Abstract Number: 956 • 2014 ACR/ARHP Annual Meeting
Real-World Validation of the Minimal Disease Activity Index in Psoriatic Arthritis: An Analysis from the Prospective, Observational, Biological Treatment Registry Across Canada
Background/Purpose A definition of minimal disease activity (MDA) in PsA was derived from the opinion of 60 PsA experts including fulfillment of ≥5 of the…Abstract Number: 955 • 2014 ACR/ARHP Annual Meeting
Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Pharmacodynamic Results of a Phase 3, Randomized, Controlled Trial
Background/Purpose Apremilast (APR) is a phosphodiesterase 4 inhibitor that helps regulate the immune response that causes inflammation and skin disease associated with psoriatic arthritis (PsA).…Abstract Number: 954 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Monoclonal Antibody to Interleukin-17A, Provides Significant and Sustained Inhibition of Joint Structural Damage in Active Psoriatic Arthritis Regardless of Prior TNF Inhibitors or Concomitant Methotrexate: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study
Background/Purpose Approximately two-thirds of patients (pts) with psoriatic arthritis (PsA) experience progressive joint damage associated with varying degrees of disability. Here we present the 1-year…Abstract Number: 927 • 2014 ACR/ARHP Annual Meeting
Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 (TRPA1) Deficient Mice – a New Potential Role for TRPA1 in Gout
Background/Purpose: In the gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor…Abstract Number: 926 • 2014 ACR/ARHP Annual Meeting
Does a Family History of Total Knee Replacement for Knee Osteoarthritis Influence Knee Pain and Structural Progression? a Prospective Longitudinal Cohort Study
Background/Purpose: Genetic factors appear to play an important role in the pathogenesis of both knee pain and radiographic osteoarthritis (OA) based on cross-sectional studies but…Abstract Number: 925 • 2014 ACR/ARHP Annual Meeting
Cortical Reorganization after Duloxetine Treatment-Related Pain Decrease in Knee Osteoarthritis
Background/Purpose: Structural brain properties of patients coping with chronic painful conditions are becoming better understood but knowledge on how pain treatment affects these properties is…Abstract Number: 924 • 2014 ACR/ARHP Annual Meeting
Characteristics of Pain Flares in Knee Osteoarthritis
Background/Purpose: For inclusion in osteoarthritis clinical trials, participants often need to have a pain ‘flare’, usually defined as a pain increase over a period of…Abstract Number: 923 • 2014 ACR/ARHP Annual Meeting
Phenotypes of Osteoarthritis-Related Knee Pain and Their Transitions over Time: The Osteoarthritis Initiative
Background/Purpose: The WOMAC questionnaire is one of most commonly used instruments to assess knee pain in persons with or at risk of knee osteoarthritis (OA).…Abstract Number: 922 • 2014 ACR/ARHP Annual Meeting
A Potential Role for TLR4 Activation in Osteoarthritis Associated Pain
Background/Purpose - Damage associated molecular patterns (DAMPs) result from cellular stress and extracellular matrix breakdown. They may contribute to osteoarthritis (OA) pathogenesis by promoting synovitis…Abstract Number: 921 • 2014 ACR/ARHP Annual Meeting
Comparison of Infection Rates in Patients Receiving Denosumab, Denosumab and Biologics and Biologics Alone in a Suburban Rheumatology Clinic
Background/Purpose: Biologics including rituximab, abatacept and belimumab increase the risk of infection in patients. Denosumab, a RANK-ligand inhibitor used in the treatment of osteoporosis may…Abstract Number: 920 • 2014 ACR/ARHP Annual Meeting
Randomized Controlled Trial to Assess the Safety and Efficacy of Odanacatib in the Treatment of Men with Osteoporosis
Background/Purpose Osteoporosis in men is an important clinical problem, associated with significant morbidity, mortality and societal expense. Men with osteoporosis represent between 20 and 25%…Abstract Number: 939 • 2014 ACR/ARHP Annual Meeting
Prenatal Methyl-Rich Diet Decreases Inflammation in Collagen Induced Arthritis
Background/Purpose: Early-life nutrition can have a profound effect on late-life disease development. Most current studies focus on macro-nutrition (calorie, carbohydrate, fat, and protein), and much…Abstract Number: 938 • 2014 ACR/ARHP Annual Meeting
C1q Is Mandatory for Disease Development in Experimental Arthritis and Expression of Its Receptors Correlates with Disease Activity in Patients
Background/Purpose The complement system is a major effector mechanism of innate and adaptive immunity. It is activated in rheumatoid arthritis (RA) patients but the pathway…Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting
A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…Abstract Number: 936 • 2014 ACR/ARHP Annual Meeting
Active Invasion of Periodontal Bacteria into Synovial Joint Exacerbates Collagen-Induced Arthritis in Disease-Prone B10 Riii Mice
Background/Purpose: Periodontitis (PD) is a chronic immunoinflammatory disease caused by complex subgingival periodontal bacteria. Rheumatoid Arthritis (RA) and PD both are chronic inflammatory disorders characterized…