ACR Meeting Abstracts

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  • Abstract Number: 263 • 2014 ACR/ARHP Annual Meeting

    Nutraceutical Products and Pain or Non-Pain Medications Use in Patients with Knee Osteoarthritis

    Mei Chung1, John B. Wong2, Shaoyu Chang3 and Chenchen Wang4, 1Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, 2Medicine/Clinical Decision Making, Tufts Medical Center, Boston, MA, 3Tufts Medical Center, Boston, MA, 4Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Knee osteoarthritis (OA) causes substantial health burden and economic costs including medications and neutraceuticals for pain. The aim of this analysis was to describe…
  • Abstract Number: 262 • 2014 ACR/ARHP Annual Meeting

    Longitudinal Assessment of Promis Pediatric Item Banks in Children with Chronic Musculoskeletal Pain

    Esi M. Morgan DeWitt1, Adam Carle2, Kimberly Barnett3, Jennifer Farrell4, Kenneth Goldschneider5, Carlton Dampier6, David D. Sherry7 and Susmita Kashikar-Zuck3, 1Department of Pediatrics, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Department of Pediatrics (Hematology-Oncology), Emory University School of Medicine, Atlanta, GA, 7Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose Assessing clinical status in musculoskeletal pain syndromes requires self-report of pain and function. Yet, the field suffers from a lack of psychometrically sound, consistently…
  • Abstract Number: 261 • 2014 ACR/ARHP Annual Meeting

    Validation of the Dutch-Flemish Promis Pain Behavior and Pain Interference Item Banks in Patients with Chronic Pain

    Martine Crins1, Leo D. Roorda2, Niels Smits3, Henrica de Vet4, Rene Westhovens5, David Cella6, Karon Cook7, Dennis Revicki8, Jaap van Leeuwen9, Maarten Boers4, Joost Dekker10 and Caroline Terwee4, 1Amsterdam Rehabilitation Research Center | Reade, Amsterdam, Netherlands, 2Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, 3VU University Medical Center EMGO Institute for Health and Care Research, Department of Epidemiology and Biostatistics, Amsterdam, Netherlands, 4Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 5University of Leuven, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration; Rheumatology, University Hospital Leuven, Leuven, Belgium, 6Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 7Center for Patient-Centered Outcomes - Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 8Outcomes Research, United BioSource Corporation, Bethesda, MD, 9CEO Leones Group BV, Amsterdam, Netherlands, 10Rehabilitation Medicine, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: In the assessment of chronic pain patients it is important to measure pain behavior and pain interference. The National Institutes of Health’s Patient-Reported Outcomes…
  • Abstract Number: 260 • 2014 ACR/ARHP Annual Meeting

    Validation of the Dutch-Flemish Promis Physical Functioning Item Bank in Patients with Chronic Pain

    Martine Crins1, Caroline Terwee2, Niels Smits3, Anton de Vries3, Henrica de Vet2, Joost Dekker4, Rene Westhovens5, David Cella6, Karon Cook7, Dennis Revicki8, Jaap van Leeuwen9, Maarten Boers2 and Leo D. Roorda10, 1Amsterdam Rehabilitation Research Center | Reade, Amsterdam, Netherlands, 2Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 3VU University Medical Center EMGO Institute for Health and Care Research, Department of Epidemiology and Biostatistics, Amsterdam, Netherlands, 4Rehabilitation Medicine, VU University Medical Center, Amsterdam, Netherlands, 5University of Leuven, Skeletal Biology and Engineering Research Center, Department of Development and Regeneration; Rheumatology, University Hospital Leuven, Leuven, Belgium, 6Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 7Center for Patient-Centered Outcomes - Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 8Outcomes Research, United BioSource Corporation, Bethesda, MD, 9CEO Leones Group BV, Amsterdam, Netherlands, 10Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands

    Background/Purpose: In the assessment of chronic pain patients it is important to measure physical functioning. The National Institutes of Health’s Patient-Reported Outcomes Measurement Information System…
  • Abstract Number: 259 • 2014 ACR/ARHP Annual Meeting

    Development of Pediatric Item Banks to Measure Pain Behavior in the Patient Reported Outcomes Measurement Information System

    Esi M. Morgan DeWitt1, Kimberly Barnett2, Wen-Hung Chen3, Jennifer Farrell4, Dennis Revicki5, Adam Carle6, Karon Cook7, Kenneth Goldschneider8, Carlton Dampier9, David D. Sherry10 and Susmita Kashikar-Zuck2, 1Department of Pediatrics, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Evidera, Bethesda, MD, 4Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Outcomes Research, Evidera, Bethesda, MD, 6Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Center for Patient-Centered Outcomes - Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 8Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Department of Pediatrics (Hematology-Oncology), Emory University School of Medicine, Atlanta, GA, 10Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose The NIH Patient Reported Outcomes Measurement Information System (PROMIS) has created publicly available patient reported outcomes measures in several domains of physical, social and…
  • Abstract Number: 277 • 2014 ACR/ARHP Annual Meeting

    Nearly 20% of Children ARE NOT Correctly Classified According to Current ILAR Classification in a Printo Dataset of More THAN 12,000 Juvenile Idiopathic Arthritis Patients

    Alessandro Consolaro1, Francesca Bovis2, Ekaterina Alekseeva3, Violeta Vladislava Panaviene3, Jordi Anton3, Susan Nielsen3, Gordana Susic3, Maria Trachana4, Troels Herlin5, Nico Wulffraat3, Pavla Dolezalova3, Yosef Uziel6, Nahid Shafaie3, Ingrida Rumba-Rozenfelde3, Valda Stanevicha3, Nicolino Ruperto7, Daniel Lovell8, Angelo Ravelli9 and Alberto Martini10, 1Pediatria II, Istituto Giannina Gaslini, Genova, Italy, 2Pediatria II, PRINTO, PRINTO - Istituto Giannina Gaslini, Genoa, Italy, 3Istituto Giannina Gaslini, Genoa, Italy, 4Aristotle University, Thessaloniki, Greece, 5Aarhus, Genoa, Italy, 6Tel-Aviv University, Sackler School of Medicine, Tel-Aviv, Israel, 7Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy, 8PRCSG, Cincinnati, OH, 9Istituto Gaslini-PRINTO, Genova, Italy, 10Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose Juvenile idiopathic arthritis (JIA) is an exclusion diagnosis that encompasses all forms of arthritis that begin before the age of 16 years, persist for…
  • Abstract Number: 276 • 2014 ACR/ARHP Annual Meeting

    Growth during Tocilizumab Therapy for Polyarticular-Course Juvenile Idiopathic Arthritis: 2-Year Data from a Phase 3 Clinical Trial

    Kamal N. Bharucha1, Hermine I. Brunner2, Nicola Ruperto3, David A. Cabral2, Abraham Gedalia2, Valeria Gerloni3, Christian Jorgensen3, Athimalaipet Ramanan3, Daniel Lovell2, Alberto Martini4, James Frane5, Chris Wells6 and Fabrizio De Benedetti Sr.7, 1Genentech, South San Francisco, CA, 2PRCSG, Cincinnati, OH, 3PRINTO, Genoa, Italy, 4Istituto Giannina Gaslini, Genova, Italy, 5Consultant, Santa Monica, CA, 6Roche Products Ltd., Welwyn Garden City, United Kingdom, 7Department of Pediatric Medicine, Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy

    Background/Purpose: Elevated interleukin-6 (IL-6) levels have been associated with low growth velocity in patients with juvenile idiopathic arthritis (JIA).1 The efficacy of tocilizumab (TCZ), an…
  • Abstract Number: 267 • 2014 ACR/ARHP Annual Meeting

    Selective and Peripheral-Specific Trk Inhibitor Shows Potent Analgesic Effect Comparable to Morphine in Rat Osteoarthritis Model without CNS Toxicity

    Takeshi Nagaura1, Tetsuya Yasuhiro2, Keisuke Oda2, Yuya Ezaki2, Takashi Koyanagi2, Satoshi Itadani2, Hiroyuki Nitta2, Hiroshi Wakazono2, Seishi Katsumata2 and Yasushi Hirota2, 1Discovery Research Laboratories I, Department of Biology & Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan, 2Ono Pharmaceutical Co., Ltd., Osaka, Japan

    Background/Purpose Tropomyosin receptor kinase (Trk) receptors are a family of three closely related receptor tyrosine kinases; TrkA, TrkB and TrkC. Especially, the peripheral TrkA in…
  • Abstract Number: 238 • 2014 ACR/ARHP Annual Meeting

    RANKL and OPG Gene Polymorphisms: Association with Vertebral Fractures and Bone Mineral Density in Premenopausal Systemic Lupus Erythematosus

    Alessandra C. Bonfa1, Luciana P.C. Seguro2, Valéria Caparbo3, Eloisa Bonfa3 and Rosa M R Pereira3, 1Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose To evaluate single nucleotide polymorphisms (SNPs) of the receptor activator of NF-κB ligand (RANKL), RANK and osteoprotegerin (OPG) genes in premenopausal systemic lupus erythematosus…
  • Abstract Number: 237 • 2014 ACR/ARHP Annual Meeting

    Analysis of Vitamin D Receptor Gene Polymorphisms and Bone Mineral Density in a Population of Women with Rheumatoid Arthritis in Use of Steroid

    Juliana Lucena1, Fernanda G. G Chaer2, Rogerio Castro Reis3 and Branca Souza1, 1Rheumatology, Santa Casa Sao Paulo, sao paulo, Brazil, 2Reumatologia, Santa Casa de Sao Paulo, São Paulo, Brazil, 3Reumatologia, Santa Casa de Sao Paulo, São Paulo, Brazil

    Background/Purpose: To determinate the association between vitamin D receptor (VDR) gene alleles and  bone mineral density (BMD), comparing a group of healthy pre-menopausal white women…
  • Abstract Number: 257 • 2014 ACR/ARHP Annual Meeting

    Quality of Life Assessment of Adults Patients with X-Linked Hypophosphoremia

    Karine Briot1, Hélène Ché1, Adrien Etcheto1, Anya Rothenbuhler2, Peter Kamenicky,2, Agnès Linglart2 and Christian Roux3, 1Cochin Hospital, Paris Descartes University, Paris, France, 2Hôpital Bicêtre, Kremlin Bicêtre, France, 3Paris Descartes University, Cochin Hospital, Paris, France

    Background/Purpose: X-Linked Hypophosphatemia (XLH) is the most common form of heritable rickets. Although disease severity is variable, adults with XLH may suffer from skeletal symptoms…
  • Abstract Number: 256 • 2014 ACR/ARHP Annual Meeting

    Characteristics of Pain in Fabry Disease

    Olivier Lidove1, Esther Noel2, Eric Hachulla3, Francis Gaches4, Claire Douillard5, Bernadette Darne6, Kim Heang Ly7, Christian Lavigne8, Agathe Masseau9, Laurent Aaron10, Boris Bienvenu11, Thierry Zenone12, Philippe Vitielli6, Vanessa Leguy-Seguin13 and Jean Marc Ziza14, 1Médecine interne, Hôpital Croix-Saint-Simon, PARIS, France, 2CHU de Strasbourg - Hopital Civil, Strasbourg, France, 3Faculté de Médecine Henri Warembourg, Université Lille Nord de France, Lille, France, 4Hopital Joseph Ducuing, Toulouse, France, 5CHU Lille, Lille, France, 6Monitoring Force, Maisons-Laffitte, France, 7CHU Dupuytren, Limoges, Limoges, France, 8CHU d'Angers, Angers, France, 9Internal Medicine Department, Nantes University Hospital, Nantes, France, 10Internal Medicine, Hôpital Jacques Coeur, Bourges, Bourges, France, 11Médecine interne, CHU Côte de Nacre, CAEN, France, 12CH de Valence, Valence, France, 13CHU Dijon, Dijon, France, 14Hopital Croix-Saint-Simon, Paris Cedex 20, France

    Background/Purpose Fabry disease (FD) is an X-linked disorder caused by a deficiency of lysosomal alpha-galactosidase A resulting in accumulation of glycosphingolipids. Clinical manifestations include a…
  • Abstract Number: 255 • 2014 ACR/ARHP Annual Meeting

    Pain As Predictor of Organ Involvement in Fabry Disease

    Pierre Kaminsky1, Frederic Barbey2, Roland Jaussaud3, Francis Gaches4, Vanessa Leguy-Seguin5, Eric Hachulla6, Thierry Zenone7, Christian Lavigne8, Claire Douillard9, Isabelle Marie10, Boris Bienvenu11, Bertrand Dussol12 and Olivier Lidove13, 1Internal Medicine, CHU Nancy, Vandoeuvre, France, 2CHU Vaudois, Lausanne, Switzerland, 3CHU de Reims, Reims, France, 4Hôpital Ducuing, Toulouse, France, 5CHU Dijon, Dijon, France, 6Medicine Interne et Oncologie Medicale Centre Pole, Lille University, Lille, France, 7CH de Valence, Valence, France, 8CHU d'Angers, Angers, France, 9CHU Lille, Lille, France, 10CHU de Rouen, Rouen, France, 11Médecine interne, CHU Côte de Nacre, CAEN, France, 12AP Marseille, Marseille, France, 13Médecine interne, Hôpital Croix-Saint-Simon, PARIS, France

    Background/Purpose Fabry disease (FD) in a X-linked hereditary lysosomal disorder due to alphagalactosidase A deficiency, leading to the accumulation of its substrate (globotriaosylceramide) in vessels,…
  • Abstract Number: 254 • 2014 ACR/ARHP Annual Meeting

    The Effect of Milnacipran on Pain in Rheumatoid Arthritis Patients with Widespread Pain:  a Randomized Blinded Crossover Trial

    Yvonne C. Lee1, Elena Massarotti2, Robert R. Edwards3, Bing Lu4, Chih-Chin Liu5, Yuanyu Lo4, Alyssa Wohlfahrt4, Nancy Kim6, Daniel J. Clauw7 and Daniel H. Solomon8, 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 2Rheumatology/PBB-3, Brigham & Women's Hosp, Boston, MA, 3Anesthesiology, Brigham & Womens Hospital, Chestnut Hill, MA, 4Brigham and Women's Hospital, Boston, MA, 5Rheumatology & Immunology, Brigham & Women's Hospital, Boston, MA, 6Div of Rheumatology, Massachusetts General Hospital, Charlestown, MA, 7Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, 8Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Clinical trials have shown that serotonin norepinephrine reuptake inhibitors, such as milnacipran, decrease pain in chronic non-inflammatory pain conditions like fibromyalgia and osteoarthritis. We…
  • Abstract Number: 252 • 2014 ACR/ARHP Annual Meeting

    Preliminary Validation of the Michigan Body Map

    Chad M. Brummett1, Jenna Goesling2, Rishi Bakshi3, Jennifer Wolfe4, Stephanie Moser5, David A. Williams6 and Afton L. Hassett7, 1Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 2Department of Anesthesiology, University of Michigan Health System, Ann Arbor, MI, 3Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI, 4Anesthesiology, University of Michigan Health System, Ann Arbor, MI, 5Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 6Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, 7Anesthesiology, University of Michigan, Ann Arbor, MI

    Background/Purpose One of the hallmark features of fibromyalgia and other centralized pain states is widespread body pain.  We developed the Michigan Body Map (MBM) to…
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