Abstract Number: 998 • 2014 ACR/ARHP Annual Meeting
β2 Adrenoceptor Signal Is Augmented in B Cells in the Course of Arthritis to Increase IL-10
Background/Purpose Splenic B cells from collagen-induced arthritis (CIA) mice react to a β2-adrenoceptor (AR) stimulus with increased IL-10 production and adoptive transfer of these cells…Abstract Number: 997 • 2014 ACR/ARHP Annual Meeting
Explore Translational Pharmacokinetics/Pharmacodynamics Response/Efficacy Relationship of a Novel Bruton’s Tyrosine Kinase Inhibitor in Rat Collagen-Induced Arthritis Model
Background/Purpose: Abnormal B cell activation is an essential part of autoimmune inflammation. B cell depletion is proven to be an efficacious treatment in patients as…Abstract Number: 996 • 2014 ACR/ARHP Annual Meeting
Memory B Cell Subtype Modulation in Patients with Rheumatoid Arthritis
Background/Purpose . Memory B cells have been shown to play important roles in the pathogenesis of rheumatoid arthritis (RA). With the advent of B cell…Abstract Number: 995 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients Have Alterations in Inherently Autoreactive 9G4+ B-Cell Subpopulations in Peripheral Blood
Background/Purpose B-cells utilizing the VH-region immunoglobulin gene VH4-34 produce natural autoreactive antibodies. The rat monoclonal antibody 9G4 recognizes B-cells with VH4-34-encoded B-cell receptors (9G4+ B-cells)…Abstract Number: 994 • 2014 ACR/ARHP Annual Meeting
IL-7 Modulates B Cell Immunoglobulin Isotype Production and Increases B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Synovial Fibroblasts from Osteoarthritis (OA) and Rheumatoid Arthritis (RA) Patients
Background/Purpose Interleukin(IL)-7 is increased in synovial fluid from rheumatoid arthritis (RA) patients as compared to osteoarthritis (OA) patients and has been attributed a proinflammatory role,…Abstract Number: 993 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Proteins Antibodies Promote Synovial Fibroblast Migration in Rheumatoid Arthritis
Background/Purpose The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with aggressive disease phenotype and bone destruction. As synovial fibroblasts (SFs) are considered…Abstract Number: 992 • 2014 ACR/ARHP Annual Meeting
Differential Antigen-Presenting B-Cell Phenotype from Synovial Microenvironment of Rheumatoid Arthritis and Psoriatic Arthritis Patients
Background/Purpose The systemic depletion of B cells induced by mabthera, a monoclonal antibody against human CD20, has shown to be an effective therapy for controlling…Abstract Number: 991 • 2014 ACR/ARHP Annual Meeting
The Alternative CD20 Transcript Variant Is Not a Factor for Resistance to Rituximab in Patients with Rheumatoid Arthritis
Background/Purpose: the identification of predictive factors for the response, or alternatively factors for resistance to biological agents is a relevant goal in the management of…Abstract Number: 961 • 2014 ACR/ARHP Annual Meeting
Outcome of Lupus Nephritis and Impact on Health Related Quality of Life: Results from an International, Prospective, Inception Cohort Study
Background/Purpose: Improved immunosuppressive therapies have changed the treatment of lupus nephritis (LN) over the past decade. We examined the outcome of LN with current standard…Abstract Number: 960 • 2014 ACR/ARHP Annual Meeting
Allogeneic Mesenchymal Stem Cell Transplantation for Lupus Nephritis Patients Refractory to Conventional Therapy
Background/Purpose Allogeneic mesenchymal stem cell transplantation (MSCT) has been shown to be clinically efficacious in the treatment of various autoimmune diseases. Here we analyzed the…Abstract Number: 977 • 2014 ACR/ARHP Annual Meeting
Randomized Clinical Trial of a Patient and Provider Intervention for Managing Osteoarthritis in Veterans
Background/Purpose: Adequate management of osteoarthritis (OA) requires both medical and behavioral strategies. However, some recommended therapies are under-utilized in clinical settings, and there is low…Abstract Number: 976 • 2014 ACR/ARHP Annual Meeting
Measurement Properties of the Health Assessment Questionnaire Disability Index (HAQ-DI) in Patients with Generalized Osteoarthritis (GOA)
Background/Purpose: The involvement of multiple joints is common in osteoarthritis (OA), often referred to as generalized OA (GOA). Individuals with GOA typically suffer from limitations…Abstract Number: 975 • 2014 ACR/ARHP Annual Meeting
Chronic Pain Predicts Reduced Physical Activity in a Large Population Cohort Study
Background/Purpose: Chronic musculoskeletal pain (CP) is associated with reduced levels of physical activity (PA), however few studies have examined the prospective nature of CP on…Abstract Number: 974 • 2014 ACR/ARHP Annual Meeting
Obesity Paradox in Osteoarthritis Progression – What Effects Are We Measuring?
Background/Purpose: While obesity is a well-established risk factor for incident knee osteoarthritis (OA), it has a null association with OA progression. Among various potential explanations…Abstract Number: 973 • 2014 ACR/ARHP Annual Meeting
Relation of Pelvic Drop during Walking to Risk of Incident Medial Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Background/Purpose: During walking, the contralateral pelvis tends to drop as the weight bearing limb enters midstance. If excessive, pelvic drop (PD) can result in increased…
ACR Meeting Abstracts