Abstract Number: 972 • 2014 ACR/ARHP Annual Meeting
Racial, Gender and Geographic Differences in Systemic Lupus Erythematous and Lupus Nephritis Mortality Rates in the Unites States, 1968-2010
Title: Racial, Gender and Geographic Differences in Systemic Lupus Erythematous and Lupus Nephritis Mortality Rates in the Unites States, 1968-2010Background/Purpose: Many epidemiologic studies of systemic…Abstract Number: 970 • 2014 ACR/ARHP Annual Meeting
Risk of Developing Antiphospholipid Syndrome Following Infection: A Systematic Review and Meta-Analysis of Observational Studies
Background/Purpose: Infection has been increasingly reported in the literature as an environmental trigger inducing the development of anti-phospholipid antibodies or antiphospholipid syndrome in genetically predisposed…Abstract Number: 971 • 2014 ACR/ARHP Annual Meeting
The Long-Term Efficacy of an Anti-Pneumococcal Polysaccharide Vaccine (PPSV23, Pneumovax) Among Autoimmune Inflammatory Rheumatic Patients
Background/Purpose: Vaccination with Pneumovax is recommended for adult patients with auto-immune inflammatory rheumatic diseases (AIIRD). Re-vaccination is recommended after 5 years in this population although…Abstract Number: 969 • 2014 ACR/ARHP Annual Meeting
Caspase-8 Prevents Lung Fibrosis in a Murine SSc-like Disease Model By Preventing Macrophage Differentiation
Background/Purpose Pulmonary fibrosis has emerged as the leading cause of death in patients with Systemic Sclerosis (SSc). Currently available therapies are only marginally effective in…Abstract Number: 968 • 2014 ACR/ARHP Annual Meeting
Priming of WNT Signalling during Fibrosis Is Mediated By TGF-β Induced Axin-2 Downregulation
Background/Purpose Systemic Sclerosis (SSc) is characterized by autoimmune activation, vasculopathy and tissue fibrosis. Recently, activation of the Wnt/β-catenin signaling pathway in SSc fibroblasts has been…Abstract Number: 966 • 2014 ACR/ARHP Annual Meeting
Adiponectin Is an Endogenous Anti-Fibrotic and Target in Systemic Sclerosis: Novel Link Between Fibrosis and Metabolism
Background/Purpose :Systemic sclerosis (SSc) skin fibrosis is associated with attenuated cutaneous adipose tissue and adipogenic gene expression. Levels of the adipose-derived cytokine adiponectin (APN) and…Abstract Number: 965 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR4 Signaling By TAK242 Ameliorates Experimental Organ Fibrosis
Background/Purpose Our recent studies implicate innate immune signaling through Toll like receptor 4 (TLR4) in scleroderma pathogenesis. Aberrant production and accumulation of the endogenous TLR4…Abstract Number: 964 • 2014 ACR/ARHP Annual Meeting
Skin Collagen Synthesis Rates Distinguish Between Early and Late Diffuse Scleroderma Patients
Background/Purpose The synthesis and degradation of extracellular matrix (ECM), particularly collagen, is one of the central mechanisms perturbed in scleroderma (SSc). Understanding the kinetics of…Abstract Number: 962 • 2014 ACR/ARHP Annual Meeting
A Systematic Review and Network Meta-Analysis of the Risk of Serious Infections with Immunosuppressives for Lupus Nephritis
Background/Purpose To compare the risk of serious infections of immunosuppressive medications used for the treatment of lupus nephritis. Methods We performed an up to date…Abstract Number: 979 • 2014 ACR/ARHP Annual Meeting
Genome-Wide Association Study for Severe Radiographic Knee Osteoarthritis
Background/Purpose Knee osteoarthritis (OA) is a heritable common joint disorder. In previously reported genetic studies, cases were usually defined with a radiographic Kellgren and Lawrence…Abstract Number: 978 • 2014 ACR/ARHP Annual Meeting
Socioeconomic Status Measures Are Associated with Increasing Pain, Stiffness and Physical Function Among Individuals with Knee and Hip Osteoarthritis
Background/Purpose The determinants of disability progression (DP) among those with knee and/or hip osteoarthritis (OA) are not well known. Our aim was to explore whether…Abstract Number: 963 • 2014 ACR/ARHP Annual Meeting
Reduction in Proteinuria and Normalization of C4 Complement Levels Predict Response to Treatment of Lupus Nephritis with Low-Dose Pulse Cyclophosphamide and Abatacept
Background/Purpose: The response to treatment of lupus nephritis is unpredictable. There is a need to identify clinical and biochemical characteristics that can predict treatment outcome…Abstract Number: 967 • 2014 ACR/ARHP Annual Meeting
Mir-145 Protects Against Skin Fibrosis in Vivo by targeting TGF-β Signaling
Background/Purpose In vitro, miR-145 exerts anti-fibrotic effects in systemic sclerosis (SSc) by downregulating TGF-β signaling. In turn, ectopic TGF-β downregulates miR-145 thereby optimizing TGF-β signaling…Abstract Number: 953 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Human Anti–Interleukin-17A Monoclonal Antibody, Improves Active Psoriatic Arthritis and Inhibits Radiographic Progression: Efficacy and Safety Data from a Phase 3 Randomized, Multicenter, Double-Blind, Placebo-Controlled Study
Background/Purpose Secukinumab has demonstrated significant and rapid efficacy in the treatment of psoriasis in two phase 3 studies. We present the first randomized, multicenter, double-blind,…Abstract Number: 952 • 2014 ACR/ARHP Annual Meeting
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Multicenter Study to Evaluate the Efficacy and Safety of Clazakizumab, an Anti-IL-6 Monoclonal Antibody, in Adults with Active Psoriatic Arthritis
Background/Purpose: New treatment options for psoriatic arthritis (PsA) are needed and interleukin-6 (IL-6), a cytokine with a central role in chronic inflammation, is a potential…
ACR Meeting Abstracts