ACR Meeting Abstracts

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  • Abstract Number: 401 • 2014 ACR/ARHP Annual Meeting

    Association of Anti-Thyroid Autoantibodies with Fibromyalgia in Rheumatoid Arthritis

    Jowairiyya Ahmad1, Helena Blumen2, Claudene George3, Asha Shrestha4 and Clement Tagoe5, 1Geriatrics, Albert Einstein College of Medicine/Montefiore Medical Centre, Bronx, NY, 2Geriatrics, Albert Einstein College of Medicine, Bronx, NY, 3Geriatrics, Albert Einstein College of Medicine/Montefiore Medical centre, Bronx, NY, 4Rheumatology, Albert Einstein College of Medicine/Montefiore Medical Centre, Bronx, NY, 5Rheumatology, Albert Einsetin College of Medicine/Montefiore Medical Centre, Bronx, NY

    Background/Purpose Autoimmune thyroiditis has been linked independently with fibromyalgia and chronic widespread pain. We studied how the presence of autoimmune thyroiditis affects the clinical presentation…
  • Abstract Number: 400 • 2014 ACR/ARHP Annual Meeting

    Clinical Utility of 14-3-3η in the Evaluation of Inflammatory Arthritis

    Lance Feller1, Paul Tuttle IV2 and Terry L. Moore3, 1Rheumatology, Saint Louis University, St. Louis, MO, 2Rheumatology, Saint Louis University, Saint Louis, MO, 3Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO

    Background/Purpose 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…
  • Abstract Number: 399 • 2014 ACR/ARHP Annual Meeting

    Lipid Concentrations and Particle Sizes in Drug Naive Patients with Rheumatoid Arthritis

    Aulikki Kononoff1, Hannu Kautiainen2, Pasi Soininen3,4, Antti Kangas3,4, Leena Laasonen5, Leena Arstila1,6, Pia Elfving1, Elina Savolainen7, Helena Niinisalo8,9, Mika Ala-Korpela3,4,10,11 and Oili Kaipiainen-Seppanen1, 1Department of Medicine, Kuopio University Hospital, Kuopio, Finland, 2Unit of Primary Health Care, Kuopio University Hospital, Kuopio, Finland, 3Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland, 4NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland, 5Helsinki Medical Imaging Center, Helsinki University Hospital, Helsinki, Finland, 6Iisalmi Hospital, Iisalmi, Finland, 7Kuopio Municipal Hospital, Kuopio, Finland, 8Varkaus Hospital, Varkaus, Finland, 9Suonenjoki Health Center, Suonenjoki, Finland, 10Oulu University Hospital, Oulu, Finland, 11Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

    Background/Purpose Excess mortality attributed to cardiovascular causes has been described among patients with rheumatoid arthritis (RA). Atherosclerotic lipid profile has been reported in patients with…
  • Abstract Number: 418 • 2014 ACR/ARHP Annual Meeting

    Prevalence of Morning Stiffness in a US Registry Population of Rheumatoid Arthritis Patients

    Vibeke Strand1, Robert J. Holt2, Katherine C. Saunders3, Jeffery D. Kent4, Ping Xu5, Amy Y. Grahn4, Marc Mason3 and Carol J. Etzel6,7, 1Stanford University, Palo Alto, CA, 2University of Illinois - Chicago, Chicago, IL, 3Corrona, LLC., Southborough, MA, 4Horizon Pharma, Inc., Deerfield, IL, 5Axio Research LLC, Seattle, WA, 6PO Box 786, Corrona, LLC., Southborough, MA, 7Department of Epidemiology, UT MD Anderson, Houston, TX

    Background/Purpose : Morning stiffness is a symptom of rheumatoid arthritis (RA) that is frequently reported and thought to reflect disease activity, but its etiology is…
  • Abstract Number: 417 • 2014 ACR/ARHP Annual Meeting

    Normal Scores of “0” (floor effects) Are Seen in 33-83% of Patients with Rheumatoid Arthritis (RA) on 8 HAQ Activities Which Also Are Found on the MDHAQ, but in Fewer Than 32% of Patients on 2 Unique MDHAQ Complex Activities “Walk 2 Miles or 3 Kilometers,” and “Participate in Recreation and Sports.”

    Isabel Castrejón1, Martin J. Bergman2, Kathryn A. Gibson3, John Meyerhoff4 and Theodore Pincus1, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Taylor Hospital, Ridley Park, PA, 3Liverpool Hospital, Liverpool, Australia, 4Sinai Hospital, Baltimore, MD

    Background/Purpose: Patients with rheumatoid arthritis (RA) have significantly better clinical status in recent years compared with previous decades.1 Health assessment questionnaire (HAQ) scores were almost…
  • Abstract Number: 416 • 2014 ACR/ARHP Annual Meeting

    Using Patient Reported Outcome Measures to Classify Disease Activity States in Rheumatoid Arthritis: A Comparison of Patient-Derived Versions of Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI) and Disease Activity Score 28 (DAS28)

    Erin Carruthers1, Noura AL Osaimi2, Charles H Goldsmith3, Paul Adam4 and Diane Lacaille5, 1Arthritis Research Centre of Canada, Richmond, BC, Canada, 2Rheumatology, University of Ottawa, Ottawa, ON, Canada, 3Health Sciences, Simon Fraser University, Burnaby, BC, Canada, 4Mary Pack Arthritis Centre, Vancouver, BC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada

    Background/PurposeIn RA the target for treatment is clinical remission or minimal disease activity. Patient self- monitoring of disease activity may enhance treatment by providing early…
  • Abstract Number: 415 • 2014 ACR/ARHP Annual Meeting

    a Dual-Center, Double Blind Randomized Study for a New Scientific Approach in Assessment of Tender Joints in Inflammatory Arthritis Using the Smart Joint Assessor Glove Device (Smart JAG Device)

    Mohammad Khan1, Larry Willis2, Swapan Nath3, Cheryl Guest2, Lindsey Gillispie4 and Mary Jane Rorick4, 1Arthritis & Rheumatology Center of Oklahoma, Oklahoma City, OK, 2Research, Arthritis & Rheumatology Center of Oklahoma, PLLC, Oklahoma City, OK, 3Department of Pediatrics and Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Rheumatology, McBride Orthopedic Hospital, Oklahoma City, OK

    Background/Purpose Tender Joint Count (TJC) is a vital quality measure to assess the progression of Inflammatory Arthritis both from a therapeutic and a diagnostic standpoint.…
  • Abstract Number: 414 • 2014 ACR/ARHP Annual Meeting

    Relationship Between Range of Motion of Joints in Upper Limbs and Physical Function in Patients with Long-Standing Rheumatoid Arthritis: Multicenter Prospective Cohort Study for Evaluation of Joint Surgery on Physical Function

    Toshihisa Kojima1, Hajime Ishikawa2, Keiichiro Nishida3, Jun Hashimoto4, Hisaaki Miyahara5, Sakae Tanaka6, Nobuhiko Haga7, Yasuo Niki8, Masayo Kojima9 and Naoki Ishiguro1, 1Orthopaedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 2Orthopedic Surgery, Niigata Rheumatic Center, Niigata, Japan, 3Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama city, Japan, 4Immunology, National Hospital Organization, Osaka Minami Medical Center, Kawachinagano, Japan, 5Orthopedic Surgery, National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan, 6Orthopaedic Surgery and Spinal Surgery, The University of Tokyo Hospital, Tokyo, Japan, 7Rehabilitation Medicine, The University of Tokyo Hospital, Tokyo, Japan, 8Keio University School of Medicine, Tokyo, Japan, 9Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

    Background/Purpose Even now, in clinical practice, most of RA patients have long-standing disease and structural damage in their joints. Reconstructive joint surgery should be needed…
  • Abstract Number: 413 • 2014 ACR/ARHP Annual Meeting

    Association of Antinuclear Antibodies with Lung Disease, Malignancy and Joint Replacement in Rheumatoid Arthritis

    Reshmi Raveendran1, Bobby Kwanghoon Han2, Quan-Zhen Li3 and Nancy J. Olsen1, 1Medicine, Penn State MS Hershey Medical Center, Hershey, PA, 2Rheumatology, Cooper Medical School of Rowan University, Camden, NJ, 3Immunology, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose Antinuclear antibodies (ANAs) are present in a significant proportion of patients with rheumatoid arthritis (RA).  Positivity for ANA in RA has been associated with…
  • Abstract Number: 411 • 2014 ACR/ARHP Annual Meeting

    ABCB1 and ABCG2 Drug-Efflux Transporters Function and Its Association with Disease Activity in a Cohort of Patients with Rheumatoid Arthritis

    Yemil Atisha-Fregoso1, Hilda Fragoso-Loyo2, Juan Jakez-Ocampo3, Guadualupe Lima4, Miguel Baños2, Virginia Pascual-Ramos5, Irazu Contreras-Yañez2 and Luis Llorente6, 1Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, Mexico, 4Immunology and Rheumatology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubirán, Mexico City, Mexico, 5Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 6Immunology and Rheumatology Department, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico

    Background/Purpose ABCB1 (P-gp) and ABCG2 (BCRP) are part of the adenine triphosphate (ATP)-binding cassette (ABC) transporter proteins. These proteins mediate efflux of drugs from inside…
  • Abstract Number: 412 • 2014 ACR/ARHP Annual Meeting

    Determinants of Radiological Progression in Rheumatoid Arthritis: Relationship with Serum Levels of OPG, RANKL and DKK-1

    Carmen Gómez-Vaquero1, Irene Martín-Esteve1, Jose Ivorra2, Jose Antonio Narvaez3, Javier Hernandez Gañan3, Pedro Alia4 and Javier Narváez5, 1Rheumatology Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, 2Department of Rheumatology, Hospital Universitario y Politécnico La Fe., Valencia, Spain, 3Radiology Department, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, 4Clinical Laboratory Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, 5Rheumatology, Hospital Universitario de Bellvitge. Barcelona. Spain, Barcelona, Spain

    Background/Purpose: Osteoprotegerin (OPG), RANKL, and DKK-1 act as regulators of bone resorption and formation. The uncoupling of bone remodelling that occurs in rheumatoid arthritis (RA)…
  • Abstract Number: 410 • 2014 ACR/ARHP Annual Meeting

    Vascular Endothelial Function Changes during Treatment in Patients with Rheumatoid Arthritis

    Johana Zacariaz1, Eliana Lancioni1, Tomas Cazenave2, Florencia Marengo3, Emilce Edith Schneeberger2, Lucas Aparicio4, Margarita Morales4, Jorge Norscini5, Gabriel Waisman4, Javier Rosa6, Gustavo Citera3 and Enrique R. Soriano7, 1Rheumatology Unit, Internal Medicine Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Hypertension Section, Internal Medicine Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 5Neurology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 6Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 7Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina

    Background/Purpose: Rheumatoid Artrhitis (RA) patients have an increased risk for accelerated atherosclerosis. Endothelial dysfunction and arterial stiffness, assessed by measurement of carotid-femoral pulse wave velocity…
  • Abstract Number: 409 • 2014 ACR/ARHP Annual Meeting

    Soluble CD163 Is a Marker of Disease Activity in Early Rheumatoid Arthritis and Reflects TNFα Levels

    Stinne Greisen1, Holger Jon Møller2, Kristian Steengaard-Petersen3, Merete Lund Hetland4, Kim Hoerslev-Petersen5, Peter Junker6, Mikkel Ostergaard7, Malene Hvid1 and Bent Deleuran1, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4DANBIO, Center for Rheumatology and Spine Diseases, Glostrup University Hospital, Glostrup, Denmark, Glostrup, Denmark, 5Rheumatology, Research Unit at King Christian X Hospital for Rheumatic Diseases, Graasten, Denmark, 6Odense University Hospital, Odense, Denmark, 7Copenhagen University Hospital at Glostrup, Copenhagen, Denmark

    Background/Purpose Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and eventually destruction, where TNFa is a central mediator of both processes.…
  • Abstract Number: 408 • 2014 ACR/ARHP Annual Meeting

    14-3-3η Auto-Antibody Positivity Informs Better Clinical Outcomes in RA

    D. van Schaardenburg1, Mairead Murphy2, Samina Turk3, Walter P. Maksymowych4 and Anthony Marotta5, 1Jan van Breemen Research Institute, Amsterdam, Netherlands, 2Augurex Life Sciences Corp., North Vancouver, BC, Canada, 3Reade, Amsterdam, Netherlands, 4University of Alberta, Edmonton, AB, Canada, 51423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada

    Background/Purpose We have previously reported pilot data that patients who are only positive for 14-3-3η auto-antibodies (AAb) and negative for the 14-3-3η protein have a…
  • Abstract Number: 407 • 2014 ACR/ARHP Annual Meeting

    Serum 14-3-3η Protein Supplements Traditional Rheumatoid Arthritis Biomarkers

    Olga Zhukov1, Jonnielyn Rivera1, Charles M. Rowland2, Joanna M. Popov1 and Stanley J. Naides3, 1Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, 2Bioinformatics, Celera, Alameda, CA, 3Immunology, Quest Diagnostics, San Juan Capistrano, CA

    Background/Purpose: The 14-3-3 family of chaperonin proteins consists of 7 isomers.  The tissue distribution of the 14-3-3η (eta) isoform is limited to synovial tissue and…
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