Abstracts Archive - Page 1987 of 2607 - ACR Meeting Abstracts

Abstract Number: 1743 • 2015 ACR/ARHP Annual Meeting
Gender Differences in Ankylosing Spondylitis: Men Derive Greater Benefit from Tumor Necrosis Factor Alpha Inhibitors
Jennifer Mandal¹, Michael M. Ward², Michael Weisman³, Jillian Simard⁴, Matthew A. Brown⁵, MinJae Lee⁶, Mohammad H. Rahbar⁷, John D. Reveille⁸ and Lianne S. Gensler⁹, ¹Medicine, University of California San Francisco, San Francisco, CA, ²NIH/NIAMS, Bethesda, MD, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵The University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, ⁷The University of Texas Health Science Center at Houston, Houston, TX, ⁸Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Ankylosing spondylitis (AS) manifests differently in men and women. Women with AS have less severe radiographic disease, yet tend to report more severe symptoms.…
Abstract Number: 1744 • 2015 ACR/ARHP Annual Meeting
Free DKK-1 Serum Levels Are Unchanged in Spondyloarthritis Patients Treated By Etanercept
Corinne Miceli-Richard¹, Bernard Combe², Francis Berenbaum³, Thierry Schaeverbeke⁴, Maria Dilleen⁵, Nandan Koppiker⁶, Isabelle Logeart⁷, Arnaud Dubanchet⁷ and Maxime Dougados⁸, ¹Rhuematology, Cochin Hospital, Paris Descartes University, Paris, France, ²Rheumatology, Hopital Lapeyronie, Montpellier, France, ³Rheumatology and Paris VI University, Saint-Antoine Hospital, Paris, France, ⁴Rheumatology, CHU Bordeaux, Bordeaux, France, ⁵Pfizer GIPB, Sandwich, United Kingdom, ⁶Pfizer PGRD, Sandwich, United Kingdom, ⁷Pfizer, Paris, France, ⁸Paris-Descartes University, Paris, France
Background/Purpose: DKK-1 and SOST are two inhibitory proteins of the Wnt signaling pathway that lead to decreased bone formation by osteoblasts and osteocytes, respectively. Functional…
Abstract Number: 1745 • 2015 ACR/ARHP Annual Meeting
Predictors of Sustained Remission on Anti-TNF in an Observational Cohort of Patients with Ankylosing Spondylitis: The Role of MRI Parameters of Inflammation and Structural Damage
Susanne Juhl Pedersen¹, Stephanie Wichuk², Praveena Chiowchanwisawakit³, Zheng Zhao⁴, Sasha Bernatsky⁵, Robert GW Lambert⁶, Barbara Conner-Spady⁷, Don Spady⁸ and Walter Maksymowych⁹, ¹Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark, ²Department of Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ³Rheumatology, Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Rheumatology, Chinese PLA General Hospital, Beijing, China, ⁵Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, ⁶Department of Radiology & Diagnostic Imaging, Radiology, University of Alberta, Edmonton, AB, Canada, ⁷Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ⁸Medicine, University of Alberta, Edmonton, AB, Canada, ⁹Medicine/Rheumatic Dis Unit, Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Sustained clinical remission is one of the key benchmarks for treatment of AS over the long term. We aimed to determine the factors predictive…
Abstract Number: 1746 • 2015 ACR/ARHP Annual Meeting
Patient’s Ability of Coping Is Influencing the Correlation Between Clinical and Ultrasonographic Evidence of Disease Activity in Psoriatic Arthritis
Brigitte Michelsen¹, Andreas P Diamantopoulos^1,2, Hilde Berner Hammer³, Dag Magnar Soldal⁴, Arthur Kavanaugh⁵ and Glenn Haugeberg^1,6,7, ¹Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ²Rheumatology, Haugesund Hospital for Rheumatic Diseases, Haugesund, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, ⁵University of California, San Diego School of Medicine, LaJolla, CA, ⁶Rheumatology, Martina Hansens Hospital, Gjettum, Norway, ⁷Rheumatology, The Norwegian University of Science and Technology, Trondheim, Norway
Background/Purpose: Coping may be defined as the set of adaptive processes a patient uses to live well with aspects of disease such as pain. Coping…
Abstract Number: 1747 • 2015 ACR/ARHP Annual Meeting
Predictors of Survival on Anti-TNF in an Observational Cohort of Patients with Ankylosing Spondylitis: The Role of MRI Parameters of Inflammation and Structural Damage
Walter Maksymowych¹, Zheng Zhao², Stephanie Wichuk¹, Praveena Chiowchanwisawakit³, Robert G Lambert⁴, Sasha Bernatsky⁵, Barbara Conner-Spady¹, Donald Spady¹ and Susanne Juhl Pedersen⁶, ¹Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Chinese PLA General Hospital, Beijing, China, ³Rheumatology, Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ⁴Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Rheum/Clin. Epid., McGill MUHC/RVH, Montreal, QC, Canada, ⁶Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: There has been no data reported evaluating MRI parameters of inflammation and structural damage. We aimed to identify factors influencing survival on anti-TNF therapy…
Abstract Number: 1748 • 2015 ACR/ARHP Annual Meeting
Degenerative Changes at the Lumbar Spine in Patients with Axial Spondyloarthritis and Non-Specific Mechanical Low Back Pain: A Magnetic Resonance Imaging Study
Serkan Senol¹, Gamze Kilic², Sevgi Baspinar², Erkan Kilic³ and Salih Ozgocmen⁴, ¹Division of Neuroradiology, Erciyes University, Faculty of Medicine, Radiology, Kayseri, Turkey, ²Dept. PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ³Dept PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ⁴Dept.PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey
Background/Purpose: Magnetic resonance imaging (MRI) has become an invaluable tool for early diagnosis of axial spondyloarthritis (axSpA) and several MRI-based studies have identified SpA-related inflammatory…
Abstract Number: 1749 • 2015 ACR/ARHP Annual Meeting
Clinical Characteristics of Axial Spondyloarthritis Patients Progressing from Non-Diagnostic to Diagnostic Radiographic Sacroiliitis
Ismail Sari¹, Jonathan Chan², Ahmed Omar¹, Mohamed Bedaiwi¹, Nigil Haroon¹ and Robert D Inman³, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Rheumatology, Spondylitis program, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³Immunlogy and Institute of Medical Science, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the axial skeleton in which the diagnosis includes diagnostic X-ray changes in the…
Abstract Number: 1750 • 2015 ACR/ARHP Annual Meeting
Identification of Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) That Causes Systemic Lupus Erythematosus (SLE) As DOCK8+ CD4 T Cell: Proof of Concept of Self-Organized Criticality Theory
Shunichi Shiozawa¹, Yumi Miyazaki², Kazuko Shiozawa³ and Ken Tsumiyama², ¹Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ²Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ³Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan
Background/Purpose: We have shown that repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4 T…
Abstract Number: 1751 • 2015 ACR/ARHP Annual Meeting
Modulation of IRF4 Function Promotes Expansion of Effector Tregs in Lupus
Alessandra B. Pernis¹, Uma Chandrasekaran², Woelsung Yi², Sanjay Gupta³, Chien-Huan Weng⁴, Eugenia Giannopoulou², Yurii Chinenov⁵, Govind Bhagat⁶, Rolf Jessberger⁷ and Casey Weaver⁸, ¹Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ⁴Weill Cornell Medical College, New York, NY, ⁵Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁶Department of Pathology & Cell Biology, Columbia University, New York, NY, ⁷Dresden University of Technology, Dresden, Dresden, Germany, ⁸University of Alabama, Birmingham, AL
Background/Purpose: Acquisition of an effector phenotype is critical for Treg function in chronic inflammatory settings such as those encountered in autoimmune diseases like lupus. Although…
Abstract Number: 1752 • 2015 ACR/ARHP Annual Meeting
Characterization of Epitopes Identified with Cerebral Vasculature Injury
Melissa Butts¹, Jess Edison¹, Christopher Tracy¹, Brian Stout¹, Huazhen Chen² and Chantal Moratz², ¹Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ²Medicine, Uniformed Services University School of Health Sciences, Bethesda, MD
Background/Purpose: There is an association between natural antibodies, such as anti-phospholipid antibodies, and vasculature injury in stroke and in SLE models of systemic ischemic damage. …
Abstract Number: 1753 • 2015 ACR/ARHP Annual Meeting
Response Gene to Complement-32 Promotes Plasma Cell Differentiation and Enhances Lupus-like Chronic Graft Versus Host Disease
Vinh Nguyen¹, Alexandru Tatomir², Armugam Mekala³, Horea Rus⁴ and Violeta Rus⁵, ¹Medicine, University of Maryland Schoole of Medicine, Baltimore, MD, ²Neurology, University of Maryland School of Medicine, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD, ⁴Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ⁵Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD
Background/Purpose: Response Gene to Complement (RGC)-32 is an intracellular protein initially discovered in rat oligodendrocytes in response to complement activation. It plays a role in…
Abstract Number: 1754 • 2015 ACR/ARHP Annual Meeting
BANK1 Controls the Development of SLE By Modulating TLR7 Signaling and Type I IFN-Induced Translation Initiation Pathway in B Cells
Ying-Yu Wu¹, Ramesh Kumar², Harini Bagavant¹ and Marta E. Alarcon Riquelme³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma Cty, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK
Background/Purpose: BANK1 is a susceptibility gene for SLE, and we have shown that stimulation of TLR9 agonist leads to a reduction in the activation of…
Abstract Number: 1755 • 2015 ACR/ARHP Annual Meeting
The Lymphotoxin/Megakaryoblastic Leukemia 1/Actin Axis As a Master Regulator of TLR Signaling in Lupus
John D. Mountz¹, Jun Li², Jennie Hamilton³, PingAr Yang⁴, Qi Wu⁵, Bao Luo⁶, Yanna Ding³, Hao Li⁶, David Crossman⁷, Erik Malarkey⁸, Yong Zhou², Yang-Xin Fu⁹ and Hui-Chen Hsu⁵, ¹Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL, ²Medicine, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁸Cell, Development, and Integrated Biology, University of Alabama at Birmingham, Birmingham, AL, ⁹Department of Pathology, The University of Chicago, Chicago, IL
Background/Purpose: Marginal zone macrophages (MZMs) of the spleen are essential for rapid and tolerogenic clearance of apoptotic cells (ACs). MZMs are decreased in two…
Abstract Number: 1756 • 2015 ACR/ARHP Annual Meeting
The Oxidative Burst Mediates Anti-Inflammatory Clearance of Dead Cells in a Mouse Model of SLE and Inflammatory Arthritis
Jonas Hahn¹, Deborah Kienhöfer¹, Luis Munoz¹, Martin Herrmann², Gerhard Krönke³, Rikard Holmdahl⁴, Georg Schett⁵ and Markus Hoffmann¹, ¹Medicine III, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medicine III, Rheumatology and Immunology, University of Erlangen-Nuremberg, Osterreich, Germany, ³Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Background/Purpose: The production of reactive oxygen species (ROS) via the oxidative burst has recently been implicated in regulation of inflammation and protection from arthritis, multiple…
Abstract Number: 1757 • 2015 ACR/ARHP Annual Meeting
Absence of Estrogen Receptor Alpha Is Protective Against Nephrotoxic Serum-Induced Nephritis
Chelsea Corradetti¹, Neelakshi Jog², Michael Madaio³ and Roberto Caricchio⁴, ¹Temple University, Philadelphia, PA, ²Rheumatology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Medicine, Medical College of Georgia, Augusta, GA, ⁴Medicine, Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Glomerulonephritis (GN) is one of the most serious manifestations of systemic lupus erythematous (SLE). Lupus GN is characterized by severe inflammation and necrosis and…

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