Abstracts Archive - Page 2010 of 2425 - ACR Meeting Abstracts

Abstract Number: 622 • 2014 ACR/ARHP Annual Meeting
Gut Microbiota Variations Correlate with Disease Activity in Spondyloarthritis (SpA) and Rheumatoid Arthritis (RA)
Julien Tap^1,2, Jad Abou-Ghantous¹, Ariane Leboime³, Roula Said Nahal³, Philippe Langella¹, Henri-Jean Garchon⁴, Gilles Chiocchia⁵, Jean-Pierre Furet¹ and Maxime Breban^3,4, ¹UMR INRA-AgroParisTech 1319, Equipe ProbiHote, MICALIS Institute, National Institute for Agronomical research (INRA), Jouy-en-Josas, France, ²Metagenopolis, INRA, Jouy-en-Josas, France, ³Service de Rhumatologie, Hopital Ambroise Pare, Boulogne-Billancourt, France, ⁴INSERM U987, Faculté des Sciences de la Santé Simone Veil, Montigny-le-Bretonneux, France, ⁵Versailles Saint Quentin en Yvelines University, INSERM U987, UFR des Sciences de la Santé, Montigny-le-Bretonneux, France
Background/Purpose Inflammatory bowel diseases (IBD) are associated with changes in microbiota which may be responsible for sustained gut inflammation and/or a consequence of it. Whether…
Abstract Number: 621 • 2014 ACR/ARHP Annual Meeting
ERAP1 Knockdown Affects HLA-B27 Misfolding and Endoplasmic Reticulum Stress in HLA-B27 Transgenic Rat Macrophages
Sohee Hong and Robert A. Colbert, NIAMS/NIH, Bethesda, MD
Background/Purpose Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in the processing of peptide cargo for major histocompatibility complex (MHC) class I complexes,…
Abstract Number: 620 • 2014 ACR/ARHP Annual Meeting
Innate Immune Stimulation Triggers Altered IL-1a/b Gene Expression and Experimental Spondyloarthritis in HLA-B27/huβ2m Transgenic Rats
Melissa N. van Tok^1,2, Leonie M. van Duivenvoorde³, Nimman Satumtira⁴, Martha L. Dorris⁴, Joel D. Taurog⁴ and Dominique L. Baeten¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ³Experimental Immunology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX
Background/Purpose: Spondyloarthritis (SpA) does not display typical features of autoimmune diseases such as female predominance, presence of autoantibodies, or clinical response to T- and/or B…
Abstract Number: 639 • 2014 ACR/ARHP Annual Meeting
Lack of Response Gene to Complement-32 Impairs Th17 Differentiation and Attenuates Lupus-like Chronic Graft Versus Host Disease
Vinh Nguyen¹, Cosmin Tegla², Cornelia Cudrici³, Tudor Badea⁴, Horea Rus² and Violeta Rus¹, ¹Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ²Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ³Neurology, University of Maryland School of Medicine, Baltimore, MD, ⁴NIH, National Eye Institute, Bethesda, MD
Background/Purpose . Response Gene to Complement (RGC)-32 was cloned and characterized by our group as one of the genes induced by complement activation. It encodes…
Abstract Number: 638 • 2014 ACR/ARHP Annual Meeting
Commensal Microbiota Influence Systemic Autoimmune Responses
Jens Van Praet¹, Erin Donovan², Michael Drennan¹, Fons Van de Loo³, Sylvie Rabot⁴, Jeroen Raes⁵, Tom Van De Wiele⁶, Carl Ware⁷ and Dirk Elewaut⁸, ¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ²department of Rheumatology, Ghent University Hospital, ghent, Belgium, ³Rheumatology, Raboud University Medical Center, Utrecht, Netherlands, ⁴AgroParisTech, Micalis,, Jouy-en-Josas, France, ⁵Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium, ⁶Laboratory of Microbial Ecology and Technology, Ghent University Hospital, Ghent, Belgium, ⁷Infectious and Inflammatory Disease Center,, Sanford-Burnham Medical Research Institute, La Jolla, CA, ⁸Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose Antinuclear antibodies are a hallmark feature of generalized autoimmune diseases, including systemic lupus erythematosus and systemic sclerosis. However, the processes underlying the loss of…
Abstract Number: 637 • 2014 ACR/ARHP Annual Meeting
Decreased Inflammatory Dendritic Cells in Lupus-Prone Estrogen Receptor Alpha Knockout (ERαKO) Mice Correlate with Increased Survival
Melissa A. Cunningham¹, Jena R. Wirth², Jackie G. Eudaly³, Jennifer L. Scott⁴, Osama S. Naga³ and Gary S. Gilkeson⁵, ¹Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ²Med/Rheumatology, MUSC, Charleston, SC, ³Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: SLE is a disease that disproportionately affects females. The etiology of the sex bias in this disease is unclear. We previously showed that a…
Abstract Number: 636 • 2014 ACR/ARHP Annual Meeting
Liposomal-Glucocorticoids: A Novel Approach to the Therapy of SLE
Yaakov Naparstek¹, Eli Moallem², Rina Ulmansky³, Erez Koren³ and Yechezkel Barenholz³, ¹Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ²Dept. of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ³Hadassah - Hebrew University Medical Center, Jerusalem, Israel
Background/Purpose Glucocorticoids (GCs) have been known for years to be the most effective therapy in SLE. Their use is however limited by the need of…
Abstract Number: 635 • 2014 ACR/ARHP Annual Meeting
Mir-663 Impairs the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on MRL/Lpr Mice
Linyu Geng¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Previously we have shown that miR-663 was increased in bone marrow derived mesenchymal stem cells (BMSCs) from SLE patients and involved in the functional…
Abstract Number: 616 • 2014 ACR/ARHP Annual Meeting
In Situ Analysis of Mechanisms of New Bone Formation in Zygapophyseal Joints from Patients with Ankylosing Spondylitis
Janine Bleil¹, Joachim Sieper², Rene Maier³, Uwe Schlichting⁴, Axel Hempfing⁵, Heiner Appel⁶ and Uta Syrbe⁷, ¹Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Deutsches Rheumaforschungszentrum, Berlin, Germany, ⁴Department of Pathology, Charite, Berlin, Germany, ⁵Werner-Wicker-Klinik, Bad Wildungen, Germany, ⁶Rheumatology and Nephrology Practice, Hamm, Germany, ⁷Charité, Berlin, Germany
Background/Purpose Osteoproliferation leading to joint ankylosis is a characteristic feature of ankylosing spondylitis (AS). In general, there are two ways of bone formation: a) endochondral…
Abstract Number: 615 • 2014 ACR/ARHP Annual Meeting
Analysis of the Gut Transcriptome in HLA-B27 Transgenic Rats By RNA-Seq Reveals Prominent Interferon and IL-23/IL-17 Axis Signatures
Tejpal Gill¹, Mark Asquith², Steve Brooks¹, James T. Rosenbaum² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²OHSU, Portland, OR
Background/Purpose: Expression of HLA-B27 and human beta 2-microglobulin (hb2m) in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). SpA overlaps with IBD in…
Abstract Number: 614 • 2014 ACR/ARHP Annual Meeting
The Association of PPM1A with Inflammasome Activation in Ankylosing Spondylitis
Soo Min Ahn¹, Seung-Hyeon Bae¹, Seokchan Hong¹, Eun-Ju Lee¹, Eun-Jin Lee², Eun-Ju Chang², Doo-Ho Lim¹, Yong-Gil Kim¹, Chang-Keun Lee¹ and Bin Yoo¹, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
The Association of PPM1A with Inflammasome Activation in Ankylosing SpondylitisBackground/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disorder usually affecting axial skeleton and joints. The…
Abstract Number: 613 • 2014 ACR/ARHP Annual Meeting
The Amount of Free Heavy Chain and β2-Microglobulin in the Cytoplasm of B*2705 Ankylosing Spondylitis Patients Compared to B*2705 and B*2709 Healthy Subjects Does Not Support the UPR Theory. Influence of ERAP1 Polymorphisms
Alberto Cauli, Grazia Dessole, Giovanni Porru, Matteo Piga, Alessandra Vacca and Alessandro Mathieu, Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy
Background/Purpose : Ankylosing Spondylitis (AS) is a chronic inflammatory disease of the spine strongly associated with the majority of HLA-B27 alleles, with the exception of…
Abstract Number: 612 • 2014 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and beta1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seong-Wook Kang¹, Seung-Taek Song¹, Su-Jin Yoo², Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴, In-Seol Yoo², Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁴Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea
Background/Purpose Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 611 • 2014 ACR/ARHP Annual Meeting
Autophagy and Unfolded Protein Response: A Fine Balance That Can Influence the Pathogenesis of Ankylosing Spondylitis and Inflammatory Bowel Disease
Nigil Haroon¹, Giuliana Guggino², Zhenbo Zhang¹, Kirby Yee³, Hasan Abdullah⁴, Ricardo Alessandro⁵, Stefania Raimondo⁵, Giovanni Triolo⁵ and Francesco Ciccia², ¹Toronto Western Research Institute, Toronto, ON, Canada, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³McMaster University, Hamilton, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Palermo, Palermo, Italy
Background/Purpose We have shown an increase in the unfolded protein response (UPR) with decreased ERAP1 or ERAP2 function in an in vitrosystem. Similarly UPR has…
Abstract Number: 610 • 2014 ACR/ARHP Annual Meeting
Functional Implications of the Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Association with Ankylosing Spondylitis and Crohn’s Disease: Impact on the Unfolded Protein Response
Zhenbo Zhang¹, Francesco Ciccia², Kirby Yee³, Giuliana Guggino², Hasan Abdullah⁴, Ricardo Alessandro⁵, Stefania Raimondo⁵, Giovanni Triolo⁵ and Nigil Haroon^1,6,7, ¹Toronto Western Research Institute, Toronto, ON, Canada, ²Rheumatology Unit, University of Palermo, Palermo, Italy, ³McMaster University, Hamilton, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Palermo, Palermo, Italy, ⁶Rheumatology, University Health Network, Toronto, ON, Canada, ⁷Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) has found to be associated with AS and Crohn’s Disease (CD). The functional implications of this association have not…

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