Abstracts Archive - Page 2009 of 2607 - ACR Meeting Abstracts

Abstract Number: 2074 • 2015 ACR/ARHP Annual Meeting
Dominant Chilblain Lupus Due to an Activating Mutation of Sting – Suppression of Constitutive Type I Interferon Activation By JAK Inhibition
Christoph Fiehn¹, Nadja König², Christine Wolf², Mathias Lesche³, Andreas Dahl³, Claudia Guenther⁴, Hanns-Martin Lorenz⁵ and Min Ae Lee-Kirsch², ¹ACURA Centre for Rheumatic Diseases, Baden-Baden, Germany, ²Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ³Department of Dermatology, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, ⁴Biotechnology Center, Technische Universität Dresden, Dresden, Germany, ⁵Department of Internal Medicine 5, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
Background/Purpose: Familial chilblain lupus is a monogenic form of cutaneous lupus erythematosus caused by mutations in the nucleases TREX1 or SAMHD1. The adapter molecule stimulator…
Abstract Number: 2075 • 2015 ACR/ARHP Annual Meeting
A Unique Naturally-Occurring Regulatory T Cell Subset Associated with Disease Activity in Patients with Systemic Lupus Erythematosus
Tetsuya Nishimoto¹, Yuka Okazaki², Hironari Hanaoka¹, Tsutomu Takeuchi³ and Masataka Kuwana², ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ³Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Foxp3 is a lineage-specifying transcription factor for CD4+ regulatory T cells (Tregs), but recent studies have shown plasticity and heterogeneity within CD4+Foxp3+ cells, which…
Abstract Number: 2076 • 2015 ACR/ARHP Annual Meeting
Development of Lupus Nephritis: Preclinical Evaluation of Patients Who Subsequently Develop Systemic Lupus Erythematosus Demonstrate Elevation of Select Soluble Mediators Prior to and at Disease Classification in Patients with Nephritis
Melissa E. Munroe¹, Jourdan R. Anderson¹, Julie M. Robertson¹, Timothy B. Niewold², George C. Tsokos³, Michael P. Keith⁴, Joan T. Merrill⁵, Jill P. Buyon⁶, John B. Harley⁷ and Judith A. James⁸, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁴Walter Reed National Military Medical Center, Bethesda, MD, ⁵Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: SLE is a heterogeneous autoimmune disease marked by immune dysregulation and a spectrum of pathogenic autoantibodies. Why some patients have only moderate symptoms and…
Abstract Number: 2077 • 2015 ACR/ARHP Annual Meeting
Does Dysbiosis within the Intestinal Microbiome Contribute to SLE Pathogenesis?
Gregg J. Silverman¹, Lelise Getu², Haitao Niu³, Hanane El Bannoudi³, Adriana Heguy⁴, Alexander Alekseyenko⁵, Jill P. Buyon⁶ and Doua Azzouz³, ¹Dept of Medicine, NYU School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Medicine, NYU School of Medicine, New York, NY, ⁴Pathology, NYU School of Medicine, New York, NY, ⁵Medicine, NYU SChool of Medicine, New York, NY, ⁶Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is the archetypic systemic autoimmune disease, caused by a combination of genetic and environmental factors. Animal models in other inflammatory…
Abstract Number: 2078 • 2015 ACR/ARHP Annual Meeting
Reserve Capacity: Explaining the Link Between Socioeconomic Status and Depression/Anxiety Among Patients with Systemic Lupus Erythematosus
Desiree Azizoddin¹, Julia Ayeroff², Geraldine Zamora-Racaza³, Taylor Draper⁴, Sarah R. Ormseth⁵, Michael H. Weisman⁶, Lekeisha Sumner⁷ and Perry M. Nicassio⁸, ¹Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, CA, ²Postbaccalaureate Premedical Program, University of Southern California, Los Angeles, CA, CA, ³Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Psychology, Loma Linda University, Loma Linda, CA, ⁵Cousins Center for PNI, University of California, Los Angeles, Los Angeles, CA, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Department of Psychology,, Alliant University, Alhambra, CA, ⁸Cousins Center for PNI, UCLA, LA, CA
Background/Purpose: The purpose of this study was to assess the influence of socioeconomic status (SES) and measures of reserve capacity on depression and anxiety in…
Abstract Number: 2079 • 2015 ACR/ARHP Annual Meeting
Effectiveness of Renoprotective Approaches in Lupus Nephritis: More Than Just Immunosuppression
Maite Castro¹, Eduardo Ferreira Borba¹, Michelle Lopes¹, Sandra G. Pasoto², Eloisa Bonfá¹ and Luciana Seguro², ¹Rheumatology, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Hypertension and persistent proteinuria are risk factors for renal disease progression and are associated with high salt intake, poor adherence to medication and smoking.…
Abstract Number: 2080 • 2015 ACR/ARHP Annual Meeting
Teaching Fellows in Lupus: Rheumatology Fellows Are Successful Educators in Improving Lupus Recognition By Frontline Healthcare Providers
Amy Caron¹, S. Sam Lim², Lexi Rene³, Diane Gross⁴, Maria Dall'Era⁵, Rosalind Ramsey-Goldman⁶ and Amanda Sammut⁷, ¹Lupus Research Institute, New York City, NY, ²Emory University School of Medicine, Atlanta, GA, ³Rollins School of Public Health, Emory University, Atlanta, GA, ⁴S.L.E. Lupus Foundation/Lupus Research Institute, New York, NY, ⁵University of California San Francisco School of Medicine, San Francisco, CA, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Columbia University Medical Center and Harlem Hospital Center, New York, NY
Background/Purpose: The heterogeneity and non-specific features of lupus may delay diagnosis. This delay can lead to accrual of organ damage and an increased risk of…
Abstract Number: 2081 • 2015 ACR/ARHP Annual Meeting
The SLE Workshop: An Evaluation of a Long-Standing Hospital-Based Psychoeducational Program
Melissa T. Flores¹, Roberta Horton¹, Jillian A. Rose¹, Stephen A. Paget² and Michael Lockshin³, ¹Social Work Programs, Hospital for Special Surgery, New York, NY, ²Division of Rheumatology, Hospital for Special Surgery, New York, NY, ³Barbara Volcker Center for Women & Rheumatic Disease, Hospital for Special Surgery, New York, NY
Background/Purpose: An evaluation was conducted of a monthly hospital-based psychoeducational support group, ongoing since 1985, for people with lupus. Each 2-hour session begins with a…
Abstract Number: 2082 • 2015 ACR/ARHP Annual Meeting
Evaluations of Social Support Are Associated with Well-Being Outcomes in Women with Systemic Lupus Erythematosus (SLE)
Stacey E. Morrison¹, Monique A.M. Gignac², Paul R. Fortin³ and Dorcas Beaton⁴, ¹Div Rheumatology Rm MP-10-304, Toronto Western Hospital, Toronto, ON, Canada, ²Instititue for Work and Health, Toronto, ON, Canada, ³Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, ⁴Mobility Program Clinical Research Unit, St Michael's Hospital, Toronto, ON, Canada
Background/Purpose : Research on SLE and social support has often focused on the total amount of support provided. However, studies also report that some individuals…
Abstract Number: 2083 • 2015 ACR/ARHP Annual Meeting
Predictors of Health Perceptions Among Women with Lupus
Patricia P. Katz¹, Eliza Chakravarty², Robert S. Katz³ and Kaleb Michaud⁴, ¹Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Rush University Medical Center, Chicago, IL, ⁴Internal Medicine, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Health perceptions, such as self-rated health, have been shown to predict multiple adverse health outcomes and to have a strong socioeconomic status (SES) gradient. …
Abstract Number: 2084 • 2015 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Modulates Bone Resorption in Inflammatory Arthritis and Fracture Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li⁴, Michael Thullen², Brendan Boyce⁵, Christopher T. Ritchlin⁶ and Javier Rangel-Moreno⁷, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁷Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Osteoclasts (OC) direct pathologic bone resorption in osteoporosis and inflammatory arthritis. We previously demonstrated that DC-STAMP (Dendritic Cell-Specific Transmembrane protein), a 7-pass transmembrane protein,…
Abstract Number: 2085 • 2015 ACR/ARHP Annual Meeting
DC-STAMP Regulates Osteoclastogenesis through the Ca2+ /NFATc1 Axis
Yahui Grace Chiu¹, Dongge Li², Yue-Xin Xu³, Tzong-Ren Sheu⁴, Minsoo Kim⁵ and Christopher T. Ritchlin⁶, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ³Microbiology & Immunology, University of Rochester, Rochester, NY, ⁴Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ⁵Microbiology and Immunology, University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Osteoclasts (OC) are the only cell type known to erode bone. Many bone diseases including osteoporosis and arthritis are caused by excessive OC activity.…
Abstract Number: 2086 • 2015 ACR/ARHP Annual Meeting
Inhibition of Macrophage Inflammatory Protein 1-Alpha (CCL3) Significantly Reduced Bone Resorption in Vitro and the Development of Erosive Joint Pathology in Collagen-Induced Arthritis
Lauren A. Jordan¹, Ruth Davies¹, Alastair J. D. Robertson², Ann K. Harvey¹, Ernest H. Choy¹, Malin Erlandsson³, Maria I. Bokarewa⁴, Rachel J. Errington¹ and Anwen S. Williams¹, ¹Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, ²William Harvey Hospital, Willesborough, Ashford, United Kingdom, ³University of Goteborg, Goteborg, Sweden, ⁴Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose: The destruction of bone is a common feature of diseases like rheumatoid arthritis (RA) and multiple myeloma (MM). CCL3 is significantly elevated in the…
Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Julia F. Charles¹ and Joerg Ermann², ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
Abstract Number: 2088 • 2015 ACR/ARHP Annual Meeting
Immature Dendritic Are Potent OC Precursors in RA and Are Targeted By RA-Specific Antibodies
Akilan Krishnamurthy¹, Vijay Joshua², Heidi Wähämaa³, Vivianne Malmström³, Khaled Amara¹, Jimmy Ytterberg⁴ and Anca I Catrina³, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Immature dendritic cells (iDC) have been shown to act as OC precursors and are important cell players in the pathogenesis of RA. We aimed…

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