Abstracts Archive - Page 1992 of 2607 - ACR Meeting Abstracts

Abstract Number: 1819 • 2015 ACR/ARHP Annual Meeting
Comparison of Electrocardiographic ST-T Changes and QTc Duration in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Laura Geraldino-Pardilla¹, Yevgeniya Gartshteyn², Jon T. Giles³, Thania Perez⁴, Anca D. Askanase⁵ and Joan M. Bathon⁶, ¹Division of Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ²Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, ³Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Columbia University, College of Physicians & Surgeons, New York, NY, ⁵Department of Medicine Rhemuatology, Colombia University, New York, NY, ⁶Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose: Cardiovascular disease (CVD) is a leading cause of death in systemic lupus erythematosus (SLE) and in rheumatoid arthritis (RA). Longer corrected QT segments (QTc)…
Abstract Number: 1820 • 2015 ACR/ARHP Annual Meeting
Prevalence and Risk-Factors for Asymptomatic Coronary-Artery Calcifications in Young Patients with Systemic Lupus Erythematosus
Juanita Romero-Diaz¹, Rocio Moran-Contla², Eric Kimura-Hayama³, Sergio Criales-Vera³, Carlos Núñez-Álvarez², Roberto Ivan Acosta-Hernandez⁴, Mario César Ocampo-Torres⁵ and Jorge Sánchez-Guerrero⁶, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ²Instituto Nacional de Cs Medicas y Nutricion Salvador Zubiran, Mexico city, Mexico, ³Radiology Department, Instituto Nacional de Cardiologia, Mexico City, Mexico, ⁴Society for Worldwide Med Exchange, North Bay Village, FL, ⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁶Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: Premature atherosclerosis is a major cause of morbidity and mortality in females with systemic lupus erythematosus (SLE), but little is known about the frequency,…
Abstract Number: 1821 • 2015 ACR/ARHP Annual Meeting
Leptin, Adiponectin, and Resistin As Serum Markers of Fatigue in Systemic Lupus Erythematosus: A Pilot Study
Mary Mahieu¹, Grace Ahn², Joan S. Chmiel³, Dorothy D. Dunlop⁴, Irene Helenowski³, Pamela Semanik⁵, Jing Song⁴, Rowland W. Chang³ and Rosalind Ramsey-Goldman⁶, ¹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology, Falls Medical Specialists, Baltimore, MD, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Nursing, Rush University College of Nursing, Chicago, IL, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Fatigue, a common symptom in systemic lupus erythematosus (SLE) patients, is ameliorated by physical activity. Adiposity and adipokines may be associated with patient-reported fatigue.…
Abstract Number: 1822 • 2015 ACR/ARHP Annual Meeting
Pharmacokinetics of the Selective B-Cell Lymphoma-2 (Bcl-2) Inhibitor, ABT-199, in Female Subjects with Systemic Lupus Erythromatosus
Mukul Minocha¹, Shekman Wong², Jiewei Zeng², Peng Lu³, Jeroen Medema² and Ahmed Othman⁴, ¹Clinical Pharmacology and Pharmacometrics, AbbVie, North Chicago, IL, ²AbbVie Inc., North Chicago, IL, ³AbbVie Inc., Worcester, MA, ⁴AbbVie, North Chicago, IL
Background/Purpose: Selective Inhibition of Bcl-2 pathway may offer clinical efficacy in Systemic Lupus Erythromatosus (SLE) by restoring apoptosis in autoreactive cells, which may lead to…
Abstract Number: 1823 • 2015 ACR/ARHP Annual Meeting
Visceral Adiposity in Premenopausal Lupus Patients: Correlation with Systemic Inflammation
Luciana Seguro¹, Valéria Caparbo², Eloisa Bonfá¹ and Rosa M R Pereira³, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: SLE is associated with high prevalence of metabolic syndrome and obesity, which can be related to the high risk of cardiovascular events in this…
Abstract Number: 1824 • 2015 ACR/ARHP Annual Meeting
Tripterygium Wilfordii for the Treatment of Systemic Lupus Systematosus: Meta-Analysis of Randomized Controlled Trials
Yixia Ye¹, Bo Chen², Robert A. Kalish³ and Chenchen Wang⁴, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Orthopaedics and Traumatology, Shuguang Hospital affiliated to Shanghai University of T.C.M., Shanghai, China, ³Medicine, Tufts Medical Center, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Bosotn, MA
Background/Purpose: Tripterygium Wilfordii (TPW), a Chinese herbal medication, has been widely used in China for various chronic inflammatory and autoimmune diseases, including systemic lupus erythematosus…
Abstract Number: 1825 • 2015 ACR/ARHP Annual Meeting
Osteoprotegerin Is Associated with Lupus and with Coronary Artery Calcification
Indu Poornima¹, Kelly J. Shields², Susan Manzi³, Rosalind Ramsey-Goldman⁴, Carrie Richardson⁵, Lewis Kuller⁶, George Kondos⁷, James Carr⁵, Craig Langman⁵, Heather Price⁵, Daniel Edmundowicz⁸ and Rachel Mackey⁹, ¹Division of Cardiology, Allegheny Health Network, Pittsburgh, PA, ²Rheumatology, Allegheny Singer Research Institute, Pittsburgh, PA, ³Rheumatology, Allegheny Health Network, Pittsburgh, PA, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern University, Evanston, IL, ⁶Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁷University of Illinois in Chicago, Chicago, IL, ⁸Cardiology, Temple University School of Medicine, Philadelphia, PA, ⁹Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: In the general population, we and others have reported that higher osteoprotegerin (OPG), a protein involved in bone remodeling, is associated with higher levels…
Abstract Number: 1826 • 2015 ACR/ARHP Annual Meeting
Small LDL-P Increases with Increased Disease Activity in SLE
Laura Durcan¹, Deborah Winegar², Margery Connelly², James Otvos², Laurence S Magder³ and Michelle Petri¹, ¹Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ²LabCorp, Raleigh, NC, ³Epidemiology and Preventive Medicine, University of MD, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) associates with accelerated atherosclerotic cardiovascular (CV) disease which is not fully explained by traditional CV risk factors. Disease activity, prednisone…
Abstract Number: 1827 • 2015 ACR/ARHP Annual Meeting
Plasma Myeloperoxidase Levels Are Inversely Associated with Carotid Plaque in SLE
Maureen A. McMahon^1,2, Jennifer M. Grossman^3,4,5, Lori Sahakian^6,7, Elaine Lourenco⁸, John FitzGerald^9,10, Christina Charles-Schoeman³, Alan Gorn^3,10, Michael Weisman¹¹, Daniel J Wallace^12,13, Bevra H. Hahn^3,14 and Brian Skaggs³, ¹Div of Rheumatology, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ²Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ³Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ⁴Div of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁵Rheumatology, UCLA, Los Angeles, CA, ⁶Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ⁷Division of Rheumatology, Department of Medicine,, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁸UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ⁹Rheumatology, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ¹⁰Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ¹¹Rheumatology, Cedars-Sinai Medical Center, West Hollywood, CA, ¹²Division of Rheumatology, Cedars-Sinai Medical Center/David Geffen School of Medicine at UCLA, Los Angeles, CA, ¹³Cedars-Sinai Medical Center, West Hollywood, CA, ¹⁴Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA
Background/Purpose: : Women with SLE have increased risk of atherosclerosis (ATH) that is not adequately explained by traditional risk factors. We previously discovered that a…
Abstract Number: 1828 • 2015 ACR/ARHP Annual Meeting
Target Modulation of a Type I Interferon Gene Signature and Pharmacokinetics of Anifrolumab in a Phase IIb Study of Patients with Moderate to Severe Systemic Lupus Erythematosus
Philip Brohawn¹, Lingning Santiago², Chris Morehouse¹, Brandon Higgs¹, Gabor Illei¹ and Koustubh Ranade¹, ¹MedImmune, Gaithersburg, MD, ²MedImmune, Mountain View, CA
Background/Purpose: Anifrolumab is a fully human IgG1 monoclonal antibody directed against subunit 1 of the type I interferon receptor (IFNAR1). Anifrolumab blocks the binding of…
Abstract Number: 1829 • 2015 ACR/ARHP Annual Meeting
Heart Rate Variability Is Associated with SLE Flare and with TNF- and IFN-Mediated Signaling
Aikaterini Thanou¹, Stavros Stavrakis², John Dyer², Stan Kamp³, Melissa E. Munroe¹, David Albert⁴, Judith A. James⁵ and Joan T. Merrill³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Heart Rhythm Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴AliveCor, Inc., San Francisco, CA, ⁵Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Decreased heart rate variability (HRV), associated with adverse outcomes in cardiovascular diseases, is frequently seen in patients with SLE. The LF/HF ratio, a HRV…
Abstract Number: 1830 • 2015 ACR/ARHP Annual Meeting
Periodontal Disease in Lupus Erythematosus and Cardiovascular Risk Factors
Maria Cecilia Goizueta¹, Luciana Gonzalez Lucero¹, Maria Constanza Bertolaccini², Ramiro Maldonado¹, Raul Sueldo¹, Raul Nicolas Martinez¹, María Silvia Yacuzzi¹, Maximiliano Machado Escobar¹, Mirta Santana¹, Jose Rodriguez Skegro¹, Eugenia fatima del Valle Reynoso¹, Patricia Morales¹, Liliana Galindo¹, Veronica Bellomio¹ and Eleonora Lucero¹, ¹Hospital Angel Cruz Padilla, Tucumán, Argentina, ²Rheumatology, Hospital Angel Cruz Padilla, Tucumán, Argentina
Background/Purpose: The aim of this study was to determine the prevalence of periodontal disease (POD) in patients with Systemic Lupus Erythematosus (SLE) and its relationship with…
Abstract Number: 1831 • 2015 ACR/ARHP Annual Meeting
Initial Risk Factor Profile and Long-Term Cardiovascular Outcome in Women with Systemic Lupus Erythematosus
Konstantinos Tselios¹, Dafna Gladman², Jiandong Su², Olga Ace³, Arthy Sabapathy³, Anne MacKinnon³ and Murray Urowitz^4,5, ¹Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: We previously reported the influence of traditional and disease-related risk factors on the development of cardiovascular disease (CVD) in patients with systemic lupus erythematosus…
Abstract Number: 1832 • 2015 ACR/ARHP Annual Meeting
Recurrence-Rate of Thrombotic Events in SLE Patients Negative for Antiphospholipid Antibodies
Mohammed Attar¹, Jiandong Su², Stacey E. Morrison³, Samar Alharbi⁴, Khawla Al-Ghanim⁵, Dafna Gladman², Murray Urowitz^6,7 and Jorge Sánchez-Guerrero⁸, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Div Rheumatology Rm MP-10-304, Toronto Western Hospital, Toronto, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada, ⁵Rheumatology, TWH, Toronto, ON, Canada, ⁶University of Toronto, Toronto, ON, Canada, ⁷Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada
Background/Purpose: Thrombotic events (TE) are common in patients with SLE. Antiphospholipid antibodies (aPL) are a risk factor for incident and recurrent TE; therefore these patients…
Abstract Number: 1833 • 2015 ACR/ARHP Annual Meeting
Musculoskeletal Complications of Systemic Lupus Erythematosus: Risk Factors for and Prevalence of Avascular Necrosis and Osteoporosis
Maeve Gamble¹ and Janet E. Pope², ¹Medicine, University of Western Ontario, London, ON, Canada, ²University of Western Ontario, London, ON, Canada
Background/Purpose: Osteoporosis (OP) and avascular necrosis (AVN) are well-recognized musculoskeletal complications of systemic lupus erythematosus (SLE) and cause morbidity. Steroid therapy and the underlying disease…

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