Abstracts Archive - Page 2025 of 2425 - ACR Meeting Abstracts

Abstract Number: 406 • 2014 ACR/ARHP Annual Meeting
The Utility of HLA-DR Genotypification As a Complementary Tool to Discriminate Undifferentiated and Rheumatoid Arthritis Patients in Early Arthritis
Fernando Dal Pra¹, Gustavo Citera², Margarita Landi³, Christian A. Waimann⁴, Luis Alejandro Cayetti², Sergio Paira⁵, Federico Ceccatto⁶, Teresita Alvarellos⁷, Luciana Mas⁷, Josefina Marcos⁸, Mercedes García⁸, A Salas⁸, Alejandro Martinez⁹, Rafael Chaparro¹⁰, Oscar Luis Rillo¹¹, Edson Veloso¹², Ricardo V. Juárez¹³, Maria Elena Crespo¹⁴, Antonio Catalán Pellet¹⁵, Anastasia Secco¹⁵, Lucila Marino¹⁶ and V Martire¹⁵, ¹Instituto de Rehabilitacion Psicofisica, Buenos Aires, Argentina, ²Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Rheumatology, Instituto Rehabilitacion Psicofisica, Buenos Aires, Argentina, ⁴Rheumatology, Hospital Olavarria, Olavarria, Argentina, ⁵Section of Rheumatology, Hospital Jose Maria Cullen, Santa Fe, Argentina, ⁶Rheumatology, Hospital Jose María Cullen, Santa Fé, Argentina, ⁷Laboratorio de Histocompatibilidad, Hospital Privado Centro Medico De Córdoba, Cordoba, Argentina, ⁸HIGA San Martín, La Plata, Argentina, ⁹Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ¹⁰Rheumatology, Hospital Gral. de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ¹¹Rheumatology Section, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ¹²Sanatorio y Universidad Adventista Del Plata, Entre Rios, Argentina, ¹³Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, ¹⁴Hospital Señor Del Milagro, Salta, Argentina, ¹⁵Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ¹⁶Rheumathology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina
Background/Purpose: Only half of patients with undifferentiated arthritis (UA) will progress to rheumatoid arthritis (RA) after two years of follow-up. Particular human leukocyte antigens class…
Abstract Number: 405 • 2014 ACR/ARHP Annual Meeting
14-3-3η: A Mechanistic Biomarker That Supports the Concept of “Uncoupling” of Inflammation and Joint Damage
Dirkjan van Schaardenburg¹, Mairead Murphy², Yuan Gui², Samina Turk³, Walter P. Maksymowych⁴, Kelly Young⁵ and Anthony Marotta⁶, ¹Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands, ²Augurex Life Sciences Corp., North Vancouver, BC, Canada, ³Reade, Amsterdam, Netherlands, ⁴Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Rheumatoid Patient Foundation, Cocoa, FL, ⁶1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose In RA, irreversible joint damage often begins within the first year of symptom onset. A compelling and growing body of data describing the "uncoupling"…
Abstract Number: 404 • 2014 ACR/ARHP Annual Meeting
The Relationship Between Disease Activity and Levels of HMGB1 in Patients with Rheumatoid Arthritis
David S. Pisetsky^1,2, Diane Spencer³, Stephen R. Wisniewski⁴, Jason Lyons⁴, Melissa Saul⁵, Mandy J. McGeachy⁶, Yong Gil Hwang⁷, Heather Eng⁴ and Larry W. Moreland⁶, ¹Medical Research Service, Durham VAMC, Durham, NC, ²Duke University Medical Center, Durham, NC, ³Medicine, Duke University Medical Center, Durham, NC, ⁴Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁵Biomedical Informatics, University of Pittsburgh, School of Medicine, Pittsburgh, PA, ⁶Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Department of Medicine, University of Pittsburgh, Pittsburgh, PA
Background/Purpose HMGB1 (High Mobility Group Box 1), a non-histone nuclear protein, is a prototypic alarmin that displays immunological activity following release during cell death or…
Abstract Number: 383 • 2014 ACR/ARHP Annual Meeting
How Low Is Low Disease Activity? an Analysis from a Prospective, Observational Registry
Edward C. Keystone¹, Boulos Haraoui², John Kelsall³, Carter Thorne⁴, Philip Baer⁵, William Bensen⁶, Denis Choquette⁷, Regan Arendse⁸, Dalton Sholter⁹, Niall Jones¹⁰, Algis Jovaisas¹¹, Emmanouil Rampakakis¹², John S. Sampalis¹², Francois Nantel¹³, May Shawi¹³, Allen J Lehman¹⁴ and Susan Otawa¹⁴, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²University of Montreal Hospital Centre, Montreal, QC, Canada, ³The Mary Pack Arthritis Centre, Vancouver, BC, Canada, ⁴Southlake Regional Health Centre, Newmarket, ON, Canada, ⁵Private Practice, Scarborough, ON, Canada, ⁶St Josephs Hospital and McMaster University, Hamilton, ON, Canada, ⁷Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁸University of Saskatchewan, Saskatoon, SK, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Dept of Rheumatology, University of Alberta, Edmonton, AB, Canada, ¹¹194 Main Street, University of Ottawa, Ottawa, ON, Canada, ¹²JSS Medical Research, Montreal, QC, Canada, ¹³Janssen Inc., Toronto, ON, Canada, ¹⁴Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Composite measures of disease activity can facilitate clinical decision-making to achieve treatment goals, and treating-to-target has been shown to improve outcomes. Both CRA and…
Abstract Number: 384 • 2014 ACR/ARHP Annual Meeting
Using Patient Reported Outcome Measures to Classify Disease Activity States in Rheumatoid Arthritis: A Comparison of Patient Activity Score (PAS) and Routine Assessment of Patient Index Data (RAPID)
Erin Carruthers¹, Noura AL Osaimi², Charles H Goldsmith³, Paul Adam⁴ and Diane Lacaille⁵, ¹Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Rheumatology, University of Ottawa, Ottawa, ON, Canada, ³Health Sciences, Simon Fraser University, Burnaby, BC, Canada, ⁴Mary Pack Arthritis Centre, Vancouver, BC, Canada, ⁵Arthritis Research Centre of Canada, Vancouver, BC, Canada
Background/PurposeIn RA the target for treatment is clinical remission or minimal disease activity. Patient involvement in monitoring their disease activity could enhance treatment by providing…
Abstract Number: 382 • 2014 ACR/ARHP Annual Meeting
What Is More Predictive of Achieving Remission at 12 Months: The Percentage of Baseline Improvement or the Actual Disease State Achieved at 6 Months?
Edward C. Keystone¹, Carter Thorne², Michael Starr³, Jude Rodrigues⁴, Philip Baer⁵, Regan Arendse⁶, J. Antonio Avina-Zubieta⁷, Denis Choquette⁸, Emmanouil Rampakakis⁹, John S. Sampalis⁹, May Shawi¹⁰, Francois Nantel¹⁰, Allen J Lehman¹¹ and Susan Otawa¹¹, ¹Medicine, University of Toronto, Toronto, ON, Canada, ²Southlake Regional Health Centre, Newmarket, ON, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴Clinical Research and Arthritis Centre, Windsor, ON, Canada, ⁵Private Practice, Scarborough, ON, Canada, ⁶University of Saskatchewan, Saskatoon, SK, Canada, ⁷Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁸Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Janssen Inc., Toronto, ON, Canada, ¹¹Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: The aim of rheumatoid arthritis (RA) treatment is to optimize symptom control and, when possible, achieve sustained remission. Therefore, identification of clinical signs predicting…
Abstract Number: 381 • 2014 ACR/ARHP Annual Meeting
Distribution and Clinical Significance of Anti-Heterogenic Nuclear Ribonucleoprotein A2 Antibody in Connective Tissue Diseases
Wang Yong Sr.¹, Mu Fangxiang¹, Wu Hong² and Fang Yongfei², ¹Department of Rheumatology,, Southwest Hospital, Third Military Medical University, Chongqing, China, ²Department of Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing, China
Distribution and clinical significance of anti-heterogeneous nuclear ribonucleoprotein A2 antibody in connective tissue diseasesAbstract: Background/Purpose:The heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been described as an…
Abstract Number: 379 • 2014 ACR/ARHP Annual Meeting
What Level of Disease Activity at 6 Months Predicts Achieving or Sustaining Remission at 12 Months?
Edward Keystone¹, Philip Baer², Boulos Haraoui³, J Antonio Avina-Zubieta⁴, Andrew Chow⁵, Dalton Sholter⁶, Denis Choquette⁷, Emmanouil Rampakakis⁸, John S. Sampalis⁸, Francois Nantel⁹, Allen J Lehman¹⁰, May Shawi⁹ and Susan Otawa¹⁰, ¹Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ²Private Practice, Scarborough, ON, Canada, ³University of Montreal Hospital Centre, Montreal, QC, Canada, ⁴Experimental Medicine, University of British Columbia, Department of Experimental Medicine, Vancouver, BC, Canada, ⁵McMaster University, Hamilton and Credit Valley Hospital, Mississauga, ON, Canada, ⁶University of Alberta, Edmonton, AB, Canada, ⁷Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁸JSS Medical Research, Montreal, QC, Canada, ⁹Janssen Inc., Toronto, ON, Canada, ¹⁰Medical Affairs, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Achievement of clinical remission in rheumatoid arthritis (RA) is a process that may take several months. Identification of clinical signs predicting future remission may…
Abstract Number: 398 • 2014 ACR/ARHP Annual Meeting
Anti-Rheumatic Therapy Decreases Syndecan-1 Shedding in Rheumatoid Arthritis (RA)
Ivana Hollan¹, Gunnbjørg Hjeltnes², Torstein Lyberg³, Stefan Agewall³, Allan Wiik⁴, Knut Mikkelsen⁵, Øystein T. Førre⁶, Tram T. Vuong³ and Svein O. Kolset³, ¹Rheumatology, Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ²Medicine, Innlandet Hospital Trust, Lillehammer, Norway, ³University of Oslo, Oslo, Norway, ⁴Clinical Biochem/Immunology, Statens Serum Institute, Copenhagen S, Denmark, ⁵Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁶Oslo University Hospital, Oslo, Norway
Background/Purpose Intact glycocalyx is of importance for healthy endothelial function. Changes in the endothelial glycocalyx, characterized by increased levels of circulating syndecan-1, might be related…
Abstract Number: 397 • 2014 ACR/ARHP Annual Meeting
Th9 Lymphocytes in Rheumatoid Arthritis
Rossella Talotta¹, Angela Berzi², Fabiola Atzeni¹, Donata Dell'Acqua¹, Piercarlo Sarzi-Puttini¹ and Daria Trabattoni², ¹Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ²Chair of Immunology, Department of Biomedical and Clinical Sciences “L. Sacco, Milan, Italy
Background/Purpose Th9 cells are IL-9-secreting Th lymphocytes that are involved in the immunological responses underlying parasitic infections and allergic diseases. In the case of autoimmune…
Abstract Number: 396 • 2014 ACR/ARHP Annual Meeting
Disease Activity Scoring: Comparing Patient and Physician Global Assessment of Disease Activity in Rheumatoid Arthritis
Boulos Haraoui¹, Denis Choquette¹, Jean-Pierre Raynauld¹, Jean Pierre Pelletier¹, Louis Bessette², Edith Villeneuve¹, Marie-Anaïs Rémillard³, Isabelle Fortin⁴, Diane Sauvageau¹ and Louis Coupal¹, ¹Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ²Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada, ³Rhumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, ⁴Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada
Background/Purpose: Visual analogue scales (VAS) are routinely used in daily clinical practice and are part of the different composite outcome measures. Studies often report weak…
Abstract Number: 395 • 2014 ACR/ARHP Annual Meeting
Could Osteoprotegerin and TNF-Related Apoptosis-Inducing Ligand Assessments Help Us to Manage Early Rheumatoid Arthritis? Results from the Espoir Cohort
Rachel Audo¹, Claire I. Daien², Laura Papon¹, Cédric Lukas³, O Vittecoq⁴, B Combe⁵ and Jacques Morel⁶, ¹IGMM, CNRS UMR5535, Montpellier, Montpellier, France, ²Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ³Immuno-Rhumatologie, Hopital Lapeyronie, Montpellier, France, ⁴Rouen University Hospital & Inserm U905, Rouen, France, ⁵Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁶Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France
Background/Purpose : TNF-Related Apoptosis Inducing Ligand (TRAIL) is a member of the TNF familly. Its soluble receptor Osteoprotegerin (OPG) also inhibits Receptor activator of nuclear…
Abstract Number: 394 • 2014 ACR/ARHP Annual Meeting
Very Low or High Body Mass Index Negatively Affects patients’ Ability to Achieve Sustained Remission in Early RA in a Multicenter Canadian Cohort
Susan M. Goodman¹, Yan Ma², Wei Zhang³, Elizabeth Schulman⁴, Janet E. Pope⁵, Carol Hitchon⁶, Susan J. Bartlett⁷, Boulos Haraoui⁸, Daming Lin⁹, Gilles Boire¹⁰, Diane Tin¹¹, J. Carter Thorne¹², Shahin Jamal¹³, Edward C. Keystone¹⁴ and Vivian P. Bykerk^1,15, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Research - Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ³Healthcare Research Institute, Hospital for Special Surgery, New York, NY, ⁴Rheumatology, New York Presbyterian - Cornell Campus - HSS, New York, NY, ⁵St Joseph Health Care, London, ON, Canada, ⁶Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁷Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁸University of Montreal Hospital Centre, Montreal, QC, Canada, ⁹Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ¹⁰Rheumatology Division, CHUS - Sherbrooke University, Sherbrooke, QC, Canada, ¹¹The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²Southlake Regional Health Centre, Newmarket, Newmarket, ON, Canada, ¹³Vancouver General Hospital, Vancouver, BC, Canada, ¹⁴Medicine, University of Toronto, Toronto, ON, Canada, ¹⁵Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: To determine if patients with a very low body mass index (BMI) (
Abstract Number: 393 • 2014 ACR/ARHP Annual Meeting
Influence of Body Mass Index on Disease Activity and Radiographic Joint Damage in Rheumatoid Arthritis : A Systematic Review and Meta-Analysis
Celine Vidal¹, Thomas Barnetche², Jacques Morel³, Bernard Combe⁴ and Claire Daien⁵, ¹Rheumatology, Hopital Lapeyronie, Montpellier, France, ²rheumatology, Rheumatology department, Bordeaux University Hospital, bordeaux, France, ³Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, ⁴Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁵Hopital Lapeyronie, Montpellier, France
Background/Purpose: Overweight and obesity in patients with rheumatoid arthritis (RA) are rising conditions. Adipose tissue has pro inflammatory properties by producing adipokines which could play…
Abstract Number: 392 • 2014 ACR/ARHP Annual Meeting
Neuroendocrine Hormone and Metabolic Peptide Levels in the Earliest Phases of Rheumatoid Arthritis – Do Free Fatty Acids Play a Role?
Man Wai Tang¹, Frieda A. Koopman², Jan P.M. Visscher², Marjolein J.H. de Hair², Danielle M. Gerlag^2,3 and Paul P. Tak^2,4, ¹Division of Clinical Immunology and Rheumatology & Department of Experimental Immunology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ²Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³GlaxoSmithKline, Cambridge, United Kingdom, ⁴University of Cambridge, Cambridge and GlaxoSmithKline, Stevenage, United Kingdom
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with several neuroendocrine hormones and metabolic peptides. The crosstalk between the hormones and the immune…

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