Abstracts Archive - Page 2008 of 2425 - ACR Meeting Abstracts

Abstract Number: 656 • 2014 ACR/ARHP Annual Meeting
Breach of B Cell Tolerance in New Zealand Black Chromosome 1 Congenic Mice
Kieran Manion^1,2, Nan-Hua Chang³, Yuriy Baglaenko^1,2 and Joan Wither^1,3, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ³Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Mapping studies in the lupus-prone New Zealand Black (NZB) mouse strain identified an interval from 170.8-181 Mb on chromosome 1 sufficient to induce B…
Abstract Number: 655 • 2014 ACR/ARHP Annual Meeting
Hydroxycholorquine Is Cardioprotective in an In Vivo Rat Model of Myocardial Ischaemic Reperfusion Injury
Lauren Bourke^1,2, Valerie Taylor³, James McCormick⁴, Charis Pericelous¹, John Franklin¹, Daniel Stuckey³, Mark Lythgoe⁵, Anastasis Stephanou⁶ and Yiannis Ioannou^2,7, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ³Centre for Advanced Biomedical Imaging (CABI), University College London, London, United Kingdom, ⁴Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ⁵Centre for Advanced Biomedical Imaging, Centre for Advanced Biomedical Imaging (CABI), University College London, London, United Kingdom, ⁶Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, ⁷Centre for Rheumatology Research, University College Hospital London, London, United Kingdom
Background/Purpose A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 654 • 2014 ACR/ARHP Annual Meeting
Type I Interferon Induces the Depletion and Dysfunction of Endothelial Progenitor Cells in Gld. ApoE-/- C57BL/6 Mice
Linyu Geng¹, Shiying Wang¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose To study whether the accelerated atherosclerosis in SLE is mediated by type I interferon (IFN-I) through the regulation of endothelial progenitor cells (EPCs) in…
Abstract Number: 653 • 2014 ACR/ARHP Annual Meeting
Dermal Injury Promotes Nephritis Flare in Lupus-Prone NZM2328 Mice
Kaitlyn Clark¹, Tamra J. Reed¹, Jeffrey B. Hodgin² and J. Michelle Kahlenberg³, ¹Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Pathology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus is an autoimmune disease with pleotropic manifestations, including severe skin disease, hematologic abnormalities and nephritis. Clinically, lupus is characterized by episodes…
Abstract Number: 652 • 2014 ACR/ARHP Annual Meeting
Identification of Eat-2 As a Lupus Susceptibility Gene in New Zealand Black (NZB) Mice That Regulates Dendritic Cell Function
Nafiseh Talaei¹ and Joan E. Wither², ¹Genetics and Development, Toronto Western Research Institute, Toronto, ON, Canada, ²1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: We have previously shown that B6 mice with an introgressed homozygous NZB chromosome (c) 1 interval (70 to 100 cM) develop high titres of…
Abstract Number: 651 • 2014 ACR/ARHP Annual Meeting
Inhibiting Tweak (TNF-like weak inducer of apoptosis) Signaling Improves Blood Brain Barrier Integrity and Protects from Neuronal Damage in Murine Neuropsychiatric Lupus
Jing Wen¹, Jessica Doerner¹, Ariel Stock², Jennifer Michaelson³, Linda Burkly³, Maria Gulinello² and Chaim Putterman⁴, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Biogen Idec, Cambridge, MA, ⁴The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: While neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is relatively common and appears early, the underlying mechanisms are not fully understood. The disruption of…
Abstract Number: 650 • 2014 ACR/ARHP Annual Meeting
Decreased Severity of Pristane Induced Lupus in miR155 Deficient Mice
Harald Leiss¹, Wilhelm Salzberger², Irina Gessl¹, Barbara Schwarzecker³, Nicolas Kozakowski⁴, Stephan Blüml¹, Antonia Puchner¹, Birgit Niederreiter³, Carl-Walter Steiner⁵, Josef Smolen³ and Georg H. Stummvoll², ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose MicroRNAs (miRs) are an important class of regulators of gene expression that are associated with a variety of biological functions. Deregulation of endogenous miR155…
Abstract Number: 649 • 2014 ACR/ARHP Annual Meeting
Enhance Translatability Using Multi-Modality Disease Evaluation Approach in Lupus Model
Jie Zhang-Hoover¹, Alan Byford¹, Mark Zielstorff¹, Robert Faltus², Joseph Eckman², Kimberly Bettano³, Gain Robinson³, Raquel Sevilla³, Bindu Bennet⁴, Lisa LaFranco-Scheuch⁴, Franklin Vives⁵, Michael Judo⁵, Gulesi Ayanoglu⁵, Weisheng Zhang³ and Milenko Cicmil², ¹Pharmacology, Merck Research Laboratories, Boston, MA, ²Merck Research Laboratories, Boston, MA, ³Imaging Group, Merck Research Laboratories, Boston, MA, ⁴SALAR-Pathology, Merck Research Laboratories, West Point, PA, ⁵Immunoassay Group, Merck Research Laboratories, Palo Alto, CA
Background/Purpose: Rodent models mimic some aspects of human lupus disease manifestations in various tissues, such as kidney, skin, joint, and CNS. NZB/NZW F1 and MRL/lpr…
Abstract Number: 648 • 2014 ACR/ARHP Annual Meeting
Influenza A (H1N1) Virus Infection Triggers Severe Pulmonary Inflammation in Lupus-Prone Mice Following Viral Clearance
Samantha Slight-Webb¹, Harini Bagavant¹, Sherry Crowe¹, Jourdan R. Anderson² and Judith A. James³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Each year, up to one fifth of the United States population is infected with influenza virus. Although mortality rates are low, hundreds of thousands…
Abstract Number: 647 • 2014 ACR/ARHP Annual Meeting
Helminthes Derivative for Treating Lupus and Colitis in Mice Models
Miri Blank¹, Tomer Bashi¹, Dana Ben-Ami Shor¹, Mati Fridkin², Iris Barshack³, Alexander Volkov⁴ and Yehuda Shoenfeld¹, ¹Zabludowicz Center for Autoimmune Diseases, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Organic Chemistry, Weizmann Institute for Sciences, Rehovot, Israel, ³Institute of Pathology, Sheba Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel, ⁴Institute of Pathology, Sheba Medical Center, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Tel-Aviv, Israel
Background/Purpose: In areas where helminthes infections are common, autoimmune diseases are rare. Treatment with ova from helminthes, improved clinical findings of inflammatory bowel disease and…
Abstract Number: 645 • 2014 ACR/ARHP Annual Meeting
The Combination of Metformin and 2-Deoxy-D-Glucose Normalizes CD4 T Cell Metabolism and Functions, and Reverse Disease in Murine Models of Lupus
Laurence Morel¹, Yiming Yin², Seung-Chul Choi², Eric S. Sobel³ and Byron Croker², ¹Pathology/Immunology/Lab Medical, University of Florida, Gainesville, FL, ²University of Florida, Gainesville, FL, ³Medicine/Div of Rheumatology, University of Florida, Gainesville, FL
Background/Purpose: Autoreactive CD4 T cells are key effectors in Systemic Lupus Erythematosus (SLE). Cell metabolism is an important checkpoint for T cell activationand differentiation. Both…
Abstract Number: 644 • 2014 ACR/ARHP Annual Meeting
HM-0523, a Novel Syk Inhibitor Blocks Glomerulonephritis and Extends Life Spans in Lupus Prone MRL/Lpr Mice
Yu Cai¹, Zhipeng Wu¹, Ping Ren¹, Xiaoming Dai¹, Jianlin He¹, Fang Yin¹, Wei Deng¹, Guangxiu Dai¹, Weiguo Su¹ and Xiong Li², ¹Hutchison Medipharma Limited, Shanghai, China, ²Building 4, 720 Cai Lun Road,, Hutchison Medipharma Limited, Shanghai, China
Background/Purpose: Syk is a key mediator of signaling events downstream of a wide array of receptors important for immune functions, including the B cell receptor,…
Abstract Number: 643 • 2014 ACR/ARHP Annual Meeting
The Effect of TNF Inhibition on the Autoreactive B Cell Repertoire in SLE Prone Mice
Anne Davidson, Weiqing Huang and Ranjit Sahu, Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY
Background/Purpose: TNF inhibitors are widely used for inflammatory diseases but often induce ANAs that sometimes progress to overt SLE. TNF deficient mice fail to generate…
Abstract Number: 642 • 2014 ACR/ARHP Annual Meeting
Treatment with a Glycolipid Ameliorates Lupus Dermatitis and Expands Skin ãä T Cells That Promote the Migration of Langerhans Dendritic Cells
Ram Raj Singh^1,2,3, Anna Eriksson¹, Darshan Randhawa¹ and Miguel-Angel Gutierrez¹, ¹Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, UCLA, Los Angeles, CA, ²Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, ³Interdepartmental Program in Molecular Toxicology, UCLA, Los Angeles, CA
Background/Purpose: Self antigens are taken from tissues to local lymphoid organs to acquire ability to avoid self-reactivity. This important immune function is accomplished by dendritic…
Abstract Number: 641 • 2014 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase Inhibition Mitigates NET Formation and Protects Against Kidney, Skin, and Vascular Disease in Lupus-Prone MRL/Lpr Mice
Jason S. Knight¹, Venkataraman Subramanian², Alexander A. O'Dell¹, Srilakshmi Yalavarthi¹, Wenpu Zhao³, Carolyne K. Smith³, Jeffrey B. Hodgin⁴, Paul Thompson² and Mariana J. Kaplan³, ¹Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²The Scripps Research Institute, Jupiter, FL, ³Systemic Autoimmunity Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Department of Pathology, University of Michigan, Ann Arbor, MI
Background/Purpose: An imbalance between neutrophil extracellular trap (NET) production and NET degradation has been observed in systemic lupus erythematosus (SLE), potentially contributing to autoantigen externalization,…

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