Abstract Number: 356 • 2014 ACR/ARHP Annual Meeting
The Rheumatoid Arthritis Impact of Disease Score Is Associated with Disease Activity By Clinical, Laboratory and Ultrasonographic Measures: Validation in an inception Cohort of DMARD naïve Patients with Rheumatoid Arthritis
Background/Purpose: The Rheumatoid arthritis impact of disease (RAID) score is a relatively new patient-derived composite score assessing the seven most important domains of the impact…Abstract Number: 355 • 2014 ACR/ARHP Annual Meeting
Increased Left Ventricular Mass Index and Decreased Ejection Fraction Are Associated with Disease Activity in Rheumatoid Arthritis Patients without Cardiac Symptoms; Comparison Between Non-Biologic and Biologic Dmards Treatment Groups, Using a Cardiac Magnetic Resonance Imaging
Background/Purpose Patients with rheumatoid arthritis (RA) experience an excess risk of congestive heart failure (CHF), but effects of disease-modifying anti-rheumatic drugs (DMARDs) on cardiac structure…Abstract Number: 354 • 2014 ACR/ARHP Annual Meeting
Increased Vascular Wall Inflammation in Patients with Active Rheumatoid Arthritis As Measured By an 18F-FDG-PET/CT Scan
Background/Purpose : Patients with rheumatoid arthritis (RA) have an elevated risk of developing cardiovascular disease (CVD). Like active RA, atherosclerosis is an inflammatory process. There…Abstract Number: 353 • 2014 ACR/ARHP Annual Meeting
Sensitivity of Unique Multidimensional Health Assessment Questionnaire Items Compared to Items on Both the HAQ and MDHAQ in Patients with RA and SLE
Background/Purpose: Patients with rheumatic diseases have significantly better clinical status in recent years than in previous decades, including rheumatoid arthritis (RA)1 and systemic lupus erythematosus…Abstract Number: 352 • 2014 ACR/ARHP Annual Meeting
Remaining Pain in Spite of Suppressed Inflammation in Early Rheumatoid Arthritis – Long-Term Strongly Increased Risk for Widespread Pain and Fatigue
Background/Purpose: Pain is common in rheumatoid arthritis (RA), even after adequate inflammatory disease control. Important long-term health effects of RA are fatigue, sleeping disturbances and…Abstract Number: 351 • 2014 ACR/ARHP Annual Meeting
Doctor, Will My Fatigue be Better If I’m in Remission? an Exploratory Analysis of 1284 Rheumatoid Arthritis (RA) Patients Indicates Fatigue Is the Only Aspect of Patient-Perceived Impact to Remain Significant in ACR/EULAR Boolean Remission
Background/Purpose Fatigue is an important issue for patients with rheumatoid arthritis (RA). The ACR/EULAR Boolean definition of remission comprises values 1/10) is a status which…Abstract Number: 350 • 2014 ACR/ARHP Annual Meeting
Rho-Associated Protein Kinase (ROCK) Activity Is Elevated in Rheumatoid Arthritis (RA) Patients and May be Responsive to RA Therapies
Background/Purpose: Rho-associated protein kinases (ROCKs) regulate cytoskeletal reorganization and gene expression through protein phosphorylation, and are implicated in the pathogenesis of a wide range of…Abstract Number: 349 • 2014 ACR/ARHP Annual Meeting
Galectin-3 in the Systemic Circulation Is Increased in Newly Diagnosed Rheumatoid Arthritis and Is Associated with Anti-CCP and Bone Marrow Edema
Background/Purpose: Galectin-3 (Gal-3), a 26kD beta-galactoside binding protein, has been implicated as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA) in humans. Thus,…Abstract Number: 348 • 2014 ACR/ARHP Annual Meeting
Smoking Status Is Associated with Inflammatory Cytokine Profile and Disease Activity: Decreased Inflammation and Disease Improvement with Smoking Cessation?
Background/Purpose: Cigarette smoking is a risk factor for RA and has been associated with increased disease severity and lower rates of disease remission. We examined…Abstract Number: 347 • 2014 ACR/ARHP Annual Meeting
Salt Aggravates Arthritis By Th17 Polarization
Background/Purpose Sodium chloride (NaCl) recently has been shown to drive autoimmune diseases through the induction of pathogenic interleukin 17-producing T helper (Th17) cells. This study…Abstract Number: 346 • 2014 ACR/ARHP Annual Meeting
Treatment of Collagen Induced Artritis with Human Embrionic Stem Cell-Derived Multipotent Mesenchymal Stromal Cells (hESC-MSC)
Background/Purpose Inhibition of TGFβ signaling in human Embryonic Stem Cells (hESC) generates mesenchymal stromal cells (hESC-MSC) with osteogenic, adipogenic and chondrogenic potential. These cells have…Abstract Number: 345 • 2014 ACR/ARHP Annual Meeting
A Low Salt Diet Ameliorates Clinical Manifestations in Collagen-Induced Arthritis
Background/Purpose A genetic predisposition, but also environmental factors including infections and smoking modulate manifestation and severity of inflammatory autoimmune disease like rheumatoid arthritis (RA). Recently,…Abstract Number: 344 • 2014 ACR/ARHP Annual Meeting
Reduced Macrophages in the Synovium Contribute to the Effective Treatment of Spontanneous Arthritis Observeded in Human TNF-Transgenic Mice
Background/Purpose Macrophages in rheumatoid arthritis (RA) synovial tissue (ST) produce high levels of inflammatory cytokines/chemokines and exhibit enhanced differentiation into osteoclasts in the pannus, playing…Abstract Number: 342 • 2014 ACR/ARHP Annual Meeting
Vascular Permeability As an Imaging Biomarker for Chronic Inflammatory Arthritis: A Dynamic Contrast Enhanced Magnetic Resonance Imaging Study
Vascular permeability as an imaging biomarker for chronic inflammatory arthritis: A dynamic contrast enhanced magnetic resonance imaging study Background/Purpose Rheumatoid arthritis (RA) is a chronic…Abstract Number: 343 • 2014 ACR/ARHP Annual Meeting
The Caspase 8/RIPK3 Signaling Axis Has Opposing Roles in Myeloid and Dendritic Cells during Progression of a Murine Model of Acute Inflammatory Arthritis
Background/Purpose Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction. Both myeloid cells and…
ACR Meeting Abstracts