treatment Response in Rheumatoid Arthritis
Meghna Jani¹, Hector Chinoy^1,2, Richard B. Warren³, Christopher E.M Griffiths³, Ann W. Morgan⁴, Anthony G. Wilson⁵, Kimme L. Hyrich¹, John Isaacs⁶, Darren Plant^1,2 and Anne Barton^1,7, ¹Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom, ³Dermatology Centre, University of Manchester, Manchester, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Ireland, ⁶Institute of Cellular Medicine, University of Newcastle, Newcastle, United Kingdom, ⁷NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose Up to 40% of RA patients on anti-TNF treatment fail to respond either due to primary inefficacy or loss of response. One explanation is…
Abstract Number: 2925 • 2014 ACR/ARHP Annual Meeting
Serum MMP-3 Predicts a Subgroup with No Radiographic Progression in Rheumatoid Arthritis Patients with Low-Dose Methotrexate (MTX) Monotherapy
Kazuko Shiozawa¹, Takashi Yamane², Miki Murata¹, Chihiro Tanaka¹, Noriaki Yo², Ryosuke Yoshihara¹, Yasushi Tanaka¹, Ken Tsumiyama³ and Shunichi Shiozawa⁴, ¹The Rheumatic Diseases Center, Kohnan Kakogawa Hospital, Kakogawa, Japan, ²Kohnan Kakogawa Hospital, Kakogawa, Japan, ³Department of Rheumatology, Kyushu University Beppu Hospital, Beppu, Japan, ⁴Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: Studies have shown that treating rheumatoid patients with methotrexate (MTX) monotherapy initially and later providing an option to step up to combination therapy produces…
Abstract Number: 2926 • 2014 ACR/ARHP Annual Meeting
Calprotectin Serum Levels Reflect Residual Inflammatory Activity in Patients with Rheumatoid Arthritis and Psoriatic Arthritis on Clinical Remission or Low Disease Activity Undergoing TNF-Antagonists Therapy
Jose Inciarte-Mundo¹, M. Victoria Hernández¹, Sonia Cabrera-Villalba¹, Julio Ramirez¹, Andrea Cuervo¹, Virginia Ruiz-Esquide¹, Azucena González Navarro², Jordi Yagüe³, Juan D. Cañete¹ and Raimon Sanmarti¹, ¹Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ²Immunology Department, Hospital Clínic of Barcelona, Barcelona, Spain, ³Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain
Background/Purpose: Calprotectin is a major S100 leucocyte protein, is associated to disease activity in rheumatoid arthritis (RA) and Psoriatic Arthritis (PsA) patients. Calprotectin is a potentially…
Abstract Number: 2927 • 2014 ACR/ARHP Annual Meeting
Baseline Serum Interferon Beta/Alpha Ratio Predicts Response to Tumor Necrosis Factor Alpha Inhibition in Rheumatoid Arthritis
Priyanka Vashisht¹, Jessica M. Dorschner², Mark A. Jensen³, Beverly Chrabot⁴, Theresa Wampler Muskardin⁵, Marlena Kern⁶, Tetrad Investigators⁷, ABCoN Consortium⁸, S. Louis Bridges Jr.^9,10, P.K. Gregersen¹¹ and Timothy B. Niewold², ¹Division of Rheumatology and Department of Immunology, University of Nebraska Medical Center, Omaha, NE, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁴Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, ⁵Div of Rheumatology, Mayo Clinic, Rochester, MN, ⁶North Shore Univ Hospital, Feinstein Institute for Medical Research, Manhasset, NY, ⁷AL, ⁸NY, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹¹The Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose Response to tumor necrosis factor alpha (TNF-α) inhibition is variable in rheumatoid arthritis (RA). Previous studies have suggested that circulating type I interferon (IFN)…
Abstract Number: 2928 • 2014 ACR/ARHP Annual Meeting
Serum IL-33 Level Is Increased in Rheumatoid Arthritis and Predicts Response to Rituximab in Combination with High Serum IgG Level and Autoantibody Positivity: An Open-Label, Prospective, Multicentre Biological Trial
Jérémie Sellam¹, Houria Chavez², Stéphanie Rouanet³, Nathalie Vernet³, Bineta Ly⁴, Sandrine Marion-Thore⁵, Bernard Combe⁶, Jean Sibilia⁷, Jacques Tebib⁸, Gilles Chiocchia⁹, Maxime Dougados¹⁰, Yassine Taoufik² and Xavier Mariette¹¹, ¹AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, ²Biologic Immunology, Hopital Bicetre, Université Paris Sud, AP-HP, Kremlin Bicetre, France, ³Biostatistics, Roche France, Boulogne-Billancourt, France, ⁴INSERM U1012, Universite Paris-Sud, Kremlin Bicetre, France, ⁵INSERM U1016, Université Versailles Saint-Quentin, Montigny le Bretonneux, France, ⁶Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁷Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ⁸Rheumatology, University Hospital Lyon, Lyon, France, ⁹Université Versailles-Saint Quentin, Montigny le Bretonneux, France, ¹⁰INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ¹¹rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France
Background/Purpose . The recent discovered cytokine interleukin-33 (IL33) could be involved in B-cell activation as well as in RA pathophysiology. After a whole-blood transcriptomic analysis…
Abstract Number: 2929 • 2014 ACR/ARHP Annual Meeting
Molecular Diagnostics for Patient Subsetting in Sjögren’s Syndrome
John C. Hall¹, Alan N. Baer¹, Mi Y. Lam², Lindsey A. Criswell³, Antony Rosen¹ and Livia Casciola Rosen¹, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Orofacial Sciences, University of California San Francisco, San Francisco, CA, ³Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose Sjögren’s syndrome (SS) is a chronic autoimmune disease which targets exocrine glands, particularly salivary and lacrimal glands. While all SS patients have abnormal secretory…
Abstract Number: 2930 • 2014 ACR/ARHP Annual Meeting
Precisely Quantified Fibrosis in Labial Salivary Glands Predicts Sjögren’s Syndrome Classification in a Multiple Regression Model
Kerry M. Leehan^1,2, Michael Brown¹, Courtney Montgomery¹, Astrid Rasmussen¹, David M. Lewis³, Lida Radfar⁴, Donald U. Stone⁵, Stephen Young³, R. Hal Scofield^1,6, Kathy L. Sivils^1,2 and A. Darise Farris^2,7, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Department of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Primary Sjögren's Syndrome (pSS) is a systemic, progressive autoimmune exocrinopathy that presents diagnostic challenges. Focal lymphocytic infiltrates in labial salivary gland (SG) biopsies, serum…
Abstract Number: 2931 • 2014 ACR/ARHP Annual Meeting
Longitudinal Examination with Salivary Gland Ultrasonography (SGUS) of Patients with Primary Sjogren’s Syndrome: A Single Center Experience
Chiara Baldini¹, Nicoletta Luciano¹, Francesca Sernissi¹, Daniela Martini¹, Francesco Ferro¹, Marta Mosca² and Stefano Bombardieri², ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Recently, convincing data have been published on the diagnostic value of salivary gland ultrasonography (SGUS) in primary Sjögren’s syndrome (pSS). However, a limited number…

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