Abstracts Archive - Page 1989 of 2425 - ACR Meeting Abstracts

Abstract Number: 956 • 2014 ACR/ARHP Annual Meeting
Real-World Validation of the Minimal Disease Activity Index in Psoriatic Arthritis: An Analysis from the Prospective, Observational, Biological Treatment Registry Across Canada
Proton Rahman¹, Saeed Shaikh², Michael Starr³, William Bensen⁴, Denis Choquette⁵, Wojciech Olszynski⁶, Maqbool Sheriff⁷, Michel Zummer⁸, Emmanouil Rampakakis⁹, John S. Sampalis⁹, Allen J Lehman¹⁰, Susan Otawa¹⁰, Francois Nantel¹¹, Vincent Letourneau¹¹ and May Shawi¹¹, ¹Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²McMaster University, Hamilton, ON, Canada, ³Montreal General Hospital, Montreal, QC, Canada, ⁴Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ⁵Rheumatology, Notre Dame Hospital, Montreal, QC, Canada, ⁶University of Saskatchewan, Saskatoon, SK, Canada, ⁷Nanaimo Regional General Hospital, Nanaimo, BC, Canada, ⁸Université de Montréal, Montreal, QC, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹¹Janssen Inc., Toronto, ON, Canada
Background/Purpose A definition of minimal disease activity (MDA) in PsA was derived from the opinion of 60 PsA experts including fulfillment of ≥5 of the…
Abstract Number: 955 • 2014 ACR/ARHP Annual Meeting
Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Pharmacodynamic Results of a Phase 3, Randomized, Controlled Trial
Peter Schafer¹, Peng Chen², Lorraine Fang², Andrew Wang² and Rajesh Chopra³, ¹Department of Translational Development, Celgene Corporation, Summit, NJ, ²Biostatistics, Celgene Corporation, Warren, NJ, ³Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose Apremilast (APR) is a phosphodiesterase 4 inhibitor that helps regulate the immune response that causes inflammation and skin disease associated with psoriatic arthritis (PsA).…
Abstract Number: 954 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Monoclonal Antibody to Interleukin-17A, Provides Significant and Sustained Inhibition of Joint Structural Damage in Active Psoriatic Arthritis Regardless of Prior TNF Inhibitors or Concomitant Methotrexate: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
Désirée van der Heijde¹, Robert B. M. Landewé², Philip J. Mease³, Iain B. McInnes⁴, Philip G. Conaghan⁵, Luminita Pricop⁶, Gregory Ligozio⁷, Hanno Richards⁸ and Shephard Mpofu⁹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ³Rheumatology Research, Swedish Medical Center, Seattle, WA, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁶Integrated Hospital Care (IHC) Franchise, Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Clinical Immunology / Dermatology, Novartis Pharma AG, Basel, Switzerland, ⁹Novartis Pharma AG, Basel, Switzerland
Background/Purpose Approximately two-thirds of patients (pts) with psoriatic arthritis (PsA) experience progressive joint damage associated with varying degrees of disability. Here we present the 1-year…
Abstract Number: 927 • 2014 ACR/ARHP Annual Meeting
Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 (TRPA1) Deficient Mice – a New Potential Role for TRPA1 in Gout
Lauri J Moilanen, Mari Hämäläinen, Lauri Lehtimäki, Riina Nieminen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
Background/Purpose: In the gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor…
Abstract Number: 926 • 2014 ACR/ARHP Annual Meeting
Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study
Feng Pan¹, Hussain Khan¹, Changhai Ding¹, Tania Winzenberg², Johanne Martel-Pelletier³, Jean-Pierre Pelletier³, Flavia Cicuttini⁴ and Graeme Jones¹, ¹Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia, ³Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada, ⁴Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Genetic factors appear to play an important role in the pathogenesis of both knee pain and radiographic osteoarthritis (OA) based on cross-sectional studies but…
Abstract Number: 925 • 2014 ACR/ARHP Annual Meeting
Cortical Reorganization after Duloxetine Treatment-Related Pain Decrease in Knee Osteoarthritis
Pascal Tetreault¹, Marwan Baliki¹, Etienne Vachon-Presseau¹, Renita Evonne Yeasted², Thomas J. Schnitzer³ and A. Vania Apkarian^1,4, ¹Physiology, Northwestern University, Chicago, IL, ²PM&R, Northwestern University, Chicago, IL, ³PM&R and Int Med, Northwestern University, Chicago, IL, ⁴Anaesthesia and Surgery, Northwestern University, Chicago, IL
Background/Purpose: Structural brain properties of patients coping with chronic painful conditions are becoming better understood but knowledge on how pain treatment affects these properties is…
Abstract Number: 924 • 2014 ACR/ARHP Annual Meeting
Characteristics of Pain Flares in Knee Osteoarthritis
Susan L. Murphy¹, Angela K. Lyden², Arnold Gammaitoni³, David A. Williams⁴, Daniel J. Clauw⁵, J. Ryan Scott⁶ and Kristine Phillips⁷, ¹Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ²Department of Anesthesiology, University of Michigan, Ann Arbor, MI, ³Zogenix, Inc, San Diego, CA, ⁴Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, ⁵Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ⁶Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: For inclusion in osteoarthritis clinical trials, participants often need to have a pain ‘flare’, usually defined as a pain increase over a period of…
Abstract Number: 923 • 2014 ACR/ARHP Annual Meeting
Phenotypes of Osteoarthritis-Related Knee Pain and Their Transitions over Time: The Osteoarthritis Initiative
Na Lu¹, Tuhina Neogi¹, K. Douglas Gross², Jingbo Niu³, Hyon K. Choi⁴ and Yuqing Zhang¹, ¹Boston University School of Medicine, Boston, MA, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: The WOMAC questionnaire is one of most commonly used instruments to assess knee pain in persons with or at risk of knee osteoarthritis (OA).…
Abstract Number: 922 • 2014 ACR/ARHP Annual Meeting
A Potential Role for TLR4 Activation in Osteoarthritis Associated Pain
Rachel E. Miller¹, Shingo Ishihara², Phuong Tran³, Richard J. Miller⁴ and Anne-Marie Malfait⁵, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Rheumatology, Rush University Medical Center, Chicago, IL, ⁴Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁵Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose - Damage associated molecular patterns (DAMPs) result from cellular stress and extracellular matrix breakdown. They may contribute to osteoarthritis (OA) pathogenesis by promoting synovitis…
Abstract Number: 921 • 2014 ACR/ARHP Annual Meeting
Comparison of Infection Rates in Patients Receiving Denosumab, Denosumab and Biologics and Biologics Alone in a Suburban Rheumatology Clinic
Sajina Prabhakaran¹ and Charles Pritchard², ¹Drexel Rheumatology, Drexel University College of Medicine, Philadelphia, PA, ²Drexel University College of Medicine, Willow Grove, PA
Background/Purpose: Biologics including rituximab, abatacept and belimumab increase the risk of infection in patients. Denosumab, a RANK-ligand inhibitor used in the treatment of osteoporosis may…
Abstract Number: 920 • 2014 ACR/ARHP Annual Meeting
Randomized Controlled Trial to Assess the Safety and Efficacy of Odanacatib in the Treatment of Men with Osteoporosis
Eric Orwoll¹, Silvano Adami², Neil Binkley³, Roland Chapurlat⁴, Bente Langdahl⁵, Steven Doleckyj⁶, Hilde Giezek⁷, Boyd Scott⁸ and Arthur Santora⁸, ¹Oregon Health and Science University, Portland, OR, ²Rheumatology Department, University of Verona, Verona, Italy, ³University of Wisconsin, Madison, WI, ⁴Pavillon F Rheumatology, Hopital Edouard Herriot, Lyon, France, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Merck & Co., Inc., Whitehouse Station, NJ, ⁷MSD Belgium, Brussels, Belgium, ⁸Merck Sharp & Dohme Corp., Whitehouse Station, NJ
Background/Purpose Osteoporosis in men is an important clinical problem, associated with significant morbidity, mortality and societal expense. Men with osteoporosis represent between 20 and 25%…
Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Sanjay Garg¹, Dipak R. Patel² and Raymond Yung³, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Internal Med-Univ Michigan, University of Michigan, Ann Arbor, MI
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…
Abstract Number: 938 • 2014 ACR/ARHP Annual Meeting
C1q Is Mandatory for Disease Development in Experimental Arthritis and Expression of Its Receptors Correlates with Disease Activity in Patients
Matthieu Ribon¹, Julie Mussard¹, Roxane Herve¹, Marina Botto², Marie-Christophe Boissier³ and Patrice Decker¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²Centre for Complement & Inflammation Research, Imperial College, London, United Kingdom, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose The complement system is a major effector mechanism of innate and adaptive immunity. It is activated in rheumatoid arthritis (RA) patients but the pathway…
Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting
A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis
W. Alexander Stinson¹, Phillip L. Campbell¹, Jeffrey Ruth², Gautam Edhayan², Ray A. Ohara², Nicholas Lepore³, Alisa E. Koch⁴, David A. Fox² and M. Asif Amin², ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
Abstract Number: 936 • 2014 ACR/ARHP Annual Meeting
Active Invasion of Periodontal Bacteria into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice
Sasanka Chukkapalli¹, Mercedes Rivera-Kweh¹, Irina Velsko¹, Indraneel Bhattacharyya², S. John Calise³, Edward Chan⁴, Minoru Satoh⁵ and Lakshmyya Kesavalu¹, ¹Periodontology, College of Dentistry, University of Florida, Gainesville, FL, ²Oral Diagnostic Sciences, College of Dentistry, University of Florida, Gainesville, FL, ³Oral Biology, University of Florida, Gainesville, FL, ⁴Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, ⁵Clinical Nursing, Univ. Occupational and Environmental Health, Kitakyushu, Fukuoka, FL, Japan
Background/Purpose: Periodontitis (PD) is a chronic immunoinflammatory disease caused by complex subgingival periodontal bacteria. Rheumatoid Arthritis (RA) and PD both are chronic inflammatory disorders characterized…

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