Abstract Number: 1020 • 2014 ACR/ARHP Annual Meeting
Changes in Peripheral Blood Immune Cell Composition in Osteoarthritis
Background/Purpose: Healthy ageing and the occurrence of the common age-related disease osteoarthritis (OA) result from varying degrees of interaction between many determinants (genetic, lifestyle). Immuno-senescence…Abstract Number: 1019 • 2014 ACR/ARHP Annual Meeting
Targeting the Bone-Driven Metabolic OA Phenotype By a Novel Dual Amylin Calcitonin Receptor Agonist, KBP-056
Background/Purpose: Osteoarthritis (OA) may be segregated into different disease phenotypes based on disease drivers; cartilage damage, joint inflammation or subchondral bone remodelling. Each phenotype may…Abstract Number: 1018 • 2014 ACR/ARHP Annual Meeting
Monolayer Culture Induced the Expression of Zyxin-Related Protein 1 (ZRP-1), αvβ3 integrin Complex and Leptin in Human Articular Chondrocytes
Background/Purpose During Osteoarthritis (OA), chondrocytes loose their initial anabolic properties, undergoing morphological and biochemical modifications similar to those encountered during chondrocyte dedifferentiation. However, the molecular…Abstract Number: 989 • 2014 ACR/ARHP Annual Meeting
Fcgamma Receptor IIb Facilitates Rapid Internalisation of Rituximab (type 1 anti-CD20 antibody) in B Cells from Patients with RA and SLE and Contributes to Less Efficient B Cell Lysis Than Type 2 Anti-CD20 Antibodies, in Vitro
Background/Purpose Incomplete B-cell depletion using rituximab (RTX) is associated with poor clinical response in some individuals with RA and SLE, in particular. However, the precise…Abstract Number: 988 • 2014 ACR/ARHP Annual Meeting
Serum CXCL13 As a Biomarker of Disease Activity and Severity in Rheumatoid Arthritis: Comparison with Acute Phase Reactants and the Autoantibody Profile
Background/Purpose The B cell chemoattractant CXCL13 has recently emerged as a new candidate biomarker of disease activity capable of identifying patients with persistent synovitis and…Abstract Number: 987 • 2014 ACR/ARHP Annual Meeting
Novel Auto-Antigen in Aortic Aneurysms of Large Vessel Vasculitis
Background/Purpose Large Vessel Vasculitides (LVV) are a group of autoimmune diseases characterized by injury and anatomic modifications of large vessels that may include the aorta…Abstract Number: 986 • 2014 ACR/ARHP Annual Meeting
Integrated Comprehensive Analysis of Immune Cell Subsets and Serum Protein Profile Identifies the Role of Pre-Germinal Center B Cells in Sjogren’s Syndrome Pathogenesis
Background/Purpose Whole blood flow cytometric analysis and serum protein profiling were commonly utilized to characterize disease-specific alterations in a wide variety of autoimmune diseases. However,…Abstract Number: 985 • 2014 ACR/ARHP Annual Meeting
Labial Salivary Gland Antibody-Secreting Cell Specificity and Characteristics in Sjögren’s Patients
Background/Purpose Studies were approved by the OMRF and the University of Oklahoma Health Sciences Center Institutional Review Boards. Samples and data were obtained from 9…Abstract Number: 984 • 2014 ACR/ARHP Annual Meeting
Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease
Background/Purpose Borrelia burgdorferi-induced autoimmunity in affected joints has been hypothesized to be a contributing factor to antibiotic-refractory Lyme arthritis (ARLA). Our prior study, which combined…Abstract Number: 983 • 2014 ACR/ARHP Annual Meeting
Identification of Annexin A2 As an Autoantigen in Rheumatoid Arthritis and in Lyme Arthritis
Background/Purpose Disease-associated HLA-DR molecules are the greatest genetic risk factor for rheumatoid arthritis (RA) and for antibiotic-refractory Lyme arthritis (LA). We have developed a novel…Abstract Number: 982 • 2014 ACR/ARHP Annual Meeting
Identification of Potential SERUM Autoantibody Biomarkers in Rheumatic Diseases Using a New Generation of Protein Arrays
Background/Purpose Osteoarthritis (OA) is characterized by the loss of structural components from the extracelullar matrix (ECM) of articular cartilage. The progressive release of proteins from…Abstract Number: 981 • 2014 ACR/ARHP Annual Meeting
The Effect of Compression Gloves in Hand Osteoarthritis: A Pre-Post-Test Trial
Background/Purpose: Compression gloves are used in Hand Osteoarthritis (HOA) to reduce pain (day and/or night), stiffness and improve hand function. A systematic review identified only…Abstract Number: 980 • 2014 ACR/ARHP Annual Meeting
Annual Medical Care Expenditures Among US Adults with Osteoarthritis, 2008 – 2011
Background/Purpose: As the US population ages, concerns continue to grow about the cost of medical treatment for osteoarthritis (OA). We estimated all-cause medical care expenditures…Abstract Number: 1000 • 2014 ACR/ARHP Annual Meeting
Pathogenic Role of CXC Chemokine receptor 3-Positive B Cells in Bone Destruction of Rheumatoid Arthritis
Background/Purpose ：B cells can function as potent effector cells by production of autoantibody, immune complex formation and inflammatory cytokines. Clinical efficacy of B-cell depletion therapy…Abstract Number: 999 • 2014 ACR/ARHP Annual Meeting
Microrna-155 As an Epigenetic Regulator of B-Cell Activation in Rheumatoid Arthritis: In Vivo and in Vitro Evidences
Background/Purpose: MicroRNAs (miRs) are a novel class of post-transcriptional regulators. miR-155 was shown to be a regulator of B cell biology in haematological diseases as…
ACR Meeting Abstracts