Abstracts Archive - Page 2033 of 2607 - ACR Meeting Abstracts

Abstract Number: 2439 • 2015 ACR/ARHP Annual Meeting
Methotrexate Failure in Pediatric Uveitis
Courtney McCracken¹, Steven Yeh², Kirsten Jenkins³, Daneka Stryker⁴, Steven Tommasello⁵, Curtis Travers¹, Scott R. Lambert², Carolyn Drews-Botsch⁶ and Sheila T. Angeles-Han^1,2,3, ¹Pediatrics, Emory University School of Medicine, Atlanta, GA, ²Ophthalmology, Emory University School of Medicine, Atlanta, GA, ³Children's Healthcare of Atlanta, Atlanta, GA, ⁴Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, ⁵University of Alabama, Birmingham, AL, ⁶Epidemiology, Emory University School of Public Health, Atlanta, GA
Background/Purpose: Pediatric uveitis can lead to ocular complications and vision loss. Treatment consists of steroid drops, methotrexate (MTX), and anti-tumor necrosis factor (TNF) drugs. Only…
Abstract Number: 2440 • 2015 ACR/ARHP Annual Meeting
Using Patient-Relevant Variables to Describe the Disease Course in Children with Juvenile Idiopathic Arthritis
Jaime Guzman¹, Andrew Henrey², Thomas Loughin², Roberta Berard³, Natalie Shiff⁴, Roman Jurencak⁵, Susanne Benseler⁶, Lori B. Tucker⁷ and ReACCh-Out Investigators, ¹Rheumatology, Division of Rheumatology, BC Children's Hospital, Vancouver, BC, Canada, ²Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada, ³Children's Hospital of Western Ontario, London, ON, Canada, ⁴Pediatric Rheumatology, University of Saskatchewan, Saskatoon, SK, Canada, ⁵University of Ottawa, Ottawa, ON, Canada, ⁶Alberta Children's Hospital Research Institute/University of Calgary, Calgary, AB, Canada, ⁷Rheumatology, BC Children's Hospital, Vancouver, BC, Canada
Background/Purpose: To define distinct disease course groups among children with Juvenile Idiopathic Arthritis (JIA) based on observed changes in quality of life, pain, medication requirements,…
Abstract Number: 2441 • 2015 ACR/ARHP Annual Meeting
Serum 14-3-3η Is Present in JIA and Is Not Associated with RF+ Polyarthritis
Alan M. Rosenberg¹, Walter Maksymowych², Yuan Gui³ and Anthony Marotta³, ¹Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., Vancouver, BC, Canada
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a collective term used to denote clinically discrete subtypes, which include: Enthesitis-related arthritis, Oligoarthritis, Polyarthritis, Psoriatic arthritis, Systemic arthritis…
Abstract Number: 2442 • 2015 ACR/ARHP Annual Meeting
The Family Journey to Diagnosis with Systemic Juvenile Idiopathic Arthritis As Evidenced through Changing Social Media Presence
Renee F Modica¹, Kathleen G Lomax², Pamela Batzel³, Leah Shapardanis³, Kimberly A Compton³ and Melissa E Elder⁴, ¹UF Health Shands Children’s Hospital, Gainesville, FL, ²Medical Affairs, Immunology and Dermatology, Novartis Pharmaceuticals Corporation, East Hanover, NJ, ³TREATO, Princeton, NJ, ⁴Pediatrics, Univ of Florida, Gainesville, FL
Background/Purpose: Patients with systemic juvenile idiopathic arthritis (SJIA) frequently encounter delays from symptom onset to SJIA diagnosis (dx), partly due to the broad differential of…
Abstract Number: 2443 • 2015 ACR/ARHP Annual Meeting
Pediatric Tele-Rheumatology: A Pilot Project to Assess Accuracy of Physical Examination Findings and Diagnostic Concordance at a Distance
Michael Henrickson¹, Jody Raugh², Kelsey Hofacer³ and Adam Furnier⁴, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Occupational and Physical Therapy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Center for Telehealth, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Quality Improvement Systems, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Telemedicine (TM) offers a strategic means of extending limited clinical pediatric rheumatology (PR) workforce capacity to improve access to care for patients in remote…
Abstract Number: 2444 • 2015 ACR/ARHP Annual Meeting
Accelerometer-Assessed Daily Physical Activity in Relation to Pain Cognitions and Quality of Life in Juvenile Idiopathic Arthritis
Mette Noergaard¹, Johanne Lomholt², Mikael Thastum², Morten Herlin³, Marinka Twilt⁴ and Troels Herlin⁴, ¹Department of Physiotherapy, Aarhus University Hospital, Aarhus, Denmark, ²Psychology and Social Sciences, Aarhus University, Aarhus, Denmark, ³Pediatrics, Aarhus University Hospital, Aarhus, Denmark, ⁴Pediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) has been associated with decreased physical activity (PA). However, accurate, objective measurements of PA related to potential factors limiting PA…
Abstract Number: L25 • 2014 ACR/ARHP Annual Meeting
Efficacy and Safety of Subcutaneous Tabalumab in Patients with Systemic Lupus Erythematosus (SLE): Results from 2 Phase 3, 52-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trials
David A. Isenberg¹, Murray B. Urowitz², Joan T. Merrill³, Robert W. Hoffman⁴, Matthew D. Linnik⁴, MaryAnn Morgan-Cox⁴, Melissa F. Veenhuizen⁴, Noriko Iikuni⁴, Michelle Petri⁵ and ILLUMINATE-1 Investigators, ¹University College London, London, United Kingdom, ²University of Toronto, Toronto Western Hospital, Toronto, ON, ³Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: B-cell Activating Factor (BAFF) is a key regulator of B-cell development, survival, and activation. Tabalumab is a human IgG4 monoclonal antibody, administered subcutaneously, that binds…
Abstract Number: 3017 • 2014 ACR/ARHP Annual Meeting
Program Evaluation of ‘the Joint Clinic’: An Innovative Clinical Service for Patients with Hip or Knee Osteoarthritis
J. Haxby Abbott¹, Helen Harcombe², Chris Crane³, Liam Hutton³, Kirsten Stout³, Cathy Chapple⁴ and David Gwynne-Jones⁵, ¹Centre for Musculoskeletal Outcomes Research, Department of Surgical Sciences, University of Otago, Dunedin, New Zealand, ²Centre for Musculoskeletal Outcomes Research, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand, ³Dunedin Hospital, Southern District Health Board, Dunedin, New Zealand, ⁴School of Physiotherapy, University of Otago, Dunedin, New Zealand, ⁵Orthopaedic Surgery, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
Background/Purpose: In socialized healthcare systems with free public access to healthcare, there are circumstances wherein patients referred by general medical practitioners (GPs) for specialist physician…
Abstract Number: 3018 • 2014 ACR/ARHP Annual Meeting
Testing of a Newly Developed Computerized Animated Activity Questionnaire for Assessing Activity Limitations in Patients with Hip and Knee Osteoarthritis
Wilfred FH Peter¹, Mick Loos², Henrica de Vet³, Maarten Boers³, Jaap Harlaar⁴, Leo D. Roorda⁵, Rudolf Poolman⁶, Vanessa Scholtes⁶, Jan Bogaard⁷, Hilda Buitelaar¹, Martijn P.M. Steultjens⁸, Ewa M. Roos⁹, Anne-Christine Rat¹⁰, Francis Guillemin¹¹, Maria Grazia Benedetti¹², Antonio Escobar Martinez¹³, Nina Østerås¹⁴ and Caroline Terwee³, ¹Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, ²Epidemiology and Biostatistics and the EMGO Institute for Health and Care research, VU University Medical Center, Amsterdam, Netherlands, ³Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, ⁴Dep of Rehabilitation Medicine and MOVE research institute, VU University Medical Center, Amsterdam, Netherlands, ⁵Amsterdam Rehabilitation Research Center | Reade, Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁶Department of Orthopedics, Joint Research, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands, ⁷Dep of Epidemiology and Biostatistics and the EMGO Institute for Health and Care research, VU University Medical Center, Amsterdam, Netherlands, ⁸Institute for Applied Health Research and School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, ⁹Inst Sports and Biomechanics, University of Southern Denmark, Odense, Denmark, ¹⁰University Paris Descartes, EA 4360 APEMAC, University of Lorraine, Nancy, France, ¹¹INSERM, Centre d'Investigation Clinique - Epidémiologie Clinique (CIC-EC) CIE6, Nancy, France, ¹²Physical Medicine and Rehabilitation Unit, Istituto Ortopedico Rizzoli, Bologna, Italy, ¹³Health Service Research Network on Chronic Diseases (REDISSEC), Basurto University Hospital, Bilbao, Spain, ¹⁴Department of rheumatology, National Advisory Unit for rehabilitation in rheumatology, Diakonhjemmet Hospital, Oslo, Norway

Background/Purpose Self-report questionnaires and performance-based tests correlate moderately in measuring activity limitations, indicating that they measure different aspects. Self-reports measure mainly how patients think they…
Abstract Number: 2997 • 2014 ACR/ARHP Annual Meeting
Development and External Validation of a Five-Year Mortality Risk Stratification Tool for Early Diffuse Systemic Sclerosis Patients
Robyn T. Domsic¹, Svetlana I. Nihtyanova², Mary Lucas³, Stephen R. Wisniewski⁴, Michael J. Fine⁵, C. Kent Kwoh⁶, Christopher P. Denton⁷ and Thomas A. Medsger Jr.⁸, ¹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Department of Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ³Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁵General Medicine, University of Pittsburgh and Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare, Pittsburgh, PA, ⁶1501 N. Campbell Avenue, Room 8303, The University of Arizona Arthritis Center, Tucson, AZ, ⁷Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ⁸Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose : Knowledge of mortality risk and predictors is important in systemic sclerosis (SSc) patient care and clinical trial design. There is no validated 5-year…
Abstract Number: 2998 • 2014 ACR/ARHP Annual Meeting
Screening for Interstitial Lung Disease in Systemic Sclerosis: Performance of High-Resolution Computed Tomography with Limited Number of Slices – a Prospective Study
Thomas Frauenfelder¹, Anna Winklehner¹, Thi Dan Linh Nguyen¹, Rucsandra Dobrota^2,3, Stephan Baumüller¹, Britta Maurer² and Oliver Distler², ¹Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland, ²Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Internal Medicine and Rheumatology, Dr.I.Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Background/Purpose Early diagnosis of interstitial lung disease (ILD), currently the main cause of death in systemic sclerosis (SSc), is needed. The gold standard is high…
Abstract Number: 2999 • 2014 ACR/ARHP Annual Meeting
Development of a Composite Index for Clinical Trials in Early Diffuse Cutaneous Systemic sclerosis—the Combined Response Index in Systemic Sclerosis
Dinesh Khanna¹, Veronica Berrocal², Edward Giannini³, Maureen Mayes⁴, Peter A. Merkel⁵, Jeffrey Siegel⁶, James R. Seibold⁷, Murray Baron⁸, Philip J. Clements⁹, Yannick Allanore¹⁰, Virginia D. Steen¹¹, Christopher P. Denton¹², Oliver Distler¹³, Sindhu R. Johnson¹⁴, Marco Matucci-Cerinic¹⁵, Lazlo Czirjak¹⁶, Janet E. Pope¹⁷, Susanna Proudman¹⁸, Weng Kee Wong¹⁹, Athol U. Wells²⁰ and Daniel E. Furst⁹, ¹University of Michigan Scleroderma Program, Ann Arbor, MI, ²Department of Biostatistics- School of Public Health, University of Michigan, Ann Arbor, MI, ³Ped Rheum/Pav 2-129, Childrens Hosp Med Ctr, Cincinnati, OH, ⁴Internal Medicine/Rheumatology, University of TX Health Science Center -Houston, Houston, TX, ⁵Vasculitis Center, E5, Boston University School of Medicine, Boston, MA, ⁶Genentech, South San Francisco, CA, ⁷Scleroderma Research Consultants LLC, Avon, CT, ⁸Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁹University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ¹⁰Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ¹¹Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹²Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom, ¹³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁴Medicine, Division of Rheumatology, Toronto Western Hospital, University Health Network Pulmonary Hypertension Programme, Toronto General Hospital, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ¹⁵Dept of Medicine/Div of Rheum, University of Florence, Florence, Italy, ¹⁶Immunology and Rheumatology, University of Pécs, Pécs, Hungary, ¹⁷Medicine, Western University, London, ON, Canada, ¹⁸Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ¹⁹Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, ²⁰Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, London, United Kingdom
Background/Purpose: Diffuse systemic sclerosis (dcSSc) is a multisystem disease that involves skin and internal organs. Our objective was to develop a composite response index in…
Abstract Number: 3000 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Sclerosis Subsets As Predictors of Mortality and Morbidity
Hebah Alhajeri¹, Marie Hudson^2,3, Canadian Scleroderma Research Group CSRG⁴ and Murray Baron⁵, ¹Rheumatology, McGill University, Montreal, QC, Canada, ²Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ³Division of Rheumatology, McGill University, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada
Background/Purpose: Identifying systemic sclerosis (SSc) subsets that predict mortality and morbidity could provide useful prognostic information. We undertook this study to compare the predictive ability…
Abstract Number: 3001 • 2014 ACR/ARHP Annual Meeting
Targeting IL-6 By Both Passive or Active Immunization Strategies Prevents Inflammation-Driven Skin Fibrosis
Jerome Avouac¹, Lucille Desallais², Maxime Fréchet³, Muriel Elhai³, Jean François Zagury² and Yannick Allanore¹, ¹Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, ²Chaire de Bioinformatique, Laboratoire Génomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et Métiers, Paris, France, ³INSERM U1016, Cochin Institute, Paris, France
Background/Purpose: Interleukin 6 (IL-6) is a pleiotropic cytokine involved in inflammatory and autoimmune processes. Preliminary data have suggested that IL-6 might contribute to systemic sclerosis…
Abstract Number: 3002 • 2014 ACR/ARHP Annual Meeting
Anti-Fibrotic Effects of a Newly Discovered HGF Receptor Carboxy-Terminal Fragment in Systemic Sclerosis
Yuichiro Shirai¹, Ilia Atanelishvili², Tanjina Akter¹, Richard Silver³ and Galina Bogatkevich¹, ¹Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, ³Division of Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic sclerosis (SSc) is an irreversible fibrotic disorder with interstitial lung disease (ILD) being a major complication and leading cause of mortality. African American…

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