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  • Abstract Number: 580 • 2014 ACR/ARHP Annual Meeting

    MRI Is Often Negative in Clinically Suspected Non-Radiographic Axial Spondyloarthritis

    M.L. John1, M.a.C. van der Weijden1,2, C.M.a. van der Bijl1, S.T.G. Bruijnen1, C.J. van der Laken1, M.T. Nurmohamed1,2 and I.E. van der Horst-Bruinsma1, 1Rheumatology, VU University Medical Center, Amsterdam, Netherlands, 2Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands

    Background/Purpose The diagnosis of ankylosing spondylitis (AS) is based on disease specific bone damage seen on plain radiography of the pelvis. Recent developments in magnetic…
  • Abstract Number: 599 • 2014 ACR/ARHP Annual Meeting

    Is There Any Gender Specific Difference in the Cut Off Values of Ankylosing Spondylitis Disease Activity Score (ASDAS) in Patients with Axial Spondyloarthritis?

    Erkan Kilic1, Gamze Kilic1 and Salih Ozgocmen2, 1Division of Rheumatology, Dept. PRM, Erciyes University, Faculty of Medicine, Kayseri, Turkey, 2Division of Rheumatology, Dept.PRM, Erciyes University, Faculty of Medicine, Kayseri, Turkey

    Background/Purpose Axial spondyloarthritis (ax-SpA) consisted patients with advanced axial SpA or ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-axSpA). Evaluation of disease activity in axSpA…
  • Abstract Number: 598 • 2014 ACR/ARHP Annual Meeting

    Anti-Drug Antibodies As a Predictor for the Discontinuation of Anti-TNF Agents in Patients with Spondyloarthrtis

    Jiwon Hwang1, In young Kim1, Seulkee Lee1, Hyemin Jeong1, Hyungjin Kim1, Jaejoon Lee2, Eun-mi Koh2 and Hoon-Suk Cha1, 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose : Tumor necrosis factor (TNF) blocking agent has shown to be effective in patients with axial spondyloarthritis (SpA) including ankylosing spondylitis (AS) as up…
  • Abstract Number: 564 • 2014 ACR/ARHP Annual Meeting

    Cardiovascular Events in Ankylosing Spondylitis. an Updated Meta-Analysis

    Sylvain Mathieu1 and Martin Soubrier2, 1Hopital Gabriel Montpied, Clermont Ferrand, France, 2Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France

    Background/Purpose: Rheumatoid arthritis is associated with increased cardiovascular risk. In the guidelines, ankylosing spondylitis (AS) is considered to have an equally high cardiovascular risk. The…
  • Abstract Number: 563 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Clinical Parameters and Quality of Life in Smokers with Ankylosing Spondylitis: Results from the Scotland Registry for Ankylosing Spondylitis

    Linda E. Dean1, Fabiola Azeni1,2, Tiara Ratz1, Alan G. MacDonald3, Roger D. Sturrock1,4, John Hunter5, David Marshall6, Gary J. Macfarlane1 and Gareth T. Jones1, 1Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 2Rheumatology Unit, L.Sacco University Hospital, Milan, Italy, 3Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Department of Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom, 6Department of Rheumatology, Inverclyde Royal Hospital, Greenock, United Kingdom

    Background/Purpose: Several studies have shown that smoking is associated with increased disease activity, worse physical function and poor quality of life in ankylosing spondylitis (AS). …
  • Abstract Number: 562 • 2014 ACR/ARHP Annual Meeting

    Clinical Response and Remission in Patients with Non-Radiographic Axial Spondyloarthritis after Three Years of Adalimumab Therapy

    Désirée M. van der Heijde1, Joachim Sieper2, Walter P. Maksymowych3, Dominique L. Baeten4, Yinglin Xia5, Jaclyn K. Anderson5 and Aileen L. Pangan5, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Charité Universitätsmedizin Berlin, Berlin, Germany, 3Department of Medicine, University of Alberta, Edmonton, AB, Canada, 4Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 5AbbVie Inc., North Chicago, IL

    Background/Purpose: Adalimumab (ADA) has been previously shown to be effective for the treatment of non-radiographic axial spondyloarthritis (nr-axSpA) patients (pts) in the ABILITY-1 trial.1 Week…
  • Abstract Number: 561 • 2014 ACR/ARHP Annual Meeting

    A Psychometric Analysis of Outcome Measures in Trials of Peripheral Spondyloarthritis

    Sofia Ramiro1, Maureen C. Turina2, Dominique L. Baeten3, Philip J. Mease4, Jacqueline E. Paramarta2, In-Ho Song5, Aileen L. Pangan6 and Robert Landewé7, 1Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center/University of Amsterdam, Amsterdam, Netherlands, 2Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 4Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, 5AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 6AbbVie Inc., North Chicago, IL, 7Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: We assessed the discriminatory aspects of disease activity measures and response criteria between adalimumab (ADA) and placebo (PBO) in 2 studies of patients (pts)…
  • Abstract Number: 560 • 2014 ACR/ARHP Annual Meeting

    High Sensitivity of the ASAS Classification Criteria in Patients with HLA-B27 Positive Undifferentiated Spondyloarthritis with Onset of Disease after Age 45

    Ignazio Olivieri1, Michele Gilio2, Salvatore D'Angelo1, Angela Padula1, Pietro Leccese1, Silvana Di Bello1, Norullah Akkoc3, Nicola Ferrara4 and Carlo Palazzi1, 1Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy, 2San Carlo Hospital, Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Potenza, Italy, 3Department of Internal Medicine, Division of Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, 4Department of Translational Medical Sciences, Federico II University, Naples, Italy

    Background/Purpose: The spondyloarthritis (SpA) complex also includes forms that do not meet criteria for the definite forms and are called undifferentiated SpA (uSpA). Recently the…
  • Abstract Number: 578 • 2014 ACR/ARHP Annual Meeting

    Female Patients but Not Male Patients with Ankylosing Spondylitis Are at Increased Risk of Developing Ischemic Heart Disease: A Population-Based Cohort Study

    Ivette Essers1,2, Carmen Stolwijk1,2, Annelies Boonen3,4, Marie L. De Bruin5, Marloes Bazelier5, Frank de Vries5,6,7,8 and Astrid Van Tubergen1,2, 1School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, 2Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 3Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 4Care and Public Health Research Institute, Maastricht University Medical Center, Maastricht, Netherlands, 5Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, 6Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center, Maastricht, Netherlands, 7MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, United Kingdom, 8Care and Public Health Research Institute, Maastricht University, Maastricht, Netherlands

    Background/Purpose: It is well recognized that rheumatoid arthritis is an independent risk factor for cardiovascular disease. For ankylosing spondylitis (AS), the literature on this risk…
  • Abstract Number: 577 • 2014 ACR/ARHP Annual Meeting

    A Substantial Decrease in Work Productivity and Physical Health-Related Quality of Life in Chronic Back Pain of Recent Onset: Data from the SPACE-Cohort

    A Roeterink1, M de Hooge2, R. van den Berg2, H Dagfinrud3, M Turina4, M. van Oosterhout5, D. van der Heijde1 and F van Gaalen2, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Oslo City Dept of Rheumat, Diakonhjemmet Hospital, Oslo, Norway, 4Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Groene Hartziekenhuis, Gouda, Netherlands

    Background/Purpose: Ankylosing spondylitis is associated with work productivity (WP) loss and a decreased health-related quality of life (HRQoL).  Little is known about WP loss and…
  • Abstract Number: 576 • 2014 ACR/ARHP Annual Meeting

    Dikkopf-1 (Dkk-1) Serum Levels in Axial Spondyloarthritis (axSpA) Are Related to Disease Duration

    Victoria Navarro-Compán1, Enrique Melguizo-Madrid2, Concepción González-Rodríguez3, Federico Navarro-Sarabia4 and Rafael Ariza-Ariza4, 1Rheumatology, University Hospital La Paz and Leiden University Medical Center, Madrid, Spain, 2Biochemistry, University Hospital Virgen Macarena, Sevilla, Spain, 3University Hospital Virgen Macarena, Sevilla, Spain, 4Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain

    Background/Purpose: Tumor necrosis factor (TNF) alpha is responsible for induction of dkk-1 which down-regulates bone formation. Therefore, it was expected that TNF-blocker therapy would inhibit…
  • Abstract Number: 575 • 2014 ACR/ARHP Annual Meeting

    Disease Activity Strongly Influences Work Productivity and Physical Health Related Quality of Life in Early Axial Spondyloarthritis: Data from the SPACE-Cohort

    A Roeterink1, M de Hooge2, R. van den Berg2, H Dagfinrud3, R Landewé4, M. van Oosterhout5, R Ramonda6, D. van der Heijde1 and F van Gaalen2, 1Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Oslo City Dept of Rheumat, Diakonhjemmet Hospital, Oslo, Norway, 4Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Groene Hartziekenhuis, Gouda, Netherlands, 6Rheumatology Unit, University of Padova, Padova, Italy

    Background/Purpose: In early onset axial spondyloarthritis (axSpA), not much is known about the relationship between disease activity and work productivity loss (WPL) or disease activity…
  • Abstract Number: 574 • 2014 ACR/ARHP Annual Meeting

    Do Extra-Articular Manifestations Influence Outcome in Ankylosing Spondylitis? a 12 Year Follow-up Study

    Ivette Essers1,2, Sofia Ramiro3,4, Carmen Stolwijk1,2, Marc Blaauw5, Robert Landewé6,7, Désirée M. van der Heijde8, Filip van Den Bosch9, Maxime Dougados10 and Astrid van Tubergen2,11, 1School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands, 2Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 3Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center/University of Amsterdam, Amsterdam, Netherlands, 4Rheumatology, Hospital Garcia de Orta, Almada, Portugal, 5Department of Internal Medicine, Catharina Hospital, Eindhoven, Netherlands, 6Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 7Rheumatology, Atrium Medical Center, Heerlen, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium, 10Rheumatology, Hopital Cochin, Descartes University, Paris, France, 11Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose: Extra-articular manifestations (EAMs), such as acute anterior uveitis (AAU), inflammatory bowel disease (IBD), and psoriasis contribute to diagnosis, classification criteria, and choice of treatment…
  • Abstract Number: 573 • 2014 ACR/ARHP Annual Meeting

    Three-Year Course and Prediction of Physical Functioning in Ankylosing Spondylitis Patients Treated with TNF-Inhibitors

    Salima F.E. van Weely1, Eva L. Kneepkens1, Mike T. Nurmohamed1, Joost Dekker1,2 and Irene E. van der Horst-Bruinsma3, 1Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 2Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 3Rheumatology, VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Currently, only limited information is available on the long-term course of limitations in physical functioning and spinal mobility in Ankylosing Spondylitis (AS) patients receiving…
  • Abstract Number: 572 • 2014 ACR/ARHP Annual Meeting

    Objective Evaluation of Physical Functioning after TNFi Therapy in Ankylosing Spondylitis Patients; A Selection of Three Feasible Performance-Based Tests

    Salima F.E. van Weely1, Joost Dekker1,2, Martijn P.M. Steultjens3, Christiaan J. Van Denderen1, Mike T. Nurmohamed1, Ben A.C. Dijkmans4 and Irene E. van der Horst-Bruinsma4, 1Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, 2Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, 3Institute for Applied Health Research and School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, 4Rheumatology, VU University Medical Centre, Amsterdam, Netherlands

    Background/Purpose: Physical functioning is considered an important outcome domain for the evaluation of the effectiveness of therapy and the course of the disease. In an effort…
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